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Search Results: 1 - 10 of 17915 matches for " Marina;Rosa "
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Hereditary gastrointestinal polyposis: Diagnosis, genetic test and risk assessment  [PDF]
Marina De Rosa, Francesca Duraturo, Raffaella Liccardo, Paola Izzo
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.32A3008
Abstract: Colorectal cancer (CRC) is the second cause of cancer deaths, with over 1 million new cases estimated every year. Familial adenomatous polyposis, MUTYH-associated polyposis and hamartomatous polyposis are inherited syndromes that account for 2%-5% of all colon cancer. The mutated genes responsible for the vast majority of these disorders, are now known (MLH1, MSH2, MSH6, PMS2, APC, MYH, LKB1, SMAD4, BMPR1A, and PTEN) and specific mutations have been identified. Molecular caracterization of inherited CRCs allows pre-symptomatic diagnosis identifying at-risk individuals and improving cancer surveillance. Adenomatous polyposis includes familial adenomatous polyposis (FAP), attenuated FAP (AFAP), and MUTYH-associated polyposis (MAP). Hamartomatous polyposis comprises Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS) and “PTEN hamartoma tumour syndrome” (PHTS). MAP is an autosomal recessive condition, while all other disorders are inherited in an autosomal dominant manner. Differential dyagnosis could be very difficult between syndromes because of their phenotypic variability. Attenuated FAP, MAP and Lynch syndrome could be all associated with fewer numbers of adenomas (3-10 polyps), nevertheless, each syndrome has distinct cancer risks, characteristic clinical features, and separate genetic etiologies. Thus, differential diagnosis is essential for correct management of the specific disease. In our laboratory we set up a methodology for genetic tests of the colorectal polyposis syndrome. In these reviews we summarize the literature data and our experience about diagnosis, genetic tests and cancer risk assesment associated with colorectal polyposis. According to literature data, in our experience, there is a portion of analyzing patients that remain without identified mutation, after molecular screening of the specific gene involved in the pathogenesis of the disease. Since the sensibility of used techniques, such as DHPLC, MLPA and sequencing, is now very high, we suggest that a different approach to molecular diagnosis of polyposis syndromes is necessary. In our laboratory, we are now planning to set up analysis of a larger pannel of genes that could be involved in colorectal poliposis syndromes, using a next generation sequencing techniques. In our opinion, a better characterization of molecular basis of the polyposis syndromes will allow a more efficient cancer prevention.
Agaricales Fungi from atlantic rain forest fragments in Minas Gerais, Brazil
Rosa, Luiz Henrique;Capelari, Marina;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000400015
Abstract: two atlantic rain forest fragments in minas gerais state were studied to access their agaricales fungal richness. a total of 187 specimens were collected and 109 species, 39 genera, and eight families were identified. thirty-three species were cited for the first time in brazil.
Raz?es de desmame e de introdu??o da mamadeira: uma abordagem alternativa para seu estudo
Rea,Marina Ferreira; Cukier,Rosa;
Revista de Saúde Pública , 1988, DOI: 10.1590/S0034-89101988000300004
Abstract: reasons, alleged by mothers, for early weaning and for the introduction of breast-milk substitutes were studied, in 1985, in a public maternity hospital of s. paulo city. these mothers were part of an intervention project to support and promote breast-feeding through public health services. eight hundred and seventy-five women were followed up from delivery to the 4th month of the baby's life. reasons for weaning were collected immediately afterwards ("single interview") and were also again asked for when the mother returned to the health unit ("multiple interview"). all the reasons given were collected and classified according to "responsibility": of the mother (her own desire to wean), of her baby (attributed to the baby), of her body (the mother's physical reasons) and of other people (doctor, husband, neighbor, etc.). the most prevalent reasons for the introduction of breast-milk substitutes, according to "multiple interview", were: mother had to work out (20.5%), got agitated (12.5%) and convenience (11.0%). according to "single interview" they were: the baby's crying (23.0%), prior conceptions of infant feeding (12.5%), working out (11.0%). these differences were not so evident among the reasons for complete weaning; however, considering weaning as a long process in which the reasons for the introduction of breast-milk substitutes may be linked to reasons for the "sevrage", the advantages of utilizing all the answers of different contacts with the women ("multiple interview") over against just one answer given on one ocasion as a contribution to the clarification of the weaning process in each cultural site, is indicated. the reasons gathered and classified according to "responsibility" show that "multiple interview" beings to light more answers related to the desire to wean on the part of the mother herself than the baby, or the mother's body. it is argued that the health system has limits to its ability to intervene in the most prevalent reasons for early we
Diagnósticos de enfermagem identificados em idosos com distúrbio mental
Teixeira, Marina Borges;Fernandes, Rosa áurea Quintella;
Revista Brasileira de Enfermagem , 2003, DOI: 10.1590/S0034-71672003000600005
Abstract: this is a descriptive, exploratory study with a qualitative and quantitative approach, whose aim is to identify nursing diagnosis in elderly people suffering from mental disorders. forty-eigth elders of the mental open clinic were interviewed, by means of an instrument on quality of life, translated and validated. data collected helped to identify sixteen nursing diagnoses, based in north american nursing diagnosis association ( nanda). the most common ones were those related to difficulties in daily activities in an individual going through the aging process, such as: dysfunctional sorrow feeling, lack of recreational activity (83.%); impaired walking ( 81.2%), risk of trauma (68.7%), and anxiety ( 62.5%).
