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Search Results: 1 - 10 of 207 matches for " Marwa Shehab "
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Validation and implementation of array comparative genomic hybridisation as a first line test in place of postnatal karyotyping for genome imbalance
Joo Wook Ahn, Kathy Mann, Sally Walsh, Marwa Shehab, Sarah Hoang, Zoe Docherty, Shehla Mohammed, Caroline Mackie Ogilvie
Molecular Cytogenetics , 2010, DOI: 10.1186/1755-8166-3-9
Abstract: Following a validation period, an oligoarray platform was chosen. In order to minimise costs and increase efficiency, a patient/patient hybridisation strategy was used, and analysis criteria were set to optimise detection of pathogenic imbalance. A customised database application with direct links to a number of online resources was developed to allow efficient management and tracking of patient samples and facilitate interpretation of results. Following introduction into our routine diagnostic service for patients with suspected genome imbalance, array CGH as a follow-on test for patients with normal karyotypes (n = 1245) and as a first-line test (n = 1169) gave imbalance detection rates of 26% and 22% respectively (excluding common, benign variants). At least 89% of the abnormalities detected by first line testing would not have been detected by standard karyotype analysis. The average reporting time for first-line tests was 25 days from receipt of sample.Array CGH can be used in a diagnostic service setting in place of G-banded chromosome analysis, providing a more comprehensive and objective test for patients with suspected genome imbalance. The increase in consumable costs can be minimised by employing appropriate hybridisation strategies; the use of robotics and a customised database application to process multiple samples reduces staffing costs and streamlines analysis, interpretation and reporting of results. Array CGH provides a substantially higher diagnostic yield than G-banded chromosome analysis, thereby alleviating the burden of further clinical investigations.Karyotype analysis of G-banded chromosomes is the cytogenetic standard for the detection of copy number imbalance across the genome, or balanced chromosome rearrangements, in children with such features as idiopathic developmental delay, learning difficulties, congenital abnormalities or autism. However, this technique has a resolution of only 3-5 Mb, and interpretation is operator-dependent, req
Correlation between Group B Streptococcal Genotypes, Their Antimicrobial Resistance Profiles, and Virulence Genes among Pregnant Women in Lebanon
Antoine Hannoun,Marwa Shehab,Marie-Therese Khairallah,Ahmad Sabra,Roland Abi-Rached,Tony Bazi,Khalid A. Yunis,George F. Araj,Ghassan M. Matar
International Journal of Microbiology , 2009, DOI: 10.1155/2009/796512
Abstract: The antimicrobial susceptibility profiles of 76 Streptococcus agalactiae (Group B Streptococci [GBS]) isolates from vaginal specimens of pregnant women near term were correlated to their genotypes generated by Random Amplified Polymorphic DNA analysis and their virulence factors encoding genes cylE, lmb, scpB, rib, and bca by PCR. Based on the distribution of the susceptibility patterns, six profiles were generated. RAPD analysis detected 7 clusters of genotypes. The cylE gene was present in 99% of the isolates, the lmb in 96%, scpB in 94.7%, rib in 33%, and bca in 56.5% of isolates. The isolates demonstrated a significant correlation between antimicrobial resistance and genotype clusters denoting the distribution of particular clones with different antimicrobial resistance profiles, entailing the practice of caution in therapeutic options. All virulence factors encoding genes were detected in all seven genotypic clusters with rib and bca not coexisting in the same genome.
Assessing Improvement in Quality of Life and Patient Satisfaction following Body Contouring Surgery in Patients with Massive Weight Loss: A Critical Review of Outcome Measures Employed
Shehab Jabir
Plastic Surgery International , 2013, DOI: 10.1155/2013/515737
Abstract: Body contouring following massive weight loss is a rapidly expanding field in plastic surgery. However, healthcare payers are reluctant to fund such procedures, viewing them as purely cosmetic. This has resulted in a flurry of studies assessing quality of life (QoL) and patient satisfaction following body contouring surgery in this cohort of patients to establish an evidence base to support the idea that body contouring is as much (or even more) a functional procedure as it is cosmetic. However, the methods employed in these studies are seldom ideal, and hence the conclusions are unreliable. The gold standard to assess QoL and patient satisfaction is to use patient specific psychometrically validated patient reported outcome (PRO) measures. Developing such measures consists of a three-step process which includes a review of the current literature, qualitative patient interviews to determine what patients consider the most important, and expert opinion. This study aims to appraise the currently available literature on assessment of QoL and patient satisfaction in body contouring surgery patients. This will hopefully provide an understanding of methodological weaknesses in current studies and inform future investigators of the design of ideal instruments for assessing QoL and patient satisfaction in body contouring patients. 