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Search Results: 1 - 10 of 247218 matches for " Martin Rühl "
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Fruiting Body Production and Aroma Profile Analysis of Agrocybe aegerita Cultivated on Different Substrates  [PDF]
Vanessa Kleofas, Laura Sommer, Marco A. Fraatz, Holger Zorn, Martin Rühl
Natural Resources (NR) , 2014, DOI: 10.4236/nr.2014.56022
Abstract:

The industrial cultivated basidiomycete Agrocybe aegerita, also known as “Pioppino” in Italy or “Samthaube” in Germany, is a high quality mushroom with a delicious aroma. Cultivation of A. aegerita on wheat straw supplemented with different residues of the food industry showed the highest yields in fruiting body production with a biological efficiency of 36% when black tea pomace was added. The addition of other substrates resulted in biological efficiencies of 23% to 33%. Besides the mushroom yields, the number and size of fruiting bodies harvested on the different substrates were determined. A comparison of the aroma profiles of A. aegerita grown on wheat straw and on wheat straw supplemented with black tea by means of GC/MS/MS/O is presented.

Review of the Use of Electroencephalography as an Evaluation Method for Human-Computer Interaction
rémy Frey,Christian Mühl,Fabien Lotte,Martin Hachet
Computer Science , 2013,
Abstract: Evaluating human-computer interaction is essential as a broadening population uses machines, sometimes in sensitive contexts. However, traditional evaluation methods may fail to combine real-time measures, an "objective" approach and data contextualization. In this review we look at how adding neuroimaging techniques can respond to such needs. We focus on electroencephalography (EEG), as it could be handled effectively during a dedicated evaluation phase. We identify workload, attention, vigilance, fatigue, error recognition, emotions, engagement, flow and immersion as being recognizable by EEG. We find that workload, attention and emotions assessments would benefit the most from EEG. Moreover, we advocate to study further error recognition through neuroimaging to enhance usability and increase user experience.
Effects of Guideline-Based Training on the Quality of Formal Ontologies: A Randomized Controlled Trial
Martin Boeker, Ludger Jansen, Niels Grewe, Johannes Rhl, Daniel Schober, Djamila Seddig-Raufie, Stefan Schulz
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061425
Abstract: Background The importance of ontologies in the biomedical domain is generally recognized. However, their quality is often too poor for large-scale use in critical applications, at least partially due to insufficient training of ontology developers. Objective To show the efficacy of guideline-based ontology development training on the performance of ontology developers. The hypothesis was that students who received training on top-level ontologies and design patterns perform better than those who only received training in the basic principles of formal ontology engineering. Methods A curriculum was implemented based on a guideline for ontology design. A randomized controlled trial on the efficacy of this curriculum was performed with 24 students from bioinformatics and related fields. After joint training on the fundamentals of ontology development the students were randomly allocated to two groups. During the intervention, each group received training on different topics in ontology development. In the assessment phase, all students were asked to solve modeling problems on topics taught differentially in the intervention phase. Primary outcome was the similarity of the students’ ontology artefacts compared with gold standard ontologies developed by the authors before the experiment; secondary outcome was the intra-group similarity of group members’ ontologies. Results The experiment showed no significant effect of the guideline-based training on the performance of ontology developers (a) the ontologies developed after specific training were only slightly but not significantly closer to the gold standard ontologies than the ontologies developed without prior specific training; (b) although significant differences for certain ontologies were detected, the intra-group similarity was not consistently influenced in one direction by the differential training. Conclusion Methodologically limited, this study cannot be interpreted as a general failure of a guideline-based approach to ontology development. Further research is needed to increase insight into whether specific development guidelines and practices in ontology design are effective.
Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases
Christian Wybranski, Martin Zeile, David L?wenthal, Frank Fischbach, Maciej Pech, Friedrich-Wilhelm Rhl, Günther Gademann, Jens Ricke, Oliver Dudeck
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-43
Abstract: Thirty patients with a total of 43 metastases underwent CT- or MRI-guided HDR-BT. In 13 of these patients a total of 15 additional lesions were identified, which were not treated at the initial session and served for comparison. Magnetic resonance imaging (MRI) including breathhold echoplanar DWI sequences was performed prior to therapy (baseline MRI), 2 days after HDR-BT (early MRI) as well as after 3 months (follow-up MRI). Tumor volume (TV) and intratumoral apparent diffusion coefficient (ADC) were measured independently by two radiologists. Statistical analysis was performed using univariate comparison, ANOVA and paired t test as well as Pearson's correlation.At early MRI no changes of TV and ADC were found for non-treated colorectal liver metastases. In contrast, mean TV of liver lesions treated with HDR-BT increased by 8.8% (p = 0.054) while mean tumor ADC decreased significantly by 11.4% (p < 0.001). At follow-up MRI mean TV of non-treated metastases increased by 50.8% (p = 0.027) without significant change of mean ADC values. In contrast, mean TV of treated lesions decreased by 47.0% (p = 0.026) while the mean ADC increased inversely by 28.6% compared to baseline values (p < 0.001; Pearson's correlation coefficient of r = -0.257; p < 0.001).DWI is a promising imaging biomarker for early prediction of tumor response in patients with colorectal liver metastases treated with HDR-BT, yet the optimal interval between therapy and early follow-up needs to be elucidated.The liver with its dual blood supply is a predisposed organ for metastatic disease [1]. Colorectal carcinoma (CRC) represents the most frequent malignancy with isolated hepatic metastases [2]. Hepatic resection has become the standard of care and has been shown to lead to a significant improvement of long-term survival, however curative resection is possible in less than 25% of the patients with isolated hepatic metastases [3]. For unresectable metastases selective internal radiation therapy (SIRT) a
Universities Cooperate in Online Teaching. The Experience of the Bavarian Virtual University
Paul RüHL
EduAction : Electronic Education Magazine , 2010,
Abstract: The Bavarian Virtual University (BVU) is an institute set up by the universities and universities of Applied Sciences of the Free State of Bavaria, one of the 16 German L nder. The BVU is supported by the Bavarian Ministry of Higher Education. At present, there are more than 60,000 course enrolments by more than 25,000 Bavarian students per academic year. The BVU provides online-courses with an equivalent of two to six credit points (by ECTS standards) which the member universities, all of them traditional brick-and-mortar universities, can integrate into their courses of study. Students of the member universities can attend the courses free of charge. The BVU offers neither complete courses of study nor degrees of its own. The basic and most important principles of the BVU are: Blended learning at the macro level of the course of study, not at the micro-level of the single course, priority given to asynchronous forms of communication; offering courses which are completely online, thus facilitating the import and export of online-courses between all 31 member universities and allowing a maximum of flexibility to the students. The BVU finances the developing as well as the conducting of its courses. This supports teachers in providing tuition to students from other universities.
Targeted therapy for esophagogastric cancers: a review
Khattak MA, Martin HL, Karapetis CS
OncoTargets and Therapy , 2012, DOI: http://dx.doi.org/10.2147/OTT.S25117
Abstract: rgeted therapy for esophagogastric cancers: a review Review (2462) Total Article Views Authors: Khattak MA, Martin HL, Karapetis CS Published Date May 2012 Volume 2012:5 Pages 91 - 102 DOI: http://dx.doi.org/10.2147/OTT.S25117 Received: 24 February 2012 Accepted: 27 March 2012 Published: 21 May 2012 Muhammad A Khattak,1 Hilary L Martin,2 Christos S Karapetis1,3 1Flinders Medical Centre, Adelaide, South Australia; 2Calvary Hospital, Adelaide, SA, Australia; 3Flinders University, Adelaide, SA, Australia Abstract: The incidence of esophagogastric cancers is increasing rapidly in the Western population. Despite better understanding of the biology and intense research in the treatment of these cancers, the long-term survival remains poor both in the locally advanced and metastatic settings. The addition of combined modality strategies has resulted in modest improvement in 5-year survival rates. A number of biologic agents targeting epidermal-derived growth factor receptor, vascular endothelial derived growth factor and its receptor, and mammalian target of rapamycin (mTOR) are being currently evaluated in Phase II and III clinical trials. Some of these, like trastuzumab, cetuximab, and bevacizumab, have shown promising results. This review provides a brief overview of the recent developments in biologic agents for the treatment of esophagogastric cancers.
