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Search Results: 1 - 10 of 241 matches for " Marzia Ragone "
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The TrkAIII Oncoprotein Inhibits Mitochondrial Free Radical ROS-Induced Death of SH-SY5Y Neuroblastoma Cells by Augmenting SOD2 Expression and Activity at the Mitochondria, within the Context of a Tumour Stem Cell-like Phenotype
Pierdomenico Ruggeri, Antonietta R. Farina, Natalia Di Ianni, Lucia Cappabianca, Marzia Ragone, Giulia Ianni, Alberto Gulino, Andrew R. Mackay
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094568
Abstract: The developmental and stress-regulated alternative TrkAIII splice variant of the NGF receptor TrkA is expressed by advanced stage human neuroblastomas (NBs), correlates with worse outcome in high TrkA expressing unfavourable tumours and exhibits oncogenic activity in NB models. In the present study, we report that constitutive TrkAIII expression in human SH-SY5Y NB cells inhibits Rotenone, Paraquat and LY83583-induced mitochondrial free radical reactive oxygen species (ROS)-mediated death by stimulating SOD2 expression, increasing mitochondrial SOD2 activity and attenuating mitochondrial free radical ROS production, in association with increased mitochondrial capacity to produce H2O2, within the context of a more tumour stem cell-like phenotype. This effect can be reversed by the specific TrkA tyrosine kinase inhibitor GW441756, by the multi-kinase TrkA inhibitors K252a, CEP-701 and G?6976, which inhibit SOD2 expression, and by siRNA knockdown of SOD2 expression, which restores the sensitivity of TrkAIII expressing SH-SY5Y cells to Rotenone, Paraquat and LY83583-induced mitochondrial free radical ROS production and ROS-mediated death. The data implicate the novel TrkAIII/SOD2 axis in promoting NB resistance to mitochondrial free radical-mediated death and staminality, and suggest that the combined use of TrkAIII and/or SOD2 inhibitors together with agents that induce mitochondrial free radical ROS-mediated death could provide a therapeutic advantage that may also target the stem cell niche in high TrkA expressing unfavourable NB.
Inclusion of Students with Autism Spectrum Disorders in Italian Schools: From Theory to Practice  [PDF]
Marzia Mazzer
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.39014
Abstract:

The purpose of this paper is to provide a general overview about the issue of inclusion of students with Autism Spectrum Disorders in Italian Schools. Firstly, we will present an overall picture of the inclusion processes of students with disabilities in the Italian school system. Secondly, we will focus on teaching-learning strategies designed to meet the educational needs of students with ASD and to move towards an “inclusive classroom” in which all students, with their different abilities, are welcomed in the learning community. Finally, in order to put theory into practice, we will discuss a “case study” of a 6-year-old pupil with ASD in an Italian primary school, identifying specific barriers and facilitators to accessibility and inclusion.

Trabalhadores urbanos e domésticos: a constitui??o federal e sua assimetria
Mattos, Miguel Ragone de;
Revista Estudos Feministas , 2009, DOI: 10.1590/S0104-026X2009000300015
Abstract: the brazilian constitution established a lower level of protection rights to domestic servants, if compared with the rights given to regular workers. this asymmetry can be explained by particularities of this kind of job and the need to keep costs down, specially considering that domestic servants are not part of a capitalistic enterprise. however there are a series of non-recognized rights to the domestic servants that can not be explained by its incompatibility or cost. perhaps this group is the focus of the next step of constitutional change, reducing the asymmetry between the rights of the domestic workers and the regular ones
Prelación, isonomía y agrupamiento de créditos en la ejecución civil
Pérez Ragone,álvaro;
Revista de derecho (Valparaíso) , 2011, DOI: 10.4067/S0718-68512011000200011
Abstract: ?"conditio creditoris pars" or "prior in tempore potior in iure" as principles and framework for concurrent execution creditors in the singular? this article does not focus on a particular positive law, but rather aims to compare the performance of different systems (and criteria) distribution with concurrent civil enforcement of creditors.the reference to both the history of civil procedure as compared models should help to identify the arguments for and against different views. the alternative explanation equality isolated (or contribution), priority and allow grouping founded on the principles of background and emerging models with inner exceptions.therefore, rather than advocating a particular principle, it is justified where the benefits of a prime priority as combined with other competing rights and the state or common debtor's insolvency.it seems that the recognition of freedom and responsibility (ultimately the game of autonomy) to require executive-protection of a credit does not correspond to equal treatment and artificial-contribution of losses and benefits together with other creditors. the reasons for justice to choose a model over another are the focus of attention in this research.