1. Introduction Body contouring surgery has undergone a rapid expansion in the last decade, becoming one of the fastest growing areas within plastic surgery. As the number of obese individuals continues to increase, bariatric surgery has come to the fore as the method of choice for rapidly losing excess weight with approximately one quarter of patients opting for bariatric surgery [1]. However, when a previously obese or morbidly obese individual loses a massive amount of weight, it results in cutaneous contour deformities on various parts of the body. These cutaneous deformities may then lead to psychological distress as well as functional problems, offsetting the positive benefits brought about by weight loss surgery [2–4]. Hence body contouring surgery would intuitively appear to be the next step in rehabilitating the obese patient with massive weight loss (MWL). However, it has been a challenge to convince healthcare payers of the importance of body contouring procedures to the overall outcome of massive weight loss patients. Whereas funding for bariatric surgery has become easier to obtain due to mounting evidence of its benefits on the health of obese individuals and the economic implications of this benefit, it has yet to
Genotypes and serotype distribution of macrolide resistant invasive and non- invasive Streptococcus pneumoniae isolates from Lebanon
Nedal Taha, George F Araj, Rima H Wakim, Souha S Kanj, Zeina A Kanafani, Ahmad Sabra, Marie-Therese Khairallah, Farah J Nassar, Marwa Shehab, Maysa Baroud, Ghassan Dbaibo, Ghassan M Matar
Annals of Clinical Microbiology and Antimicrobials , 2012, DOI: 10.1186/1476-0711-11-2
Abstract: Forty four macrolide resistant and 21 macrolide susceptible S. pneumoniae clinical isolates were tested for antimicrobial susceptibility according to CLSI guidelines (2008) and underwent molecular characterization. Serotyping of these isolates was performed by Multiplex PCR-based serotype deduction using CDC protocols. PCR amplification of macrolide resistant erm (encoding methylase) and mef (encoding macrolide efflux pump protein) genes was carried out.Among 44 isolates resistant to erythromycin, 35 were resistant to penicillin and 18 to ceftriaxone. Examination of 44 macrolide resistant isolates by PCR showed that 16 isolates harbored the erm(B) gene, 8 isolates harbored the mef gene, and 14 isolates harbored both the erm(B) and mef genes. There was no amplification by PCR of the erm(B) or mef genes in 6 isolates. Seven different capsular serotypes 2, 9V/9A,12F, 14,19A, 19F, and 23, were detected by multiplex PCR serotype deduction in 35 of 44 macrolide resistant isolates, with 19F being the most prevalent serotype. With the exception of serotype 2, all serotypes were invasive. Isolates belonging to the invasive serotypes 14 and 19F harbored both erm(B) and mef genes. Nine of the 44 macrolide resistant isolates were non-serotypable by our protocols.Macrolide resistance in S. pneumoniae in Lebanon is mainly through target site modification but is also mediated through efflux pumps, with serotype 19F having dual resistance and being the most prevalent and invasive.Streptococcus pneumoniae continues to be a major cause of morbidity and mortality in humans. It is one of the most significant bacterial pathogens causing community acquired infections, most notably pneumonia, otitis media, bacteremia, and meningitis [1,2]. Treatment of pneumococcal infections is becoming difficult due to the high prevalence of penicillin-resistant strains and to the rapid development of resistance to other antimicrobials including macrolides. These drugs are extensively used for the treat
Cognitive and autonomic dysfunction measures in normal controls, white coat and borderline hypertension
Abdullah Shehab, Abdishakur Abdulle
BMC Cardiovascular Disorders , 2011, DOI: 10.1186/1471-2261-11-3
Abstract: We performed a cross-sectional study in a cohort of 69 subjects (mean age ± SD; 38.2 ±10.8 years) comprising comparable number of normal controls, WCHT, and BLH. We measured clinic and 24-hour ambulatory blood pressure monitoring (ABPM), cognitive function parameters, and heart rate variability (HRV). All subjects underwent 24-hour ambulatory electrocardiography monitoring which was analyzed for HRV measurements. We performed a routine echocardiography (ECHO) for all subjects.Multiple comparison between the three groups revealed significant (p < 0.04) differences in mean day-time ABPM (systolic and diastolic). In the state anxiety inventory (SAI), both subjects with WCHT and BLH had significantly (p < 0.006) higher anxiety levels than the control group. In memory tasks WCHT subjects scored significantly (p < 0.004) lower in comparison with the other two groups. WCHT significantly (p < 0.001) performed less in memory tests, whereas BLH subjects had significantly (p < 0.001) lower reaction time. We found a significant (p < 0.05) difference in the 24-hour RMSSD and SDNN between the three groups. There was significant correlation between 24-hour RMSSD and computer CANTAB scores. The Echocardiography assessment revealed no significant differences in LV mass indices and diastolic function.WCHT and BLH subjects showed lower cognitive performance and higher levels of anxiety when compared to controls. Autonomic function reflected by HRV indices was lower in WCHT and BLH in contrast to control, though not significantly. Our results suggest that WCHT may not be a benign condition as it may contribute to the overall risk for cardiovascular disease and LV damage. Longitudinal studies of patients with WCHT should clarify the transient, persistent or the progressive nature of this condition.White coat hypertension (WCHT), a transient increase in blood pressure (BP) measured in a medical setting, is a significant clinical condition with haemodynamic differences and presence of fun
