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Search Results: 1 - 10 of 191722 matches for " Marvin D Tark "
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Tolerability of NGX-4010, a capsaicin 8% dermal patch, following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with post-herpetic neuralgia
Lynn R Webster, Margarita Nunez, Marvin D Tark, Edwin D Dunteman, Biao Lu, Jeffrey K Tobias, Geertrui F Vanhove
BMC Anesthesiology , 2011, DOI: 10.1186/1471-2253-11-25
Abstract: Twenty-four patients with PHN were pretreated with lidocaine 2.5%/prilocaine 2.5% cream for 60 minutes before receiving a single 60-minute application of NGX-4010. Tolerability was assessed by measuring patch application duration, the proportion of patients completing over 90% of the intended treatment duration, application site-related pain using the Numeric Pain Rating Scale (NPRS), and analgesic medication use to relieve such pain. Safety was assessed by monitoring adverse events (AEs) and dermal irritation using dermal assessment scores.The mean treatment duration of NGX-4010 was 60.2 minutes and all patients completed over 90% of the intended patch application duration. Pain during application was transient. A maximum mean change in NPRS score of +3.0 was observed at 55 minutes post-patch application; pain scores gradually declined to near pre-anesthetic levels (+0.71) within 85 minutes of patch removal. Half of the patients received analgesic medication on the day of treatment; by Day 7, no patients required medication. The most common AEs were application site-related pain, erythema, edema, and pruritus. All patients experienced mild dermal irritation 5 minutes after patch removal, which subsequently decreased; at Day 7, no irritation was evident. The maximum recorded dermal assessment score was 2.NGX-4010 was well tolerated following pretreatment with lidocaine 2.5%/prilocaine 2.5% cream in patients with PHN. The tolerability of the patch application appeared comparable with that seen in other studies that used 4% lidocaine cream as the pretreatment anesthetic. This study is registered at http://www.clinicaltrials.gov webcite as number NCT00916942.Neuropathic pain is pain arising as a direct consequence of a lesion or disease affecting the somatosensory system [1]. Post-herpetic neuralgia (PHN) is a common type of neuropathic pain occurring as a complication of reactivation of the varicella zoster virus (shingles). PHN is caused by damage to the small-diamet
Effect of duration of postherpetic neuralgia on efficacy analyses in a multicenter, randomized, controlled study of NGX-4010, an 8% capsaicin patch evaluated for the treatment of postherpetic neuralgia
Lynn R Webster, Marvin Tark, Richard Rauck, Jeffrey K Tobias, Geertrui F Vanhove
BMC Neurology , 2010, DOI: 10.1186/1471-2377-10-92
Abstract: This multicenter, double-blind, controlled study randomized 155 patients 2:1 to receive either NGX-4010 or a 0.04% capsaicin control patch. Patients were at least 18 years old with PHN for at least 3 months, and an average Numeric Pain Rating Scale (NPRS) score of 3 to 9. The primary efficacy endpoint was the percentage change in NPRS score from baseline to weeks 2-8.The mean percent reduction in "average pain for the past 24 hours" NPRS scores from baseline to weeks 2-8 was greater in the NGX-4010 group (36.5%) compared with control (29.9%) although the difference was not significant (p = 0.296). PGIC analysis demonstrated that more NGX-4010 recipients considered themselves improved (much, or very much) compared with control at weeks 8 and 12, but the differences did not reach statistical significance. Post hoc analyses of patients with PHN for at least 6 months showed significantly greater reductions in "average pain for the past 24 hours" NPRS scores from baseline to weeks 2-8 in NGX-4010 patients compared to controls (37.6% versus 23.4%; p = 0.0291). PGIC analysis in this subgroup demonstrated that significantly more NGX-4010 recipients considered themselves much or very much improved compared with control at week 12 (40% versus 20%; p = 0.0403;).Although treatment appeared to be safe and well tolerated, a single 60-minute application of NGX-4010 failed to show efficacy in this study which included patients with PHN for less than 6 months. Large reductions in pain observed among control patients with pain for less than 6 months may have been due to spontaneous resolution of PHN, may have confounded the results of the prespecified analyses, and should be taken into account when designing PHN studies.NCT00068081Postherpetic neuralgia (PHN) is a painful complication of acute herpes zoster (shingles) that is caused by reactivation of the varicella zoster virus usually contracted in childhood. Acute herpes zoster is often very painful. Usually this pain subsides, but
A Measure of Decision Flexibility
Ross D. Shachter,Marvin Mandelbaum
Computer Science , 2013,
Abstract: We propose a decision-analytical approach to comparing the flexibility of decision situations from the perspective of a decision-maker who exhibits constant risk-aversion over a monetary value model. Our approach is simple yet seems to be consistent with a variety of flexibility concepts, including robust and adaptive alternatives. We try to compensate within the model for uncertainty that was not anticipated or not modeled. This approach not only allows one to compare the flexibility of plans, but also guides the search for new, more flexible alternatives.
