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Search Results: 1 - 10 of 26242 matches for " Martin Daniaux "
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Sequencing strategy for the whole mitochondrial genome resulting in high quality sequences
Liane Fendt, Bettina Zimmermann, Martin Daniaux, Walther Parson
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-139
Abstract: We amplified whole mitochondrial genomes as two overlapping PCR-fragments comprising each about 8500 bases in length. We developed a set of 96 primers that can be applied to a (manual) 96 well-based technology, which resulted in at least double strand sequence coverage of the entire coding region (codR).This elaborated sequencing strategy is straightforward and allows for an unambiguous sequence analysis and interpretation including sometimes challenging phenomena such as point and length heteroplasmy that are relevant for the investigation of forensic and clinical samples.Investigations of the human mt genome are in the focus of biological and medical scientific disciplines. Compared to nuclear DNA (nDNA), mitochondrial DNA (mtDNA) is more vulnerable to oxidative damage and undergoes a higher rate of mutation [1]. Because of these features the analysis of the mt genome has become a proven tool in population genetics. A multi-copy genome without recombination which accumulates mutations allows for the establishment of phylogenetic trees [2]. It was the information from the highly variable mitochondrial control region (CR) that lifted the secret of human evolution starting in Africa about 150000 years ago and gave an insight in human migration all over the world within the past 60000 years [3,4]. Sequences of full mt genomes are necessary to decipher yet not defined haplotypes and assign them to their phylogeographic environment.Mitochondrial DNA mutations in the coding region (codR) have been associated with several pathologies [5] including cancer [6-9]. During oxidative phosphorylation (OXPHOS) mitochondria produce reactive oxidative species (ROS) that potentially induce DNA mutations. Such an initial mutation is heteroplasmic with the mutated variant constituting a minority [10]. In the course of several replications the heteroplasmic mutation may become dominant leading to cancer [8]. This theory is based on the results of several investigations on cancer tissue
Introduction of organised mammography screening in Tyrol: results following first year of complete rollout
Willi Oberaigner, Martin Daniaux, Sabine Geiger-Gritsch, Rudolf Knapp, Uwe Siebert, Wolfgang Buchberger
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-673
Abstract: Working from the results of the pilot phase, we extended the organised mammography system to all counties in Tyrol. All women living in Tyrol and covered by compulsory social insurance were invited for a mammography, in the age group 40-59 annually and in the age group 60-69 biennially. Screening mammography was offered mainly by radiologists in private practice, with further assessment performed at hospitals. Using the screening database, all well-established performance indicators were analysed and compared with accepted/desired levels as per the EU guidelines.From June 2008 to May 2009, 120,440 women were invited. Per 1000 mammograms, 14 women were recalled for further assessment, nine underwent biopsy and four cancer cases were detected. Of invasive breast cancer cases, 32.3% and 68.4% were ≤ 10 mm and ≤ 15 mm in size, respectively, and 79.2% were node-negative. The positive predictive value for further assessment and for biopsy was 25.9% and 39.9%, respectively. Estimated two-year participation rate was 57.0%. In total, 14 interval cancer cases were detected during one year of follow-up; this is 18.4% of the background incidence rate.In Tyrol, Austria, an organised mammography screening program was implemented in a smooth transition from an existing spontaneous screening system and was completely rolled out within a short time. The high level of performance already seen in the pilot phase was maintained after rollout, and improvements resulting from the pilot phase were affirmed after one year of complete rollout.Breast cancer is the leading cause of female cancer death in all industrialised countries (and also worldwide), and the breast is also the leading incident cancer site for females [1]. Therefore, screening methods for breast cancer are of greatest public health importance. A recently published Cochrane Review, which assessed the effect of mammography screening for breast cancer on mortality and morbidity concluded that screening is likely to reduce bre
Introduction of organised mammography screening in tyrol: results of a one-year pilot phase
Willi Oberaigner, Wolfgang Buchberger, Thomas Frede, Martin Daniaux, Rudolf Knapp, Christian Marth, Uwe Siebert
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-91
