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Search Results: 1 - 10 of 18280 matches for " Mark Martens "
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Patient Preferences in the Treatment of Vaginal Candidiasis  [PDF]
Mark G. Martens
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.812116
Abstract: Vulvovaginal candidiasis (VVC) is one of the most frequent problems facing women and their healthcare professionals (HCP). It is difficult for providers to understand the prevalence of VVC because effective over the counter treatments (OTC), are available. It is expected that there are a great many more episodes of VVC in our patient population, as the frequency of self-treatment, success and satisfaction for those that use OTC products prior to seeing a women’s health care provider is unknown. In this study; healthcare providers were given OTC miconazole/tioconazole units for free distribution to patients for whom they diagnosed VVC by exam in their offices. Surveys for both HCP and patients were also distributed to determine the initial or recurrent nature of their symptoms and their satisfaction with their treatments. 1265 OBGYNs and 1821 NP/CNM/PAs reported on over 19,000 patients receiving a single complete treatment. Among HCPs, treatment efficacy was the primary reason for recommending miconazole/tioconazole. However, rapid onset of symptom relief, safety vs. fluconazole, patient preference for the less messy ovule, avoidance with drugs metabolized by the liver, and resistance to, or failure on, fluconazole were additional reasons noted for topical preference. Overall, patient satisfaction (n =
Prevalence of Non-Albicans Candida Infections in Women with Recurrent Vulvovaginal Symptomatology  [PDF]
Jason D. Mintz, Mark G. Martens
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.34035
Abstract:

Background: Candida vulvovaginitis is one of the most frequently diagnosed conditions in women’s care practices. Historically, 90% of cultured yeast species were C. albicans. However, due to a variety of interventions, the proportion of non-albicans Candida (NAC) infections appears to be increasing. We sought to estimate the current prevalence of Candida vulvovaginitis and the species-specific distribution of such infections in recurrent cases. Methods: Women with recurrent vulvovaginal symptomatology referred to an Obstetrics and Gynecology practice were tested by genital fungus culture, Candida-specific polymerase chain reaction (PCR), or both between July 2010 and February 2013. Results: A total of 103 women were tested. Mean age was 45.6 years. Including only their most recent positive test result, 29.1% (30/103) of women tested positive for Candida by any of the above testing measures. Of those, 50% (15/30) tested positive for C. albicans and 50% (15/30) tested positive for a NAC species. Across all visits, 60% (18/30) tested positive for C.

Travel in Pregnancy: The Impact of Zika  [PDF]
Erin E. Curcio, Jonathan D. Baum, Debra Gussman, Mark Martens
Open Journal of Obstetrics and Gynecology (OJOG) , 2017, DOI: 10.4236/ojog.2017.710107
Abstract: OBJECTIVE: The purpose of our study was to examine current travel patterns and behaviors of pregnant women. METHODS: We developed a questionnaire adapted from a publication by Kingman and Economides to examine the travel behavior of women during pregnancy in a suburban community. RESULTS: A convenience sample of 102 patients completed the travel questionnaire. Forty-six (45.1%) traveled during the current pregnancy. Thirty-one (30.4%) traveled more than once. A total of 257 trips were taken by the participants: 113 (43.9%) trips were taken in the first trimester, 87 (33.8%) in the second and 59 (22.9%) in the third trimester. Trip length ranged from 2-90 days with a mean of 11 days. Reasons for travel included: 193 (75.1%) for leisure, 37 (14.4%) work related, 10 (3.9%) trips for emergencies, and 3 (0.4%) trips for relocation.?Eighteen women (17.6%) traveled internationally. One (1.0%) woman was hospitalized while traveling. Manner of travel was as follows: car 167 (65.0%), plane 67 (26.1%), train 13 (5.1) %, bus 10 (3.9%) and none by boat. Nineteen (41.3%) women sought travel advice. Thirteen (68.4%) asked for advice from a doctor, 2 (10.5%) from a nurse, 2 (10.5%) from family and/or friends, 1 (5.3%) from the Internet and 1 (5.3%) from a travel book. Seventeen (37%), traveled without suitable insurance. DISCUSSION: Travel rates during pregnancy have remained surprisingly stable over the past 60 years. Almost 50% of our cohort traveled during pregnancy, and the majority did not seek advice prior to travel. In light of new infectious disease threats, obstetric practice and advice needs reassessment. The majority of travel during pregnancy remains optional. Improved patient education and consultations prior to travel could decrease health risks.
Douching: A Risk to Women's Healthcare?
Mark Martens,Gilles R. G. Monif
Infectious Diseases in Obstetrics and Gynecology , 2003, DOI: 10.1080/10647440300025511
Abstract:
Basins of Attraction for Chimera States
Erik A. Martens,Mark J. Panaggio,Daniel M. Abrams
Physics , 2015,
Abstract: Chimera states---curious symmetry-broken states in systems of identical coupled oscillators---occur only for special initial conditions. Here we analyze their basins of attraction in a simple system comprised of two populations. Using perturbative analysis and numerical simulation we evaluate asymptotic states and associated destination maps, and demonstrate that basins form a complex twisting structure in phase space. Understanding the basins' precise nature may help in development of control methods to switch between chimera patterns, with possible technological and neural system applications.
