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Search Results: 1 - 10 of 1952 matches for " Masafumi Kimura "
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Waste Research Trends in Japan in the Past Ten Years: Review of What We Had Done before the Catastrophic Events of March 2011  [PDF]
Masafumi Tateda
Journal of Environmental Protection (JEP) , 2012, DOI: 10.4236/jep.2012.311165
Abstract: This study analyzes waste research of the past decade in order to determine Japanese trends as well as to learn the problems of Japanese research. The results show that waste research has focused mainly on treatment, management, and recycling, and that research on prior processes such as reduction, collection, and transportation has been very limited. It was also found that research placed stress mostly on materials rather than people and the trend was very similar to that of a ministry oriented research fund. It seems that Japanese waste research has been neither balanced nor strategic. We therefore conclude that a government direction on waste studies might be not appropriate. Japan and Japanese researchers must change their ways of thinking in order not to repeat these mistakes.
High-Quality Three-Dimensional Computed Tomography Angiography of Abdominal Viscera with Small Focal Spot, Low Tube Voltage, and Iterative Model Reconstruction Technique  [PDF]
Masafumi Uchida
Open Journal of Radiology (OJRad) , 2015, DOI: 10.4236/ojrad.2015.51002
Abstract: Purpose: To evaluate the quality of three-dimensional (3D) CT angiography images of the abdominal viscera with small focal spot, low tube voltage, and iterative model reconstruction technique (IMR). Materials and Methods: Seven patients with suspected disease of the pancreatobiliary system had undergone CT with high-quality CTA protocol in the present study. There were 5 men and 2 women, ranging in age from 52 to 80 years (mean: 64 years). Results: Depiction of abdominal small artery, small portal vein was possible in all cases. In two cases that we were able to compare, it was superior to standard CTA in small vascular depiction in CTA made clearly in high quality protocol. Conclusions: Although the use of small focal spot, low tube voltage, and IMR can produce higher-quality images of abdominal vessels than standard CTA, this improvement is not significant at elevated radiation doses.
Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons
Tatsuro Kohno, Masafumi Kimura, Mika Sasaki, Hideaki Obata, Fumimasa Amaya, Shigeru Saito
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-45
Abstract: Intrathecal injection of milnacipran (0.1?μmol), but not citalopram (0.1?μmol) and desipramine (0.1?μmol), followed by intrathecal injection of NMDA (1?μg) suppressed thermal hyperalgesia. Milnacipran (100 μM) reduced the amplitude of NMDA (56?±?3?%, 64?±?5?% of control)-, but not AMPA (98?±?5?%, 97?±?5?% of control)-mediated currents induced by exogenous application and dorsal root stimulation, respectively. Citalopram (100 μM) and desipramine (30 μM) had no effect on the amplitude of exogenous NMDA-induced currents. The number of pERK-positive neurons in the group treated with milnacipran (100 μM), but not citalopram (100 μM) or desipramine (30 μM), followed by NMDA (100 μM) was significantly lower compared with the NMDA-alone group.The antinociceptive effect of milnacipran may be dependent on the drug’s direct modulation of NMDA receptors in the superficial dorsal horn. Furthermore, in addition to inhibiting the reuptake of monoamines, glutamate NMDA receptors are also important for analgesia induced by milnacipran.
Systemic Resistance Induced by Volatile Organic Compounds Emitted by Plant Growth-Promoting Fungi in Arabidopsis thaliana
Hushna Ara Naznin, Daigo Kiyohara, Minako Kimura, Mitsuo Miyazawa, Masafumi Shimizu, Mitsuro Hyakumachi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086882
Abstract: Volatile organic compounds (VOC) were extracted and identified from plant growth-promoting fungi (PGPF), Phoma sp., Cladosporium sp. and Ampelomyces sp., using gas chromatography–mass spectrometry (GC-MS). Among the three VOC extracted, two VOC blends (emitted from Ampelomyces sp. and Cladosporium sp.) significantly reduced disease severity in Arabidopsis plants against Pseudomonas syringae pv. tomato DC3000 (Pst). Subsequently, m-cresol and methyl benzoate (MeBA) were identified as major active volatile compounds from Ampelomyces sp. and Cladosporium sp., respectively, and found to elicit induced systemic resistance (ISR) against the pathogen. Molecular signaling for disease suppression by the VOC were investigated by treating different mutants and transgenic Arabidopsis plants impaired in salicylic acid (SA) or Jasmonic acid (JA)/ethylene (ET) signaling pathways with m-cresol and MeBA followed by challenge inoculation with Pst. Results show that the level of protection was significantly lower when JA/ET-impaired mutants were treated with MeBA, and in SA-, and JA/ET-disrupted mutants after m-cresol treatment, indicating the involvement of these signal transduction pathways in the ISR primed by the volatiles. Analysis of defense-related genes by real-time qRT-PCR showed that both the SA-and JA-signaling pathways combine in the m-cresol signaling of ISR, whereas MeBA is mainly involved in the JA-signaling pathway with partial recruitment of SA-signals. The ET-signaling pathway was not employed in ISR by the volatiles. Therefore, this study identified two novel volatile components capable of eliciting ISR that may be promising candidates in biological control strategy to protect plants from diseases.
