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Search Results: 1 - 10 of 11195 matches for " Mario Pellerano "
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Technico-Economical Evaluation of CO2 Transport in an Adsorbed Phase  [PDF]
Mildred Lemus Perez, Manuel Rodriguez Susa, Mario Pellerano, Arnaud Delebarre
Low Carbon Economy (LCE) , 2012, DOI: 10.4236/lce.2012.31004
Abstract: This work considers the possibility to transport CO2 in an adsorbed phase and analyzes its cost as a function of transported quantities, transport conditions and transportation means. CO2 adsorption capacities of 6 different adsorbents, comprising 4 activated carbons and 2 zeolites, were empirically evaluated in a given range of pressure and temperature. The adsorbent with the highest mass adsorption capacity (AC1), as well as another sorbent described in the literature (AC5) were selected to be used for CO2 transportation by ships, trains or trucks. Their characteristics and performances were then used to develop an economic analysis of transportation costs and CO2 emissions generated by the transport with or without storage. Economic evaluation of CO2 batch transport shows that CO2 transported in an adsorbed phase by train was seen to be almost competitive on distances between 250 and 500 km, in comparison to liquefied CO2. One of the activated carbon appeared to be competitive on short distances by truck when transport was not followed by storage. Ship transport of adsorbed CO2 on distances around 1500 km was competitive, when CO2 was used as delivered; there was an over cost of only 16%, when there was storage after the transport. The CO2 emissions generated by CO2 transport and storage when transport is carried out in an adsorbed phase were smaller than the ones generated by liquid phase transport below 1200 km, 500 km and 300 km by ship, train and truck respectively, as a function of the adsorbent used. Adsorbed CO2 transported on 1500 km by ship generated 27% less CO2 emissions than liquid phase and 17% by train for a distance of 250 km and 16% by truck on 150 km, although these differences were decreasing with the distance of transport.
Capas, o el modo de atravesar experiencias -Walter Benjamin-
Rut Pellerano
Límite , 2008,
Abstract: El presente artículo intenta analizar el concepto de experiencia en la obra de Walter Benjamin, proponiéndose para ello un recorrido en camino inverso; es decir, desde las últimas for-mulaciones que hallamos en Sobre el concepto de historia ir desenredando la trama conceptual para arribar de ese modo a un escrito de 1916. Esta propuesta, que no pretende originali-dad, simplemente pone en acto aquello de indicar ante todo qué capas hubo que atravesar para llegar a aquella de la que provienen los hallazgos .1
A conduta como ponto de partida universal da observa o jurídica
Hector F. Rojas Pellerano
Sequência : Estudos Juridicos e Politicos , 1984,
Antonio Pantaleo,Maria Teresa Carone,Achillle Pellerano
Journal of Agricultural Engineering , 2009, DOI: 10.4081/jae.2009.1.37
Abstract: The main objective of the proposed research is to estimate the energy potentials of the olive trees pruning residues and olive husk residues in the Apulia region (Southern Italy) and to compare the possible bioenergy conversion routes for heat and power generation. 46 006_Pantaleo(537)_37 27-07-2009 11:20 Pagina 46 The part I of the research proposes a preliminary review of the olive oil chain residues in the Apulia region and an assessment of technical potentials and biomass supply costs. The investigation is carried out through a review of existing literature, structured interviews with operators, elaboration of available statistical data, assessment of the typology and current use of the by-products, analysis of olive trees pruning techniques and olive milling processes. The results show a high potential of pruning residues (about 177 kt/year at 15% moisture content) and crude olive husk (about 915 kt/year at 50% average moisture content). The supply costs are, in most cases, compatible with the energy conversion routes, and in particular they result in the range of 45-55 €/t (35% moisture content) for rotobales and chips from PR.
Fluorescent Peptide Biosensor for Probing the Relative Abundance of Cyclin-Dependent Kinases in Living Cells
Laetitia Kurzawa, Morgan Pellerano, J. B. Coppolani, May C. Morris
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026555
Abstract: Cyclin-dependant kinases play a central role in coordinating cell growth and division, and in sustaining proliferation of cancer cells, thereby constituting attractive pharmacological targets. However, there are no direct means of assessing their relative abundance in living cells, current approaches being limited to antigenic and proteomic analysis of fixed cells. In order to probe the relative abundance of these kinases directly in living cells, we have developed a fluorescent peptide biosensor with biligand affinity for CDKs and cyclins in vitro, that retains endogenous CDK/cyclin complexes from cell extracts, and that bears an environmentally-sensitive probe, whose fluorescence increases in a sensitive fashion upon recognition of its targets. CDKSENS was introduced into living cells, through complexation with the cell-penetrating carrier CADY2 and applied to assess the relative abundance of CDK/Cyclins through fluorescence imaging and ratiometric quantification. This peptide biosensor technology affords direct and sensitive readout of CDK/cyclin complex levels, and reports on differences in complex formation when tampering with a single CDK or cyclin. CDKSENS further allows for detection of differences between different healthy and cancer cell lines, thereby enabling to distinguish cells that express high levels of these heterodimeric kinases, from cells that present decreased or defective assemblies. This fluorescent biosensor technology provides information on the overall status of CDK/Cyclin complexes which cannot be obtained through antigenic detection of individual subunits, in a non-invasive fashion which does not require cell fixation or extraction procedures. As such it provides promising perspectives for monitoring the response to therapeutics that affect CDK/Cyclin abundance, for cell-based drug discovery strategies and fluorescence-based cancer diagnostics.