A law of nature?  [PDF]
Marvin Chester
Open Journal of Ecology (OJE) , 2011, DOI: 10.4236/oje.2011.13011
Abstract: Is there an overriding principle of nature, hitherto overlooked, that governs all population behavior? A single principle that drives all the regimes observed in nature exponential-like growth, saturated growth, population decline, population extinction, oscillatory behavior? In current orthodox population theory, this diverse range of population behaviors is described by many different equations each with its own specific justification. The signature of an overriding principle would be a differential equation which, in a single statement, embraces all the panoply of regimes. A candidate such governing equation is proposed. The principle from which the equation is derived is this: The effect on the environment of a population’s success is to alter that environment in a way that opposes the success.
Cartan subalgebras in general and special linear algebras
Kyoung-Tark Kim
Mathematics , 2014,
Abstract: In this paper we study Cartan subalgebras in general and special linear algebras over a field of positive characteristic. We determined the conjugacy classes of Cartan subalgebras under the general linear groups, and count the explicit number of all Cartan subalgebras from its conjugacy when the base field is an arbitrary finite field.
Impact of the National Health Fund policy on hormone treatment for prostate cancer in Jamaica
Morrison,Belinda F.; Aiken,William D.; Reid,Marvin E.;
Revista Panamericana de Salud Pública , 2011, DOI: 10.1590/S1020-49892011000600004
Abstract: objective: to compare the proportion of patients choosing surgical versus medical castration to treat prostate cancer, before and after the national health fund (nhf) of jamaica began to subsidize hormone therapy. methods: a retrospective review was performed at the university hospital of the west indies (uhwi), jamaica. the pathology database at uhwi was searched to identify patients who had prostate biopsies between january 2000 and december 2007. these were combined with records of biopsies at external institutions. medical records of all patients with positive prostate biopsies were reviewed to determine if they had received androgen deprivation therapy (adt). patients were classified as having had surgical castration (bilateral orchiectomy) or medical castration. chi-square statistics were used to determine the difference in proportions between those choosing medical versus surgical castration before and after march 2005, when the nhf began offering subsidies for adt drugs. results: of the 1 529 prostate biopsies performed during the study period, 680 (44.0%) cases of prostate cancer were diagnosed. of these, 458 patients underwent adt and had complete records available for analysis. the mean patient age was 72 years. during the entire study period, surgical castration was performed in 265 patients (58.0%) and medical castration in 193 (42.0%). a greater proportion of orchiectomies were performed before march 2005, rather than after (p < 0.001). estrogens were the most common method of medical castration used before the nhf subsidy became available (62.0%); while luteinizing hormone-releasing hormone analogues (38.0%) and antiandrogens (36.5%) were most often chosen afterwards. conclusions: surgical castration was more common than medical castration before march 2005. after the nhf began to subsidize the cost of drugs for hormone therapy, medical castration was chosen more often. increased access to drugs for hormone therapy has changed treatment patterns in ja
Optimizing Anharmonicity in Nanoscale Weak Link Josephson Junction Oscillators
R. Vijay,J. D. Sau,Marvin L. Cohen,I. Siddiqi
Physics , 2009, DOI: 10.1103/PhysRevLett.103.087003
Abstract: Josephson tunnel junctions are widely used as nonlinear elements in superconducting circuits such as low noise amplifiers and quantum bits. However, microscopic defects in the oxide tunnel barrier can produce low and high frequency noise which can potentially limit the coherence times and quality factors of resonant circuits. Weak link Josephson junctions are an attractive alternative provided that sufficient nonlinearity can be engineered. We compute the current phase relation for superconducting weak links, with dimensions comparable to the zero temperature coherence length, connected to two and three dimensional superconducting electrodes. Our results indicate that 50-100 nm long aluminum nanobridges connected with three dimensional banks can be used to construct nonlinear oscillators for bifurcation amplification. We also show that under static current bias, these oscillators have a sufficiently anharmonic energy level structure to form a qubit. Such weak link junctions thus present a practical new route for realizing sensitive quantum circuits.
