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Search Results: 1 - 10 of 685 matches for " Masafumi Mizutani "
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Development of Oral Dissolving Gelatin Beads Containing Allopurinol for the Prevention and Treatment of Mucositis  [PDF]
Yoshifumi Murata, Takashi Isobe, Kyoko Kofuji, Masafumi Mizutani, Ryosei Kamaguchi
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.33039
Abstract: Oral dissolving gelatin beads (GBs) containing allopurinol (AP) were prepared by the seamless capsule method and their rheological properties were examined. The release profiles of both gelatin and AP from GBs were also investigated in limited dissolution medium. GBs containing AP provided an easy-to-handle dosage form, but the physical strength of the beads immediately decreased upon contact with physiological saline at 37℃. Gelatin was released from the outer layer of GBs in physiological saline, with almost all the gelatin dissolved after 5 min, together with approximately 30% of the AP contained in the inner layer of the GB. The oral administration of GBs likely results in immediate softening of the GB upon contact with saliva. The released AP acts directly at inflammation sites, in a manner similar following oral rinsing with an AP suspension. Therefore, GBs are a useful dosage form for preventing or treating localized problems in the oral cavity, such as mucositis.
Issues Related to Accounting Education for NFPs in the U.S.  [PDF]
Fuminobu Mizutani
Open Journal of Accounting (OJAcct) , 2016, DOI: 10.4236/ojacct.2016.51001
Abstract: There have been no efforts to organize existing works about accounting education for NFPs. This paper is an article reviewing existing works published in the 21st century. There is a sufficient volume of cases to use the case method. Some of the existing works were about active learning (mainly service learning). Some existing works can be used to improve lectures. Some existing works can help faculty members to design their curriculums. However, some issues still remain and these issues should be resolved in the future. As a whole, the problem of existing works is lack of sufficient concerns about other academic areas. Some of future works are hoped to be more interdisciplinary.
Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon
Yosuke Shimada, Makoto Kinoshita, Kazuo Harada, Masafumi Mizutani, Kazunori Masahata, Hisako Kayama, Kiyoshi Takeda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0080604
Abstract: Microbiota have been shown to have a great influence on functions of intestinal epithelial cells (ECs). The role of indole as a quorum-sensing (QS) molecule mediating intercellular signals in bacteria has been well appreciated. However, it remains unknown whether indole has beneficial effects on maintaining intestinal barriers in vivo. In this study, we analyzed the effect of indole on ECs using a germ free (GF) mouse model. GF mice showed decreased expression of junctional complex molecules in colonic ECs. The feces of specific pathogen-free (SPF) mice contained a high amount of indole; however the amount was significantly decreased in the feces of GF mice by 27-fold. Oral administration of indole-containing capsules resulted in increased expression of both tight junction (TJ)- and adherens junction (AJ)-associated molecules in colonic ECs in GF mice. In accordance with the increased expression of these junctional complex molecules, GF mice given indole-containing capsules showed higher resistance to dextran sodium sulfate (DSS)-induced colitis. A similar protective effect of indole on DSS-induced epithelial damage was also observed in mice bred in SPF conditions. These findings highlight the beneficial role of indole in establishing an epithelial barrier in vivo.
Waste Research Trends in Japan in the Past Ten Years: Review of What We Had Done before the Catastrophic Events of March 2011  [PDF]
Masafumi Tateda
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.311165
Abstract: This study analyzes waste research of the past decade in order to determine Japanese trends as well as to learn the problems of Japanese research. The results show that waste research has focused mainly on treatment, management, and recycling, and that research on prior processes such as reduction, collection, and transportation has been very limited. It was also found that research placed stress mostly on materials rather than people and the trend was very similar to that of a ministry oriented research fund. It seems that Japanese waste research has been neither balanced nor strategic. We therefore conclude that a government direction on waste studies might be not appropriate. Japan and Japanese researchers must change their ways of thinking in order not to repeat these mistakes.
High-Quality Three-Dimensional Computed Tomography Angiography of Abdominal Viscera with Small Focal Spot, Low Tube Voltage, and Iterative Model Reconstruction Technique  [PDF]
Masafumi Uchida
Open Journal of Radiology (OJRad) , 2015, DOI: 10.4236/ojrad.2015.51002
Abstract: Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.