Relation between $c$-$f$ hybridization and magnetic ordering in CeRu$_2$Al$_{10}$: An optical conductivity study of Ce(Ru$_{1-x}$Rh$_x$)$_2$Al$_{10}$ ($x\leq0.05$)
Shin-ichi Kimura,Hiroshi Tanida,Masafumi Sera,Yuji Muro,Toshiro Takabatake,Takashi Nishioka,Masahiro Matsumura,Riki Kobayashi
Physics , 2015, DOI: 10.1103/PhysRevB.91.241120
Abstract: A Kondo semiconductor CeRu$_2$Al$_{10}$ with an orthorhombic crystal structure shows an unusual antiferromagnetic ordering at rather high temperature $T_0$ of 27.3 K, which is lower than the Kondo temperature $T_{\rm K}\sim$ 60 K. In optical conductivity [$\sigma(\omega)$] spectra that directly reflect electronic structure, the $c$-$f$ hybridization gap between the conduction and $4f$ states is observed at around 40 meV along the three principal axes. However, an additional peak at around 20 meV appears only along the $b$ axis. With increasing $x$ to 0.05 in Ce(Ru$_{1-x}$Rh$_x$)$_2$Al$_{10}$, the $T_0$ decreases slightly from 27.3 K to 24 K, but the direction of the magnetic moment changes from the $c$ axis to the $a$ axis. Thereby, the $c$-$f$ hybridization gap in the $\sigma(\omega)$ spectra is strongly suppressed, but the intensity of the 20-meV peak remains as strong as for $x=0$. These results suggest that the change of the magnetic moment direction originates from the decreasing of the $c$-$f$ hybridization intensity. The magnetic ordering temperature $T_0$ is not directly related to the $c$-$f$ hybridization but is related to the charge excitation at 20 meV observed along the $b$ axis.
Global Properties of Evolutional Lotka-Volterra System  [PDF]
Masafumi Yoshino, Yoshinari Tanaka
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.39097
Abstract:

We will study global properties of evolutional Lotka-Volterra system. We assume that the predatory efficiency is a function of a character of species whose evolution obeys a quantitative genetic model. We will show that the structure of a solution is rather different from that of a non-evolutional system. We will analytically show new ecological features of the dynamics.

A New Approach: Chronotherapy in Acute Blood Purification for Septic Shock  [PDF]
Masafumi Yamato, Yusuke Minematsu
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.57004
Abstract: Circadian rhythms are daily oscillations of multiple biological processes. Recently, relationships between circadian rhythms and immune functions have also been described. In a mouse sepsis model, the death rate due to lipopolysaccharide (LPS)-induced endotoxic shock was found to be dependent on LPS administration as determined by circadian time. In humans, a pronounced inflammatory response to endotoxemia differs depending on whether it is daytime or night-time: Levels of tumor necrosis factor-alpha and interleukin-6 were higher during the night. Therefore, it is reasonable to assume that circadian rhythms influence not only organ dysfunction and the prognosis induced by LPS, but also the therapeutic effect of anti-LPS therapy such as Polymyxin-B direct hemoperfusion. We herein postulate the concept that it is important to discuss septic shock treatment in terms of whether or not the treatment is adjusted for the optimal time window as determined by circadian rhythms.
Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer’s Disease
Masahiro Ono, Yan Cheng, Hiroyuki Kimura, Hiroyuki Watanabe, Kenji Matsumura, Masashi Yoshimura, Shimpei Iikuni, Yoko Okamoto, Masafumi Ihara, Ryosuke Takahashi, Hideo Saji
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074104
Abstract: Imaging of β-amyloid (Aβ) plaques in the brain may facilitate the diagnosis of cerebral β-amyloidosis, risk prediction of Alzheimer’s disease (AD), and effectiveness of anti-amyloid therapies. The purpose of this study was to evaluate novel 123I-labeled pyridyl benzofuran derivatives as SPECT probes for Aβ imaging. The formation of a pyridyl benzofuran backbone was accomplished by Suzuki coupling. [123I/125I]-labeled pyridyl benzofuran derivatives were readily prepared by an iododestannylation reaction. In vitro Aβ binding assays were carried out using Aβ(1–42) aggregates and postmortem human brain sections. Biodistribution experiments were conducted in normal mice at 2, 10, 30, and 60 min postinjection. Aβ labeling in vivo was evaluated by small-animal SPECT/CT in Tg2576 transgenic mice injected with [123I]8. Ex vivo autoradiography of the brain sections was performed after SPECT/CT. Iodinated pyridyl benzofuran derivatives showed excellent affinity for Aβ(1–42) aggregates (2.4 to 10.3 nM) and intensely labeled Aβ plaques in autoradiographs of postmortem AD brain sections. In biodistribution experiments using normal mice, all these derivatives displayed high initial uptake (4.03–5.49% ID/g at 10 min). [125I]8 displayed the quickest clearance from the brain (1.30% ID/g at 60 min). SPECT/CT with [123I]8 revealed higher uptake of radioactivity in the Tg2576 mouse brain than the wild-type mouse brain. Ex vivo autoradiography showed in vivo binding of [123I]8 to Aβ plaques in the Tg2576 mouse brain. These combined results warrant further investigation of [123I]8 as a SPECT imaging agent for visualizing Aβ plaques in the AD brain.