Theory of a one-dimensional double-X atom interferometer
Marvin D. Girardeau,Kunal K. Das,Ewan M. Wright
Physics , 2002, DOI: 10.1103/PhysRevA.66.023604
Abstract: The dynamics of an atom waveguide X-junction beam splitter becomes truly 1D in a regime of low temperatures and densities and large positive scattering lengths where the transverse mode becomes frozen and the many-body Schrodinger dynamics becomes exactly soluble via a generalized Fermi-Bose mapping theorem. We analyze the interferometric response of a double-X interferometer of this type due to potential differences between the interferometer arms.
Faster mass decomposition
Kai Dührkop,Marcus Ludwig,Marvin Meusel,Sebastian B?cker
Quantitative Biology , 2013,
Abstract: Metabolomics complements investigation of the genome, transcriptome, and proteome of an organism. Today, the vast majority of metabolites remain unknown, in particular for non-model organisms. Mass spectrometry is one of the predominant techniques for analyzing small molecules such as metabolites. A fundamental step for identifying a small molecule is to determine its molecular formula. Here, we present and evaluate three algorithm engineering techniques that speed up the molecular formula determination. For that, we modify an existing algorithm for decomposing the monoisotopic mass of a molecule. These techniques lead to a four-fold reduction of running times, and reduce memory consumption by up to 94%. In comparison to the classical search tree algorithm, our algorithm reaches a 1000-fold speedup.
Treatment Recommendations among Radiation Oncologists in the Treatment of Cutaneous Squamous Cell Carcinoma with Perineural Invasion  [PDF]
Upendra Parvathaneni, Madhu Shetti, Daniel Berg, Seesha Takagishi, George E. Laramore, Chrysalyne D. Schmults, Anokhi Jambusaria-Pahlajani, Stephen D. Hess, Marvin Heyboer III, Jay J. Liao
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.711082
Abstract: Purpose: Post-operative radiotherapy (PORT) for resected cutaneous squamous cell carcinoma (CSCC) with perineural invasion (PNI) is controversial. Therefore, we conducted a survey to review treatment recommendations among Radiation Oncologists (ROs) in the management of CSCC with PNI. Materials & Methods: In March 2011, we contacted all ROs and trainees in the US through email addresses listed in the 2009 ASTRO directory. Our web-based survey presented clinical vignettes involving Mohs micrographically resected CSCC with microscopic PNI (mPNI) or clinical PNI (cPNI). For each vignette, ROs were asked to indicate if PORT was appropriate and to further specify the dose and volume to treat. Results: Three hundred fifty two responses were completed and analyzed. The majority of ROs (72%) had over 10 years of post residency experience. 64% of the sampled ROs had a special interest in treating head and neck cancers, and 64% treated 4 or more cases per year. Approximately 95% recommended PORT for cPNI whereas 59% recommended PORT for mPNI. Post residency experience (10+ yrs vs. <10 yrs) was associated with a greater propensity to recommend PORT for mPNI (48% vs. 30%, p = 0.005) and for mPNI of deep subcutaneous non-named nerve involvement (80% vs. 60%, p = 0.001). ROs treating 8 or more cases per year (vs. <7) were more likely to recommend PORT for mPNI in immunocompromised patients (74% vs. 57%, p = 0.01). Conclusions: Our study demonstrates significant variability among ROs in the management of CSCC with mPNI. For cases of cPNI, an overwhelming majority recommended PORT. In cases of mPNI, there was no consensus for recommending PORT, although
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