Abstract: In June 2007, the system of opportunistic mammography screening in Tyrol was changed to an organised system by introducing a personal invitation system, a training program, a quality assurance program and by setting up a screening database. All procedures are noted in a written protocol. Most EU recommendations for organised mammography screening were followed, except double reading. All women living in Tyrol and covered by social insurance are now invited for a mammography, in age group 40-59 annually and in age group 60-69 biannually. Screening mammography is offered mainly by radiologists in private practice. We report on the results of the first year of piloting organised mammography screening in two counties in Tyrol.56,432 women were invited. Estimated participation rate was 34.5% at one year of follow-up (and 55.5% at the second year of follow-up); 3.4% of screened women were recalled for further assessment or intermediate screening within six months. Per 1000 mammograms nine biopsies were performed and four breast cancer cases detected (N = 68). Of invasive breast cancer cases 34.4% were ≤ 10 mm in size and 65.6% were node-negative. In total, six interval cancer cases were detected during one year of follow-up; this is 19% of the background incidence rate.In the Tyrolean breast cancer screening program, a smooth transition from a spontaneous to an organised mammography screening system was achieved in a short time and with minimal additional resources. One year after introduction of the screening program, most of the quality indicators recommended by the European guidelines had been reached.However, it will be necessary to introduce double reading, to change the rule for BI-RADS 3, and to concentrate on actions toward improving the participation rate.Breast cancer is the leading cause of female cancer death in all industrialised countries (and also worldwide), and the breast is also the leading incident cancer site for females [1]. Therefore, screening metho
Multiple meningiomas in a dog: a case report
Lise A Daniaux,Beverly K Sturges,Allison L Zwingenberger
Veterinary World , 2012, DOI: 10.5455/vetworld.2012.495-498
Abstract: [Vet. World 2012; 5(8.000): 495-498]
Genetic diversity and networks of exchange: a combined approach to assess intra-breed diversity
Jean-Fran?ois Dumasy, Christel Daniaux, Isabelle Donnay, Philippe V Baret
Genetics Selection Evolution , 2012, DOI: 10.1186/1297-9686-44-17
Abstract: For each breed, between 91 and 225 sheep were genotyped with 19 microsatellites. Genetic differentiations between breeds and among herds within a breed were evaluated and the genetic structure of the breeds was described using Bayesian clustering (Structure). Exchanges of animals between 20, 46 and 95 herds according to breed were identified via semi-directed interviews and were analyzed using the concepts of the network theory to calculate average degrees and shortest path lengths between herds. Correlation between the Reynolds’ genetic distances and the shortest path lengths between each pair of herds was assessed by a Mantel test approach.Genetic differentiation between breeds was high (0.16). Overall Fst values among herds were high in each breed (0.17, 0.11 and 0.10). Use of the Bayesian approach made it possible to identify genetic groups of herds within a breed. Significant correlations between the shortest path lengths and the Reynolds’ genetic distances were found in each breed (0.87, 0.33 and 0.41), which demonstrate the influence of exchanges between herds on the genetic diversity. Correlation differences between breeds could be explained by differences in the average degree of the animal exchange networks, which is a measure of the number of exchanges per herd. The two breeds with the highest average degree showed the lowest correlation. Information from the exchange networks was used to assign individuals to the genetic groups when molecular information was incomplete or missing to identify donors for a cryobank.A fine-scale picture of the population genetic structure at the herd level was obtained for the three breeds. Network analysis made it possible to highlight the influence of exchanges on genetic structure and to complete or replace molecular information in establishing a conservation program.Local livestock breeds play an important role in providing food products and environmental services and are part of the cultural heritage. In 2006, 179 of 1
A Yield Mapping Procedure Based on Robust Fitting Paraboloid Cones on Moving Elliptical Neighborhoods and the Determination of Their Size Using a Robust Variogram  [PDF]
Martin Bachmaier
Positioning (POS) , 2010, DOI: 10.4236/pos.2010.11004
Abstract: The yield map is generated by fitting the yield surface shape of yield monitor data mainly using paraboloid cones on floating neighborhoods. Each yield map value is determined by the fit of such a cone on an elliptical neighborhood that is wider across the harvest tracks than it is along them. The coefficients of regression for modeling the paraboloid cones and the scale parameter are estimated using robust weighted M-estimators where the weights decrease quadratically from 1 in the middle to zero at the border of the selected neighborhood. The robust way of estimating the model parameters supersedes a procedure for detecting outliers. For a given neighborhood shape, this yield mapping method is implemented by the Fortran program paraboloidmapping.exe, which can be downloaded from the web. The size of the selected neighborhood is considered appropriate if the variance of the yield map values equals the variance of the true yields, which is the difference between the variance of the raw yield data and the error variance of the yield monitor. It is estimated using a robust variogram on data that have not had the trend removed.
