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Search Results: 1 - 10 of 218 matches for " Marlena Pela "
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Characterization of Neurophysiologic and Neurocognitive Biomarkers for Use in Genomic and Clinical Outcome Studies of Schizophrenia
Gregory A. Light, Neal R. Swerdlow, Anthony J. Rissling, Allen Radant, Catherine A. Sugar, Joyce Sprock, Marlena Pela, Mark A. Geyer, David L. Braff
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039434
Abstract: Background Endophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder. Ideal endophenotypes exhibit deficits in patients, are stable over time and across shifts in psychopathology, and are suitable for repeat testing. Unfortunately, many leading candidate endophenotypes in schizophrenia have not been fully characterized simultaneously in large cohorts of patients and controls across these properties. The objectives of this study were to characterize the extent to which widely-used neurophysiological and neurocognitive endophenotypes are: 1) associated with schizophrenia, 2) stable over time, independent of state-related changes, and 3) free of potential practice/maturation or differential attrition effects in schizophrenia patients (SZ) and nonpsychiatric comparison subjects (NCS). Stability of clinical and functional measures was also assessed. Methods Participants (SZ n = 341; NCS n = 205) completed a battery of neurophysiological (MMN, P3a, P50 and N100 indices, PPI, startle habituation, antisaccade), neurocognitive (WRAT-3 Reading, LNS-forward, LNS-reorder, WCST-64, CVLT-II). In addition, patients were rated on clinical symptom severity as well as functional capacity and status measures (GAF, UPSA, SOF). 223 subjects (SZ n = 163; NCS n = 58) returned for retesting after 1 year. Results Most neurophysiological and neurocognitive measures exhibited medium-to-large deficits in schizophrenia, moderate-to-substantial stability across the retest interval, and were independent of fluctuations in clinical status. Clinical symptoms and functional measures also exhibited substantial stability. A Longitudinal Endophenotype Ranking System (LERS) was created to rank neurophysiological and neurocognitive biomarkers according to their effect sizes across endophenotype criteria. Conclusions The majority of neurophysiological and neurocognitive measures exhibited deficits in patients, stability over a 1-year interval and did not demonstrate practice or time effects supporting their use as endophenotypes in neural substrate and genomic studies. These measures hold promise for informing the “gene-to-phene gap” in schizophrenia research.
Patient, doctor, disease, and informed consent
Riccardo Pela
Multidisciplinary Respiratory Medicine , 2011, DOI: 10.1186/2049-6958-6-1-8
Abstract: Taking into account the prognosis of locally advanced or metastatic lung cancer, the utility of chemotherapy is discussed more often with the patient's relatives than with the patient him/herself. But survival and quality of life (QoL) are significantly better in patients treated with chemotherapy than in those who receive the best supportive care but not chemotherapy.In this respect it has been demonstrated that the patient is more agreeable to chemotherapy than are the relatives and even the doctor, if the expected results are in terms of survival or quality of life [1]:? 57% of patients opt for chemotherapy if the oneyear-survival is at least 10%? 68% of patients opt for chemotherapy if the QoL is ameliorated? the majority of patients opt for chemotherapy if a median survival of at least 4.5 months is expected.So, a real informed consent is of paramount importance in order to obtain the patient's cooperation for the therapeutic plan. The informed participation of the patient - in the sense of understanding the disease, its therapy and the interaction between the two - is necessary for the patient to be able to deal with a critical period of his/her life. This task is even more important in the case of enrolment in clinical trials.The study by Zaric et al. in this issue [2] carried out a survey on the perception of lung cancer patients undergoing experimental treatments. The authors argue that "the patients participating in clinical trials contribute not only to their own and future patients' treatment benefits, but also to the benefits of medicine and the science itself" and they ask the question: "physicians are aware of this fact, but are the patients aware of the same fact, too?".In this respect, 59 patients with advanced lung cancer, previously treated and enrolled in a clinical therapeutic trial, filled in a questionnaire with 20 items. The patients were asked about their knowledge of their own disease (type, stage) and the kind of therapy (previously and cu
Arhitektura in komunikacija
pela Hudnik
Urbani Izziv , 2003,
Abstract: V lanku je predstavljen vpliv tehnologije, znanosti in kapitalskih strategij na spremembe tradicionalnih oblik in definicij prostora, arhitekture in telesa. Spoznava nas z novimi procesi mi ljenja in bivanja, ki se stalno preoblikujejo v novih dinami nih asovnih in prostorskih kontekstih. Prostor postaja informacijski filter, komunikacijska mre a. S prerezom treh pokrajin: pokrajine megastruktur, nomadske pokrajine in psihedeli ne pokrajine teorija prispeva k razumevanju razvoja medijev in vesoljske tehnologije, informacijske tehnologije in elektronskega jezika. Ponuja oblikovanje razli nih megastruktur, medijskih povr in in ovojev sodobne informacijske dru be: antropolo ki modul, hipertelesa in infratelesa, bioelekronska telesa in telesa populacijske genetike. Predstavlja arhitekturo komunikacije.
Architecture and communication
pela Hudnik
Urbani Izziv , 2003,
Abstract: The article presents effects of technology, science and capital strategies on changes in traditional forms and definitions of space, architecture and bodies. It confronts us with new processes of thinking and living that are constantly being transformed into new dynamic time and spatial contexts. Space is becoming the information filter, communication network. A cross-section of three landscapes: landscape of megastructures, nomadic landscapes and psychedelic landscapes, theory contributes to understanding of media and space-age technology, information technology and electronical language. It offers designs of various megastructures, media surfaces and envelopes of contemporary information society: the anthropological module, hyper- and infra-bodies, bio-electronical bodies and population genetics bodies. It presents the architecture of communication.
