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Search Results: 1 - 10 of 206532 matches for " Mark D.;Kurasaki "
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Rational emotive behavior therapy: applications for working with parents and teachers
Terjesen, Mark D.;Kurasaki, Robyn;
Estudos de Psicologia (Campinas) , 2009, DOI: 10.1590/S0103-166X2009000100001
Abstract: given the high rates of reported emotional stress among parents and teachers, the rational emotive behavior therapy approach appears to be a useful strategy to promote more effective parent and teacher emotional functioning and increase child positive behaviors and learning. the rational emotive behavior therapy model may be helpful for clinicians who work with the parents and the family by identifying and subsequently changing their unhealthy ideas, enhancing emotional functioning, and increasing their ability to make effective behavior management decisions. in addition, those who work with educators in a school-based setting may wish to consider implementing rational emotive behavior therapy methodology in their consultative and therapeutic interventions. given the data that links stress to unhealthy beliefs among educators, rational emotive behavior therapy may be an effective tool that warrants further application.
Snow Water Equivalent Estimation for a Snow-Covered Prairie Grass Field by GPS Interferometric Reflectometry  [PDF]
Mark D. Jacobson
Positioning (POS) , 2012, DOI: 10.4236/pos.2012.33005
Abstract: The amount of water stored in snowpack is the single most important measurement for the management of water supply and flood control systems. The available water content in snow is called the snow water equivalent (SWE). The product of snow density and depth provides an estimate of SWE. In this paper, snow depth and density are estimated by a nonlinear least squares fitting algorithm. The inputs to this algorithm are global positioning system (GPS) signals and a simple GPS interferometric reflectometry (GPS-IR) model. The elevation angles of interest at the GPS receiving antenna are between 50 and 300. A snow-covered prairie grass field experiment shows potential for inferring snow water equivalent using GPS-IR. For this case study, the average inferred snow depth (17.9 cm) is within the in situ measurement range (17.6 cm ± 1.5 cm). However, the average inferred snow density (0.13 g.cm-3) overestimates the in situ measurements (0.08 g.cm-3 ± 0.02 g.cm-3). Consequently, the average inferred SWE (2.33 g.cm-2) also overestimates the in situ calculations (1.38 g.cm-2 ± 0.36 g.cm-2).
Measurement of DNA damage by terminal deoxynucleotidyl transferase reaction  [PDF]
Masaaki Kurasaki, Yongkun Sun, Miyako Komori, Miki Miyajima, Toshiyuki Hosokawa, Takeshi Saito
Advances in Biological Chemistry (ABC) , 2012, DOI: 10.4236/abc.2012.23030
Abstract: An improved terminal deoxynucleotidyl transferase- mediated dUTP-biotin nick end labeling method for the quantification of DNA damage in tissues and cultured cells was developed. Many reports have revealed that histochemistry of DNA damage can be visualized using immunohistochemistry for the terminal deoxynucleotidyl transferase reaction in tissue sections. However, few reports have described quantification of DNA damage in tissues or cells. In this study, to estimate the degree of DNA damage, the confirmed method for histochemistry using biotinylated dUTP and deoxynucleotidyl transferase was applied to label the cleaved DNA ends caused by DNA damage in tissues or cells. After end-labeling, avidin-conjugated peroxidase was reacted. A significant correlation was observed between numbers of cleaved DNA ends and peroxidase activity after the reaction. The obtained signals for presented method showed higher than those for ordinary method, and correlate with degree of DNA damage caused by serum deprivation and chemical dose. In addition, DNA damage caused by apoptosis in cells treated with 6-hydroxydopamine or Cu and in the tissues of rats administered a diet containing no Zn could be evaluated quantitatively using the present method.
Assessing the Analgesic Effects of Sucrose to Cold Pressor Pain in Human Adults  [PDF]
Michele E. Mercer, Mark D. Holder
Journal of Behavioral and Brain Science (JBBS) , 2013, DOI: 10.4236/jbbs.2013.31002
Previous studies report that the ingestion of highly concentrated sweet solutions produces a morphine-like analgesia in rats, human infants, and in adult males. To determine whether sweet-induced analgesia occurs with more commonly consumed substances, 30 adult males (Mage = 22.4 years) were exposed to a cold pressor test and pain responsivity was assessed both before and after consuming either an 8% sucrose solution, water, or nothing. Between-groups comparisons revealed that relative to the Sucrose or Nothing groups, the Water group showed increased pain tolerance. Neither pain thresholds nor ratings of pain intensity and unpleasantness on a visual analogue scale differed among groups. The results support previous findings in both humans and animals that the palatability or hedonic value of food or drink may be the key predictor of its analgesic effect.