Toxicity of Xanthene Food Dyes by Inhibition of Human Drug-Metabolizing Enzymes in a Noncompetitive Manner
Takaharu Mizutani
Journal of Environmental and Public Health , 2009, DOI: 10.1155/2009/953952
Abstract: The synthetic food dyes studied were rose bengal (RB), phroxine (PL), amaranth, erythrosine B (ET), allura red, new coccine, acid red (AR), tartrazine, sunset yellow FCF, brilliant blue FCF, and indigo carmine. First, data confirmed that these dyes were not substrates for CYP2A6, UGT1A6, and UGT2B7. ET inhibited UGT1A6 (glucuronidation of p-nitrophenol) and UGT2B7 (glucuronidation of androsterone). We showed the inhibitory effect of xanthene dye on human UGT1A6 activity. Basic ET, PL, and RB in those food dyes strongly inhibited UGT1A6 activity, with IC50 values = 0.05, 0.04, and 0.015 mM, respectively. Meanwhile, AR of an acidic xanthene food dye showed no inhibition. Next, we studied the inhibition of CYP3A4 of a major phase I drug-metabolizing enzyme and P-glycoprotein of a major transporter by synthetic food dyes. Human CYP3A4 and P-glycoprotein were also inhibited by basic xanthene food dyes. The IC50 values of these dyes to inhibit CYP3A4 and P-glycoprotein were the same as the inhibition level of UGT1A6 by three halogenated xanthene food dyes (ET, PL, and RB) described above, except AR, like the results with UGT1A6 and UGT2B7. We also confirmed the noninhibition of CYP3A4 and P-gp by other synthetic food dyes. Part of this inhibition depended upon the reaction of 1O2 originating on xanthene dyes by light irradiation, because inhibition was prevented by 1O2 quenchers. We studied the influence of superoxide dismutase and catalase on this inhibition by dyes and we found prevention of inhibition by superoxide dismutase but not catalase. This result suggests that superoxide anions, originating on dyes by light irradiation, must attack drug-metabolizing enzymes. It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins on skin under lighting and may lead to rough skin.
Effective Lagrangian Study of $γp \to K^+ Λ$ (spin 3/2 resonances and their off-shell effects)
T. Mizutani
Physics , 1998,
Abstract: The purpose of the present discussion is to supplement the talk, by B.~Saghai at this workshop, on the study of the electromagnetic production of strangeness on the nucleon based upon effective Lagrangian methods. Here we focus on the proper treatment of the spin 3/2 resonances and their associated effects due to the spin 1/2 component of the corresponding fields when they are {\it off the mass shell}.
Strichartz estimates for Schr?dinger equations with variable coefficients and potentials at most linear at spatial infinity
Haruya Mizutani
Mathematics , 2011,
Abstract: In the present paper we consider Schr\"odinger equations with variable coefficients and potentials, where the principal part is a long-range perturbation of the flat Laplacian and potentials have at most linear growth at spatial infinity. We then prove local-in-time Strichartz estimates, outside a large compact set centered at origin, expect for the endpoint. Moreover we also prove global-in-space Strichartz estimates under the non-trapping condition on the Hamilton flow generated by the kinetic energy.
Strichartz estimates for Schr?dinger equations with variable coefficients and unbounded potentials II. Superquadratic potentials
Haruya Mizutani
Mathematics , 2012,
Abstract: In this paper we prove local-in-time Strichartz estimates with loss of derivatives for Schr\"odinger equations with variable coefficients and potentials, under the conditions that the geodesic flow is nontrapping and potentials grow polynomially at infinity. This is a generalization to the case with variable coefficients and improvement of the result by Yajima-Zhang. The proof is based on microlocal techniques including the semiclassical parametrix for a time scale depending on a spatial localization and the Littlewood-Paley type decomposition with respect to both of space and frequency.
Strichartz estimates for Schr?dinger equations with variable coefficients and unbounded potentials
Haruya Mizutani
Mathematics , 2012,
Abstract: The present paper is concerned with Schr\"odinger equations with variable coefficients and unbounded electromagnetic potentials, where the kinetic energy part is a long-range perturbation of the flat Laplacian and the electric (resp. magnetic) potential can grow subquadratically (resp. sublinearly) at spatial infinity. We prove sharp (local-in-time) Strichartz estimates, outside a large compact ball centered at origin, for any admissible pair including the endpoint. Under the nontrapping condition on the Hamilton flow generated by the kinetic energy, global-in-space estimates are also studied. Finally, under the nontrapping condition, we prove Strichartz estimates with an arbitrarily small derivative loss without asymptotic flatness on the coefficients.
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