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Search Results: 1 - 10 of 605506 matches for " Marilia A. C. Smith "
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Prevalence of Helicobacter pylori cagA and sabA Genotypes in Patients with Gastric Disease  [PDF]
Jéssica Nunes Pereira, Wilson A. Orcini, Rita L. Peruquetti, Marilia A. C. Smith, Spencer L. M. Pay?o, Lucas T. Rasmussen
Advances in Microbiology (AiM) , 2019, DOI: 10.4236/aim.2019.93017
Abstract: Gastric cancer is one of the most common types of cancer worldwide. Helicobacter pylori is considered one of the most important causes of this condition specially because of its virulence markers as sabA and cagA. Therefore, we aim to investigate the relation between these markers and the gastric diseases in 400 patients who underwent upper digestive endoscopy. To detect the bacteria and its genes by Polymerase Chain Reaction (PCR), the presence of H. pylori was significant when comparing the groups control vs. cancer (p value < 0.0001) OR [95% CI] 12.73 (5.45 - 29.69) and the groups control vs. chronic gastritis (p value < 0.0001) OR [95% CI] 12.99 (7.44 - 22.66). cagA was statistically significant considering its presence when comparing the chronic gastritis vs. cancer groups (p value = 0.0434) OR [95% CI] 2.44 (1.021 - 5.845). Associating both sabA and cagA, we found a statistically significant result (p value < 0.0001) OR [95% CI] 13.68 (3.95 - 47.33) considering the gastritis vs. cancer groups. Helicobacter pylori is directly associated to gastric diseases such as gastritis and cancer and its virulence markers: sabA and cagA increase the injury process to the gastric epithelium making the host more susceptible to cancer.
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families
Ary Gadelha, Vanessa Kiyomi Ota, Jose Paya Cano, Maria Isabel Melaragno, Marilia A. C. Smith, Jair de Jesus Mari, Rodrigo A. Bressan, Sintia Iole Belangero, Gerome Breen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052262
Abstract: We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN? software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63–92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4–14 cM. Of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.
Possible Connections between Seasons and Ultra-Deep Earthquakes Worldwide  [PDF]
Marilia Hagen, A. Azevedo
Natural Science (NS) , 2018, DOI: 10.4236/ns.2018.107029
Abstract: The aim of this investigation is to find possible changes in ultra-deep earthquakes (UDQ) during different seasons of the year. In the acquisition of data for our previous work we observed an inexplicable pattern of growth of ultra-deep tremors (UDQ) during the studied period. Apparently, there is no viable explanation for growth occurring at such a level, presumably in the asthenosphere. Current research and theories developed for the inner layers of the Earth do not explain such variations. Therefore, a possible explanation would be in external factors such as the seasons of the year, which are determined by changes in the Earth’s axial tilt, and therefore the portion of the earth that is angled toward the sun. This paper focuses exclusively on UDQ events. To simplify the calculations, we consider four main locations; this includes one more region than our previous paper but includes only UDQ data. The results showed that during spring and autumn UDQ events grew slightly in both Northern and Southern Hemispheres. It is also suggested that a contributor to UDQ events is friction from the subducting lithosphere against the continental plates.
Periodic modulation of gas giant magnetospheres by the neutral upper atmosphere
C. G. A. Smith
Annales Geophysicae (ANGEO) , 2006,
Abstract: Periodic signatures present in the magnetospheres of both Jupiter and Saturn have yet to be fully explained. At Jupiter the unexplained signatures are related to emissions from the Io torus ("System IV"); at Saturn they are observed in emissions of kilometric radiation (SKR) and in magnetometer data. These signatures are often interpreted in terms of magnetic field anomalies. This paper describes an alternative mechanism by which the neutral atmosphere may impose such periodic signatures on the magnetosphere. The mechanism invokes a persistent zonal asymmetry in the neutral wind field that rotates with the planet. This asymmetry must be coupled to substantial ionospheric conductivity. It is then able to drive divergent currents in the upper atmosphere that close in and perturb the magnetosphere. We estimate the conductivities and wind speeds required for these perturbations to be significant, and argue that they are most likely to be important at auroral latitudes where the conductivity may be enhanced by particle precipitation.
