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Search Results: 1 - 10 of 714 matches for " Marieke Zimmerman "
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Regenerative Therapies for Equine Degenerative Joint Disease: A Preliminary Study
Sarah Broeckx, Marieke Zimmerman, Sara Crocetti, Marc Suls, Tom Mari?n, Stephen J. Ferguson, Koen Chiers, Luc Duchateau, Alfredo Franco-Obregón, Karin Wuertz, Jan H. Spaas
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085917
Abstract: Degenerative joint disease (DJD) is a major cause of reduced athletic function and retirement in equine performers. For this reason, regenerative therapies for DJD have gained increasing interest. Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) were isolated from a 6-year-old donor horse. MSCs were either used in their native state or after chondrogenic induction. In an initial study, 20 horses with naturally occurring DJD in the fetlock joint were divided in 4 groups and injected with the following: 1) PRP; 2) MSCs; 3) MSCs and PRP; or 4) chondrogenic induced MSCs and PRP. The horses were then evaluated by means of a clinical scoring system after 6 weeks (T1), 12 weeks (T2), 6 months (T3) and 12 months (T4) post injection. In a second study, 30 horses with the same medical background were randomly assigned to one of the two combination therapies and evaluated at T1. The protein expression profile of native MSCs was found to be negative for major histocompatibility (MHC) II and p63, low in MHC I and positive for Ki67, collagen type II (Col II) and Vimentin. Chondrogenic induction resulted in increased mRNA expression of aggrecan, Col II and cartilage oligomeric matrix protein (COMP) as well as in increased protein expression of p63 and glycosaminoglycan, but in decreased protein expression of Ki67. The combined use of PRP and MSCs significantly improved the functionality and sustainability of damaged joints from 6 weeks until 12 months after treatment, compared to PRP treatment alone. The highest short-term clinical evolution scores were obtained with chondrogenic induced MSCs and PRP. This study reports successful in vitro chondrogenic induction of equine MSCs. In vivo application of (induced) MSCs together with PRP in horses suffering from DJD in the fetlock joint resulted in a significant clinical improvement until 12 months after treatment.
A. Wood, P. Stedman-Edwards, and J. Mang, editors. 2000. The Root Causes of Biodiversity Loss. World Wildlife Fund and Earthscan Publications Ltd., London, UK.
Marieke Heemskerk
Ecology and Society , 2001,
Abstract:
Sedimentêre omgewings van die Inhaca-eilandstelsel met spesiale verwysing na die petrografiese en geochemiese eienskappe van die sedimente spesiale verwysing na die petrografiese en geochemiese eienskappe van die sedimente
Marieke Peché
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie , 2011, DOI: 10.4102/satnt.v30i1.265
Abstract: Sedimentary environments on the Inhaca Island system with special reference to the petrographic and geochemical characterisation of the sediments The Inhaca system contains several high- and low-energy modern sedimentary environments, as well as four main geological units. The importance of this study lies in the influence of the sedimentation on the marine ecosystems and economy of Mozambique, and the influence global warming would have on the sediment input of the area.
De dagbladkritiek van vóór en ná Merlyn. Verschillen tussen de literatuurkritische praktijk in 1955 en 1975
Marieke Vermeulen
TS·> Tijdschrift voor Tijdschrift-studies , 2011,
Abstract: This study investigates the differences between literary reviewing in the Dutch newspapers before and after the literary magazine Merlyn. The reason to do so is the claim of many scholars that Merlyn influenced literary reviewing in the Netherlands, more specifically the kind of value judgments literary critics make. To find out whether this specific influence on the judgments is a myth or not, the reviews in the newspapers before and after Merlyn have been examined. The value judgments in prose and poetry reviews that appeared in Het Parool, de Volkskrant and Trouw in two reference years (1955 and 1975) were collected and categorized in order to make a comparison. The analysis shows several differences between 1955 and 1975 that may be interrelated with Merlyn. Although, of course, the differences found cannot be attributed to Merlyn solely, this study seems to confirm the idea that Merlyn influenced literary reviewing in the newspapers.
The curvaton scenario in supersymmetric theories
Marieke Postma
Physics , 2002, DOI: 10.1103/PhysRevD.67.063518
Abstract: We analyze the curvaton scenario in the context of supersymmety. Supersymmetric theories contain many scalars, and therefore many curvaton candidates. To obtain a scale invariant perturbation spectrum, the curvaton mass should be small during inflation $m \ll H$. This can be achieved by invoking symmetries, which suppress the soft masses and non-renormalizable terms in the potential. Other constraints on the curvaton model come from nucleosynthesis, gravitino overproduction, and thermal evaporation. The curvaton coupling to matter should be very small to satisfy these constraints ({\it e.g.} $h \lesssim 10^{-8}$ for typical soft masses $m \sim \TeV$).
Neutrino production in a time-dependent matter background
Marieke Postma
Physics , 2001, DOI: 10.1016/S0146-6410(02)00134-5
Abstract: We show that neutrinos can be produced through standard electroweak interactions in matter with time-dependent density.
M-flation and its spectators
Marieke Postma
Physics , 2010, DOI: 10.1088/1475-7516/2010/11/038
Abstract: M-flation is an implementation of assisted inflation, in which the inflaton fields are three N_c x N_c non-abelian hermitean matrices. The model can be consistently truncated to an effectively single field inflation model, with all ``spectator'' fields fixed at the origin. We show that starting with random initial conditions for all fields the truncated sector is not a late-time attractor, but instead the system evolves towards quadratic assisted inflation with all fields mass degenerate. Demanding the energy density during inflation to be below the effective quantum gravity scale, we find that the number of fields, and thus the assisted effect, is bounded N_c < 10^2.
Solitosynthesis of Q-balls
Marieke Postma
Physics , 2001, DOI: 10.1103/PhysRevD.65.085035
Abstract: We study the formation of Q-balls in the early universe, concentrating on potentials with a cubic or quartic attractive interaction. Large Q-balls can form via solitosynthesis, a process of gradual charge accretion, provided some primordial charge assymetry and initial ``seed'' Q-balls exist. We find that such seeds are possible in theories in which the attractive interaction is of the form $A H \psi^* \psi$, with a light ``Higgs'' mass. Condensate formation and fragmentation is only possible for masses $m_\psi$ in the sub-eV range; these Q-balls may survive untill present.
Constraining the curvaton scenario
Marieke Postma
Physics , 2003,
Abstract: We analyse the curvaton scenario in the context of supersymmetry. Supersymmetric theories contain many scalars, and therefore many curvaton candidates. To obtain a scale invariant perturbation spectrum, the curvaton mass should be small during inflation $m \ll H$. This can be achieved by invoking symmetries, which suppress the soft masses and non-renormalizable terms in the potential. Other model-independent constraints on the curvaton model come from nucleosynthesis, gravitino overproduction, and thermal damping. The curvaton can work for masses $m \gtrsim 10^4 \GeV$, and very small couplings (e.g. $h \lesssim 10^{-6}$ for $m \lesssim 10^8 \GeV$).
"Signature" neutrinos from photon sources at high redshift
Marieke Postma
Physics , 2000, DOI: 10.1063/1.1398160
Abstract: The temperature of the cosmic microwave background increases with redshift; at sufficiently high redshift it becomes possible for ultrahigh-energy photons and electrons to produce muons and pions through interactions with background photons. At the same time, energy losses due to interactions with radio background and intergalactic magnetic fields are negligible. The energetic muons and pions decay, yielding a flux of ``signature'' neutrinos with energies $E_\nu \sim 10^{17}$eV. Detection of these neutrinos can help understand the origin of ultrahigh-energy cosmic rays.
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