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Search Results: 1 - 10 of 26373 matches for " Mark ST Hansen "
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Comparison of buccal and blood-derived canine DNA, either native or whole genome amplified, for array-based genome-wide association studies
Gonzalo Rincon, Katarina Tengvall, Janelle M Belanger, Laetitia Lagoutte, Juan F Medrano, Catherine André, Anne Thomas, Cynthia Lawley, Mark ST Hansen, Kerstin Lindblad-Toh, Anita M Oberbauer
BMC Research Notes , 2011, DOI: 10.1186/1756-0500-4-226
Abstract: In both buccal and blood samples, whether whole genome amplified or not, 97% of the samples had SNP call rates in excess of 80% indicating that the vast majority of the SNPs would be suitable to perform association studies regardless of the DNA source. Similarly, there were no significant differences in marker intensity measurements between buccal and blood samples for copy number variations (CNV) analysis.All DNA samples assayed, buccal or blood, native or whole genome amplified, are appropriate for use in array-based genome-wide association studies. The concordance between subsets of dogs for which both buccal and blood samples, or those samples whole genome amplified, was shown to average >99%. Thus, the two DNA sources were comparable in the generation of SNP genotypes and intensity values to estimate structural variation indicating the utility for the use of buccal cytobrush samples and the reliability of whole genome amplification for genome-wide association and CNV studies.The present study was undertaken to assess the utility of buccal cytobrush derived DNA and whole genome amplified (WGA) blood or buccal-derived DNA for use on the most recent iteration of the canine SNP GWA platform. Buccal-derived DNA has been suggested as insufficient in quantity and quality for application to the high-throughput SNP array platforms [1]. Whole blood DNA and buccal-derived DNA, as well as DNA samples (from both sources) subjected to WGA, were compared using the Illumina Infinium CanineHD Genotyping BeadChip containing 173,662 SNPs. Copy number variations (CNV), while shown to account for a significant proportion of human genetic polymorphism and have been suggested to play a role in genetic causes of disease [2], is complex and technically challenging to analyze. Specifically CNV analysis is uniquely different to GWA-SNP analysis because the data is based on the intensity measurement of the SNP. Despite the technical issues, the opportunity exists to examine this important
Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study
Lavinia Paternoster, David M. Evans, Ellen Aagaard Nohr, Claus Holst, Valerie Gaborieau, Paul Brennan, Anette Prior Gjesing, Niels Grarup, Daniel R. Witte, Torben J?rgensen, Allan Linneberg, Torsten Lauritzen, Anelli Sandbaek, Torben Hansen, Oluf Pedersen, Katherine S. Elliott, John P. Kemp, Beate St. Pourcain, George McMahon, Diana Zelenika, J?rg Hager, Mark Lathrop, Nicholas J. Timpson, George Davey Smith, Thorkild I. A. S?rensen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024303
Abstract: Background Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ~1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations. Methodology/Principal Findings From two large Danish cohorts we selected all extremely overweight young men and women (n = 2,633), and equal numbers of population-based controls (n = 2,740, drawn randomly from the same populations as the extremes, representing ~212,000 individuals). We followed up novel (at the time of the study) association signals (p<0.001) from the discovery cohort in a genome-wide study of 5,846 Europeans, before attempting to replicate the most strongly associated 28 SNPs in an independent sample of Danish individuals (n = 20,917) and a population-based cohort of 15-year-old British adolescents (n = 2,418). Our discovery analysis identified SNPs at three loci known to be associated with BMI with genome-wide confidence (P<5×10?8; FTO, MC4R and FAIM2). We also found strong evidence of association at the known TMEM18, GNPDA2, SEC16B, TFAP2B, SH2B1 and KCTD15 loci (p<0.001), and nominal association (p<0.05) at a further 8 loci known to be associated with BMI. However, meta-analyses of our discovery and replication cohorts identified no novel associations. Significance Our results indicate that the detectable genetic variation associated with extreme overweight is very similar to that previously found for general BMI. This suggests that population-based study designs with enriched sampling of individuals with the extreme phenotype may be an efficient method for identifying common variants that influence quantitative traits and a valid alternative to genotyping all individuals in large population-based studies, which may require tens of thousands of subjects to achieve similar power.
