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Search Results: 1 - 10 of 6937 matches for " Marina Mata "
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HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain
Shuanglin Hao, Marina Mata, Joseph C Glorioso, David J Fink
Molecular Pain , 2006, DOI: 10.1186/1744-8069-2-6
Abstract: Subcutaneous inoculation of S4IL4 in the foot transduced lumbar DRG to produce IL-4. Transgene-mediated expression of IL-4 did not alter thermal latency or tactile threshold in normal animals, but inoculation of S4IL4 1 week after spinal nerve ligation (SNL) reduced mechanical allodynia and reversed thermal hyperalgesia resulting from SNL. Inoculation of S4IL4 1 week before SNL delayed the development of thermal hyperalgesia and tactile allodynia, but did not prevent the ultimate development of these manifestations of neuropathic pain. S4IL4 inoculation suppressed non-noxious-induced expression of c-Fos immunoreactivity in dorsal horn of spinal cord and reversed the upregulation of spinal IL-1β, PGE2, and phosphorylated-p38 MAP kinase, characteristic of neuropathic pain.HSV-mediated expression of IL-4 effectively reduces the behavioral manifestations of neuropathic pain, and reverses some of the biochemical and histologic correlates of neuropathic pain at the spinal level.Neural-immune interactions play a key role in the pathogenesis of neuropathic pain. Partial nerve injury results in the release of proinflammatory cytokines interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha from activated Schwann cells, endothelial cells, and macrophages in nerve [1] to produce direct effects on nociceptive activity [2]. Peripheral nerve damage also activates microglia and astrocytes in spinal cord to release the same proinflammatory cytokines in dorsal horn [3-6], resulting in central sensitization [7,8] and an exaggerated pain response characteristic of neuropathic pain [9-11].IL-4 is a prototypical anti-inflammatory cytokine that modulates macrophage activity through global suppression of proinflammatory cytokines [12-14], in addition to pleiotropic effects on the development of immune cells and the immune response [15]. The broad spectrum of IL-4 action makes it an attractive candidate for suppressing cytokine activation in neuropathic pain, but the short half-life of
Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
Munmun Chattopadhyay, Zhigang Zhou, Shuanglin Hao, Marina Mata, David J Fink
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-17
Abstract: Subcutaneous inoculation of the miRNA-expressing HSV vector into the feet of diabetic rats to transduce DRG resulted in a reduction in NaVα subunit levels in DRG neurons, coincident with a reduction in cold allodynia, thermal hyperalgesia and mechanical hyperalgesia.These data support the role of increased NaVα protein in DRG in the pathogenesis of pain in diabetic neuropathy, and provide a proof-of-principle demonstration for the development of a novel therapy that could be used to treat intractable pain in patients with diabetic neuropathy.Pain is a common complication of diabetic neuropathy that, despite substantial advances in understanding of pathophysiology, remains relatively refractory to treatment with available agents [1]. In rats with streptozotocin (STZ) induced diabetes and painful neuropathy, an increase in the alpha (pore-forming) subunit of voltage gated sodium channel isoform 1.7 (NaV1.7) in primary sensory afferent neurons of the dorsal root ganglia (DRG) has been reported [2], a change that correlates with increased amplitude and negative shift of the activation of tetrodotoxin (TTX)-sensitive current in those neurons. A potential pathogenic role for NaV1.7 in the development of pain in this syndrome is supported by the observation that gain of function mutations in NaV1.7 cause inherited spontaneous neuropathic pain syndromes primary erythermalgia [3,4] and paroxysmal extreme pain disorder [5].In previous studies we have constructed a series of herpes simplex virus (HSV)-based gene transfer vectors that effectively transduce DRG in vivo from skin inoculation, and have used these vectors to express inhibitory neurotransmitters [6-8] or neurotrophic factors [9-11]. In order to explicitly test the role of increased levels of NaV in DRG in the pathogenesis of pain in PDN, we constructed a non-replicating herpes simplex virus (HSV)-based vector to reduce NaVα protein in DRG, and compared the effect of NaVα subunit knockdown on pain-related behaviors i
Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
Wenwen Zheng, Handong Ouyang, Xuexing Zheng, Shue Liu, Marina Mata, David J Fink, Shuanglin Hao
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-40
Abstract: Peripheral gp120 application into the rat sciatic nerve induced mechanical allodynia for more than 7 weeks, and upregulated the expression of spinal TNFα in the mRNA and the protein levels at 2 weeks after gp120 application. Spinal TNFα was colocalized with GFAP (a marker of astrocytes) and Iba1 (a marker of microglia) in immunostaining, suggesting that glia produce TNFα in the spinal cord in this model. Peripheral gp120 application also increased TNFα in the L4/5 DRG. Furthermore, intrathecal administration of TNFα siRNA or soluble TNF receptor reduced gp120 application-induced mechanical allodynia.Our results indicate that TNFα in the spinal cord and the DRG are involved in neuropathic pain, following the peripheral HIV gp120 application, and that blockade of the glial product TNFα reverses neuropathic pain induced by HIV gp120 application.Infection