A Norton Model of a Distribution Network for Harmonic Evaluation
Shehab Abdulwadood Ali
Energy Science and Technology , 2011, DOI: 10.3968/j.est.1923847920110201.576
Abstract: This paper presents a Norton model for modelling distribution networks where the system configuration is not fully known. Traditionally harmonic studies use complex distribution networks modelled by harmonic current sources for specific frequencies. Although this model has been proved to be adequate for some studies, this may not be adequate for other applications. When changing the operating conditions of the supply-side system, the harmonic currents injected by the distribution network might change and to investigate these harmonic currents, the Norton model is used. The change of operating condition is obtained by switching shunt capacitors. The estimated model can be used to analyze, for example, the effect of harmonic filters under different supply system configurations or operating conditions. The method of estimating the Norton models is illustrated on a test system, simulated on the well-known simulation program EMTP-ATPDraw. Key words: Norton model; Distribution network; Operating conditions; Harmonic currents and voltages
Capacitor Banks Switching Transients in Power Systems
Shehab Abdulwadood Ali
Energy Science and Technology , 2011, DOI: 10.3968/j.est.1923847920110202.121
Abstract: This study provides an introduction to capacitor bank switching transients, illustrates the effects of the capacitor banks switching in the utility primary distribution system at different places of the power system, but specially at the customer’s plant. Study covers different operational cases to find the suitable method or techniques can be used to limit the effect of capacitor switching transients. Transient disturbances in power systems may damage key equipment, potentially having a great impact on system reliability. These transients may be introduced during normal switching operations, lightning strikes, or because the equipment failure. Therefore, time-domain computer simulations are developed to study dangers cases due to transient occurrences. The simulations are performed using the simulation software Electromagnetic Transient Program (EMTP). In this study, the Alternative Transients Program (ATP) version 5.7p2 was applied on a simple industry network.Key words: Capacitor banks; Transient overvoltage and current; Energization inrush; Back-to-back switching; Preinsertion resistor and inductor
Intra-Articular Autologous Platelet-Rich Plasma Hip Injection May Result in Osteogenesis Depicted as an Increase in Femoral Neck Bone Density  [PDF]
Marwa A. Ahmed, Andre Panagos
Open Journal of Regenerative Medicine (OJRM) , 2014, DOI: 10.4236/ojrm.2014.32005

Osteoporosis has become one of the most prevalent bone diseases in developed countries. As the world’s population ages, this complex skeletal disorder is predicted to become an even more widespread and serious health condition, posing greater societal economic burden. Current therapeutic agents are limited by clinically significant side effects. In this report, we present a case that suggests intra-articular platelet-rich plasma (PRP) injectate may improve bone mineral density (BMD). This observation raises a question with exciting implications—can PRP serve as a viable and relatively safe, targeted treatment option to improve bone density?

Enhanced Thermal Stability of Promising Nano-Porous Silicon Powder  [PDF]
Marwa Nabil, Hussien A. Motaweh
Advances in Nanoparticles (ANP) , 2016, DOI: 10.4236/anp.2016.54021
A direct synthesis method is introduced to prepare nano-porous silicon-nickel nanocomposite (nPS/Ni) powder for thermal isolation applications. In this paper, we study the thermal stability of nanocomposites consisting of nanoparticles metal incorporated into the pores of a porous silicon by a very simple method. The nickel element is chemically deposited whereas the nanoparticles are precipitated on the pore surfaces. The (nPS) and (nPS/Ni) nano-materials are thermally measured under nitrogen at temperatures of 40 - 1000, noticeable, demonstrating better thermal stability of (nPS/Ni) until 900 than in the case of (nPS) at 600. Then, the improving of the thermal stability of the nPS powder is facilitated using it in many applications of the thermal insulation process.
Shape Control of Silica Powder Formation  [PDF]
Marwa Nabil, Hussien A. Motaweh
Journal of Materials Science and Chemical Engineering (MSCE) , 2019, DOI: 10.4236/msce.2019.73004
Abstract: The purpose of the present research is the different morphologies production of crystalline and amorphous-silica powder. It’s a basic material for many pharmaceutical and environmental applications as well. And, it’s produced using the combination of the alkali chemical etching process and the ultra-sonication technique. The critical preparation conditions are KOH concentration (weight %) and the sonication time (hour). The paper presents the chemical mechanism of the silica particle formation as well as the different morphology. The results show the formation of crystalline and amorphous-porous-silica particles in the micrometer range with the porous order network that has pore sizes range in micrometer too. This synthetic uses commercial silicon, which could be useful for large-scale production. Also, the nano-sphere and nano-cubic shapes of silica powder are formed starting by commercial silicon powder.
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