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Search Results: 1 - 10 of 16590 matches for " Marie-Jose Kabedi-Bajani "
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Multidrug-Resistant Tuberculosis in the Democratic Republic of Congo: Analysis of Continuous Surveillance Data from 2007 to 2016  [PDF]
Serge Bisuta-Fueza, Jean Marie Kayembe-Ntumba, Marie-Jose Kabedi-Bajani, Pascale Mulomba Sabwe, Hippolyte Situakibanza-Nani Tuma, Jean-Pierre Simelo, Ernest Sumaili-Kiswaya, John Ditekemena-Dinanga, Patrick Kayembe-Kalambayi
Journal of Tuberculosis Research (JTR) , 2019, DOI: 10.4236/jtr.2019.71004
Abstract: Background: For countries with limited resources such as the Democratic Republic of the Congo (DRC), the diagnosis of Multidrug-resistant tuberculosis (MDR-TB) is still insufficient. The MDR-TB identification is done primarily among at-risk groups. The knowledge of the true extent of the MDR-TB remains a major challenge. This study tries to determine the proportion of MDR-TB in each group of presumptive MDR-TB patients and to identify some associated factors. Methods: This is an analysis of the DRC surveillance between 2007 and 2016. The proportions were expressed in Percentage. The logistic regression permits to identify the associated factors with the RR-/MDR-TB with adjusted Odds-ratio and 95% CI. Significance defined as p ≤ 0.05. Results: Overall, 83% (5407/6512) of the MDR-TB presumptive cases had each a TB test. 86.5% (4676/5407) had each a culture and drug sensitive testing (DST) on solid medium, and 24.3% (1312/5407) had performed an Xpert MTB/RIF test. The proportion of those with at least one first-line drug resistance was 59.3% [95% CI 57.2 - 61.4] among which 50.1%, [95% CI 47.9 - 52.3] for the isoniazid, 45.6% [95% CI 43.4 - 47.8] for the rifampicin, 49.9% [95% CI 47.8 - 52.1] for ethambutol and 35.8% [95% CI 33.7 - 37.9] for streptomycin. The confirmation of MDR-TB was 42.8% [95% CI 38.4 - 47.8]. Combining both tests, the proportion of RR-/MDR-TB was 49.6% [95% CI 47.9 - 51.4] for all presumptives. This proportion was 60.0% for failures, 40.7% for relapses and 34.7% for defaulters. Associated factors with the diagnosis of MDR-TB were: aged less than 35 years; prior treatment failure; defaulters; the delay between the collection of sputum and the test completion. Conclusion: The proportion of RR-/MDR-TB among the presumptives has been higher than those estimated generally. The National tuberculosis programme (NTP) should improve patient follow-up to reduce TB treatment failures and defaulting. Moreover, while increasing the use of molecular tests, they should reduce sample delivery times when they use culture and DST concomitantly.
Statistics of stable marriages
Michael Dzierzawa,Marie-Jose Omero
Physics , 2000, DOI: 10.1016/S0378-4371(00)00344-7
Abstract: In the stable marriage problem N men and N women have to be matched by pairs under the constraint that the resulting matching is stable. We study the statistical properties of stable matchings in the large N limit using both numerical and analytical methods. Generalizations of the model including singles and unequal numbers of men and women are also investigated.
Network Coding Meets Information-Centric Networking
Marie-Jose Montpetit,Cedric Westphal,Dirk Trossen
Computer Science , 2012,
Abstract: The focus of user behavior in the Internet has changed over the recent years towards being driven by exchanging and accessing information. Many advances in networking technologies have utilized this change by focusing on the content of an exchange rather than the endpoints exchanging the content. Network coding and information centric networking are two examples of these technology trends, each being developed largely independent so far. This paper brings these areas together in an evolutionary as well as explorative setting for a new internetworking architecture. We outline opportunities for applying network coding in a novel and performance-enhancing way that could eventually push forward the case for information centric network itself.
IP and Broadcasting Systems Convergence
Georgios Gardikis,George Xilouris,Marie-Jose Montpetit,Alessandro Vanelli-Coralli
International Journal of Digital Multimedia Broadcasting , 2010, DOI: 10.1155/2010/382931
Guy Flouzat,Florence Laporterie,Marie-Jose Lefevre-Fonollosa,Erick Lopez-Ornelas
Image Analysis and Stereology , 2002, DOI: 10.5566/ias.v21.ps87-s97
Abstract: This paper presents remote sensing sensors: SPOT and LANDSAT systems are the most important providers of data in the 10-30 m spatial resolution range; NOAA (AVHRR radiometer) and SPOT4-5 (VEGETATION radiometer) provide coarse spatial resolution (-1 km) but high frequency data. Microwave sensors are more recently available (radar on board of ERSl, ERS2, and RADARSAT). The principal methods of data cooperation to get benefits of these new technologies are described. Many combinations in the field of data fusion will contribute to enhance the perception of the terrestrial surfaces. A tentative review of this domain is proposed after a recall of a general definition. Finally, the present trends in image analysis for remote sensing coming from the evolution of the orbital sensors are developed.
