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Search Results: 1 - 10 of 1594 matches for " Marko Salmi "
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Inventions Utilizing Satellite Navigation Systems in the Railway Industry: An Analysis of Patenting Activity
Salmi,Pekka; Torkkeli,Marko;
Journal of technology management & innovation , 2009, DOI: 10.4067/S0718-27242009000300005
Abstract: applications based on the global navigation satellite system (gnss), in combination with different communication systems, have significantly helped to increase safety, efficiency and system capacity of operations in different modes of transportation. here railway transport is no exception, although the number of applications based on gnss has been considerably behind the number of those used in road transport. since incorporating e.g. gps receivers into modern signaling, train control and other railway systems has become usual, it is interesting to examine gnss/gps-based inventions and patenting trends more closely in this context. this paper analyses gnss/gps-related patents in the railway industry in order to shed light on the patenting activity in different countries/regions and to identify (and to a certain extent make a classification of) the main application areas for this technology.
Inventions Utilizing Satellite Navigation Systems in the Railway Industry – An Analysis of Patenting Activity Inventions Utilizing Satellite Navigation Systems in the Railway Industry – An Analysis of Patenting Activity Inventions Utilizing Satellite Navigation Systems in the Railway Industry – An Analysis of Patenting Activity
Pekka Salmi,Marko T. Torkkeli
Journal of technology management & innovation , 2009,
Abstract: Applications based on the Global Navigation Satellite System (GNSS), in combination with different communication systems, have significantly helped to increase safety, efficiency and system capacity of operations in different modes of transportation. Here railway transport is no exception, although the number of applications based on GNSS has been considerably behind the number of those used in road transport. Since incorporating e.g. GPS receivers into modern signaling, train control and other railway systems has become usual, it is interesting to examine GNSS/GPS-based inventions and patenting trends more closely in this context. This paper analyses GNSS/GPS-related patents in the railway industry in order to shed light on the patenting activity in different countries/regions and to identify (and to a certain extent make a classification of) the main application areas for this technology. Applications based on the Global Navigation Satellite System (GNSS), in combination with different communication systems, have significantly helped to increase safety, efficiency and system capacity of operations in different modes of transportation. Here railway transport is no exception, although the number of applications based on GNSS has been considerably behind the number of those used in road transport. Since incorporating e.g. GPS receivers into modern signaling, train control and other railway systems has become usual, it is interesting to examine GNSS/GPS-based inventions and patenting trends more closely in this context. This paper analyses GNSS/GPS-related patents in the railway industry in order to shed light on the patenting activity in different countries/regions and to identify (and to a certain extent make a classification of) the main application areas for this technology. Applications based on the Global Navigation Satellite System (GNSS), in combination with different communication systems, have significantly helped to increase safety, efficiency and system capacity of operations in different modes of transportation. Here railway transport is no exception, although the number of applications based on GNSS has been considerably behind the number of those used in road transport. Since incorporating e.g. GPS receivers into modern signaling, train control and other railway systems has become usual, it is interesting to examine GNSS/GPS-based inventions and patenting trends more closely in this context. This paper analyses GNSS/GPS-related patents in the railway industry in order to shed light on the patenting activity in different countries/regions an
Inventions Utilizing Satellite Navigation Systems in the Railway Industry – An Analysis of Patenting Activity
Pekka Salmi,Marko T. Torkkeli
Journal of technology management & innovation , 2009,
Abstract: Applications based on the Global Navigation Satellite System (GNSS), in combination with different communication systems, have significantly helped to increase safety, efficiency and system capacity of operations in different modes of transportation. Here railway transport is no exception, although the number of applications based on GNSS has been considerably behind the number of those used in road transport. Since incorporating e.g. GPS receivers into modern signaling, train control and other railway systems has become usual, it is interesting to examine GNSS/GPS-based inventions and patenting trends more closely in this context. This paper analyses GNSS/GPS-related patents in the railway industry in order to shed light on the patenting activity in different countries/regions and to identify (and to a certain extent make a classification of) the main application areas for this technology.