of the central nervous system with the human immunodeficiency virus type 1 (HIV-1) can lead to cognitive, motor and sensory disorders. HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms of peripheral neuropathy, affecting about 30% of people with acquired immune deficiency syndrome (AIDS) [1,2]. The symptoms of HIV-SN are dominated by neuropathic pain [3,4]. The mechanisms underlying HIV-SN remain unclear. Astrocytosis and subsequent neuron death are two hallmarks of HIV infection in the central nervous system[5]. Direct infection of neurons by HIV is thought to be unlikely [6,7]; HIV-1 binds via the external envelope proteins (e.g., gp120) to the chemokine receptors CXCR4 and/or CCR5 (co-receptors of gp120) on the cells. Previous reports have suggested that gp120 application contributes to neurotoxicity in in vitro and nociceptive behaviour in rodents [8-11]. Indeed, it has been demonstrated that gp120 application is capable of producing pain when administered peripherally [12] or centrally [13]. Proposed mechanisms underlying gp120 application induced a chronic nociceptive effect included spin
Histología de branquias, hígado y ri ón de juveniles del pez neotropical Colossoma macropomum (Characiformes, Characidae) expuesto a tres temperaturas Histology of gill, liver and kidney in juvenile fish Colossoma macropomum exposed to three temperatures
Luz-Marina Rojas,Claunis Mata,Aridays Oliveros,Raquel Salazar-Lugo
Revista de Biología Tropical , 2013,
Abstract: Colossoma macropomum es uno de los peces tropicales de agua dulce con mayor éxito en el cultivo en aguas continentales tropicales. Se realizó una evaluación histológica de branquias, hígado y ri ón de este pez expuesto a tres temperaturas (T18, T29 y T35oC). Se utilizaron 18 ejemplares juveniles con índices biométricos de 17.87±7.88cm y 87.69±34.23g. Los análisis histológicos fueron hechos de acuerdo a técnicas previamente descritas. Se encontró que las branquias, el hígado y el ri ón de los peces T29 presentaron citoarquitectura normal. Por el contrario, en las branquias de los peces T18, se observaron gotas lipídicas inmersas en el tejido branquial; los peces T35 presentaron desorganización en la estructura del tejido branquial y necrosis celular. El hígado de los peces T18, mostró hepatocitos claros y oscuros y el de T35, presentó células con granulaciones citoplasmáticas y da o en la membrana plasmática. En el ri ón de los T18, se observaron alteraciones en la distribución del tejido hematopoyético. La característica más resaltante en el ri ón de los peces T35, fue la desorganización del tejido glomerular. En conclusión, la temperatura de 18°C se puede considerar crítica para la cachama y la de 35oC severa. De los tres órganos evaluados, el hígado y las branquias resultaron ser los más sensibles a los da os inducidos por las temperaturas en esta especie. Water temperature is an important factor that affects growth and antioxidant enzyme activities in fish, and when adverse, it may trigger diseases in fish populations. C. macropomum is a freshwater neotropical fish widely distributed in South America and abundant in river basins as the Amazon and Orinoco. It is highly used for intensive aquaculture development and is a very important product for the local riverside economy in Venezuela. The purpose of our study was to examine the water temperature effect on gills, liver and kidneys of juvenile fishes of C. macropomum. Eighteen juveniles with biometrical index of 17.87±7.88cm and 87.69±34.23g were respectively exposed to three culture temperatures (T18, T29 and T35oC) during a period of 21 days. Histological analyses on gills, liver and kidney were made according to standard methodologies. Our results showed that these tissues exhibited normal citoarchitecture at T29. On the contrary, T18-gills displayed brachiallipid droplets inside brachial epithelium; and disorganization in the brachial tissue was observed at T35. Furthermore, we observed two kinds of hepatocytes (dark and light) on T18°C-liver. The T35-liver samples showed cytoplasmatic granulatio
The 2nd Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair  [PDF]
Maria Teresa Moreno-Flores, Francois Ferón, Victor Arvanian, Armin Blesch, Armin Curt, David J. Fink, Marina Mata, Kinichi Nakashima, Xavier Navarro, Francisco Javier Rodríguez, Michal Schwartz, Mikael Svensson, Erik Sundstrom, Joan Romero, Filip Lim
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.67A2003
Abstract: On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.
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Análise Psicológica , 2004,
Abstract: one important activity in family literacy practices is storybook reading. some studies have emphasized that storybook reading is an informal and positive way to create important and enjoyable opportunities to transmit concepts, knowledge, conventions and competences about literacy which are associated with reading motivation and success in terms of literacy acquisition. therefore, we have attempted to characterize some aspects of storybook reading practices in families with 5-6 year old children (e.g. frequency, time; interest; reasons why parents read to their children and at what age they begin doing it). we also studied associations between storybook reading practices and emergent literacy knowledge. our results showed an evident association between some aspects of storybook reading practices, and children's conceptualizations about written language, their perceptions about the functions of reading and writing, and also some aspects of their motivational profile.