Efficient Test Application for Core-Based Systems Using Twisted-Ring Counters
Anshuman Chandra,Krishnendu Chakrabarty,Mark C. Hansen
VLSI Design , 2001, DOI: 10.1155/2001/75139
Abstract: We present novel test set encoding and pattern decompression methods for core-based systems. These are based on the use of twisted-ring counters and offer a number of important advantages–significant test compression (over 10X in many cases), less tester memory and reduced testing time, the ability to use a slow tester without compromising test quality or testing time, and no performance degradation for the core under test. Surprisingly, the encoded test sets obtained from partially-specified test sets (test cubes) are often smaller than the compacted test sets generated by automatic test pattern generation programs. Moreover, a large number of patterns are applied test-per-clock to cores, thereby increasing the likelihood of detecting non-modeled faults. Experimental results for the ISCAS benchmark circuits demonstrate that the proposed test architecture offers an attractive solution to the problem of achieving high test quality and low testing time with relatively slower, less expensive testers.
Modeling Preparative Chromatographic Separation of Heavy Rare Earth Elements and Optimization of Thulium Purification  [PDF]
Mark Max-Hansen, Hans-Kristian Knutson, Christian J?nsson, Marcus Degerman, Bernt Nilsson
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.55016
Abstract: Rare Earth Elements are in growing demand globally. This paper presents a case study of applied mathematical modeling and multi objective optimization to optimize the separation of heavy Rare Earth Elements, Terbium-Lutetium, by means of preparative solid phase extraction chromatography, which means that an extraction ligand, HDEHP, is immobilized on a C18 silica phase, and nitric acid is used as an eluent. An ICP-MS was used for online detection of the Rare Earths. A methodology for calibration and optimization is presented, and applied to an industrially relevant mixture. Results show that Thulium is produced at 99% purity, with a productivity of 0.2 - 0.5 kg Tm per m3 stationary phase and second, with Yields from 74% to 99%.
Controlling pH in a Precipitation Plant
Kjell St?le-Hansen,Bjarne A. Foss
Modeling, Identification and Control , 1997, DOI: 10.4173/mic.1997.4.2
Abstract: This paper deals with pH control in a precipitation and dissolution process. The process is a part of the electrolyte purification plant at Falconbridge Nikkelverk in Kristiansand, Norway. The process including the present strategy for pH control are presented, and experienced weaknesses with this strategy are described. A rigorous dynamic model of the process is briefly summarized. This model was developed in earlier work with the purpose of being a tool for control design. Because of the precipitation in form of hydroxides and the limited dissolution rate of nickel carbonate, the process is approximately linear in pH. Therefore, an alternative strategy for pH control based on adding derivative and feed forward action is suggested. The alternative control strategy is by simulations shown to give severe improvements in performance. The robustness of the proposed controller is briefly analysed.
Density driven currents in the Barents Sea calculated by a numerical model
Dag Slagstad,Kjell St?le-Hansen,Harald Loeng
Modeling, Identification and Control , 1990, DOI: 10.4173/mic.1990.4.1
Abstract: A baroclinic, 3-D model is described. It is adapted to a Barents Sea situation in order to simulate the currents in this area. The model is of a so-called level type which contains fixed, but permeable levels. It also includes thermodynamics which allow freezing and melting of ice. Using density data obtained during the autumn of 1988, a current pattern, driven by density and bottom topography is simulated. No wind is applied. The simulated current pattern gives an overall picture which is similar to what is observed through the few measurements that are available. Good agreements with the observations is found on the Svalbard bank, Troms flaket and along the Novaya Zemlya Coast. In the Bear Island/Hopen depth the model predicts a large eddy which has not been observed. Several smaller, topographical steared eddies are seen in the eastern part of the model area.
Auxerre (Yonne), la cathédrale Saint-étienne
Christian Sapin,Sylvain Aumard,Stéphane Büttner,Heike Hansen
Bulletin du Centre d’études Médiévales d’Auxerre , 2006, DOI: 10.4000/cem.478
Abstract: Dans un programme continu et croisé entre chantiers archéologiques, étude de bati et suivi de la restauration de la cathédrale Saint-étienne d’Auxerre, le Centre d’études médiévales, en concertation avec le Conseil scientifique de la cathédrale, poursuit ses recherches. Nous livrons comme l’an passé dans ce bulletin, les premiers résultats, en annon ant dès à présent le colloque international envisagé les 27-28 septembre 2007 à Auxerre, où sera présenté et discuté l’ensemble des travaux, des ...