Prevalence of Non-Albicans Candida Infections in Women with Recurrent Vulvovaginal Symptomatology  [PDF]
Jason D. Mintz, Mark G. Martens
Advances in Infectious Diseases (AID) , 2013, DOI: 10.4236/aid.2013.34035

Background: Candida vulvovaginitis is one of the most frequently diagnosed conditions in women’s care practices. Historically, 90% of cultured yeast species were C. albicans. However, due to a variety of interventions, the proportion of non-albicans Candida (NAC) infections appears to be increasing. We sought to estimate the current prevalence of Candida vulvovaginitis and the species-specific distribution of such infections in recurrent cases. Methods: Women with recurrent vulvovaginal symptomatology referred to an Obstetrics and Gynecology practice were tested by genital fungus culture, Candida-specific polymerase chain reaction (PCR), or both between July 2010 and February 2013. Results: A total of 103 women were tested. Mean age was 45.6 years. Including only their most recent positive test result, 29.1% (30/103) of women tested positive for Candida by any of the above testing measures. Of those, 50% (15/30) tested positive for C. albicans and 50% (15/30) tested positive for a NAC species. Across all visits, 60% (18/30) tested positive for C.

Effects of Fiber Volume on Modal Response of Through-Thickness Angle Interlock Textile Composites  [PDF]
Marco Villa, Richard D. Hale, Mark Ewing
Open Journal of Composite Materials (OJCM) , 2014, DOI: 10.4236/ojcm.2014.41005

Prior static studies of three-dimensionally woven carbon/epoxy textile composites show that large interlaminar normal and shear strains occur as a result of layer waviness under static compression loading. This study addresses the dynamic response of 3D through-thickness angle interlock textile composites, and how interaction between different layer waviness influences the modal frequencies. The samples have common as-woven textile architecture, but they are cured at varying compaction pressures to achieve varying levels of fiber volume and fiber architecture distortion. Samples produced have varying final cured laminate thickness, which allows observations on the influence of increased fiber volume (generally believed to improve mechanical performance) weighed against the increased fiber distortion (generally believed to decrease mechanical performance). The results obtained from this study show that no added damping was developed in the as-woven identical panels. Furthermore, a linear relation exists between modal frequency and thickness (fiber volume).

Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide
Y Hori,S Sato,J Yamate,M Kurasaki
European Journal of Histochemistry , 2003, DOI: 10.4081/842
Abstract: Macrophage migration inhibitory factor (MIF) is a molecule known to regulate macrophage accumulation at sites of inflammation. To elucidate the role of MIF in progression of liver fibrosis, the immunohistochemical localization of MIF and macrophages in the liver were examined. Male Wistar rats received thioacetamide (TA) injections (200 mg/kg, i.p.) for 1 or 6 weeks. In biochemical and histological tests, it was confirmed that liver fibrosis was induced. In immunohistochemical analyses, the expression of MIF protein was seen in hepatocytes in the areas extending out from the central veins to the portal tracts. In particular, at 6 weeks, immunoreactivity was detected in degenerated hepatocytes adjacent to the fibrotic areas but hardly observed in the fibrotic areas. On the other hand, a number of exudate macrophages stained by antibody ED1 were seen in the areas from the central veins to the portal tracts at 1 week and in the fibrotic areas at 6 weeks. Macrophages also showed a significant increase in number as compared with controls. These results revealed that there was a close relationship between the appearance of MIF expression and ED1-positive exudate macrophages in degenerated hepatocytes during the progression of TA-induced liver fibrosis.
