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Search Results: 1 - 10 of 469 matches for " Mariko Obayashi "
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Increased Cerebral Cortex Perfusion in Stroke Patients with Cognitive Disorder Following Cilostazol Administration, Two Cases Report  [PDF]
Yukihiro Hara, Shigeru Obayashi
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.34043

Objective: In our search for a new augmentation therapy for stroke patients, we administered cilostazol, an antiplatelet agent. Subjects: The patients suffered from mild hemiparesis or cognitive disorder showing reduced cerebral perfusion in the prefrontal cortex. Methods: We evaluated the functional cerebral blood flow (CBF) before and after the administration of cilostazol using near-infrared resonance spectroscopy (NIRS) during a verbal fluency task (VFT). Results: For the patient with cognitive disorder, statistically significant improvements were observed in the number of generated words in the VFT before and after administration of 50 mg cilostazol (p < 0.05, Mann-Whitney U test). Another patient without cognitive disorder, however, showed no significant VFT improvement after administration of cilostazol. Effect size data revealed large or very large effects of cilostazol on brain activation (oxy-Hb levels) at the affected side prefrontal cortex for both patients. The patient with cognitive disorder showed significant improvement in VFT performance as well as an increase in bilateral prefrontal CBF after cilostazol administration. Discussion: These findings suggest that, for patients with cerebrovascular lesions suffering from cognitive disorder, cilostazol may be promising as a drug to improve cognitive function in addition to preventing recurrent cerebral infarction.

Active Stall Control System on NACA0012 by Using Synthetic Jet Actuator  [PDF]
Hiroaki Hasegawa, Shigeru Obayashi
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2019, DOI: 10.4236/jfcmv.2019.71005
Abstract: Flow separation is typically an undesirable phenomenon, and boundary layer control is an important technique for the separation problems on airfoils. The synthetic jet actuator is considered as a promising candidate for flow control applications because of its compact nature and ability to generate momentum without the need for fluidic plumbing. In the present study, an active separation control system using synthetic jets is proposed and practically applied to the stall control of the NACA0012 airfoil in a wind tunnel test. In our proposed system, the flow conditions (stalled or unstalled) can be judged by calculating from two static pressure holes on the airfoil upper surface alone. The experimental results indicate that the maximum lift coefficient increases by 11% and the stall angle rises by 4° in contrast to the case under no control. It is confirmed that our proposed system can suppress the stall on the NACA0012 airfoil and that the aerodynamic performance of the airfoil can be enhanced. The proposed system can also be operated prior to the onset of stall. Therefore, separation control is always attained with no stall for all flow fields produced by changing the angle of attack that were examined.
(1→3)-β-D-glucanemia in deep mycosis
Taminori Obayashi
Mediators of Inflammation , 1997, DOI: 10.1080/09629359791604
Reach of Future Accelerator and Reactor Neutrino Efforts
Y. Obayashi
Physics , 2008,
Abstract: Numbers of accelerator and reactor neutrino oscillation experiments aiming to search finite value of $\theta_{13}$ are starting within a few years. T2K experiment is a next generation long baseline neutrino experiment starts on 2009, in Japan. A main goal of the T2K experiment is to discover a finite $\theta_{13}$ by observing $\nu_e$ appearance. Determining $\theta_{13}$ leads a next search of CP violation in the lepton sector. Status of T2K experiment and prospects for CP measurement are reported in the report.
MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer
Elsayed Mohamed Deraz, Yasusei Kudo, Maki Yoshida, Mariko Obayashi, Takaaki Tsunematsu, Hirotaka Tani, Samadarani B. S. M. Siriwardena, Mohammad Reza Kiekhaee, Guangying Qi, Shinji Iizuka, Ikuko Ogawa, Giuseppina Campisi, Lorenzo Lo Muzio, Yoshimitsu Abiko, Akira Kikuchi, Takashi Takata
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0025438
Abstract: Background Periostin, IFN-induced transmembrane protein 1 (IFITM1) and Wingless-type MMTV integration site family, member 5B (Wnt-5b) were previously identified as the invasion promoted genes of head and neck squamous cell carcinoma (HNSCC) by comparing the gene expression profiles between parent and a highly invasive clone. We have previously reported that Periostin and IFITM1 promoted the invasion of HNSCC cells. Here we demonstrated that Wnt-5b overexpression promoted the invasion of HNSCC cells. Moreover, stromelysin-2 (matrix metalloproteinase-10; MMP-10) was identified as a common up-regulated gene among Periostin, IFITM1 and Wnt-5b overexpressing HNSCC cells by using microarray data sets. In this study, we investigated the roles of MMP-10 in the invasion of HNSCC. Methods and Findings We examined the expression of MMP-10 in HNSCC cases by immunohistochemistry. High expression of MMP-10 was frequently observed and was significantly correlated with the invasiveness and metastasis in HNSCC cases. Next, we examined the roles of MMP-10 in the invasion of HNSCC cells in vitro. Ectopic overexpression of MMP-10 promoted the invasion of HNSCC cells, and knockdown of MMP-10 suppressed the invasion of HNSCC cells. Moreover, MMP-10 knockdown suppressed Periostin and Wnt-5b-promoted invasion. Interestingly, MMP-10 overexpression induced the decreased p38 activity and MMP-10 knockdown induced the increased p38 activity. In addition, treatment with a p38 inhibitor SB203580 in HNSCC cells inhibited the invasion. Conclusions These results suggest that MMP-10 plays an important role in the invasion and metastasis of HNSCC, and that invasion driven by MMP-10 is partially associated with p38 MAPK inhibition. We suggest that MMP-10 can be used as a marker for prediction of metastasis in HNSCC.