Sources of inaccuracy when estimating economically optimum N fertilizer rates  [PDF]
Martin Bachmaier
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.33037
Abstract: Nitrogen rate trials are often performed to determine the economically optimum N application rate. For this purpose, the yield is modeled as a function of the N application. The regression analysis provides an estimate of the modeled function and thus also an estimate of the economic optimum, Nopt. Obtaining the accuracy of such estimates by confidence intervals for Nopt is subject to the model assumptions. The dependence of these assumptions is a further source of inaccuracy. The Nopt estimate also strongly depends on the N level design, i.e., the area on which the model is fitted. A small area around the supposed Nopt diminishes the dependence of the model assumptions, but prolongs the confidence interval. The investigations of the impact of the mentioned sources on the inaccuracy of the Nopt estimate rely on N rate trials on the experimental field Sieblerfeld (Bavaria). The models applied are the quadratic and the linear-plus-plateau yield regression model.
Waiting for Redemption in The House of Asterion: A Stylistic Analysis  [PDF]
Martin Tilney
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.22007
Abstract: The House of Asterion is a short story by Jorge Luis Borges that retells the classical myth of the Cretan Minotaur from an alternate perspective. The House of Asterion features the Minotaur, aka Asterion, who waits for “redemption” in his labyrinth. Many literary critics have suggested that the Borgesian labyrinth is a metaphor for human existence and the universe itself. Others have correctly interpreted Asterion’s ironic death at the hands of Theseus as his eagerly awaited redemption. Borges’ subversion of the reader’s expectations becomes the departure point for a systemic functional stylistic analysis of the story in one of its English translations, revealing how deeper-level meanings in the text are construed through its lexicogrammatical structure. A systemic functional stylistic reading suggests that on a higher level of reality, Asterion’s redemption is not only the freedom that death affords, but also a transformation that transcends his fictional universe. Asterion’s twofold redemption is brought about not only by the archetypal hero Theseus but also by the reader, who through the process of reading enables Asterion’s emancipation from the labyrinth.
A Macroeconomic Model of Biodiversity Protection  [PDF]
David Martin
Theoretical Economics Letters (TEL) , 2013, DOI: 10.4236/tel.2013.35A1006

Many biodiversity researchers have responded to the financial constraints faced by policy makers to develop models based upon the “Noah’s Ark” metaphor, implying that society can save only a limited amount of biodiversity. Unfortunately, as Herman Daly (Land Economics, 1991) pointed out, such microeconomic rules can allow an ark to sink albeit in some optimal fashion. So, I step back to look at the macroeconomic question, how big should the ark be? I start with Norgaard’s (Ecological Economics, 2010) framework, which is based upon the concept of a production possibility frontier combined with a sustainability criterion. I develop a model from that starting point by shifting to an isoquant framework while maintaining the strong sustainability criterion. I demonstrate how this model allows for identifying and addressing the key biodiversity protection policy criteria at the macroeconomic level. One key conclusion from this modeling is that Daly’s analysis remains remarkably prescient.

Analysis of the Navier-Stokes Equations  [PDF]
Helmut Martin
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.210106
Abstract: The Navier-Stokes equations for incompressible fluid flows with impervious boundary and free surface are analyzed by means of a perturbation procedure involving dimensionless variables and a dimensionless perturbation parameter which is composed of kinematic viscosity of fluid, the acceleration of gravity and a characteristic length. The new dimensionless variables are introduced into the equation system. In addition, the perturbation parameter is introduced into terms for deriving approximations systems of different orders. Such systems are obtained by equating coefficients of like powers of perturbation parameter for the successive coefficients in the series. In these systems several terms are analyzed with regards to size and significance. Based on those systems, suitable solutions of NS equations can be found for different boundary conditions. For example, a relation for stationary channel flow is obtained as approximation to the NS equations of the lowest order after transformation back to dimensional variables.
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