Use of Ghrelin as a Treatment for Inflammatory Bowel Disease: Mechanistic Considerations
Mark D. DeBoer
International Journal of Peptides , 2011, DOI: 10.1155/2011/189242
Abstract: Inflammatory bowel diseases (IBD)—and in particular Crohn's disease—are immune-mediated processes that result in denuded intestinal mucosa and can produce decreased appetite, weight loss, and systemic inflammation. Current treatments include anti-inflammatory medications, immunomodulators, and feeding interventions. Ghrelin is an endogenous orexigenic hormone that directly stimulates growth hormone release, increases gut motility, and has cardiovascular and anti-inflammatory properties. Although ghrelin levels are elevated in active IBD, administration of ghrelin in most (but not all) animal models of colitis has produced improvements in disease activity and systemic inflammation. The mechanism for these effects is not known but may relate to decreased inflammation, increased motility, increased appetite, and increased colonic blood flow. Human trials have not been performed, however, and more research is clearly needed. 1. Introduction Inflammatory bowel diseases (IBD)—including Crohn’s disease and ulcerative colitis—are immune-mediated processes that result in denuding of intestinal mucosa [1]. Treatment largely focuses on targeting local and systemic inflammation, including via administration of steroids, immunomodulating agents, and biologic medications such as monoclonal antibodies to inflammatory cytokines [2]. Alternate treating regimens include nutritional interventions in which high-calorie feedings are given via nasogastric tube, which—despite less frequently used—have been also shown to be effective [3]. One intriguing agent that has been shown to ameliorate IBD in animal models is the orexigenic hormone ghrelin [4–6]. Following initial identification in 1999, ghrelin has attracted extensive attention for its role in physiology and its potential role as a treatment in disease states [7]. Ghrelin is released predominantly by the endocrine cells of the stomach and acts on appetite-regulating centers in the hypothalamus to stimulate increased food intake [8]. Ghrelin also acts at the level of the pituitary to stimulate growth hormone release [4]. Interestingly, ghrelin also has been shown to have anti-inflammatory [9–11] and prokinetic properties [12, 13]. It remains unclear which of these properties is responsible for its efficacy in animal models of IBD. This paper will focus on data regarding the physiology of ghrelin in the setting of IBD, its effects in the setting of animal models of IBD treatment, and potential mechanisms whereby ghrelin may act to improve pathophysiology of IBD. As we will see, though the exact mechanism of ghrelin’s
Inferring Snow Water Equivalent for a Snow-Covered Ground Reflector Using GPS Multipath Signals
Mark D. Jacobson
Remote Sensing , 2010, DOI: 10.3390/rs2102426
Abstract: A nonlinear least squares fitting algorithm is used to estimate both snow depth and snow density for a snow-layer above a flat ground reflector. The product of these two quantities, snow depth and density, provides an estimate of the snow water equivalent. The input to this algorithm is a simple ray model that includes a speculary reflected signal along with a direct signal. These signals are transmitted from the global positioning system satellites at 1.57542 GHz with right-hand circularly polarization. The elevation angles of interest at the GPS receiving antenna are between 5° and 30°. The results from this nonlinear algorithm show potential for inferring snow water equivalent using GPS multipath signals.
Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
Mark D Sternlicht
Breast Cancer Research , 2005, DOI: 10.1186/bcr1368
Abstract: Branching morphogenesis is fundamental to the formation of diverse ramiform tissues from the tracheal networks of insects to the lungs, kidneys and salivary glands of higher organisms [1]. Although the final forms and functions of these many arborized organs clearly differ, many of the major mechanisms that underlie their morphogenesis seem to be conserved in all branched organs, whereas other specialized mechanisms are undoubtedly responsible for their individual tissue-specific and species-specific characteristics. Thus both ubiquitous and unique mechanisms govern the branching process in each particular organ and organism. In general, this process entails the initial specification and formation of an organ anlage, its invagination, the initiation and outgrowth of its earliest branches, its spatial organization via reiterative branching events and tissue remodeling, the formation of a continuous lumen, and tissue-specific differentiation of the entire network and its terminal structures. Indeed, many salient aspects of branching morphogenesis are well or partly understood [1-4], whereas many others are waiting to be solved. This article discusses our current sense and understanding of branching morphogenesis in the context of mammary gland development, with the realization that many of these notions also apply to other areas of development and disease.The mammary gland, unlike other branched organs, undergoes most of its branching during adolescent rather than fetal development. In mice, mammary development begins shortly after mid-gestation, when bilateral epidermal ridges (or milk lines) form from forelimb to hindlimb, along which five pairs of disk-shaped placodes form at the site of each future nipple (this stage of mammary development is reviewed in the initial article in this series [5]). Each distinct placode then invaginates to form a bulb-shaped bud (the primary mammary rudiment or anlage) that penetrates the underlying mesenchyme and enters the cluster o
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