Cholecystokinin in the Pathogenesis of Bulimia Nervosa  [PDF]
Helena Trebbau López, Rosa María Molina-Ruiz, Laura Reyes Molón, Marina Díaz-Marsá
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24085
Abstract: Objective: This review aims to describe the role of the hormone cholecystokinin (CCK) in the pathogenesis of bulimia nervosa (BN), the perpetuation of this illness and the possibility of its use as a target for future therapeutic advances. Methods: Search for cholecystokinin AND bulimia nervosa in Pubmed Central, with no limits, identified 38 articles published up to the present date. Results: It is well established that CCK is altered in the pathogenesis of BN, and that its main role is in the perpetuation of the disorder rather than the cause of it. Discussion: Additional studies will be needed to further understand the mechanisms by which CCK regulates orexigenic pathways. If an orally active, longer acting analogue of CCK could be developed, it would be of significant interest as an appetite suppressant and a key adjuvant in the treatment of patients suffering from BN, particularly in refractory cases.
Histological and Morphological Study of the Intestines of Wistar Rat Fetuses in a Modified Gastroschisis Experimental Model  [PDF]
André Luis Hecht Sartori, Marina Ferreira Rosa de Vilhena, Gabriela Samaha Fran?a, Willy Marcus Fran?a
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.72010
Abstract: In gastroschisis (G), the lesion degree of exposed intestinal segments is related to the time of its contact with the amniotic fluid (AF) and exposure to meconium which is the cause of intestinal morphological and histological alterations. The outcome of these alterations is intestinal hypoperistalsis and nutrient absorption deficiency, which contribute to increased morbidity and high medical-hospital costs. In this study, morphological and histological intestine alterations were identified at two different contact occasions with AF. Experimental gastroschisis (G) was performed on Wistar rat fetuses at a single gestational age on day 18.5th. The fetuses were removed on the 20.5th (G-1) and 21.5th days (G-2). Fetuses of both groups were divided in 3 sub-groups: control (C), gastroschisis (G) and sham (S). Measurements were taken of the Whole Set including fetus, placenta and membranes with AF (WS), fetus body weight (BW), intestinal weight (IW) and their diameters (DI). The objective of the present study is to test a new gastroschisis experimental model and identify differences in morphological and histological alterations in these two gestational periods that may be directly related to intestinal motility disorders in G. The WS and BW presented no significant statistical difference when compared G1 and G2. The results of the intestine average weight of G2 fetuses were significantly higher when compared to G1 fetuses in all subgroups (C: p = 0.02; G: p = 0.01; S: p = 0.02, Mann Whitney). The results of the intestinal average diameters (D/d) in G1 and G2 presented significant statistical difference only in G subgroup (p < 0.05, Kruskal Wallis). When compared intestinal average diameters, there was significant statistical difference of G fetuses in G1 and G2 (p < 0.05, Mann Whitney). In conclusion, the present experimental G model was adequate to reproduce G in rat fetuses. All G fetuses presented significant statistical difference when compared to other group in their subgroup and when compared G1 and G2 (p < 0.05). These alterations can explain the difficulties in accomplishing adequate peristalsis in G neonate bearers.
