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Search Results: 1 - 10 of 100611 matches for " Mark W. Geisler "
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Asymmetry in Resting Alpha Activity: Effects of Handedness  [PDF]
Ruth E. Propper, Jenna Pierce, Mark W. Geisler, Stephen D. Christman, Nathan Bellorado
Open Journal of Medical Psychology (OJMP) , 2012, DOI: 10.4236/ojmp.2012.14014
Abstract: Study Aim: Frontal electroencephalographic (EEG) alpha band power during rest shows increased right, and/or de-creased left, hemisphere activity under conditions of state or trait withdrawal-associated affect. Non-right-handers (NRH) are more likely to have mental illnesses and dispositions that involve such withdrawal-related affect. The aim of the study was to examine whether NRH might be characterized by increased right, relative to left, hemisphere activity during rest. Methods: The present research investigated that hypothesis by examining resting EEG alpha power in consistently-right-handed (CRH) and NRH individuals. Results: In support of the hypothesis, NRH demonstrated de-creased right hemisphere alpha power, and therefore increased right hemisphere activity, during rest, compared to CRH. Conclusions: The study demonstrates further support for an association between increased right hemisphere activity and negative affect via an association between such EEG activity and NRH.
Ordered Assembly of the Adhesive and Electrochemical Connections within Newly Formed Intercalated Disks in Primary Cultures of Adult Rat Cardiomyocytes
Sarah B. Geisler,Kathleen J. Green,Lori L. Isom,Sasha Meshinchi,Jeffrey R. Martens,Mario Delmar,Mark W. Russell
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/624719
Abstract: The intercalated disk (ID) is a complex structure that electromechanically couples adjoining cardiac myocytes into a functional syncitium. The integrity of the disk is essential for normal cardiac function, but how the diverse elements are assembled into a fully integrated structure is not well understood. In this study, we examined the assembly of new IDs in primary cultures of adult rat cardiac myocytes. From 2 to 5 days after dissociation, the cells flatten and spread, establishing new cell-cell contacts in a manner that recapitulates the in vivo processes that occur during heart development and myocardial remodeling. As cells make contact with their neighbors, transmembrane adhesion proteins localize along the line of apposition, concentrating at the sites of membrane attachment of the terminal sarcomeres. Cx43 gap junctions and ankyrin-G, an essential cytoskeletal component of voltage gated sodium channel complexes, were secondarily recruited to membrane domains involved in cell-cell contacts. The consistent order of the assembly process suggests that there are specific scaffolding requirements for integration of the mechanical and electrochemical elements of the disk. Defining the relationships that are the foundation of disk assembly has important implications for understanding the mechanical dysfunction and cardiac arrhythmias that accompany alterations of ID architecture.
Frequency and Energy Difference Detection of Dolphin Biosonar Signals Using a Decomposition Algorithm  [PDF]
Mark W. Muller
Open Journal of Acoustics (OJA) , 2016, DOI: 10.4236/oja.2016.61001
Abstract: A set of dolphin echolocation signals previously collected from an Atlantic bottlenose dolphin in Kaneohe Bay, Hawai’i are decomposed using a matching pursuit algorithm to further investigate the role of four types of echolocation signals outlined elsewhere [1]. The method decomposes the echolocation signals into optimal linear expansions of waveforms, which are Gabor functions defined in a dictionary. The method allows for study of the changes in frequency content within a dolphin’s functional bandwidth during discrimination tasks. We investigate the role of the functional bandwidth in terms of the signal energy levels and echolocations task performance. Furthermore, ROC analysis is applied to the relative energies of the matched waveforms to determine probability of discrimination. The results suggest that dolphins may discriminate by inspection of the relevant frequency differences between targets. In addition, the results from the ROC analysis provides insight into the role of the different classes of dolphin signals and of the importance of modification of the outgoing echolocation clicks, which may be fundamental to a dolphin’s ability to identify and discriminate targets.
