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Search Results: 1 - 10 of 205772 matches for " Mark G Lefsrud "
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Effect of Pulsed Ultraviolet Light on the Total Phenol Content of Elderberry (Sambucus nigra) Fruit  [PDF]
Ramesh Murugesan, Valérie Orsat, Mark Lefsrud
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.36104
Abstract: The changes in total polyphenolics in elderberry (Sambucus nigra) following treatment with various doses of pulsed ultraviolet rays (UV) were investigated. Four pulsed UV durations (5, 10, 20, 30 seconds) at three energy dosages (4500, 6000, 11,000 J/m2/pulse) were considered for the research. All treated elderberry fruits were incubated for 24 h at room temperature (25℃) following treatment to ensure enough response duration for enhanced development of polyphenols by the berries. The highest increase in total phenolics around 50% was found with 11,000 J/m2/pulse for a 10 seconds treatment while nearly 40% increase in total phenolics was found at an energy dosage of 11,000 J/m2/pulse after 5 seconds exposure. Even though most of the treatments indicated an increase in total polyphenols, some treatment expressed a decrease in phenolics content when compared to untreated fruits.
Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose
Kumaran Sivagnanam, Vijaya GS Raghavan, Manesh Shah, Robert L Hettich, Nathan C Verberkmoes, Mark G Lefsrud
Proteome Science , 2011, DOI: 10.1186/1477-5956-9-66
Abstract: We identified 894 different proteins in C. acetobutylicum from ABE fermentation process by two dimensional - liquid chromatography - tandem mass spectrometry (2D-LC-MS/MS) method. This includes 717 proteins from glucose and 826 proteins from the xylose substrate. A total of 649 proteins were found to be common and 22 significantly differentially expressed proteins were identified between glucose and xylose substrates.Our results demonstrate that flagellar proteins are highly up-regulated with glucose compared to xylose substrate during ABE fermentation. Chemotactic activity was also found to be lost with the xylose substrate due to the absence of CheW and CheV proteins. This is the first report on the shotgun proteomic analysis of C. acetobutylicum ATCC 824 in ABE fermentation between glucose and xylose substrate from a single time data point and the number of proteins identified here is more than any other study performed on this organism up to this report.Clostridium acetobutylicum is a gram positive, spore forming, obligate anaerobic bacteria and is one of the few microorganisms capable of converting a wide variety of sugars into three main products acetone, butanol and ethanol (ABE) [1]. ABE fermentation process was the primary source of butanol for over 40 years until the mid-1950s and is one of the oldest large-scale industrial fermentations [2]. ABE fermentation could not compete with the chemical synthesis of ABE solvents from petroleum since the mid-1950s [3]. However, increased concern over depletion of fossil fuels has led to renewed research interest in producing solvents via microbial fermentation processes.Lignocellulosic biomass is an abundant renewable resource that can be used for the production of alternative fuels [4]. It is advantageous to use lignocellulosic biomass such as rice straw, wheat straw, corn stover and agricultural residues for biofuel production as they have limited impact on food supplies [5]. Glucose is the most abundant sugar fou
Study of Pea Accessions for Development of an Oilseed Pea
Ehsan Khodapanahi,Mark Lefsrud,Valerie Orsat,Jaswinder Singh,Tom D. Warkentin
Energies , 2012, DOI: 10.3390/en5103788
Abstract: Global interest in stable energy resources coupled with growing demand for bio-oils in various conventional and arising industries has renewed the importance of vegetable oil production. To address this global interest, oilseed production has been increased in recent decades by different approaches, such as extending the cultivation area of oil crops, or breeding and growing genetically modified plants. In this study, pea ( Pisum sativum L.) accessions were screened for lipid content using a rapid extraction method. This method quantifies lipid concentration in pea seeds and was developed by assessing and comparing the results of existing extraction methods used for canola and soybean, the top two Canadian oilseeds. Seeds of 151 field pea accessions were grown to maturity in 2009 and 2010 at McGill University (Quebec, Canada). Overall, lipid concentration in pea seeds ranged from 0.9 to 5.0%. Among several seed characteristics, only seed shape (wrinkled verses round) had a significant effect on the total lipid production in the seeds. Peas are a valuable source of protein and starch, but the lipid concentration in their seeds has been undervalued. This research supports the idea of developing a novel dual-purpose oilseed pea that emulates the protein and oil production in soybean seeds while being conveniently adapted to a colder climate.
