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Search Results: 1 - 10 of 2078 matches for " Masahiko Hashimoto "
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Microfluidic Behavior of Ternary Mixed Carrier Solvents Based on the Tube Radial Distribution in Triple-Branched Microchannels in a Microchip  [PDF]
Naoya Jinno, Masahiko Hashimoto, Kazuhiko Tsukagoshi
Journal of Analytical Sciences, Methods and Instrumentation (JASMI) , 2012, DOI: 10.4236/jasmi.2012.22010
Abstract: Microfluidic behavior of ternary mixed carrier solvents of water-acetonitrile-ethyl acetate (2:3:1 volume ratio) was examined by use of a microchip incorporating microchannels in which one wide channel was separated into three narrow channels, i.e., triple-branched microchannels. When the ternary carrier solution containing the fluorescent dyes, hydrophobic perylene (blue) and relatively hydrophilic Eosin Y (green), was fed into the wide channel under laminar flow conditions, the carrier solvent molecules or fluorescence dyes were radially distributed in the channel, forming inner (organic solvent-rich major; blue) and outer (water-rich minor; green) phases in the wide channel. And then, in the narrow channels, perylene molecules mostly appeared to flow through the center narrow channel and Eosin Y, which is distributed in the outer phases in the wide channel, flowed through the both side narrow channels. A metal ion, Cu(II) as a model, dissolved in the ternary mixed carrier solution was also examined. The Cu(II) showed fluidic behavior, transferring from the homogeneous carrier solution to the water-rich solution in the side narrow channels through the triple-branched microchannels.
Experiments and Considerations through the Phase Diagram in Open Tubular Capillary Chromatography Based on Tube Radial Distribution of Ternary Mixed Solvents Using a Fused-Silica Capillary Tube  [PDF]
Yusuke Tanigawa, Naoya Jinno, Masahiko Hashimoto, Kazuhiko Tsukagoshi
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.34041
Abstract: Capillary chromatography using an untreated open tubular capillary tube and a ternary solvent mixture consisting of water-hydrophilic/hydrophobic organic solvent as a carrier solution has been developed. The system is called tube radical distribution chromatography (TRDC). Separation performance of the TRDC system using a fused-silica capillary tube was examined through the phase diagram for the ternary water-acetonitrile-ethyl acetate solvent mixture. The TRDC system required homogeneous carrier solutions with solvent component ratios around the boundary curve between homogeneous and heterogeneous solution in the phase diagram. The data obtained using the fused-silica capillary tube were compared with those obtained using a polytetrafluoroethylene capillary tube in our previous study.
Mechanism of Case Processing in the Brain: An fMRI Study
Satoru Yokoyama, Hideki Maki, Yosuke Hashimoto, Masahiko Toma, Ryuta Kawashima
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040474
Abstract: In sentence comprehension research, the case system, which is one of the subsystems of the language processing system, has been assumed to play a crucial role in signifying relationships in sentences between noun phrases (NPs) and other elements, such as verbs, prepositions, nouns, and tense. However, so far, less attention has been paid to the question of how cases are processed in our brain. To this end, the current study used fMRI and scanned the brain activity of 15 native English speakers during an English-case processing task. The results showed that, while the processing of all cases activates the left inferior frontal gyrus and posterior part of the middle temporal gyrus, genitive case processing activates these two regions more than nominative and accusative case processing. Since the effect of the difference in behavioral performance among these three cases is excluded from brain activation data, the observed different brain activations would be due to the different processing patterns among the cases, indicating that cases are processed differently in our brains. The different brain activations between genitive case processing and nominative/accusative case processing may be due to the difference in structural complexity between them.
