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Search Results: 1 - 10 of 17838 matches for " Mark Liebow "
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Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer
Kristin L White, Robert A Vierkant, Catherine M Phelan, Brooke L Fridley, Stephanie Anderson, Keith L Knutson, Joellen M Schildkraut, Julie M Cunningham, Linda E Kelemen, V Shane Pankratz, David N Rider, Mark Liebow, Lynn C Hartmann, Thomas A Sellers, Ellen L Goode
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-170
Abstract: We used a case-control study to evaluate the association between single nucleotide polymorphisms (SNPs) in NFKBIA and NFKBIB (the genes encoding IκBα and IκBβ, respectively) and risk of epithelial ovarian cancer. We queried 19 tagSNPs and putative-functional SNPs among 930 epithelial ovarian cancer cases and 1,037 controls from two studies.The minor allele for one synonymous SNP in NFKBIA, rs1957106, was associated with decreased risk (p = 0.03).Considering the number of single-SNP tests performed and null gene-level results, we conclude that NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles. Due to its biological significance in ovarian cancer, additional genes encoding NF-κB subunits, activating and inhibiting molecules, and signaling molecules warrant interrogation.Despite estimates of more than 21,000 newly diagnosed cases of ovarian cancer and 15,000 related deaths each year in the United States [1], the etiology of ovarian cancer remains poorly understood. Known risk factors include increased risk with family history and use of fertility drugs, and decreased risk with oral contraceptive use, parity, and long duration of breast feeding [2]. Rare, high-penetrant mutations in BRCA1 and BRCA2 account for approximately 40% of familial risk, leaving most inherited risk unexplained [3,4]. The search for additional loci includes thoughtful selection of candidate genes in key biological pathways, an approach which has been successful in identifying new risk alleles for a variety of cancers [5].Inflammation has been implicated in ovarian carcinogenesis because of its role in ovulation and post-ovulatory repair. During ovulation the ovarian epithelial surface is damaged, requiring a repair process involving the recruitment of leukocytes and inflammatory cytokines, release of nitrous oxide, DNA repair, and tissue restructuring [6-9]. Over time, this continuous repair of the ovarian epithelial tissue increases the likelihood of errors during replicatio
Risk of Ovarian Cancer and Inherited Variants in Relapse-Associated Genes
Abraham Peedicayil,Robert A. Vierkant,Lynn C. Hartmann,Brooke L. Fridley,Zachary S. Fredericksen,Kristin L. White,Elaine A. Elliott,Catherine M. Phelan,Ya-Yu Tsai,Andrew Berchuck,Edwin S. Iversen Jr,Fergus J. Couch,Prema Peethamabaran,Melissa C. Larson,Kimberly R. Kalli,Matthew L. Kosel,Vijayalakshmi Shridhar,David N. Rider,Mark Liebow,Julie M. Cunningham,Joellen M. Schildkraut,Thomas A. Sellers,Ellen L. Goode
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0008884
Abstract: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk.
The Mind’s Irreducible Structure  [PDF]
Mark Simes
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23033
Abstract: The human mind is one of our most compelling subjects of scientific inquiry—and perhaps our most elusive. Despite impressive biological advances, neuroscience has yet to produce a logical and empirical analysis of the mind that exhibits universal, objective explanatory power of human mental phenomena on both an individual and species level. This article first explores the limitations of the current neuroscientific approach to the human mind and then argues for a reconceptualization of the relationship between human mental phenomena and the brain. Here I introduce a new interpretation of neuroscientific data and argue that this framework has the capacity to causally explain the link between social, psychological and biological levels of analysis.
Why Asynchronous Computer-Mediated Communication (ACMC) Is a Powerful Tool for Language Learning  [PDF]
Mark Brooke
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.23016
Abstract: Tertiary institutions are increasingly using online virtual environments such as Blackboard to upload course content for students. However, there is still limited usage of the online blogging and discussion tools. This study describes the language used by tertiary students involved in blogging and discussions online. It also demonstrates learning processes observed through the interactions of participants over time. Findings suggest that this unique discourse mode is a potentially powerful tool for language learning.
Enhancing Pre-Service Teacher Training: The Construction and Application of a Model for Developing Teacher Reflective Practice Online  [PDF]
Mark Brooke
Open Journal of Modern Linguistics (OJML) , 2012, DOI: 10.4236/ojml.2012.24023
Abstract: Reflective practice is an essential component of pre-service teacher training programs. It facilitates the linking of theory and practice and empowers trainees to seek reasons behind their practices and their beliefs. These help novices to evolve as they witness their own teaching philosophies emerging. This research took place over 18 months and comprised 3 case studies of eight weeks with 3rd year ESOL trainees on their first intensive block practice in Hong Kong state schools. The research suggests that an online environment is an effective one in supporting and developing reflective practice during these periods. This was facilitated by asking trainees to apply an online model to scaffold reflections. These reflections were then posted and discussed by all case study members. They were also explored further using online moderator asynchronous Socratic dialogue to prompt further reflection. Findings demonstrate that a deep level of reflection is attainable in this context, albeit relatively rare, using the online medium.