Barriers to Open Innovation: Case China
Savitskaya,Irina; Salmi,Pekka; Torkkeli,Marko;
Journal of technology management & innovation , 2010, DOI: 10.4067/S0718-27242010000400002
Abstract: the notion of open innovation suggests that firms can boost their innovative performance by both acquiring knowledge from outside the company and deploying external paths to market for commercialization of non-core technologies. as innovations emerge increasingly from interorganisational cooperation, the background for such cooperation can also have an impact on the involvement of companies into open innovation processes. thereby this paper proposes to analyze the barriers towards open innovation from three different aspects, such as internal firms' environment, institutional factors or innovation system and cultural background. our findings indicate that economic systems and institutions (in particular the protection of iprs) may have large effects on the behaviour of firms with respect to their engagement in open innovation practices. on the other hand, our results also suggest that the importance of appropriability regime may differ in the buy and sell sides of knowledge, and finally we demonstrate the influence of peculiarities of national cultures upon the adoption of certain elements of open innovation model.
The “Open Innovation” paradigm: A contingency perspective
Marko T. Torkkeli,Carl Joachim Kock,Pekka A. S. Salmi
Journal of Industrial Engineering and Management , 2009, DOI: 10.3926/jiem..v2n1.p176-207
Abstract: The “open innovation” model is currently being touted as a superior path for achieving long-term success. Rather than relying on their own, limited resources for research and development in the traditional, closed invention system, firms are encouraged to share knowledge across firm boundaries to enhance their innovative potential. Yet, such sharing may also have adverse consequences by reducing the rarity of a firm’s inventions. This paper accordingly attempts to identify and analyze the parameters that determine whether open or closed types of innovation management are most appropriate for a given firm. Following a contingency perspective, we examine these determinants as various internal and external constraints (situational factors). More specifically, applying concepts related to absorptive capacity, complementary resources, game theory and others, we derive testable propositions and provide case study evidence regarding the value generating properties of open innovation.
CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain
Natalia Kulesskaya, Vootele V?ikar, Marjaana Peltola, Gennady G. Yegutkin, Marko Salmi, Sirpa Jalkanen, Heikki Rauvala
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066896
Abstract: CD73 (ecto-5’-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5′-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological functions at this location remain elusive. Here we found, using immunohistochemistry of wild-type and CD73 deficient mice, that CD73 is prominently expressed in the basal ganglia core comprised of striatum (caudate nucleus and putamen) and globus pallidus. Furthermore, meninges and the olfactory tubercle were found to specifically express CD73. Analysis of wild type (wt) and CD73 deficient mice revealed that CD73 confers the majority of 5’-nucleotidase activity in several areas of the brain. In a battery of behavioural tests and in IntelliCage studies, the CD73 deficient mice demonstrated significantly enhanced exploratory locomotor activity, which probably reflects the prominent expression of CD73 in striatum and globus pallidus that are known to control locomotion. Furthermore, the CD73 deficient mice displayed altered social behaviour. Overall, our data provide a novel mechanistic insight into adenosinergic signalling in brain, which is implicated in the regulation of normal and pathological behaviour.
Functional Modulation of Vascular Adhesion Protein-1 by a Novel Splice Variant
Sam Kaitaniemi, Kirsi Gr?n, Heli Elovaara, Marko Salmi, Sirpa Jalkanen, Kati Elima
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0054151
Abstract: Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating transmigration of leukocytes into the inflamed tissue. Screening of a human lung cDNA library revealed the presence of an alternatively spliced shorter transcript of VAP-1, VAP-1Δ3. Here, we have studied the functional and structural characteristics of VAP-1Δ3, and show that the mRNA for this splice variant is expressed in most human tissues studied. In comparison to the parent molecule this carboxy-terminally truncated isoform lacks several of the amino acids important in the formation of the enzymatic groove of VAP-1. In addition, the conserved His684, which takes part in coordinating the active site copper, is missing from VAP-1Δ3. Assays using the prototypic amine substrates methylamine and benzylamine demonstrated that VAP-1Δ3 is indeed devoid of the semicarbazide-sensitive amine oxidase (SSAO) activity characteristic to VAP-1. When VAP-1Δ3-cDNA is transfected into cells stably expressing VAP-1, the surface expression of the full-length molecule is reduced. Furthermore, the SSAO activity of the co-transfectants is diminished in comparison to transfectants expressing only VAP-1. The observed down-regulation of both the expression and enzymatic activity of VAP-1 may result from a dominant-negative effect caused by heterodimerization between VAP-1 and VAP-1Δ3, which was detected in co-immunoprecipitation studies. This alternatively spliced transcript adds thus to the repertoire of potential regulatory mechanisms through which the cell-surface expression and enzymatic activity of VAP-1 can be modulated.