La subjectivité littéraire dans _La cité des dames_
pela ?akelj
Voix Plurielles , 2011,
Abstract: L’expression du féminisme dans la littérature médiévale est liée à l’expression de la subjectivité. En refusant d’être une femme incompétente ou un objet sexuel Christine de Pizan décide de répondre à la misogynie médiévale à travers ses oeuvres littéraires, surtout dans la Cité des Dames, ville imaginaire construite selon le go t des femmes.
On the image of a noncommutative polynomial
pela ?penko
Mathematics , 2012,
Abstract: Let $F$ be an algebraically closed field of characteristic zero. We consider the question which subsets of $M_n(F)$ can be images of noncommutative polynomials. We prove that a noncommutative polynomial $f$ has only finitely many similarity orbits modulo nonzero scalar multiplication in its image if and only if $f$ is power-central. The union of the zero matrix and a standard open set closed under conjugation by $GL_n(F)$ and nonzero scalar multiplication is shown to be the image of a noncommutative polynomial. We investigate the density of the images with respect to the Zariski topology. We also answer Lvov's conjecture for multilinear Lie polynomials of degree at most 4 affirmatively.
Metaphorical conceptualization of some notions in depressive disorders: Is PLEASURE an insipid milky jelly?
Marlena Bartczak
Psychology of Language and Communication , 2008, DOI: 10.2478/v10057-008-0005-y
Abstract: The study concerned the process of metaphor creation in a group of depressive and of non-depressive people. It was assumed that due to some deficits in working memory and inhibition processes, depressive people would have difficulties with metaphorical processing and would produce fewer metaphors than do healthy individuals. It was also presumed that subjects with depression as compared to non-depressive individuals would produce more metaphors for negative notions, and generally would create more negative metaphors, independently of the semantics and valence of a notion. The results obtained in this study aren't univocal. However, it seems that there exists a tendency to produce a smaller number of metaphors in depressive people (especially concerning the notion of FUTURE), which could indicate the existence of some difficulties in metaphorical processing connected with depression. Furthermore, depressive subjects produced more negative metaphors for some notions but not for all of them. This points to the need of attention to semantics in studies on the mechanisms of metaphorical processing in a group of depressive people.
Ad Alta : Journal of Interdisciplinary Research , 2011,
Abstract: Presently, the success of each organisation depends on the effective use of knowledge,skills and on motivation system. It is possible only when the organisation has anecessary at a given time and place human capital and it is able to efficiently manageit [6, 22 p.]. The aim of this article is to present, on the basis of business organisationand public institution, the differences and similarities in the field of human capitalmanagement in those entities. The article constitutes an attempt to answer the questionconcerning the way in which the type of organisation and its connection to public orprivate sector determines the character of human capital management. The article endswith conclusions in terms of theory and practise and determines the direction forfuture studies in the field.
Active Protein Aggregates Produced in Escherichia coli
pela Peternel,Radovan Komel
International Journal of Molecular Sciences , 2011, DOI: 10.3390/ijms12118275
Abstract: Since recombinant proteins are widely used in industry and in research, the need for their low-cost production is increasing. Escherichia coli is one of the best known and most often used host organisms for economical protein production. However, upon over-expression, protein aggregates called inclusion bodies (IBs) are often formed. Until recently IBs formation represented a bottleneck in protein production as they were considered as deposits of inactive proteins. However, recent studies show that by choosing the appropriate host strain and designing an optimal production process, IBs composed from properly folded and biologically active recombinant proteins can be prepared. Such active protein particles can be further used for the isolation of pure proteins or as whole active protein particles in various biomedical and other applications. Therefore interest in understanding the mechanisms of their formation as well as their properties is?increasing.
Isolation of biologically active nanomaterial (inclusion bodies) from bacterial cells
pela Peternel, Radovan Komel
Microbial Cell Factories , 2010, DOI: 10.1186/1475-2859-9-66
Abstract: To prepare large quantities of a high quality product, the whole bioprocess has to be optimised. This includes not only the cultivation of the bacterial culture, but also the isolation step itself, which can be of critical importance for the production process.To determine the most appropriate method for the isolation of biologically active nanoparticles, three methods for bacterial cell disruption were analyzed.In this study, enzymatic lysis and two mechanical methods, high-pressure homogenization and sonication, were compared.During enzymatic lysis the enzyme lysozyme was found to attach to the surface of IBs, and it could not be removed by simple washing. As this represents an additional impurity in the engineered nanoparticles, we concluded that enzymatic lysis is not the most suitable method for IBs isolation.During sonication proteins are released (lost) from the surface of IBs and thus the surface of IBs appears more porous when compared to the other two methods. We also found that the acoustic output power needed to isolate the IBs from bacterial cells actually damages proteins structures, thereby causing a reduction in biological activity.High-pressure homogenization also caused some damage to IBs, however the protein loss from the IBs was negligible. Furthermore, homogenization had no side-effects on protein biological activity.The study shows that among the three methods tested, homogenization is the most appropriate method for the isolation of active nanoparticles from bacterial cells.In recent years, the rapid expansion of biotechnology has lead to the production of a wide spectrum of recombinant proteins. To this end, a range of host organisms, from bacteria to mammalian cell-culture systems are being used. Even though bacteria have some disadvantages, Escherichia coli is still one of the most commonly used organisms for the production of recombinant proteins [1-3].The over-expression of recombinant proteins in bacteria often leads to their aggregation
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