Patient Preferences in the Treatment of Vaginal Candidiasis  [PDF]
Mark G. Martens
Open Journal of Obstetrics and Gynecology (OJOG) , 2018, DOI: 10.4236/ojog.2018.812116
Abstract: Vulvovaginal candidiasis (VVC) is one of the most frequent problems facing women and their healthcare professionals (HCP). It is difficult for providers to understand the prevalence of VVC because effective over the counter treatments (OTC), are available. It is expected that there are a great many more episodes of VVC in our patient population, as the frequency of self-treatment, success and satisfaction for those that use OTC products prior to seeing a women’s health care provider is unknown. In this study; healthcare providers were given OTC miconazole/tioconazole units for free distribution to patients for whom they diagnosed VVC by exam in their offices. Surveys for both HCP and patients were also distributed to determine the initial or recurrent nature of their symptoms and their satisfaction with their treatments. 1265 OBGYNs and 1821 NP/CNM/PAs reported on over 19,000 patients receiving a single complete treatment. Among HCPs, treatment efficacy was the primary reason for recommending miconazole/tioconazole. However, rapid onset of symptom relief, safety vs. fluconazole, patient preference for the less messy ovule, avoidance with drugs metabolized by the liver, and resistance to, or failure on, fluconazole were additional reasons noted for topical preference. Overall, patient satisfaction (n =
The Influence of Radial Area Variation on Wind Turbines to the Axial Induction Factor  [PDF]
Kedharnath Sairam, Mark G. Turner
Energy and Power Engineering (EPE) , 2014, DOI: 10.4236/epe.2014.611034
Abstract: Improvements in the aerodynamic design will lead to more efficiency of wind turbines and higher power production. In the present study, a 3D parametric gas turbine blade geometry building code, 3DBGB, has been modified in order to include wind turbine design capabilities. This approach enables greater flexibility of the design along with the ability to design more complex geometries with relative ease. The NREL NASA Phase VI wind turbine was considered as a test case for validation and as a baseline by which modified designs could be compared. The design parameters were translated into 3DBGB input to create a 3D model of the wind turbine which can also be imported into any CAD program. Design modifications included replacing the airfoil section and modifying the thickness to chord ratio as a function of span. These models were imported into a high-fidelity CFD package, Fine/TURBO by NUMECA. Fine/TURBO is a specialized CFD platform for turbo-machinery analysis. A code-geomturbo was used to convert the 3D model of the wind turbine into the native format used to define geometries in the Fine/TURBO meshing tool, AutoGrid. The CFD results were post processed using a 3D force analysis code. The radial force variations were found to play a measurable role in the performance of wind turbine blades. The radial component of the blade surface area as it varies in span is the dominant contributor of the radial forces. Through the radial momentum equation, this radial force variation is responsible for creating the streamline curvature that leads to the expansion of the streamtube (slipstream) that is responsible for slowing the wind velocity ahead of the wind turbine leading edge, which is quantified as the axial induction factor. These same radial forces also play a role in changing the slipstream for propellers. Through the design modifications, simulated with CFD and post-processed appropriately, this connection with the radial component of area to the radial forces to the axial induction factor, and finally the wind turbine power is demonstrated. The results from the CFD analysis and 3D force analysis are presented. For the case presented, the power increases by 5.6% due to changes in airfoil thickness only.
Prevalence of Non-Albicans Candida Infections in Women with Recurrent Vulvovaginal Symptomatology  [PDF]
Jason D. Mintz, Mark G. Martens
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.34035

Background: Candida vulvovaginitis is one of the most frequently diagnosed conditions in women’s care practices. Historically, 90% of cultured yeast species were C. albicans. However, due to a variety of interventions, the proportion of non-albicans Candida (NAC) infections appears to be increasing. We sought to estimate the current prevalence of Candida vulvovaginitis and the species-specific distribution of such infections in recurrent cases. Methods: Women with recurrent vulvovaginal symptomatology referred to an Obstetrics and Gynecology practice were tested by genital fungus culture, Candida-specific polymerase chain reaction (PCR), or both between July 2010 and February 2013. Results: A total of 103 women were tested. Mean age was 45.6 years. Including only their most recent positive test result, 29.1% (30/103) of women tested positive for Candida by any of the above testing measures. Of those, 50% (15/30) tested positive for C. albicans and 50% (15/30) tested positive for a NAC species. Across all visits, 60% (18/30) tested positive for C.

Gold complexes for nonlinear optics
Mark G Humphrey
Gold Bulletin , 2000, DOI: 10.1007/BF03215485
Abstract: The nonlinear optical (NLO) properties of gold complexes are reviewed. Experimental procedures which have been used to determine NLO behaviour of gold complexes are summarized, structure / NLO property correlations are presented, and the potential of gold complexes for nonlinear optics is discussed.
The Role of Oxygen in Cardiac Arrest Resuscitation
Signa Vitae , 2010,
Abstract: The heart is incapable of storing significant oxygen or substrates and thus is entirely dependent on a continuous delivery of flow in order to support its high metabolic state. Following cardiac arrest, myocardial tissue oxygen tension falls rapidly and aerobic production of ATP ceases. Without re-oxygenation of the ischemic myocardium, return of spontaneous circulation (ROSC) cannot be achieved. The oxygen paradox which has been described regarding other ischemia-reperfusion conditions seems to have application in cardiac arrest. It is clear that some level of oxygenation is necessary to achieve ROSC, however post ROSC there appears to be increased toxicity associated with hyperoxia. The optimal conditions for re-oxygenation in the setting of cardiac arrest remain ill defined at present.
Review: Thomas Jefferson: Draftsman of a Nation, by Natalie S. Bober
Spencer, Mark G.
Journal of Historical Biography , 2010,
Mediodorsal thalamus and cognition in non-human primates
Mark G. Baxter
Frontiers in Systems Neuroscience , 2013, DOI: 10.3389/fnsys.2013.00038
Abstract: Several recent studies in non-human primates have provided new insights into the role of the medial thalamus in different aspects of cognitive function. The mediodorsal nucleus of the thalamus (MD), by virtue of its connectivity with the frontal cortex, has been implicated in an array of cognitive functions. Rather than serving as an engine or relay for the prefrontal cortex, this area seems to be more specifically involved in regulating plasticity and flexibility of prefrontal-dependent cognitive functions. Focal damage to MD may also exacerbate the effects of damage to other subcortical relays. Thus, a wide range of distributed circuits and cognitive functions may be disrupted from focal damage within the medial thalamus (for example as a consequence of stroke or brain injury). Conversely, this region may make an interesting target for neuromodulation of cognitive function via deep brain stimulation or related methods, in conditions associated with dysfunction of these neural circuits.
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