Ovum pick-up and in vitro production technology in field conditions in the North East of Argentina
G. Pellerano,B. Gasparrini,G. Crudeli,L. Zicarelli
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2007.s2.743
Abstract: The aim of this work was to assess the feasibility of ovum pick-up and in vitro embryo production technology in field conditions in buffalo and crossbreed cattle. This study represents the first trial of in vitro fertilization carried out in North East Argentina. Buffalo (n=11) and bovine (n=3) donors underwent Ovum pick-up twice per week for 2 weeks. The equipment was hand-made, resulting in the impossibility of controlling the aspiration pressure. A higher number of cumulus-oocyte-complexes were recovered in bovine vs buffalo (6.3 vs 3.6 per donor respectively). In bovine the quality of the COCs was also superior (53.9 vs 26.6 % of highest quality COCs in bovine and buffalo respectively). A significantly higher incidence of denuded oocytes was found in buffalo (38.0 vs 11.8 %), indicating a higher sensitivity of buffalo oocytes to mechanical damages. Despite the poor oocyte quality and the suboptimal culture conditions, the latter related to the lack of lab facilities, buffalo embryo cleaved (35.7 %) and developed up to the tight-morula stage (22.5 %). This preliminary trial sets the basis for future studies in Argentina.
Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors
Marion Peyressatre,Camille Prével,Morgan Pellerano,May C. Morris
Cancers , 2015, DOI: 10.3390/cancers7010179
Abstract: Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play central roles in regulation of cell cycle progression, transcription and other major biological processes including neuronal differentiation and metabolism. Constitutive or deregulated hyperactivity of these kinases due to amplification, overexpression or mutation of cyclins or CDK, contributes to proliferation of cancer cells, and aberrant activity of these kinases has been reported in a wide variety of human cancers. These kinases therefore constitute biomarkers of proliferation and attractive pharmacological targets for development of anticancer therapeutics. The structural features of several of these kinases have been elucidated and their molecular mechanisms of regulation characterized in depth, providing clues for development of drugs and inhibitors to disrupt their function. However, like most other kinases, they constitute a challenging class of therapeutic targets due to their highly conserved structural features and ATP-binding pocket. Notwithstanding, several classes of inhibitors have been discovered from natural sources, and small molecule derivatives have been synthesized through rational, structure-guided approaches or identified in high throughput screens. The larger part of these inhibitors target ATP pockets, but a growing number of peptides targeting protein/protein interfaces are being proposed, and a small number of compounds targeting allosteric sites have been reported.
Different architectures of collagen fibrils enforce different fibrillogenesis mechanisms  [PDF]
Mario Raspanti
Journal of Biomedical Science and Engineering (JBiSE) , 2010, DOI: 10.4236/jbise.2010.312152
Abstract: According to current knowledge on collagen fibril-logenesis, collagen fibrils are formed by a cooperative process involving lateral fusion of small protofibrils. Almost all the experimental research, however, was carried out on tendon collagen, whose fibrils are characterized by approximately straight subfibrils. By contrast, in most tissues the collagen fibril sub-units follow a helical course in which geometrical constraints prevent lateral fusions, thereby implying a different mechanism where collagen fibrils grow by addition of individual microfibrils rather than by lateral fusion of pre-assembled subfibrils. The proc-ess at the origin of these fibrils may provide a simple, automatic explanation for the remarkable uniformity in fibrils size observed in most tissues without re-quiring the intervention of unknown mechanisms of diameter control. Other mechanisms of growth con-trol remain indispensable to terminate the fibril-logenesis process in tendons and ligaments.
Methods to Be Developed for Some First Applications of Mitochondrial Filamentation  [PDF]
Mario Gosalvez
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.31A006

The new field of mitochondrial filamentation and its first potential applications are just getting underway (1-7), following a series of pilot experiments in our laboratory over the past few decades (8-14). I should like to give a brief overview of the role that some new methods are playing in this emerging area of physiological bioenergetics, supported by a few references to our contributions as I scarcely have the faculties now to understand other specific contributions. This new field is brimming with promises for medicine, science and society, in general. I cannot and must not be concrete or comprehensive, because I honestly feel that it is now that matters are really beginning to take off, assisted by the most appropriate international capabilities.

Metabolic control of respiration and glycolysis of tumoral cells  [PDF]
Mario Gosalvez
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.31011

The contribution of the author’s groups on the control of energy metabolism of cancer cells has been concisely reviewed. It is proposed that Otto Warburg’s “respiratory defect” of tumoral cells resides in an alteration of the recurrent filamentation cycle of mitochondria. These give those organelles an affinity lower for ADP than the affinity of the tumor cell isoenzyme of pyruvate kinase. These two findings may explain the essentials of the intimate mechanism of the aerobic glycolysis of cancer cells.

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