Resolution of Amenorrhea and Chronic Constipation in an Adult Patient with Idiopathic Scoliosis Wearing a Scoliosis Activity Suit for 6 Months: A Case Report  [PDF]
Mark W. Morningstar
Open Journal of Therapy and Rehabilitation (OJTR) , 2018, DOI: 10.4236/ojtr.2018.62007
Abstract: Objective: To report the symptomatic and radiographic changes in an adult scoliosis patient with a history of amenorrhea and chronic constipation. Clinical Features: Patient presented for treatment with an 8-year history of amenorrhea and chronic constipation. Radiographic study showed a right thoracic/left lumbar double major scoliosis. Intervention and Outcome: Patient was fitted for a scoliosis activity suit and given instructions for continued home use, building up to 3 - 4 hours total daily. After 6 months of use, her amenorrhea and chronic constipation had resolved, and both scoliosis Cobb angles also improved. Scores on before and after SRS-22r questionnaires, as well as a quadruple numerical pain rating scale, also improved. Conclusion: A patient wearing a scoliosis activity suit for 6 months reported symptomatic changes as well as radiographic, pain, and quality of life improvements. The results of this case cannot be generalized. More investigation into the association of scoliosis and other organic symptoms is warranted.
Cyclosporine and Hepatitis C  [PDF]
Ryan Caballes, Mark W. Russo
Open Journal of Organ Transplant Surgery (OJOTS) , 2012, DOI: 10.4236/ojots.2012.24009
Abstract: End stage liver disease from hepatitis C is a leading indication for liver transplantation. Recurrent hepatitis C after liver transplant may lead to cirrhosis and graft failure in up to 25% of recipients five years after liver transplantation. Anti-viral therapy is challenging after liver transplantation due to increased side effects including cytopenias and decreased efficacy compared to the nontransplant population. Tacrolimus and cyclosporine are the most common immunosuppressants used to prevent graft rejection. Tacrolimus is more potent than cyclosporine and may be preferred to cyclosporine. However, cyclosporine may have activity against hepatitis C and may have a theoretical advantage to tacrolimus in hepatitis liver transplant recipients. Cyclosporine may inhibit NS5B and NS5A protein complexes and increase endogenous interferon activity. Cyclophilin inhibitors without immunosuppressive properties are under development and represent a novel mechanisms for inhibiting HCV replication.
Revisitando o conceito de cidadania: notas para uma educa??o politécnica
Geisler, Adriana;
Trabalho, Educa??o e Saúde , 2006, DOI: 10.1590/S1981-77462006000200008
Abstract: in opposition to a community and school project which have been denying the effective citizenship to a great contingent of youth and brazilian workers, the polytechnic conception emerges as a part of an emancipating project which is far from the liberal ideology and from its reflexes on the education and work fields. retaking the issue of the citizenship meaning nowadays, this text aims to identify to which citizenship concept the polytechnic conception belongs, considering the educational practices field and its connection to the current aspect of the world of work.
Expression of a prokaryotic P-type ATPase in E. coli Plasma Membranes and Purification by Ni2+-affinity chromatography
Geisler Markus
Biological Procedures Online , 1998, DOI: 10.1251/bpo9
Abstract: In order to characterize the P-type ATPase from Synechocystis 6803 [Geisler (1993) et al. J. Mol. Biol. 234, 1284] and to facilitate its purification, we expressed an N-terminal 6xHis-tagged version of the ATPase in an ATPase deficient E. coli strain. The expressed ATPase was immunodetected as a dominant band of about 97 kDa localized to the E. coli plasma membranes representing about 20-25% of the membrane protein. The purification of the Synecho-cystis 6xHis-ATPase by single-step Ni-affinity chromatography under native and denaturating conditions is described. ATPase activity and the formation of phosphointermediates verify the full function of the enzyme: the ATPase is inhibited by vanadate (IC50= 119 &mgr;M) and the formation of phosphorylated enzyme intermediates shown by acidic PAGE depends on calcium, indicating that the Synechocystis P-ATPase functions as a calcium pump.