Literacia - O papel da família na sua apreens?o
Análise Psicológica , 1999,
Abstract: recent approaches to young children?s literacy development emphasise this process as very early one. literacy development doesn?t begin neither when children start formal instruction, nor when they begin to acquire reading and writing mechanical skills. thus the roots of literacy development are established very early in life, through real life contacts with reading and writing. so as an early social process it is very important to consider the contribute of the family in promoting these contacts and facilitating the exploration of print. when interacting socially with others and with literacy in real-life settings through reallife activities: -children will discover functions and forms of print through shared literacy activities -parents will act as models when using literacy. -parents will support and motivate the children in their discoveries. the purpose of this article is to provide a brief overview of home literacy environments and the characteristics of home reading and writing activities. we also pretend to analyse the parents? perception of these activities and the values and attitudes parents hold with respect to family literacy.
Els Adverbis d'acte de parla i el modus oracional
Meritxell Mata
Llengua & Literatura , 2007, DOI: 10.2436/l&l.vi.1211
Encuesta nacional sobre violencia intra-familiar, Costa Rica urbana, 1992
Leonardo Mata
Población y Salud en Mesoamérica , 2010,
Abstract: Esta es la primera encuesta sobre violencia doméstica que se concreta en la población general urbana de que se tiene noticia en América Central. La Bibliografía que acompa a el presente estudio muestra otros intentos sobre el tema, que desafortunadamente tienen dise os o planteamientos que no son imparciales en abordar el tema. En efecto, el abordaje del tema demanda imparcialidad total con referencia al género, como es el caso del presente estudio. Se seleccionaron aleatoriamente, en población general urbana definida por el Instituto Nacional de Estadística y Censo (INEC), y usando sus Tractos Censales y Mapas, 750 mujeres y 750 hombres de 18 a 60 a os de edad, de centros urbanos del país. El dise o demandó que las personas entrevistadas no pudieran conocerse, y de que las entrevistas evitaron sesgos y prejuicios. Muy importante fue el que las preguntas se orientaran tanto a establecer si la mujer y el hombre recibieran agresión de sus parejas, como a establecer que esas mismas ejercían agresión contra sus parejas también. Las agresiones se limitaron a establecer el grado o nivel de tranquilidad dentro del hogar, los tipos de violencia (insultos, amenazas, violencia física, etc., excluyéndose al homicidio, por razones obvias). También se trató de cuantificar esas agresiones. Lo más pertinente de la encuesta fue el establecer el testimonio de agresor o de víctima en cada persona, fuese mujer u hombre. El principal hallazgo del estudio fue determinar que tanto las mujeres como los hombres fueron similarmente víctimas de sus parejas; y que tanto las mujeres como los hombres también similarmente agresores contra sus parejas. Sin embargo, los hombres mostraron un mayor grado del uso de palabras y expresiones ofensivas que sus mujeres.
Influencia de los procesos de reparación en las propiedades de los materiales de las carrocerías. Análisis de reparabilidad y selección del procedimiento adecuado
Mata, F.
Revista de Metalurgia , 2005,
Abstract: The majority of the repair processes of the car bodies introduce residual tensions in the material, because the use of special work technologies, and heterogeneities as consequence of the application of putties, with different mechanical properties in comparison to the original sheet. The election of the repair process depends of the damage severity and it has important effects on the repair costs and the reliability of the vehicle. The variation of the elastic limit in elements of car body that have suffered an impact and later they have been repaired by different procedures is analyzed in this work. The results obtained for steel elements and two conventional processes of repair have been presented. The aim is to determine the repair process that produces a minor affect on the initial properties of the material. Finite elements simulation has been used to complete the tests. La práctica totalidad de los procesos de reparación de la chapa introducen tensiones residuales en el material, en tanto en cuanto recurren a técnicas de batido y deformación en frío o a calentamientos de forma local, y heterogeneidades como consecuencia de la aplicación de masillas de relleno, de propiedades mecánicas diferentes a las de la chapa original. La elección del proceso de reparación viene marcada por la severidad del da o y tiene implicaciones directas en el coste final de la reparación y, especialmente, en la fiabilidad del vehículo. Se analiza, en este trabajo, la variación del límite elástico en elementos de carrocería que han sufrido un impacto y posteriormente se han reparado recurriendo a diferentes procedimientos. Se presentan los resultados obtenidos para elementos de acero y dos procesos de reparación convencionales. El objetivo es determinar el proceso de reparación que afecta en menor medida a las propiedades iniciales del material. Se utiliza la técnica de simulación mediante elementos finitos como apoyo a los ensayos reales.
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