Cracks in random brittle solids: From fiber bundles to continuum mechanics
Sylvain Patinet,Damien Vandembroucq,Alex Hansen,Stéphane Roux
Physics , 2015, DOI: 10.1140/epjst/e2014-02268-9
Abstract: Statistical models are essential to get a better understanding of the role of disorder in brittle disordered solids. Fiber bundle models play a special role as a paradigm, with a very good balance of simplicity and non-trivial effects. We introduce here a variant of the fiber bundle model where the load is transferred among the fibers through a very compliant membrane. This Soft Membrane fiber bundle mode reduces to the classical Local Load Sharing fiber bundle model in 1D. Highlighting the continuum limit of the model allows to compute an equivalent toughness for the fiber bundle and hence discuss nucleation of a critical defect. The computation of the toughness allows for drawing a simple connection with crack front propagation (depinning) models.
Predictors of pneumococcal vaccination among older adults with pneumonia: findings from the Community Acquired Pneumonia Impact Study
Paul Krueger, Oona St Amant, Mark Loeb
BMC Geriatrics , 2010, DOI: 10.1186/1471-2318-10-44
Abstract: A telephone survey was used to collect detailed information from adults aged 60 years and older with clinically diagnosed CAP. This was a community wide study with participants being recruited from all radiology clinics in one Ontario community.The most important predictors of pneumococcal vaccination among older adults included: getting an influenza vaccine within the past year (OR 14.5, 95% CI 4.27 to 49.0); at least weekly contact with a friend (OR 3.97, 95% CI 1.71 to 9.24); having one or more co-morbidities/chronic conditions (OR 3.64, 95% CI 1.60 to 8.28); being 70 years of age or older (OR 2.56, 95% CI 1.21 to 5.40); having health problems that limited physical activities (OR 5.37, 95% CI 1.49 to 19.3); having little or no bodily pain (OR 2.90, 95% CI 1.25 to 6.73); and reporting having spiritual values or religious faith (OR 3.47, 95% CI 1.03 to 11.67).A wide range of factors, including demographic, co-morbidity, quality of life, social support and lifestyle were found to be associated with pneumococcal vaccination status among older adults with clinically diagnosed CAP. The findings from this study could inform future pneumococcal immunization strategies by identifying individuals who are least likely to receive the PPV.Community-acquired pneumonia (CAP) refers to pneumonia acquired outside of hospitals or extended-care facilities [1]. In Canada, CAP poses a considerable threat to the health of older adults and the incidence of CAP almost triples among those aged 65 years or older [2]. With the pending demographic influx of seniors, the prevalence of CAP is expected to substantially increase, resulting in a greater burden for older adults, their caregivers and the health care system [3]. CAP is a leading cause of hospital admissions and mortality in Canada [2,4,5] and with increasing age, there is a corresponding increase in morbidity and loss of independence for older adults [6,7]. Furthermore, case fatality rates of pneumonia with invasive pneumococcal di
Unusual duodenal perforation following endoscopic retrograde cholangiopancreatography
Martin Kobborg,Per Helligs?,Peter Altmann,Mark Berner Hansen
Gastroenterology Insights , 2011, DOI: 10.4081/gi.2011.e1
Abstract: Perforation is a known but rare complication to Endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy (ES). Most of the perforations are located in the periampullary area due to ES. This report presents an unusual perforation in the third part of the duodenum following ES. The patient an eigthy-sixt-year-old man underwent ERCP with ES. The patient had Magnetic Resonance Cholangio-pancreatography (MRCP) and Computerized Tomography (CT) verified cholelithiasis and intra- and extrahepatic cholestasis. The perforation was not found under the ERCP procedure but was clinically revealed when the patient developed pneumoscrotum after the procedure. A CT-scan with oral contrast later confirmed the duodenal perforation.
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