IP and Broadcasting Systems Convergence
Georgios Gardikis,George Xilouris,Marie-Jose Montpetit,Alessandro Vanelli-Coralli,Daniel Negru
International Journal of Digital Multimedia Broadcasting , 2010, DOI: 10.1155/2010/382931
Mahler measure of some singular K3-surfaces
Marie-Jose Bertin,Amy Feaver,Jenny Fuselier,Matilde Lalin,Michelle Manes
Mathematics , 2012,
Abstract: We study the Mahler measure of the three-variable Laurent polynomial x + 1/x + y + 1/y + z + 1/z - k where k is a parameter. The zeros of this polynomial define (after desingularization) a family of K3-surfaces. In favorable cases, the K3-surface has Picard number 20, and the Mahler measure is related to its L-function. This was first studied by Marie-Jose Bertin. In this work, we prove several new formulas, extending the earlier work of Bertin.
Surveying the Social, Smart and Converged TV Landscape: Where is Television Research Headed?
Marie-Jose Montpetit,Pablo Cesar,Maja Matijasevic,Zhu Liu,John Crowcroft,Oscar Martinez-Bonastre
Computer Science , 2012,
Abstract: The TV is dead motto of just a few years ago has been replaced by the prospect of Internet Protocol (IP) television experiences over converged networks to become one of the great technology opportunities in the next few years. As an introduction to the Special Issue on Smart, Social and Converged Television, this extended editorial intends to review the current IP television landscape in its many realizations: operator-based, over-the-top, and user generated. We will address new services like social TV and recommendation engines, dissemination including new paradigms built on peer to peer and content centric networks, as well as the all important quality of experience that challenges services and networks alike. But we intend to go further than just review the existing work by proposing areas for the future of television research. These include strategies to provide services that are more efficient in network and energy usage while being socially engaging, novel services that will provide consumers with a broader choice of content and devices, and metrics that will enable operators and users alike to define the level of service they require or that they are ready to provide. These topics are addressed in this survey paper that attempts to create a unifying framework to link them all together. Not only is television not dead, it is well alive, thriving and fostering innovation and this paper will hopefully prove it.
Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions
Ronan Jambou ,Valery Combes,Marie-Jose Jambou,Babeth B. Weksler,Pierre-Olivier Couraud,Georges E. Grau
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1001021
Abstract: Cerebral malaria, a major cause of death during malaria infection, is characterised by the sequestration of infected red blood cells (IRBC) in brain microvessels. Most of the molecules implicated in the adhesion of IRBC on endothelial cells (EC) are already described; however, the structure of the IRBC/EC junction and the impact of this adhesion on the EC are poorly understood. We analysed this interaction using human brain microvascular EC monolayers co-cultured with IRBC. Our study demonstrates the transfer of material from the IRBC to the brain EC plasma membrane in a trogocytosis-like process, followed by a TNF-enhanced IRBC engulfing process. Upon IRBC/EC binding, parasite antigens are transferred to early endosomes in the EC, in a cytoskeleton-dependent process. This is associated with the opening of the intercellular junctions. The transfer of IRBC antigens can thus transform EC into a target for the immune response and contribute to the profound EC alterations, including peri-vascular oedema, associated with cerebral malaria.
ZFP36L1 Negatively Regulates Plasmacytoid Differentiation of BCL1 Cells by Targeting BLIMP1 mRNA
Asghar Nasir, John D. Norton, Maria Baou, Anna Zekavati, Marie-Jose Bijlmakers, Steve Thompson, John J. Murphy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052187
Abstract: The ZFP36/Tis11 family of zinc-finger proteins regulate cellular processes by binding to adenine uridine rich elements in the 3′ untranslated regions of various mRNAs and promoting their degradation. We show here that ZFP36L1 expression is largely extinguished during the transition from B cells to plasma cells, in a reciprocal pattern to that of ZFP36 and the plasma cell transcription factor, BLIMP1. Enforced expression of ZFP36L1 in the mouse BCL1 cell line blocked cytokine-induced differentiation while shRNA-mediated knock-down enhanced differentiation. Reconstruction of regulatory networks from microarray gene expression data using the ARACNe algorithm identified candidate mRNA targets for ZFP36L1 including BLIMP1. Genes that displayed down-regulation in plasma cells were significantly over-represented (P = <0.0001) in a set of previously validated ZFP36 targets suggesting that ZFP36L1 and ZFP36 target distinct sets of mRNAs during plasmacytoid differentiation. ShRNA-mediated knock-down of ZFP36L1 in BCL1 cells led to an increase in levels of BLIMP1 mRNA and protein, but not for mRNAs of other transcription factors that regulate plasmacytoid differentiation (xbp1, irf4, bcl6). Finally, ZFP36L1 significantly reduced the activity of a BLIMP1 3′ untranslated region-driven luciferase reporter. Taken together, these findings suggest that ZFP36L1 negatively regulates plasmacytoid differentiation, at least in part, by targeting the expression of BLIMP1.
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