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Search Results: 1 - 10 of 5501 matches for " Markus Jaritz "
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Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component
Diana Mechtcheriakova,Yury Sobanov,Gabriele Holtappels,Erika Bajna,Martin Svoboda,Markus Jaritz,Claus Bachert,Erika Jensen-Jarolim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025611
Abstract: Activation-induced cytidine deaminase (AID) is expressed in B cells within germinal centers and is critically involved in class switch recombination and somatic hypermutation of immunoglobulin loci. Functionally active AID can additionally be detected within ectopic follicular structures developed at sites of chronic inflammation. Furthermore, AID may target non-Ig genes in B- and non-B-cell background. Therefore, AID-associated effects are of increasing interest in disease areas such as allergy, inflammation, autoimmunity, and cancer.
An RNA-Seq Strategy to Detect the Complete Coding and Non-Coding Transcriptome Including Full-Length Imprinted Macro ncRNAs
Ru Huang, Markus Jaritz, Philipp Guenzl, Irena Vlatkovic, Andreas Sommer, Ido M. Tamir, Hendrik Marks, Thorsten Klampfl, Robert Kralovics, Hendrik G. Stunnenberg, Denise P. Barlow, Florian M. Pauler
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027288
Abstract: Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head using an optimized RNA-Seq strategy. The data produced is highly reproducible in different sequencing locations and is able to detect the full length of imprinted macro ncRNAs such as Airn and Kcnq1ot1, whose length ranges between 80–118 kb. Transcripts show a more uniform read coverage when RNA is fragmented with RNA hydrolysis compared with cDNA fragmentation by shearing. Irrespective of the fragmentation method, all coding and non-coding transcripts longer than 8 kb show a gradual loss of sequencing tags towards the 3′ end. Comparisons to published RNA-Seq datasets show that the strategy presented here is more efficient in detecting known functional imprinted macro ncRNAs and also indicate that standardization of RNA preparation protocols would increase the comparability of the transcriptome between different RNA-Seq datasets.
The Lx-Tvir relation in galaxy clusters: Effects of radiative cooling and AGN heating
Rupal Mittal,Amalia Hicks,Thomas H. Reiprich,Vera Jaritz
Physics , 2011, DOI: 10.1051/0004-6361/200913714
Abstract: We present a detailed investigation of the X-ray luminosity (Lx)-gas temperature (Tvir) relation of the complete X-ray flux-limited sample of the 64 brightest galaxy clusters in the sky (HIFLUGCS). We study the influence of two astrophysical processes, active galactic nuclei (AGN) heating and intracluster medium (ICM) cooling, on the Lx-Tvir relation, simultaneously for the first time. We determine best-fit relations for different subsamples using the cool-core strength and the presence of central radio activity as selection criteria. We find the strong cool-core clusters (SCCs) with short cooling times (< 1Gyr)to display the steepest relation (Lx ~ Tvir^{3.33}) and the non-cool-core clusters (NCCs) with long cooling times (> 7.7Gyr) to display the shallowest (Lx ~ Tvir^{2.42}). This has the simple implication that on the high-mass scale (Tvir > 2.5keV) the steepening of the Lx-Tvir relation is mainly due to the cooling of the intracluster medium gas. We propose that ICM cooling and AGN heating are both important in shaping the Lx-Tvir relation but on different length-scales. While our study indicates that ICM cooling dominates on cluster scales (Tvir > 2.5keV), we speculate that AGN heating dominates the scaling relation in poor clusters and groups (Tvir < 2.5keV). The intrinsic scatter about the Lx-Tvir relation in X-ray luminosity for the whole sample is 45.4% and varies from a minimum of 34.8% for weak cool-core clusters to a maximum of 59.4% for clusters with no central radio source. We find that after excising the cooling region, the scatter in the Lx-Tvir relation drops from 45.4% to 39.1%, implying that the cooling region contributes ~ 27% to the overall scatter. Lastly, we find the true SCC fraction to be 25% lower than the observed one and the true normalizations of the Lx-Tvir relations to be lower by 12%, 7%, and 17% for SCC, WCC, and NCC clusters, respectively. [abridged]
On the Ontology of Structural Realism  [PDF]
Markus Fischer
Open Journal of Political Science (OJPS) , 2019, DOI: 10.4236/ojps.2019.91008
Abstract: Due to its systemic approach, structural realism (or neorealism) can be subsumed under methodological holism, which takes social phenomena to be wholes that cannot be reduced to their parts. The wholes posited by structural realism are the state and the international structure. Recent developments in the philosophy of social science suggest that methodological holism ought to be limited to causal explanation and complemented by ontological individualism, which requires an account of how social wholes derive from individuals. Structural realism lacks such an account because it takes the state as an empirical given, mistaking for a fact what is really a concept in need of deductive derivation from individuals. To bring the theory methodologically up to date, this essay undertakes such a derivation of the state from individuals, proceeding in the deductive manner of political theory. It thus provides structural realism with a methodologically valid ontology, which, in turn, enables the theory to better defend itself against liberal and constructivist critics who reduce the state to a transient phenomenon.