Clustering Properties of Galaxies at z~4 in the Subaru/XMM Deep Survey Field
Masami Ouchi,Kazuhiro Shimasaku,Sadanori Okamura,Mamoru Doi,Hisanori Furusawa,Masaru Hamabe,Masahiko Kimura,Yutaka Komiyama,Masayuki Miyazaki,Satoshi Miyazaki,Fumiaki Nakata,Maki Sekiguchi,Masafumi Yagi,Naoki Yasuda
Physics , 2001, DOI: 10.1086/323598
Abstract: We study the clustering properties of about 1200 z~4 Lyman Break Galaxy (LBG) candidates with i'<26 which are selected by color from deep BRi' imaging data of a 618 arcmin^2 area in the Subaru/XMM-Newton Deep Field taken with Subaru Prime Focus Camera. The contamination and completeness of our LBG sample are evaluated, on the basis of the Hubble Deep Field North (HDFN) objects, to be 17% and 45%, respectively. We derive the angular correlation function over theta = 2''-1000'', and find that it is fitted fairly well by a power law, omega(theta)=A_omega theta^{-0.8}, with A_omega = 0.71 +/- 0.26. We then calculate the correlation length r0 (in comoving units) of the two-point spatial correlation function xi(r) = (r/r0)^{-1.8} from A_omega using the redshift distribution of LBGs derived from the HDFN, and find r0=2.7 (+0.5/-0.6) h^{-1} Mpc in a Lambda-dominated universe (Omega_m=0.3 and Omega_Lambda=0.7). This is twice larger than the correlation length of the dark matter at z~4 predicted from an analytic model by Peacock & Dodds but about twice smaller than that of bright galaxies predicted by a semi-analytic model of Baugh et al. We find an excess of omega(theta) on small scales (theta < 5'') departing from the power law fit over 3 sigma significance levels. Interpreting this as due to galaxy mergers, we estimate the fraction of galaxies undergoing mergers in our LBG sample to be 3.0 +/- 0.9%, which is significantly smaller than those of galaxies at intermediate redshifts.
Statistical Properties of Lyman Break Galaxies at z~4
Masami Ouchi,Kazuhiro Shimasaku,Sadanori Okamura,Mamoru Doi,Hisanori Furusawa,Masaru Hamabe,Masahiko Kimura,Yutaka Komiyama,Masayuki Miyazaki,Satoshi Miyazaki,Fumiaki Nakata,Maki Sekiguchi,Masafumi Yagi,Naoki Yasuda
Physics , 2001,
Abstract: We study the luminosity function and the correlation function of about 1200 z~4 Lyman break galaxies (LBGs) with i'<26 that are photometrically selected from deep BRi' imaging data of a 618 arcmin^2 area in the Subaru/XMM-Newton Deep Field taken with Subaru Prime Focus Camera. The contamination and completeness of our LBG sample are evaluated, on the basis of the Hubble Deep Field-North (HDF-N) objects, to be 17% and 45%, respectively. We derive the UV (rest 1700A) luminosity functions (LFs) and find a large population of UV-luminous galaxies at z~4. The LFs of the red and blue subsamples imply that the bright LBGs are redder in the UV continuum than the average color of the LBGs. Then we calculate the correlation function over theta = 2''-1000'' and find that it is fitted fairly well by a power law, omega(theta)=A_omega theta^(-0.8), with A_omega=0.71 +/- 0.26. We estimate the correlation length r_0 (in comoving units) of the two-point spatial correlation function xi(r) = (r/r_0)^(-1.8) to be r_0=2.7 +0.5/-0.6 h^(-1) Mpc (Omega_m=0.3 and Omega_Lambda=0.7). The correlation function shows an excess of omega (theta) on small scales (theta < 5''), departing from the power-law fit at > 3 sigma significance level. Interpreting this as being due to galaxy mergers, we evaluate the fraction of galaxies undergoing mergers to be 3.0 +/- 0.9%, which is significantly smaller than those of galaxies at intermediate redshifts.
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