Josep Pla und Montaigne. Eine Skizze [Josep Pla and Montaigne. An outline]
Geisler, Eberhard
Zeitschrift für Katalanistik , 2006,
Abstract: Joseph Pla was a great admirer of French literature. As such, the writer Michel de Montaigne was of particular importance to him. Accordingly, Pla once remarked that he owed a plethora of fundamental philosophical knowledge to the author of Essais, as well as the ability to weigh and judge. In Pla’s opinion, the Frenchman was an ideal representative of a non-bombastic view of man and as a moralist. In the following passages, three further relations between the two authors will be reflected upon. To begin with, the depiction of the self and the emerging difficulty with the same phenomenon shall be treated; since the ego is not always present to itself, it vacillates between authenticity on the one hand, and convention and role on the other. Therefore the topic of the instability of human relation stands at the center of Montaigne’s observations as well as of Pla’s, which can evidently be traced in his tale “Contraban”; the theme of instability is counterbalanced by a certain consistency in these authors’ views. At last it demonstrates that both authors tend, with regard to their view of man, towards a policy of power decomposition. Thus they establish, with their understanding of nature and health, an inevitable counterimage (since Pla is defined by a profession towards antique cynicism and its use of the verb “badar”).
Wer war Joan Sales? Hinweis auf einen Autor [Who was Joan Sales? Hints on an author]
Geisler, Eberhard
Zeitschrift für Katalanistik , 2010,
Abstract: The major work of Joan Sales (1912-1983), the novel "Incerta glòria", has suffered a peculiar fate. In spite of the high praise expressed by Mercè Rodoreda in a letter to the author, the work was little acknowledged in Spain (the French translation, on the other hand, was more successful and was compared with the best novels by Bernanos). Only in recent years have critics increasingly surfaced, paying a befitting tribute to the book as a masterpiece and as a unique panorama of the Spanish Civil War and – along with the sequel "El vent de la nit" – the years of Francoism. The novel is clearly written from the view of the vanquished. This article outlines the life of Sales and demonstrates his approach of a critical, liberal and Catalan intellectual. As will be shown, the chief aim of the author is to experience and to seek the abundance of an intensive life, to create an intensity which is expressed in his literary style that is full of metaphors and, particularly, contrasts. A longer section of the article is dedicated to the vestiges of Kierkegaard in the novel. Within this it is above all the figure of the intellectual Soleràs who seems influenced by the Danish philosopher and progenitor of existentialism. The religious aspect is treated by Sales with particular tolerance. He rejects any form of power and hierarchy within religion and represents the theology of the cross, by attributing Christ as the God of the conquered. He defends a version of Catholicism which displays ecumenical traits. Of course, the classical criticism of religion (which viewed the childhood soul of the believer as a scandal) can be applied to the author, but he remains true to the spirit of the Gospel. At the end of the essay an eye is cast over poetry written by the author, in addition to his novel, and the implied attitude towards surrealism is investigated. From this a certain break with the surreal and the conception of the unconscious becomes evident. "Incerta glòria" is, by contrast, is monolithic and wholeheartedly successful. The novel encompasses the totality of the human and preaches a spirit for which any policies of exclusion are foreign.
A Theoretical Model of Directional Volume on Acquirer Stock in Cash Mergers  [PDF]
Mark W. Zikiye, Rebecca Abraham, Charles Harrington
Theoretical Economics Letters (TEL) , 2014, DOI: 10.4236/tel.2014.43033

The acquisition of a target firm in a transaction financed by cash is a cash merger. Announcements of cash mergers release the positive signal that the acquirer possesses cash reserves. As stock prices rise, informed traders may obtain abnormal returns by purchasing call options, selling put options or purchasing stock. This paper constructs a theoretical model in which call buy volume forms the upper bound of the final stock price, put sell volume forms the lower bound of the final stock price and stock purchase volume reveals the final stock price.

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