Plasticity of Blood- and Lymphatic Endothelial Cells and Marker Identification
Johannes Keuschnigg, Sirkku Karinen, Kaisa Auvinen, Heikki Irjala, John-Patrick Mpindi, Olli Kallioniemi, Sampsa Hautaniemi, Sirpa Jalkanen, Marko Salmi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074293
Abstract: The distinction between lymphatic and blood vessels is biologically fundamental. Here we wanted to rigorously analyze the universal applicability of vascular markers and characteristics of the two widely used vascular model systems human microvascular endothelial cell line-1 (HMEC-1) and telomerase-immortalized microvascular endothelial cell line (TIME). Therefore we studied the protein expression and functional properties of the endothelial cell lines HMEC-1 and TIME by flow cytometry and in vitro flow assays. We then performed microarray analyses of the gene expression in these two cell lines and compared them to primary endothelial cells. Using bioinformatics we then defined 39 new, more universal, endothelial-type specific markers from 47 primary endothelial microarray datasets and validated them using immunohistochemistry with normal and pathological tissues. We surprisingly found that both HMEC-1 and TIME are hybrid blood- and lymphatic cells. In addition, we discovered great discrepancies in the previous identifications of blood- and lymphatic endothelium-specific genes. Hence we identified and validated new, universally applicable vascular markers. Summarizing, the hybrid blood-lymphatic endothelial phenotype of HMEC-1 and TIME is indicative of plasticity in the gene expression of immortalized endothelial cell lines. Moreover, we identified new, stable, vessel-type specific markers for blood- and lymphatic endothelium, useful for basic research and clinical diagnostics.
E-Government Analysis: Sultanate of Oman Case  [PDF]
Muatasim Al Salmi, Norlena Hasnan
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.43006
Abstract:

In the current century, e-government transformation is considered as one of the biggest challenges among and within the IT-related sector from the scale and complexity perspective. Having the main objective as of adapting an existing e-government system and methodology in order to obtain new computing requirements based on the concept of citizens’ new service. Thus, increase the features of service level, quality and maintaining a high policies and rules consistency. Moreover, mission criticality and time of services, information sharing and interoperability, efficiency and productivity along with the reduction of operation expenses are all considered as priorities in this transformation project (Raymond, 2007) [1]. Such a transformation is considered crucial for the service concept as it is changing rapidly; the roadmap coherence in e-government transformation is critical (Raymond, 2007) [1]. However, there is a big aspect regarding the e-Government progress by citizens due to many aspects like: Citizens-Centricity, Facilitating Condition, Effort expectancy and Performance Expectancy. Hence, there is a need to further study in order to be able to obtain better understanding of the complete picture and to have a balanced view and concepts all under one e-Government umbrella. This paper will review and analyze through a quantitative approach in Sultanate of Oman case study. This study targeted citizens in the country to check their intention to use e-Government in Oman (e-Oman). After reviewing and discussing questionnaire outputs using SPSS program, the writer listed some recommendations and conclusion of the study and the nature of them they will be categorized upon to their point of view.


The Impact of Public R&D Funding on Open Innovation
Pekka SALMI
Economia : Seria Management , 2012,
Abstract: While the effects of public R&D funding on innovation inputs, outputs and strategies of firms have been studied extensively, little is known about the impact public R&D funding may have on open innovation practices. We made several hypotheses about different effects of public subsidies from the open innovation point of view and then tested these hypotheses with data that comes from a survey on innovation practices in China, Finland and Spain. More specifically, the prevalence of open innovation in a country was hypothesized to be related to the level of public R&D funding. The results show that Chinese firms make external technology/IP acquisitions more often, as well as engage more frequently in selling of intellectual assets, than their Spanish (and Finnish) counterparts. The results also show that Chinese firms are less likely to make new collaboration agreements after participating in publicly funded R&D projects. The findings therefore generally support the idea that a lower level of available public R&D funding facilitates the adoption of open innovation practices in firms.
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