A Critical Analysis of Selected Policy Making Decisions in the US and the UK with Regard to the Implementation of Information and Communication Technology (ICT) in National State Primary and Secondary School Education Systems  [PDF]
Mark Brooke
Open Journal of Modern Linguistics (OJML) , 2013, DOI: 10.4236/ojml.2013.31012
Abstract: Information and Communication Technology has played an important and pervasive role in modern business and everyday living over the last decade and more. The industry accounts for trillions of annual revenue. Yet, it has proved hard for a similar role for Information and Communication Technology (ICT) to emerge in education. In this paper, I will argue that policy regarding ICT use at national state levels in the UK and the US has striven to create, and continues to perpetuate, a system of education with technological divisions of labour, and marginalized innovative and communicative practical uses of technology for enhancing education in schools.
Manuel Castells and Historical Materialism  [PDF]
Mark Cowling
Open Journal of Political Science (OJPS) , 2014, DOI: 10.4236/ojps.2014.41001
Abstract:

Considering the very large volume of work produced by Castells, the relative scarcity of secondary literature discussing his theories is somewhat surprising. Castells does not really try to situate his theories about the network society in relation to Marxism. The argument of this paper is that Castells provides a plausible account of some major features of the means of production in the contemporary phase of capitalism, and also of the effects of this on society more generally. His theories could form the basis of an academically respectable version of historical materialism. Some problems with his theories are discussed.

Police Misconduct, Racism, and Excessive Use of Force-Failure Analysis, Commentary, and Recommendations  [PDF]
Mark Malmin
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.38001
Abstract: Community perceptions of police misconduct, racism, and allegations of excessive use of force vary from community to community, especially with variant population densities. Perceptual views tend to promote the idiomatic dilemma that perception is reality. This paper exegetically explores modalities of community policing, existing FBI empirical statistical evidence of Uniform Crime Reports, facts, misconceptions, the absence of uniform reporting requirements, and other perceptual contributing factors, such as media influence, that support the existing paradigm of racial profiling perceptions across the US. The pursuit and acquisition of racial justice and equality require public trust in government, unbiased factual analysis of systemic failures, better communication, community collaboration, and minority participation in the political process.
Non-Backtracking Random Walks and a Weighted Ihara’s Theorem  [PDF]
Mark Kempton
Open Journal of Discrete Mathematics (OJDM) , 2016, DOI: 10.4236/ojdm.2016.64018
Abstract: We study the mixing rate of non-backtracking random walks on graphs by looking at non-backtracking walks as walks on the directed edges of a graph. A result known as Ihara’s Theorem relates the adjacency matrix of a graph to a matrix related to non-backtracking walks on the directed edges. We prove a weighted version of Ihara’s Theorem which relates the transition probability matrix of a non-backtracking walk to the transition matrix for the usual random walk. This allows us to determine the spectrum of the transition probability matrix of a non-backtracking random walk in the case of regular graphs and biregular graphs. As a corollary, we obtain a result of Alon et al. in [1] that in most cases, a non-backtracking random walk on a regular graph has a faster mixing rate than the usual random walk. In addition, we obtain an analogous result for biregular graphs.
TrueBeam Low Dose Rate Investigation for Pulsed Reduced Dose Rate IMRT  [PDF]
Mark Geurts
International Journal of Medical Physics,Clinical Engineering and Radiation Oncology (IJMPCERO) , 2017, DOI: 10.4236/ijmpcero.2017.62013
Abstract: The capability of the TrueBeam treatment system to deliver step and shoot IMRT plans at low dose rates was evaluated. Beam characteristics during low dose rates (5 to 100 MU/min) were evaluated for consistency using a planar ion chamber array. MU constancy, linearity, and beam profile symmetry were all found to be equivalent within 0.5%. The response of the Scandi Dos Delta 4 system was also evaluated at low dose rates of using static open beams compared to ion chamber measurements, and step and shoot IMRT plans comparing 5 - 20 MU/min and 100 MU/min dose rates, with a maximum observed absolute dose difference of 0.8% and equivalence margin of 0.2%. The Gamma Index and measurement reproducibility were also found to be equivalent.
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