Targeted therapy for esophagogastric cancers: a review
Khattak MA,Martin HL,Karapetis CS
OncoTargets and Therapy , 2012,
Abstract: Muhammad A Khattak,1 Hilary L Martin,2 Christos S Karapetis1,31Flinders Medical Centre, Adelaide, South Australia; 2Calvary Hospital, Adelaide, SA, Australia; 3Flinders University, Adelaide, SA, AustraliaAbstract: The incidence of esophagogastric cancers is increasing rapidly in the Western population. Despite better understanding of the biology and intense research in the treatment of these cancers, the long-term survival remains poor both in the locally advanced and metastatic settings. The addition of combined modality strategies has resulted in modest improvement in 5-year survival rates. A number of biologic agents targeting epidermal-derived growth factor receptor, vascular endothelial derived growth factor and its receptor, and mammalian target of rapamycin (mTOR) are being currently evaluated in Phase II and III clinical trials. Some of these, like trastuzumab, cetuximab, and bevacizumab, have shown promising results. This review provides a brief overview of the recent developments in biologic agents for the treatment of esophagogastric cancers.Keywords: adenocarcinoma, squamous cell carcinoma, VEGF, trastuzumab, Her2- positive EGC
Coupling of cytoplasm and adhesion dynamics determines cell polarization and locomotion
Wolfgang Alt,Martin Bock,Christoph M?hl
Quantitative Biology , 2009,
Abstract: Observations of single epidermal cells on flat adhesive substrates have revealed two distinct morphological and functional states, namely a non-migrating symmetric unpolarized state and a migrating asymmetric polarized state. These states are characterized by different spatial distributions and dynamics of important biochemical cell components: F-actin and myosin-II form the contractile part of the cytoskeleton, and integrin receptors in the plasma membrane connect F-actin filaments to the substratum. In this way, focal adhesion complexes are assembled, which determine cytoskeletal force transduction and subsequent cell locomotion. So far, physical models have reduced this phenomenon either to gradients in regulatory control molecules or to different mechanics of the actin filament system in different regions of the cell. Here we offer an alternative and self-organizational model incorporating polymerization, pushing and sliding of filaments, as well as formation of adhesion sites and their force dependent kinetics. All these phenomena can be combined into a non-linearly coupled system of hyperbolic, parabolic and elliptic differential equations. Aim of this article is to show how relatively simple relations for the small-scale mechanics and kinetics of participating molecules may reproduce the emergent behavior of polarization and migration on the large-scale cell level.