Evaluation of Oxidative Stress, Antioxidant Power, and Antioxidant Potential of Breastmilk of Breast-Feeding Mothers  [PDF]
Naoko Kuramoto, Mariko Kitagawa
Health (Health) , 2017, DOI: 10.4236/health.2017.98083
Abstract: Purpose: The purpose of this study was to evaluate oxidative stress, antioxidant power, and antioxidant potential of breastmilk of breast-feeding mothers from the early postpartum period to the first 3 months postpartum, and to examine the dynamics and the relationships among them. Method: For 47 pu-erperant women who gave vaginal birth without any pregnancy complications, the oxidative stress levels (d-ROMs levels) and antioxidant power (BAP levels) in the maternal plasma as well as antioxidant potential of breastmilk (BAP levels in breastmilk) were measured 3 times, i.e., in the early puerperium (4 or 5 days after giving birth), one month after giving birth, and 3 months after giving birth. Results: The d-ROMs levels in the maternal plasma were significantly high in the early puerperium (p < 0.001), and decreased gradually in the post-partum period (p < 0.001). On the other hand, BAP levels were significantly low in the early puerperium (p < 0.001), and increased to the almost normal level during one month after giving birth. BAP levels in breastmilk were significantly high in the early puerperium compared with the other periods (p < 0.001), and decreased gradually until 3 months after giving birth (p < 0.001). BAP levels in breastmilk in the early puerperium were higher compared with the maternal BAP levels, and there was a positive correlation between BAP levels in breast-milk and those in the maternal plasma (p < 0.05). Discussion: Regarding the oxidative stress and the antioxidant defense system of breast-feeding mothers, the d-ROMs level was highest and the BAP level was lowest in the early puerperium. The BAP level then showed a clear tendency to recover in the first 3 months after giving birth. Conclusion: When the maternal antioxidant potential remains at a low level after giving birth, careful consideration should be given to the mother’s health and wellbeing because there is a possibility that it might affect the antioxidant potential of breastmilk.
Effects of Nonuniform Outflow and Buoyancy on Drag Coefficient Acting on a Spherical Particle  [PDF]
Mariko Watanabe, Joji Yahagi
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2017, DOI: 10.4236/jfcmv.2017.54008
Abstract: Pyrolysis gas jets out from the surface of a solid fuel particle when heated. This study experimentally observes the occurrence of gas jetsfrom heated solid fuel particles. Results reveal a local gas jet occurs from the particle’s surface when its temperature reaches the point at which a pyrolysis reaction occurs. To investigate the influence of the gas jet on particle motion, a numerical simulation of the uniform flow around a spherical particle with a nonuniform outflow or high surface temperature is conducted, and the drag force acting on the spherical particle is estimated. In the numerical study, the magnitude of the outflow velocity, direction of outflow, and Rayleigh number,?i.e., particle surface temperature, are altered, and outflow velocities and the Rayleigh number are set based on the experiment. The drag coefficient is found to decrease when an outflow occurs in the direction against the mainstream; this drag coefficient at a higher Rayleigh number is slightly higher than that at a Rayleigh number of zero.
A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants  [PDF]
Mariko Kawai, Kiyoshi Ohura
Open Journal of Stomatology (OJST) , 2017, DOI: 10.4236/ojst.2017.711046
Abstract: Dental implant therapy is a highly effective treatment for recovering occlusion after tooth loss. An important factor in the success of dental implants is establishing strong osseointegration. If more epithelial cells migrate to the implant-bone interface than mesenchymal stem cells, effective osseointegration may fail. Therefore, controlling epithelial cell adhesion and motility would be an effective strategy to increase the success rate of osseointegration. Laminin-332 is a major component of the basement membrane and is composed of three chains (α3, β3 and γ2). It is well-known that laminin-332 regulates cellular functions such as adhesion, proliferation, apoptosis and differentiation. These biological functions depend on changes in the structural arrangement of laminin-332 by proteolytic cleavage. It is well-known that cleavage of the α3 chain between its LG domains gives laminin-332 its biological function. In this study, we focused on LG domain cleavage and developed antibodies that target the LG domain cleavage site. We attempted to change the biological function of laminin-332 to control cell adhesion for the purpose of regulating dental implant therapy.
Control of Karman Vortex Street behind a Thin Airfoil at Low Reynolds Number  [PDF]
Shohei Takagi, Yasufumi Konishi, Shigeru Obayashi, Masato Asai
Journal of Flow Control, Measurement & Visualization (JFCMV) , 2016, DOI: 10.4236/jfcmv.2016.43011
Abstract: To control the Karman vortex street formed behind a thin airfoil at a certain incidence, a control cylinder was placed at the suction side apart from the airfoil in the downstream region. Both smoke visualization and hot-wire measurements confirmed that the Karman vortex street was completely suppressed. The mechanism for suppression of the vortex street was examined with a hot-wire survey.
The only constant is change
Mariko Hall
Forced Migration Review , 2011,
Abstract: Can the humanitarian community’s providers of telecommunications services keep up with the pace of change – and the pace of demand?
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