InSAR processing for the recognition of landslides
R. Supper, A. R mer, B. Jochum, G. Bieber,W. Jaritz
Advances in Geosciences (ADGEO) , 2008,
Abstract: After a large landslide event in Sibratsgf ll/Austria several exploration methods were evaluated on their applicability to investigate and monitor landslide areas. The resulting optimised strategy consists of the combined application of airborne electromagnetics, ground geoelectrical measurements and geoelectrical monitoring combined with hydrological and geological mapping and geotechnical modelling. Interdisciplinary communication and discussion was the primary key to assess this complicated hazard situation.
Nora B Medina-Jaritz,Mauricio R Palacios-Pacheco,Ricardo Valenzuela-Garza
Acta botánica mexicana , 2012,
Abstract: Se registran 24 especies de poliporoides incluidas en 14 géneros pertenecientes a cinco familias. Este estudio está basado en 93 ejemplares recolectados en el bosque tropical de los alrededores de la zona arqueológica de Yaxchilán, Chiapas. Se realizaron descripciones de cada una de las especies tomando en cuenta características macro y microscópicas, de acuerdo con los lineamientos que dicta la taxonomía moderna.
Discretisation of stochastic control problems for continuous time dynamics with delay
Markus Fischer,Markus Reiss
Mathematics , 2006,
Abstract: As a main step in the numerical solution of control problems in continuous time, the controlled process is approximated by sequences of controlled Markov chains, thus discretising time and space. A new feature in this context is to allow for delay in the dynamics. The existence of an optimal strategy with respect to the cost functional can be guaranteed in the class of relaxed controls. Weak convergence of the approximating extended Markov chains to the original process together with convergence of the associated optimal strategies is established.
Spectral covolatility estimation from noisy observations using local weights
Markus Bibinger,Markus Rei?
Statistics , 2011,
Abstract: We propose localized spectral estimators for the quadratic covariation and the spot covolatility of diffusion processes which are observed discretely with additive observation noise. The eligibility of this approach to lead to an appropriate estimation for time-varying volatilities stems from an asymptotic equivalence of the underlying statistical model to a white noise model with correlation and volatility processes being constant over small intervals. The asymptotic equivalence of the continuous-time and the discrete-time experiments are proved by a construction with linear interpolation in one direction and local means for the other. The new estimator outperforms earlier nonparametric approaches in the considered model. We investigate its finite sample size characteristics in simulations and draw a comparison between the various proposed methods.
The Influence of Surface Energy on the Washing Quality of Filter Cakes  [PDF]
Markus Wilkens, Urs A. Peuker
Advances in Chemical Engineering and Science (ACES) , 2011, DOI: 10.4236/aces.2011.14036
Abstract: The washing of filter cakes, especially the displacement washing, represents an important aspect in science researches and industrial applications. A lot of ongoing researches are focussed on impurities, which are dissolved in the mother liquid (e.g. sodium chloride) and washed out with the identical pure liquid without impurities. The project flushing focuses on systems with two chemically different liquids. The main aim is to exchange an organic solvent by water. This article focuses on the adsorption effects during a washing process with solid systems of different wetting behaviours.
Not All Shrivels Are Created Equal—Morpho-Anatomical and Compositional Characteristics Differ among Different Shrivel Types That Develop during Ripening of Grape (Vitis vinifera L.) Berries  [PDF]
Bhaskar Rao Bondada, Markus Keller
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.37105
Abstract: An understanding of physiological disorders associated with ripening of fruits triggered by abiotic stress relies on anatomical and physico-chemical analyses, as it provide insights into their origin and probable causes. The objective of this study was to analyze different ripening disorders of grape (Vitis vinifera L.) berries by dissecting their morpho-anatomy, shriveling nature, and composition. Four well-defined disorders—sunburn, prolonged dehydration (PD), late-season bunch stem necrosis (LBSN), and berry shrivel (BS) were analyzed in field-grown grapevines of the cultivar Cabernet Sauvignon. Early bunch stem necrosis (EBSN) that occurred before ripening was also included in the study. Unlike healthy spherical berries, the pericarp of disordered berries except for sunburn shriveled causing concomitant reductions in fresh weight and volume. The exocarp of PD berries developed well-ordered indentations as distinct from the wrinkles in LBSN berries, whereas BS berries were flaccid with numerous skin folds. The epicuticular wax occurred as upright platelets in all shrivel forms excluding the sun-exposed hemisphere of sunburned berries. A chlorophyllous inflorescence framework persisted in all shrivel forms but in LBSN, wherein the necrotic regions developed tylosis. Unlike the translucent mesocarp of healthy, sunburned, and PD berries, the mesocarp was collapsed in BS and LBSN berries, nevertheless all had well-developed seeds. The composition of healthy berries was optimal, whereas the disordered berries were compositionally distinct from each other, which as a whole differed from the healthy berries. The BS berries had the lowest sugar content, and although sugar concentration was higher in LBSN, sunburned and PD berries, sugar amount per berry was highest in the healthy berries, the same was true for hexoses. Healthy and BS berries exhibited highest amounts of tartaric acid followed by sunburn and PD berries, whereas the LBSN berries had the lowest values. Conversely, healthy and PD berries had the highest amounts of malic acid followed by LBSN, sunburn and BS berries, which collectively displayed similar amounts. The PD berries exhibited the highest calcium content followed by LBSN, healthy, and finally BS and sunburned berries. A linear relationship existed between potassium (K) and pH of the berries. The PD berries had the highest amounts of K followed by healthy, sunburn, LBSN, and BS berries. Overall, the results reported here provided combined morpho-anatomical and compositional analyses of different shrivel types that occurred during
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