Once Daily Valacyclovir for Reducing Viral Shedding in Subjects Newly Diagnosed with Genital Herpes
Mark G. Martens,Kenneth H. Fife,Peter A. Leone,Lynn P. Dix,Clare A. Brennan
Infectious Diseases in Obstetrics and Gynecology , 2009, DOI: 10.1155/2009/105376
Abstract: Objective. Genital herpes (GH) recurrences and viral shedding are more frequent in the first year after initial HSV-2 infection. The objective of this study was to provide the first evaluation of valacyclovir 1 g once daily compared to placebo in reducing viral shedding in subjects newly diagnosed with GH. Methods. 70 subjects were randomized to receive valacyclovir 1 g daily or placebo in a crossover design for 60 days with a 7-day washout period. A daily swab of the genital/anal-rectal area was self-collected for HSV-2 detection by PCR. Subjects attended the clinic for routine study visits and GH recurrence visits. Treatment differences were assessed using a nonparametric crossover analysis. Results. 52 subjects had at least one PCR measurement in both treatment periods and comprised the primary efficacy population. Valacyclovir significantly reduced HSV-2 shedding during all days compared to placebo (mean 2.9% versus 13.5% of all days (<.01), a 78% reduction). Valacyclovir significantly reduced subclinical HSV-2 shedding during all days compared to placebo (mean 2.4% versus 11.0% of all days (<.01), a 78% reduction). However, 79% of subjects had no GH recurrences while receiving valacyclovir compared to 52% of subjects receiving placebo (<.01). Conclusion. In this study, the frequency of total and subclinical HSV-2 shedding was greater than reported in earlier studies involving subjects with a history of symptomatic genital recurrences. Our study is the first to demonstrate a significant reduction in viral shedding with valacyclovir 1 g daily compared to placebo in a population of subjects newly diagnosed with HSV-2 infection.
Quick Minds Slowed Down: Effects of Rotation and Stimulus Category on the Attentional Blink
Sander Martens,Ozlem Korucuoglu,Henderikus G. O. M. Smid,Mark R. Nieuwenstein
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013509
Abstract: Most people show a remarkable deficit to report the second of two targets when presented in close temporal succession, reflecting an attentional restriction known as the ‘attentional blink’ (AB). However, there are large individual differences in the magnitude of the effect, with some people showing no such attentional restrictions.
The many layers of immunity
Sascha Martens
Genome Biology , 2002, DOI: 10.1186/gb-2002-3-8-reports4025
Abstract: The Cologne Spring Meeting organized by the Institute for Genetics in Cologne covers a different topic each year. This year's meeting on the theme 'Immunity' consisted of 22 talks over two and a half days. The meeting dealt with all aspects of immunity, ranging from cell-autonomous immunity, which functions in all nucleated cells, to the adaptive immune system that depends on B and T cells. It is becoming increasingly clear that the immune system has many layers, all of which are essential and highly interconnected. Here, I summarize some representative talks on different aspects of immunity.Antonio Lanzavecchia (Institute of Biomedicine, Bellinzona, Switzerland) addressed the question of how memory is maintained in the adaptive immune system. In particular, he focused on the role of cytokines derived from dendritic cells (DCs) - tumor necrosis factor (TNF) α, interleukin (IL)-6, IL-10 and IL-12 - in promoting the proliferation of CD4+ T cells in response to γc cytokines, which bind to receptors that share the γ common (γc) signaling chain, namely IL-2, IL-4, IL-7 and IL-15. Lanzavecchia reported that sensitivity to cytokines, and expression of cytokine receptors, vary with the differentiation stage of T cells. Naive human CD4+ T cells progressively acquire responsiveness to IL-7 and IL-15 and upregulate the IL-2/IL-15 receptor β chain while differentiating to central memory T (TCM) cells or effector memory T (TEM) cells. In addition, IL-7 and IL-15 act synergistically on all T-cell sub-populations but only TEM can directly proliferate in response to these cytokines. In contrast, na?ve and TCM cells also need DCs or DC-derived cytokines in order to upregulate their relevant receptors. Lanzavecchia emphasized the striking difference in the response of na?ve T cells and TCM to cytokine stimulation. Cytokine-expanded na?ve T cells maintain a lymph-node homing phenotype (CD45RA+, CCR7+) and undergo only limited differentiation. In contrast, TCM cells acquire a phenotype
The Impact of High-Stakes Assessments on Beliefs about Reading, Perceptions of Self-as-Reader, and Reading Proficiency of Two Urban Students Retained in Third Grade
Prisca Martens
Journal of Curriculum and Instruction , 2007,
Abstract: This yearlong study explores the perceptions of self-as-reader, beliefs about reading, and reading proficiency of two urban students retained in third grade on the basis of high-stakes assessment scores. The data presented focus on four individual reading and retrospective miscue analysis (RMA) sessions each student had with the researcher across one school year. When the study began, the students were less focused on reading for meaning and did not perceive themselves as good readers. In RMA sessions the students read and retold stories and then analyzed high quality miscues with the researcher facilitating their revaluation of reading as a process of constructing meaning and themselves as capable readers. Findings show that while the students grew in their understanding of the reading process and in their reading proficiency, they did not fully change their perceptions of themselves as readers. Thus the impact of the high-stakes assessment superseded the understanding the students gained while participating in more authentic reading experiences.
Community Essay: Sustainability: science or fiction?
Pim Martens
Sustainability : Science, Practice and Policy , 2006,
Abstract: It is clear that in making the concept of sustainable development concrete, one has to take into account a number of practical elements and obstacles. There is little doubt that integrated approaches are required to support sustainable development. Therefore, a new research paradigm is needed that is better able to reflect the complexity and the multidimensional character of sustainable development. The new paradigm, referred to as sustainability science, must be able to encompass different magnitudes of scales (of time, space, and function), multiple balances (dynamics), multiple actors (interests) and multiple failures (systemic faults). I also think that sustainability science has to play a major role in the integration of different styles of knowledge creation in order to bridge the gulf between science, practice, and politics—which is central to successfully moving the new paradigm forward.
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