Alimenta??o hospitalar: proposi??es para a qualifica??o do Servi?o de Alimenta??o e Nutri??o, avaliadas pela comunidade científica
Diez-Garcia,Rosa Wanda; Padilha,Marina; Sanches,Maísa;
Ciência & Saúde Coletiva , 2012, DOI: 10.1590/S1413-81232012000200020
Abstract: the scope of this paper is to validate proposals used to qualify hospital food by the brazilian scientific community. an electronic questionnaire was applied to clinical nutrition professionals registered on the lattes platform (brazilian database of institutions and researchers' curricula in the areas of science and technology). the questionnaire incorporated a likert scale and had spaces for comments. the themes dealt with patient participation, the nutritional and sensory quality of hospital diets, and planning and goals of the hospital food and nutrition service (hfns). the questionnaire also asked for the top five priorities for a hfns. proposals with total or partial adherence equal to or greater than 70% were considered to be approved. all proposals had total adherence equal to or greater than 70%. the proposal that had minimal adherence (70%) was the one that proposed that nutritional intervention must be arranged by mutual agreement with the patient. the proposal that had maximal adherence (93%) was the one advocating that there must be statistical control on diets prescribed by the hfns. the most cited priorities referred to infrastructure and training of human resources (40%), the quality of hospital food (27%) and the nutritional status of the patient.
Images of Aging in Institutionalized and Non-Institutionalized Elderly People
Marlene Lopes,Rosa Marina Afonso,Margarida Cerqueira,Henrique Pereira
Psychology, Community & Health , 2007,
Abstract: Aim: The aim of this study was to assess and compare images and stereotypes of aging in institutionalized and non-institutionalized elderly people. This is a descriptive study using a survey. Method: The instruments used were a sociodemographic questionnaire and the ImAges scale. A total of 120 elderly people, aged between 65 and 99 years, participated in this study. Results: Statistically significant differences were found, for the scale’s three factors, between institutionalized and non-institutionalized older adults. In the factor “dependence, sadness and old-fashioned”, the institutionalized participants presented a higher number of negative images and stereotypes (M = 51.8; DP = 6.01) than the non-institutionalized participants (M = 49.0; DP = 7.85), these differences were significant (t(118) = -2.16; p < 0.05). In the “maturity, activity and affectivity” factor, there were also significant differences (t(118) = 2.04; p < 0.05), the non-institutionalized participants present higher rates of positive images and stereotypes (M = 20.2; DP = 3.28), when compared to institutionalized participants (M = 19.0; DP = 3.310). Conclusion: The results suggested that institutionalized older adults presented more negative aging images than non-institutionalized.
Retención e inversión de estímulos discriminativos, y peso cortical, en ratones sometidos a diferentes tipos de ambientes a edad temprana
Nur Tatiana Rodríguez,Rosa Marina De Vera,Fabio Sabogal
Revista Latinoamericana de Psicología , 1980,
Abstract: In order to study the influence of three types of envíronments (standard laboratory, enriched laboratory, and simulation of natural envirenment). on two tasks (retention in the delayed reactíonj , and discrimina· tion (reversal shifts). two pairs of mice were raised in each of the environments. The mice used in the experíment belonged to a second generatíon, raised in the particular envíronment, Sixteen mice were randomly selected, 22 days old: half of the subjects were tested in the reversal-shift situatíon, and the other hald in the delayed-reaction test. R.esuIts indicated that mice raised in two of the environments (enriched laboratory and simulation of natural environment) had higher performance Ievels, both in the delayed-reactlon ud in the reversal·shift. than those raised in the standard laboratory environment
Cestodos de quirópteros del Parque Nacional Cerros de Amotape, Tumbes, Perú Cestodes of bats from the National Park Cerros de Amotape, Tumbes, Peru
Marina Vargas,Rosa Martínez,Manuel Tantaleán
Revista Peruana de Biología , 2011,
Abstract: En septiembre 2006, en el Parque Nacional Cerros de Amotape, departamento de Tumbes, Perú; 39 individuos de murciélagos, pertenecientes a 16 especies fueron capturados. El análisis parasitológico determino que solo dos individuos de las especies Phyllostomus hastatus (Phyllostomidae) y Noctilio leporinus (Noctilionidae) estaban parasitados. Los cestodos fueron colectados del intestino delgado e identificados como Atriotaenia hastati Vaucher, 1982 (Anoplocephalidae) y Vampirolepis sp. (Hymenolepididae). Atriotaenia hastati es un nuevo registro para el Perú y Vampirolepis sp. es registrado por primera vez en Tumbes y en un nuevo huésped, Noctilio leporinus. In September 2006, at Parque Nacional Cerros de Amotape, department of Tumbes, Peru, 39 individuals of bats belonging to 16 species were captured. Parasitological analysis determined that only two individuals of the species Phyllostomus hastatus (Phyllostomidae) and Noctilio leporinus (Noctilionidae) were parasitized. The cestodes were collected from the small intestine and identified as Atriotaenia hastati Vaucher, 1982 (Anoplocephalidae) and Vampirolepis sp. (Hymenolepididae). Atriotaenia hastati is a new record for Peru and Vampirolepis sp. is registered for the first time in Tumbes and a new host, Noctilio leporinus.
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