The odor stick identification test for Japanese differentiates Parkinson's disease from multiple system atrophy and progressive supra nuclear palsy
Masahiko Suzuki, Masaya Hashimoto, Masayuki Yoshioka, Maiko Murakami, Keiichi Kawasaki, Mitsuyoshi Urashima
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-157
Abstract: We assessed the olfactory function using the OSIT-J test in 94 Japanese patients with idiopathic PD, 15 with MSA-P, 7 with PSP, and 29 age-matched control subjects.The mean ± SD score of OSIT-J in patients with PD (4.4 ± 2.9) was significantly lower than in patients with MSA-P (8.7 ± 2.2, P < 0.0001), PSP (7.6 ± 2.2, P < 0.0057), and control subjects (10.5 ± 1.3, P < 0.0001). The area under the curve (AUC) of receiver operating characteristic (ROC) to discriminate PD from normal control using OSIT-J scores was 0.97 (95% confidence interval, 0.95-1.00), from MSA-P 0.87 (0.80-0.95), and from PSP 0.81 (0.66-0.96).The OSIT-J is a potentially useful clinical test not only for detection of olfactory deficit in PD but also for differentiating PD from MSA-P and PSP.Olfactory dysfunction is recognized as a non-motor symptom in idiopathic Parkinson's disease (PD), and is a maker for preclinical diagnosis of PD based on the appearance of pathological changes in the olfactory system before the development of motor symptoms [1]. A recent study indicated that the early appearance of impaired olfaction prior to other clinical features of PD could be a useful screening tool to detect those at high risk for the development of PD in later life [2]. In fact, several Japanese researchers employ the 12-odorant test, the Odor Stick Identification Test for Japanese (OSIT-J) in the clinical testing of PD [3-5] and have reported their findings of dysosmia and that it did not correlate with motor function, disease duration, or medication, indicating that OSIT-J scores are independent of all other measures in PD [3,4]. In addition to the practice in Japan, the results of the University of Pennsylvania 12 smell identification test (UPSIT), which is also a smell identification test [6-8], indicate that OSIT-J is a short and simple noninvasive test that is potentially useful clinically for detecting early-stage PD.The diagnosis of PD is based on clinical criteria, the accuracy of such diagnosis
Left hepatic trisectionectomy for hilar cholangiocarcinoma presenting with an aberrant biliary duct of segment 5: a case report
Nobuhisa Akamatsu, Yasuhiko Sugawara, Masahiko Komagome, Takashi Ishida, Nobuhiro Shin, Narihiro Cho, Fumiaki Ozawa, Daijo Hashimoto
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-250
Abstract: A 56-year-old Asian female initially presented with intrahepatic bile duct dilatation in the left lateral sector, left paramedian sector, and right paramedian sector. Simultaneous cholangiography from a percutaneous transhepatic biliary drainage tube in biliary duct of segment 8 and endoscopic nasobiliary drainage tube in biliary duct of segment 3 revealed drainage of the right lateral sectoral branch into the common hepatic duct and the aberrant drainage of segment 5 into the right lateral sectoral branch. The left hepatic duct, right paramedian sectoral duct, and the confluence of the right lateral sectoral duct were narrowed. Left hepatic trisectionectomy was successfully performed with careful dissection and division of the aberrant biliary duct of segment 5.For safe liver resection, it is important to perform a detailed anatomic evaluation of the intrahepatic ducts, both preoperatively and intraoperatively.Advances in surgical procedures for liver resections and partial liver transplantation have led to the need for a better, more detailed understanding of biliary anatomy and potential variations to perform a safe operation. Management of the biliary ducts during liver resection is one of the most important challenges for hepatobiliary surgeons. The biliary anatomy is variable: 24% to 57% of individuals have variant biliary patterns [1-6]. Most variant cases involve right-lobe drainage that typically arises from an anomalous insertion of the right lateral sectoral duct (draining Couinaud's segments 6 and 7) into the left hepatic duct, common hepatic duct, or common bile duct, among others [1-5].We recently experienced a case of a Klatskin tumor with rare biliary anatomy that, to our knowledge, has not been reported previously, and we present the case herein.A 56-year-old Asian woman was admitted to our hospital for bile-duct dilatation in the left lateral sector, left paramedian sector, and the right paramedian sector. First, an endoscopic nasobiliary drainage
Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report
Nobuhisa Akamatsu, Yasuhiko Sugawara, Masahiko Komagome, Takashi Ishida, Nobuhiro Shin, Narihiro Cho, Fumiaki Ozawa, Daijo Hashimoto
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-283
Abstract: A 38-year-old Asian man was referred to our hospital with complaints of severe abdominal distension and pancytopenia. Examinations at the first visit revealed a right liver hemangioma occupying the abdominal cavity, protruding into the right diaphragm up to the right thoracic cavity and extending down to the pelvic cavity, with a maximum diameter of 43 cm, complicated with "asymptomatic" Kasabach-Merritt syndrome. Based on the tumor size and the anatomic relationship between the tumor and hepatic vena cava, primary resection seemed difficult and dangerous, leading us to first perform transcatheter arterial embolization to reduce the tumor volume and to ensure the safety of future resection. The tumor volume was significantly decreased by two successive transcatheter arterial embolizations, and a conventional right trisectorectomy was then performed without difficulty to resect the tumor.To date, there have been several reports of aggressive surgical treatments, including extra-corporeal hepatic resection and liver transplantation, for huge hemangiomas like the present case, but because of its benign nature, every effort should be made to avoid life-threatening surgical stress for patients. Our experience demonstrates that a pre-operative arterial embolization may effectively enable the resection of large hemangiomas.Liver hemangiomas are the most common benign liver tumors, with a prevalence of 5 to 20%. Most hemangiomas are small and require no treatment or only follow-up. However, giant hemangiomas, having a diameter of more than 4 cm or 5 cm, may give rise to mechanical complaints or coagulopathy requiring intervention [1]. The indication for treatment of giant liver hemangiomas remains a matter of debate; hemangiomas complicated with a consumptive coagulopathy (Kasabach-Merritt syndrome) or causing severe incapacitating symptoms are generally accepted as an absolute indication for surgical resection [2,3]. Once treatment is decided on, surgical excision is the m
Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice
Masaji Okada,Yoko Kita,Noriko Kanamaru,Satomi Hashimoto,Yasushi Uchiyama,Masahiko Mihara,Yoshikazu Inoue,Yoshiyuki Ohsugi,Tadamitsu Kishimoto,Mitsunori Sakatani
Clinical and Developmental Immunology , 2011, DOI: 10.1155/2011/404929
Abstract: Objective. Our aim was to investigate the effects of IL-6 blockade on the progression of Mycobacterium tuberculosis (TB) and compare them with those of TNF-α blockade in mice. Methods. Mice were intravenously infected with TB and injected with antibodies. Survival was monitored and histological and immunological studies were carried out. Results. All anti-IL-6R Ab-treated mice and 8 of 10 control mice survived until sacrificed 224 days after TB challenge, whereas anti-TNF-α Ab-treated mice all died between 120 and 181 days. Anti-IL-6R Ab-treated mice exhibited no significant differences in TB CFU in organs, including the lungs, and no deterioration in histopathology compared to control mice at 4 weeks. In contrast, anti-TNF-α Ab-treated mice exhibited increased TB CFU and greater progression of histopathological findings in organs than control mice. Spleen cells from anti-TNF-α Ab-treated mice had decreased antigen-specific response in IFN-γ release and proliferation assays. The results in anti-IL-6R Ab-treated mice suggest that spleen cell responses were decreased to a lesser degree. Similar results were obtained in IL-6 knockout (KO) mice, compared with TNF receptor 1 (TNFR1) KO and TNFR1/IL-6 double KO (DKO) mice. Conclusion. IL-6R blockade promotes the progression of TB infection in mice far less than TNF-α blockade.
Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice
Masaji Okada,Yoko Kita,Noriko Kanamaru,Satomi Hashimoto,Yasushi Uchiyama,Masahiko Mihara,Yoshikazu Inoue,Yoshiyuki Ohsugi,Tadamitsu Kishimoto,Mitsunori Sakatani
Journal of Immunology Research , 2011, DOI: 10.1155/2011/404929
Abstract: Objective. Our aim was to investigate the effects of IL-6 blockade on the progression of Mycobacterium tuberculosis (TB) and compare them with those of TNF-α blockade in mice. Methods. Mice were intravenously infected with TB and injected with antibodies. Survival was monitored and histological and immunological studies were carried out. Results. All anti-IL-6R Ab-treated mice and 8 of 10 control mice survived until sacrificed 224 days after TB challenge, whereas anti-TNF-α Ab-treated mice all died between 120 and 181 days. Anti-IL-6R Ab-treated mice exhibited no significant differences in TB CFU in organs, including the lungs, and no deterioration in histopathology compared to control mice at 4 weeks. In contrast, anti-TNF-α Ab-treated mice exhibited increased TB CFU and greater progression of histopathological findings in organs than control mice. Spleen cells from anti-TNF-α Ab-treated mice had decreased antigen-specific response in IFN-γ release and proliferation assays. The results in anti-IL-6R Ab-treated mice suggest that spleen cell responses were decreased to a lesser degree. Similar results were obtained in IL-6 knockout (KO) mice, compared with TNF receptor 1 (TNFR1) KO and TNFR1/IL-6 double KO (DKO) mice. Conclusion. IL-6R blockade promotes the progression of TB infection in mice far less than TNF-α blockade. 1. Introduction Unregulated cell-mediated immunity may lead to chronic autoimmune inflammatory diseases such as rheumatoid arthritis (RA). Proinflammatory cytokines such as TNF-α and IL-6 play important roles in the development and progression of these diseases. As a result, TNF-α blockers, such as infliximab and etanercept, and the anti-IL-6 receptor (IL-6R) antibody (Ab) tocilizumab(TCZ) have exhibited efficacy superior to conventional DMARDs in the treatment of RA [1–6]. One concern with anti-TNF-α Ab therapy, however, is that TNF-α is essential for protection against Mycobacterium tuberculosis (TB), and it has, in fact, been reported that anti-TNF-α Ab therapy is associated with reactivation of tuberculosis [7–11]. As is well known, TB grows inside macrophages and is killed by activated macrophages. Granuloma formation is critical in preventing TB infection in which TNF plays central roles [11]. It is, therefore, thought that inhibition of granuloma formation is the major mechanism of reactivation of TB in patients treated with TNF blockers. In contrast, no published study has indicated that IL-6 plays roles in granuloma formation. Accordingly, it is expected that patients treated with TCZ will not undergo reactivation of TB. In
Intelligent Winding Machine of Plastic Films for Preventing Both Wrinkles and Slippages  [PDF]
Hiromu Hashimoto
Modern Mechanical Engineering (MME) , 2016, DOI: 10.4236/mme.2016.61003
Abstract: Flexible continuous plastic films are used to produce various products, including optical films and packaging materials, because plastic film is suited to use in mass production manufacturing processes. Generally, the web handling process is applied to convey the plastic film, which is ultimately rewound into a roll using a rewinder. In this case, wrinkles, slippage and other defects may occur if the rewinding conditions are inadequate. In this paper, the authors explain the development of a rewinder system that prevents wound roll defects—primarily starring and telescoping. The system is able to prevent such defects by optimizing the rewinding conditions of tension and nip-load. Based on the optimum design technique, the tension and nip-load are calculated using a 32-bit personal computer. Our experiments have also empirically shown that this rewinder system can prevent roll defects when applying optimized tension and nip-load. Additionally, inexperienced operators can control this system easily.
Factors Influencing the Development of “Purpose in Life”and Its Relationship to Coping with Mental Stress  [PDF]
Riichiro Ishida, Masahiko Okada
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.21005
Abstract: Factors influencing the development of purpose in life (PIL) were examined. Methods: We recruited 67 healthy students of Niigata University (34 males and 33 females, 18-35 years of age). PIL and approval motivation (AM), and memories of experiences (IME) were measured using the PIL test, Martin-Larsen Approval Motivation Scale (MLAM), and the Early Life and Youth Experiences Inventory. Confusion, heart rate, systolic blood pressure, and thumb-tip temperature were measured before and during “Evaluating-Integrating Words Task (EIWT).” Results: In the Profile of Mood States (POMS) tests, changes in the confusion scores were significantly higher in the weak PIL compared to the firm PIL group. The scores were significantly higher for the firm AM compared to the weak AM group. Changes in heart rate were significantly higher in the weak PIL compared to the firm PIL group. IME scores for memories of the beauty of nature, empathetic listening from parents and teachers were positively or negatively correlated with PIL test scores or MLAM scores for life stages: infancy, junior high school, and university. Conclusion: PIL and AM seemed to grow through the experiences of the beauty of nature and empathic understanding by parents and teachers during various developmental stages. Purpose in life had greater influence on emotional response and the autonomic nervous system response during psychological stress compared to approval motivation
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