High resolution cyclostratigraphy of the early Eocene – new insights into the origin of the Cenozoic cooling trend
T. Westerhold ,U. R hl
Climate of the Past (CP) & Discussions (CPD) , 2009,
Abstract: Here we present a high-resolution cyclostratigraphy based on X-ray fluorescence (XRF) core scanning data from a new record retrieved from the tropical western Atlantic (Demerara Rise, ODP Leg 207, Site 1258). The Eocene sediments from ODP Site 1258 cover magnetochrons C20 to C24 and show well developed cycles. This record includes the missing interval for reevaluating the early Eocene part of the Geomagnetic Polarity Time Scale (GPTS), also providing key aspects for reconstructing high-resolution climate variability during the Early Eocene Climatic Optimum (EECO). Detailed spectral analysis demonstrates that early Eocene sedimentary cycles are characterized by precession frequencies modulated by short (100 kyr) and long (405 kyr) eccentricity with a generally minor obliquity component. Counting of both the precession and eccentricity cycles results in revised estimates for the duration of magnetochrons C21r through C24n. Our cyclostratigraphic framework also corroborates that the geochronology of the Eocene Green River Formation (Wyoming, USA) is still questionable mainly due to the uncertain correlation of the "Sixth tuff" to the GPTS. Right at the onset of the long-term Cenozoic cooling trend the dominant eccentricity-modulated precession cycles of ODP Site 1258 are interrupted by strong obliquity cycles for a period of ~800 kyr in the middle of magnetochron C22r. These distinct obliquity cycles at this low latitude site point to (1) a high-latitude driving mechanism on global climate variability from 50.1 to 49.4 Ma, and (2) seem to coincide with a significant drop in atmospheric CO2 concentration below a critical threshold between 2- and 3-times the pre-industrial level (PAL). The here newly identified orbital configuration of low eccentricity in combination with high obliquity amplitudes during this ~800-kyr period and the crossing of a critical pCO2 threshold may have led to the formation of the first ephemeral ice sheet on Antarctica as early as ~50 Ma ago.
Kartografie des Imagin ren – Karten in Fantasy-Rollenspielen Hacer cartografía del imaginario – mapas en juegos de rol Mapping the Imaginary—Maps in Fantasy Role-Playing Games
Tobias Rhl,Regine Herbrik
Forum : Qualitative Social Research , 2008,
Abstract: Der Artikel besch ftigt sich mit kartografischen Darstellungen als kommunikativer Vermittlungsstrategie des Imagin ren am Beispiel von Karten in Fantasy-Rollenspielen. Im Rückgriff auf SCHüTZsche überlegungen zur Intersubjektivit t und Kommunikation verstehen wir Karten als eine der Strategien im Umgang mit der "mittleren Transzendenz" in der Kommunikation mit Anderen. Die "sozialwissenschaftliche Hermeneutik" (SOEFFNER) wird als eine methodische Herangehensweise an Karten und die Interaktionen, in denen sie Verwendung finden, vorgestellt. In unseren Analysen der in Rollenspielen genutzten Karten zeigen wir, dass Karten nicht nur dazu dienen, sich zu verorten, sondern auch ein Mittel sind, einen Ort zu erzeugen, zu dem wir in sinnhafter Beziehung stehen. Karten helfen so dabei, uns das Gefühl zu geben, zu einem (imagin ren) – nur mittelbar gegebenen – Territorium hinzugeh ren. URN: urn:nbn:de:0114-fqs0803255 Este artículo aborda las representaciones cartográficas como forma de comunicación de lo imaginario, tomando como ejemplo los juegos de rol. Con base en las reflexiones de SCHUTZ sobre intersubjetividad y comunicación entendemos los mapas como estrategias para tratar el problema de la "trascendencia mediada" en la comunicación con el otro. La hermenéutica de las ciencias sociales (SOEFFNER) se concibe como una aproximación metodológica a los mapas y las interacciones que estos implican. A través de nuestros análisis de mapas usados en juegos de rol podemos mostrar que éstos no solo sirven para situarse sino también como un medio de crear activamente un espacio significativo respecto al cual mantenemos un vínculo de sentido. Las cartas ayudan a formar un sentido de pertenencia en territorios (imaginarios) que solo nos son dados de forma mediada. URN: urn:nbn:de:0114-fqs0803255 This paper deals with cartographic representations as means of communicating the imaginary using maps in fantasy role-playing games as an example. Drawing on SCHUTZian accounts of intersubjectivity and communication we understand maps as one of many strategies to deal with the problem of "medium transcendencies" posed by communicating with others. The methodology of "sociological hermeneutics" (SOEFFNER) is introduced as means of approaching maps and the interactions they are involved in. In our analyses of maps used in role-playing games we can then show that maps are not only a means of locating oneself but also a means of actively creating a meaningful place in which we are entangled. Thus, maps help to form a sense of belonging in (imaginary) territories which are only give
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