Toll-Like Receptors in Leishmania Infections: Guardians or Promoters?
Marilia S. Faria,Flavia C. G. Reis,Ana Paula C. A. Lima
Journal of Parasitology Research , 2012, DOI: 10.1155/2012/930257
Abstract: Protozoa of the genus Leishmania cause a wide variety of pathologies ranging from self-healing skin lesions to visceral damage, depending on the parasite species. The outcome of infection depends on the quality of the adaptive immune response, which is determined by parasite factors and the host genetic background. Innate responses, resulting in the generation of mediators with anti-leishmanial activity, contribute to parasite control and help the development of efficient adaptive responses. Among those, the potential contribution of members of the Toll-like receptors (TLRs) family in the control of Leishmania infections started to be investigated about a decade ago. Although most studies appoint a protective role for TLRs, there is growing evidence that in some cases, TLRs facilitate infection. This review highlights recent advances in TLR function during Leishmania infections and discusses their potential role in restraining parasite growth versus yielding disease. 1. Introduction Infections with parasitic protozoa have been a long-term health issue in the tropical and subtropical regions of the globe. Among those, diseases caused by infections with microbes of the Leishmania genus are one of the most wide-spread infirmities. Leishmania parasites are transmitted to the vertebrate host by the sand fly bite that injects the infective metacyclic forms under the skin. The flagellated parasites are rapidly engulfed by phagocytic cells either resident or recruited to the wound site (i.e., neutrophils, macrophages and dendritic cells), reviewed in [1]. While the passage through neutrophils is believed to be transient, serving as a temporary safe hideaway, the parasites are able to establish productive infections in macrophages, where they differentiate to amastigotes and replicate inside the parasitophorous vacuole. The pathology resulting from the infection is related to the parasite species that can either induce cutaneous (i.e., L. major, L. mexicana, L. guyanensis), mucocutaneous (i.e., L. amazonensis, L. braziliensis), or visceral leishmaniasis (L. donovani, L. chagasi). The outcomes of infections are complex, depending not only on the parasite species but also on the immune status of the host. As an example, although L. amazonensis is primarily associated with cutaneous manifestations, it can also provoke mucocutaneous and/or diffuse cutaneous leishmaniasis. Infections with L. panamensis or L. braziliensis can generate a persistent hyperinflammatory response, where a mixed T-helper 1 (Th1)/T-helper 2 (Th2) response is observed, leading to nonresolving
Exciting a d-density wave in an optical lattice with driven tunneling
A. Hemmerich,C. Morais Smith
Physics , 2007, DOI: 10.1103/PhysRevLett.99.113002
Abstract: Quantum phases with unusual symmetries may play a key role for the understanding of solid state systems at low temperatures. We propose a realistic scenario, well in reach of present experimental techniques, which should permit to produce a stationary quantum state with $d_{x^2-y^2}$-symmetry in a two-dimensional bosonic optical square lattice. This state, characterized by alternating rotational flux in each plaquette, arises from driven tunneling implemented by a stimulated Raman scattering process. We discuss bosons in a square lattice, however, more complex systems involving other lattice geometries appear possible.
Reproductive modes and fecundity of an assemblage of anuran amphibians in the Atlantic rainforest, Brazil
Hartmann, Marilia T;Hartmann, Paulo A;Haddad, Célio F. B;
Iheringia. Série Zoologia , 2010, DOI: 10.1590/S0073-47212010000300004
Abstract: reproductive modes and size-fecundity relationships are described for anurans from picinguaba, a region of atlantic rainforest on the northern coast of the state of s?o paulo, brazil. we observed 13 reproductive modes, confirming a high diversity of modes in the atlantic rainforest. this diversity of reproductive modes reflects the successful use of diversified and humid microhabitats by anurans in this biome. we measured the snout-vent length of 715 specimens of 40 species of anurans. the size-fecundity relationship of 12 species was analyzed. female snout-vent lengths explained between 57% and 81% of clutch size variation. anurans with aquatic modes laid more eggs than those with terrestrial or arboreal modes. larger eggs were deposited by species with specialized reproductive modes.