Ser y estar: aspecto semántico en el pretérito e imperfecto
Caryn Witten,Agnes Ragone
Lexis , 2002,
Abstract:
Energetics of PCMDI/CMIP3 Climate Models: Energy Budget and Meridional Enthalpy Transport
Valerio Lucarini,Francesco Ragone
Physics , 2009, DOI: 10.1029/2009RG000323
Abstract: We analyze the PCMDI/CMIP3 simulations performed by climate models (CMs) using pre-industrial and SRESA1B scenarios. Relatively large biases are present for most CMs when global energy budgets and when the atmospheric, oceanic, and land budgets are considered. Apparently, the biases do not result from transient effects, but depend on the imperfect closure of the energy cycle in the fluid components and on inconsistencies over land. Therefore, the planetary emission temperature is underestimated. This may explain the CMs' cold bias. In the pre-industrial scenario, CMs agree on the location in the mid-latitudes of the peaks of the meridional atmospheric enthalpy transport, while large discrepancies exist on the intensity. Disagreements on the location and intensity of the oceanic transport peaks are serious. With increased $CO_2$ concentration, a small poleward shift of the peak and an increase in the intensity of the atmospheric transport of up to 10% are detected in both hemispheres. Instead, most CMs feature a decrease in the oceanic transport intensity in the northern hemisphere and an equatorward shift of the peak in both hemispheres. The Bjerkens compensation mechanism is active both on climatological and interannual time scales. The peak of the total meridional transport is typically around $35^\circ$ in both hemispheres and scenarios, whereas disagreements on the intensity are relevant. With increased $CO_2$ concentration, the total transport increases by up to 10%, thus contributing to polar amplification. Advances in the representation of physical processes are definitely needed for providing a self-consistent representation of climate as a non-equilibrium thermodynamical system.
A study of surface semi-geostrophic turbulence: freely decaying dynamics
Francesco Ragone,Gualtiero Badin
Physics , 2015,
Abstract: In this study we give a characterization of semi-geostrophic turbulence by performing freely decaying simulations of the semi-geostrophic equations for the case of constant uniform potential vorticity, a set of equations known as surface semi-geostrophic approximation. The equations are formulated as conservation laws for potential temperature and potential vorticity, with a nonlinear Monge-Amp\'{e}re type inversion equation for the streamfunction, expressed in a transformed coordinate system that follows the geostrophic flow. We perform model studies of turbulent surface semi-geostrophic flows in a doubly-periodic domain in the horizontal limited in the vertical by two rigid lids, allowing for variations of potential temperature at one of the boundaries, and we compare them with the corresponding surface quasi-geostrophic case. Results show that, while surface quasi-geostrophic dynamics is dominated by a symmetric population of cyclones-anticyclones, surface semi-geostrophic dynamics features a prominent role of fronts and filaments. The resulting distribution of potential temperature is strongly skewed and peaked at non-zero values at and close to the active boundary, while symmetry is restored in the interior of the domain, where small-scale frontal structures do not penetrate. In surface semi-geostrophic turbulence energy spectra are less steep than in the surface quasi-geostrophic case, with more energy concentrated at small scales for increasing Rossby number. Energy connected to frontal structures, lateral strain rate and vertical velocities are largest close to the active boundary. These results could be important for the lateral mixing of properties in geophysical flows.
Introdu??o teórica e metodológica ao projecto ?Angola em Movimento: sociabilidades e trocas económicas informais?
Grassi,Marzia;
Economia Global e Gest?o , 2007,
Abstract: in this introduction we will establish the principal theoretical concepts, methodology and objectives of the project “angola in movement” inside the theoretical ongoing debate regarding the informal trade in the globalised society. the analysis is done on the mobility patterns of people and goods in angola across trans-border and trans-national trade routes in the angolan regions involved like case-studies (namibe, cunene, route luanda-benguela-huambo and lisbon as host diaspora country).
Práticas, formas e solidariedades da integra??o de jovens de origem angolana no mercado de trabalho em Portugal
Grassi,Marzia;
Economia Global e Gest?o , 2007,
Abstract: this paper aims to present some data collected through a questionnaire applied to a population of 200 young people (between 18 and 30 years old) with angolan origin living in the area of great lisbon. the integrated questionnaire for the measurement of the social capital within the nets of angolan young was adapted from a questionnaire of the world bank (grootaert et al., 2003) to the portuguese migratory context in the scope of ?angola in movement? project. the main objective of the presentation is to discuss organized information about the performance of solidarities and trust in the familiar, social and ethnical networks, in relation with the access of young migrant people to the labour market in portugal.
Crises and Development: a Perpetual Vicious Circle for Africa
Grassi,Marzia;
Economia Global e Gest?o , 2009,
Abstract: the financial crisis that broke out in 2007 in the ?northern? [1]countries and hit formal financial institutions and investment banks does not bring the same repercussions for african countries. after all, the real economy is organized around informal structures in the majority of these states while formal institutions, the conveyers of crisis, are a recent and still rare reality. however, this does not protect from the growth crisis that followed the financial crisis and which will have a negative impact on african countries as well as all countries around the world. given the world trade balances and power relationships between countries, some authors propose that this crisis has effectively compromised any possible future for the industrialization that the development of the african continent requires (ellis, 2009). the paper is structured around a discussion of the history of ideas in the economic sciences and the impact of development policies on the african continent. we begin by reviewing the main lines of thought on development, and then go on to discuss the main ways in which africa is integrated into the world economy. we conclude that, although the models and the crises thus far experienced have only resulted in rising poverty on the continent and worsened social inequalities between african states and the ?northern? countries, as well as inequalities in effective access to resources, the current crisis may actually be considered potentially positive as it may give rise to a global rethinking of the development model and its impact at the local level. as the crisis originated in the ?northern? states thus making it clear that the negative effects of development may hit all ?global? spaces in the real globalized world, criticism of its underlying and underpinning mechanisms is inevitable. the conclusion suggests that the ideal departure point for rethinking the model of development involves intellectual honesty rather than rapid responses; critical thought
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