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Search Results: 1 - 10 of 831 matches for " Mariko Sugimoto "
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On the Convergence of Observed Partial Likelihood under Incomplete Data with Two Class Possibilities  [PDF]
Tomoyuki Sugimoto
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.42012
Abstract:

In this paper, we discuss the theoretical validity of the observed partial likelihood (OPL) constructed in a Coxtype model under incomplete data with two class possibilities, such as missing binary covariates, a cure-mixture model or doubly censored data. A main result is establishing the asymptotic convergence of the OPL. To reach this result, as it is difficult to apply some standard tools in the survival analysis, we develop tools for weak convergence based on partial-sum processes. The result of the asymptotic convergence shown here indicates that a suitable order of the number of Monte Carlo trials is less than the square of the sample size. In addition, using numerical examples, we investigate how the asymptotic properties discussed here behave in a finite sample.

Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers  [PDF]
Naoko Kuramoto, Mariko Kitagawa
Health (Health) , 2017, DOI: 10.4236/health.2017.98083
Abstract: Purpose: The purpose of this study was to evaluate oxidative stress, antioxidant power, and antioxidant potential of breastmilk of breast-feeding mothers from the early postpartum period to the first 3 months postpartum, and to examine the dynamics and the relationships among them. Method: For 47 pu-erperant women who gave vaginal birth without any pregnancy complications, the oxidative stress levels (d-ROMs levels) and antioxidant power (BAP levels) in the maternal plasma as well as antioxidant potential of breastmilk (BAP levels in breastmilk) were measured 3 times, i.e., in the early puerperium (4 or 5 days after giving birth), one month after giving birth, and 3 months after giving birth. Results: The d-ROMs levels in the maternal plasma were significantly high in the early puerperium (p < 0.001), and decreased gradually in the post-partum period (p < 0.001). On the other hand, BAP levels were significantly low in the early puerperium (p < 0.001), and increased to the almost normal level during one month after giving birth. BAP levels in breastmilk were significantly high in the early puerperium compared with the other periods (p < 0.001), and decreased gradually until 3 months after giving birth (p < 0.001). BAP levels in breastmilk in the early puerperium were higher compared with the maternal BAP levels, and there was a positive correlation between BAP levels in breast-milk and those in the maternal plasma (p < 0.05). Discussion: Regarding the oxidative stress and the antioxidant defense system of breast-feeding mothers, the d-ROMs level was highest and the BAP level was lowest in the early puerperium. The BAP level then showed a clear tendency to recover in the first 3 months after giving birth. Conclusion: When the maternal antioxidant potential remains at a low level after giving birth, careful consideration should be given to the mother’s health and wellbeing because there is a possibility that it might affect the antioxidant potential of breastmilk.
Effects of Nonuniform Outflow and Buoyancy on Drag Coefficient Acting on a Spherical Particle  [PDF]
Mariko Watanabe, Joji Yahagi
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2017, DOI: 10.4236/jfcmv.2017.54008
Abstract: Pyrolysis gas jets out from the surface of a solid fuel particle when heated. This study experimentally observes the occurrence of gas jetsfrom heated solid fuel particles. Results reveal a local gas jet occurs from the particle’s surface when its temperature reaches the point at which a pyrolysis reaction occurs. To investigate the influence of the gas jet on particle motion, a numerical simulation of the uniform flow around a spherical particle with a nonuniform outflow or high surface temperature is conducted, and the drag force acting on the spherical particle is estimated. In the numerical study, the magnitude of the outflow velocity, direction of outflow, and Rayleigh number,?i.e., particle surface temperature, are altered, and outflow velocities and the Rayleigh number are set based on the experiment. The drag coefficient is found to decrease when an outflow occurs in the direction against the mainstream; this drag coefficient at a higher Rayleigh number is slightly higher than that at a Rayleigh number of zero.
A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants  [PDF]
Mariko Kawai, Kiyoshi Ohura
Open Journal of Stomatology (OJST) , 2017, DOI: 10.4236/ojst.2017.711046
Abstract: Dental implant therapy is a highly effective treatment for recovering occlusion after tooth loss. An important factor in the success of dental implants is establishing strong osseointegration. If more epithelial cells migrate to the implant-bone interface than mesenchymal stem cells, effective osseointegration may fail. Therefore, controlling epithelial cell adhesion and motility would be an effective strategy to increase the success rate of osseointegration. Laminin-332 is a major component of the basement membrane and is composed of three chains (α3, β3 and γ2). It is well-known that laminin-332 regulates cellular functions such as adhesion, proliferation, apoptosis and differentiation. These biological functions depend on changes in the structural arrangement of laminin-332 by proteolytic cleavage. It is well-known that cleavage of the α3 chain between its LG domains gives laminin-332 its biological function. In this study, we focused on LG domain cleavage and developed antibodies that target the LG domain cleavage site. We attempted to change the biological function of laminin-332 to control cell adhesion for the purpose of regulating dental implant therapy.
Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages
Takeshi Haneda, Mariko Sugimoto, Yukie Yoshida-Ohta, Yoshio Kodera, Masamichi Oh-Ishi, Tadakazu Maeda, Satomi Shimizu-Izumi, Tsuyoshi Miki, Yoshinori Kumagai, Hirofumi Danbara, Nobuhiko Okada
BMC Microbiology , 2010, DOI: 10.1186/1471-2180-10-324
Abstract: Of the 366 examined spots, 269 proteins were successfully identified. The comparative analysis of the wild-type and ppGpp0 mutant strains revealed 55 proteins, the expression patterns of which were affected by ppGpp. Using a mouse infection model, we further identified a novel virulence-associated factor, STM3169, from the ppGpp-regulated and Salmonella-specific proteins. In addition, Salmonella strains carrying mutations in the gene encoding STM3169 showed growth defects and impaired growth within macrophage-like RAW264.7 cells. Furthermore, we found that expression of stm3169 was controlled by ppGpp and SsrB, a response regulator of the two-component system located on Salmonella pathogenicity island 2.A proteomic approach using a 2-DE reference map can prove a powerful tool for analyzing virulence factors and the regulatory network involved in Salmonella pathogenesis. Our results also provide evidence of a global response mediated by ppGpp in S. enterica.The facultative intracellular bacterium Salmonella enterica causes a broad spectrum of diseases, such as gastroenteritis and bacteremia, which are typically acquired by oral ingestion of contaminated food or water. S. enterica serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and a typhoid-like systemic infection in mice.Several virulence genes associated with Salmonella pathogenicity islands (SPIs) and the virulence plasmid have been characterized in S. Typhimurium. Two type III secretion systems (T3SS) encoded by SPI-1 and SPI-2 play central roles in Salmonella pathogenesis. SPI-1 is essential for the invasion of host cells and the induction of apoptosis in infected macrophages [1,2]. SPI-2 T3SS primarily confers survival and replication on macrophages and is required for systemic infection in the mouse infection model [3,4]. Expression of SPI-2 genes is induced within a modified phagosome, called the Salmonella-containing vacuole (SCV), in infected macrophages [5]. Induction of SPI-2 genes dep
The only constant is change
Mariko Hall
Forced Migration Review , 2011,
Abstract: Can the humanitarian community’s providers of telecommunications services keep up with the pace of change – and the pace of demand?
Expanding a Care Network for People with Dementia and their Carers Through Musicking: Participant Observation with
Mariko Hara
Voices: A World Forum for Music Therapy , 2011,
Abstract: Music use in dementia care often takes place within a music therapy context, where music therapy sessions aim to reduce agitated behaviour, access emotions or enhance inter-personal communication. Such sessions usually take place within care homes and their effect has been evaluated by a number of studies. However, there is little research on music use that takes place outside of care homes (e.g. in community centres) for people with dementia who are cared for at home by their family. This paper discusses this type of music use, focusing on the meaning of weekly local music making activities in relation to every day dementia care. I use empirical data from a study of a community based music activity called "Singing for the Brain" (SFTB) run by the Alzheimer's Society in the UK. The data was collected through extensive participant observation research and interviews with organisers, carers and care receivers. The preliminary findings from the data analysis are discussed: how SFTB can be seen as a ecological practice; its various “spin-off’ effects in the everyday care of the members with dementia; how SFTB, together with other local music groups, constitute the music and care world in the town; and how this develops into fluid support networks to support local people with dementia and their carers.
Music in Dementia Care: Increased Understanding Through Mixed Research Methods
Mariko Hara
Music and Arts in Action , 2011,
Abstract: Over the past decade there has been an increased interest in the wide variety of issues involved in the care of individuals with dementia. One particular area of research is the effect of music on those with dementia, commonly studied through the perspectives of neuroscience and (the more applied) music therapy. There is, however, a black box common to both these fields: music is seen as an input and its effect as a simple output. In treating the human (brain) as merely an object to stimulate with music or sound, the socio-cultural context of musical interaction is omitted from the analysis. This article discusses the employment of mixed research methods adapted specifically to explore the use of music in dementia care and to open this black box. In particular, this article explores the use of ethnographic participant observations and semi-structured interviews with individuals with dementia, their families/carers and (volunteer) staff of Singing for the Brain (SFTB) in a British town. The article concludes with a discussion of the preliminary themes generated by this mixed-methods approach (such as the importance of ‘relationships’), and the importance of examining music as a ‘catalyst’ in building relationships. Although the issues examined in this article are specific to dementia, similar sensitive issues may be found in research on health and other creative (therapeutic) activities for people with dementia.
Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection
Mariko Tomita
ISRN Microbiology , 2012, DOI: 10.5402/2012/978607
Abstract:
Unable or Unwilling to Leave the Nest? An Analysis and Evaluation of Japanese Parasite Single Theories
TRAN, Mariko
Electronic Journal of Contemporary Japanese Studies , 2006,
Abstract: In Japan today, there are more than 13 million so-called parasite singles, full-fledged adults who live under the same roof as their parents, contributing little to the household account and doing virtually no housework. Their parental dependency, as well as choice in lifestyle and the implications they pose for Japanese society has attracted much attention in Japan. Being an easy target, they are often criticized and blamed for Japan's current woes, leaving the true causes behind the increasing number of parasite singles inadequately investigated. This paper explores the parasite singles phenomenon and analyzes the prevailing Japanese parasite singles theories.
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