Determina??o da energia de ativa??o em hidrogéis poliméricos a partir de dados termogravimétricos
Horn, Marilia M.;Martins, Virginia C. A.;Plepis, Ana M. de G.;
Polímeros , 2010, DOI: 10.1590/S0104-14282010005000025
Abstract: polyelectrolyte hydrogels formed by chitosan/xanthan (qx) and chitosan/xanthan/collagen (qxc) were prepared and thermogravimetric curves at different heating rates were obtained, with the aim of determining kinetic parameters using the flynn-wall method. the calculated activation energy was 3.44 kj.mol-1 (qx ) and 14.84 kj.mol-1 (qxc), suggesting stronger interactions in qxc hydrogel structure than in the qx hydrogel, probably due to the presence of carboxyl groups of collagen molecules.
Ecological parameters of the endohelminths in relation to size and sex of Prochilodus argenteus (Actinopterygii: Prochilodontidae) from the Upper S?o Francisco River, Minas Gerais, Brazil
Monteiro, Cassandra M.;Santos, Michelle D.;Zuchi, Nágila A.;Brasil-Sato, Marilia C.;
Zoologia (Curitiba) , 2009, DOI: 10.1590/S1984-46702009000400021
Abstract: this research aimed to investigate the ecological indexes of the helminths of the digestive system and coelom of prochilodus argenteus spix & agassiz, 1829. a total of 150 specimens (53 males and 97 females) taken from the upper reaches of the s?o francisco river in the municipality of três marias (18o12'32"s, 45o15'41"w), state of minas gerais, brazil, were examined. the specimens were collected in july, 2003 and january, 2004. ninety-eight fish (65.3%) were infected by at least one species of helminth. five helminth species were found: one digenean, saccocoelioides nanii szidat, 1954; two eucestoda, valipora sp., and one undetermined metacestode; one nematode, spinitectus asperus travassos, artigas & pereira, 1928; and one acanthocephalan, neoechinorhynchus prochilodorum nickol & thatcher, 1971. the sex of the host did not influence parasite indexes. the total length of the hosts influenced the abundance of s. nanii (rs = -0.21, p = 0.01) and the prevalence of the metacestode (r = -0.91, p = 0.01). saccocoelioides nanii was the dominant species in the parasite fauna of p. argenteus. saccocoelioides nanii, valipora sp., s. asperus and n. prochilodorum are reported here for the first time in p. argenteus and their known distribution is expanded to the s?o francisco river.
Coupled rotational dynamics of Saturn's thermosphere and magnetosphere: a thermospheric modelling study
C. G. A. Smith,A. D. Aylward
Annales Geophysicae (ANGEO) , 2008,
Abstract: We use a numerical model of Saturn's thermosphere to investigate the flow of angular momentum from the atmosphere to the magnetosphere. The thermosphere model is driven by Joule heating and ion drag calculated from a simple model of the magnetospheric plasma flows and a fixed model of the ionospheric conductivity. We describe an initial study in which our plasma flow model is fixed and find that this leads to several inconsistencies in our results. We thus describe an improved model in which the plasma flows are allowed to vary in response to the structure of the thermospheric winds. Using this improved model we are able to analyse in detail the mechanism by which angular momentum extracted from the thermosphere by the magnetosphere is replaced by transport from the lower atmosphere. Previously, this transport was believed to be dominated by vertical transport due to eddy viscosity. Our results suggest that transport within the upper atmosphere by meridional winds is a much more important mechanism. As a consequence of this, we find that the rotational structures of the thermosphere and magnetosphere are related in a more complex way than the eddy viscosity model implies. Rather than the thermosphere behaving as a passive component of the system, the thermosphere-magnetosphere interaction is shown to be a two-way process in which rotational structures develop mutually. As an example of this, we are able to show that thermospheric dynamics offer an explanation of the small degree of super-corotation that has been observed in the inner magnetosphere. These results call into question the usefulness of the effective Pedersen conductivity as a parameterisation of the neutral atmosphere. We suggest that a two-parameter model employing the true Pedersen conductivity and the true thermospheric rotation velocity may be a more accurate representation of the thermospheric behaviour.
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