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Efficacy and tolerability of propolis special extract gh 2002 as a lip balm against herpes labialis: a randomized, double-blind three-arm dose finding study  [PDF]
Simona Holcová, Marie Hladiková
Health (Health) , 2011, DOI: 10.4236/health.2011.31010
Abstract: A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concentrations of propolis special extract GH 2002 in a lip balm (0.1%, 0.5% and 1%). The trial was designed as a double-blind, randomized dermatological study in 150 outpatients with Herpes labialis. The primary parameter was the duration in days until painless incrustation in 50% or 90% of the patients (observable in 121 patients). Secondary parameters were local pain (assessed on a visual analogue scale), itching, burning and tension/ swelling on a verbal rating scale, and tolerability. Visits were performed on days 2/3, 5/6 and 8/9. Best efficacy results with shortest healing time (3.4 and 5.4 days in the 50th and 90th percentile, respectively; p = 0.008 vs. 1% and 0.09 vs. 0.1%) and good tolerability were observed with the 0.5% concentration. All three concentrations achieved highly significant therapeutic results in comparison with baseline values (p < 0.0005) for all secondary parameters as early as day 2/3. Analgesia was the most prominent effect for the patients. Conclusion: The 0.5 % concentration of propolis special extract GH 2002 in a lip balm was found to have the best risk-benefit ratio for the treatment of Herpes labialis.
Arnica/Hydroxyethyl Salicylate Combination Spray for Ankle Distortion: A Four-Arm Randomised Double-Blind Study
Miroslav Ku?era,Pavel Kolar,Milos Barna,Alexander Ku?era,Marie Hladiková
Pain Research and Treatment , 2011, DOI: 10.1155/2011/365625
Abstract: 570 patients with acute ankle joint distortion were randomized to four treatment groups: a combination spray of arnica tincture and hydroxyethyl salicylate (HES; group A, ), arnica (B, ), HES (C, ), and placebo (D, ). The medication was applied 4-5 times daily for 10 days. Efficacy was assessed on day 3-4 by evaluating pain on motion on a visual analogue scale (VAS). Pain improvement in group A was significantly superior over groups B–D ( -test with unadjusted baseline values, and ANCOVA after adjustment, ) and approximately corresponded to the cumulative effect of the single constituents (12.1, 7.5, and 18.7?mm VAS for A versus B, A versus C, and A versus D; 95% CI 8.0–16.2, 4.7–10.4, and 14.8–22.5?mm). The combination is justified by the additive effects of the single active constituents. 1. Introduction A combination product with arnica tincture (aqueous-ethanolic extract from the flowers of Arnica montana) and hydroxyethyl salicylate (HES) as active constituents in the galenical formulation of a spray registered as a medicinal product has a long history of clinical use in ankle joint distortion in Germany and the Czech Republic, although there is little published clinical evidence from trials [1]. Topical anti-inflammatory and analgesic properties of preparations from arnica flowers are amply described in monographs [2–4]. Flavonoids and sesquiterpene lactones of the helenalin type are generally held responsible for the observed effects [5]. HES possesses local analgesic and anti-inflammatory effects, which have been confirmed in various pharmacological models [6–9], as well as in a clinical trial [10]. The local analgesic effects of the combination spray with arnica tincture and HES have been shown efficacious in a pharmacodynamic proof of concept trial in healthy volunteers using transcutaneous electric nerve stimulation for the assessment of pain threshold [11]. The study results indicated a superiority of the combination over the two single constituents. The present study has a similar design but is performed as a confirmatory clinical trial in patients. It had a twofold aim: to demonstrate the efficacy and tolerability of the combination spray against ankle joint distortion under randomized double-blind conditions versus placebo and to provide details on the contribution to efficacy of the single constituents. It was hypothesized that the effect of the combination is superior over the effect of HES or that of arnica tincture when applied as a monopreparation. 2. Materials and Methods 2.1. Trial Design The clinical trial was designed as a
Production of human polyclonal antibodies by transgenic animals  [PDF]
Louis-Marie Houdebine
Advances in Bioscience and Biotechnology (ABB) , 2011, DOI: 10.4236/abb.2011.23022
Abstract: Polyclonal antibodies collected from the blood of animals and humans experimentally immunised or spontaneously immunised respectively can be injected into patients to protect them against pathogens, toxins, tumours etc. This approach is severely limited by the availability of human polyclonal antibodies of interest. Moreover, polyclonal antibodies from animals are recognised as antigens by patients and are thus rapidly rejected and inactivated. To circumvent this problem, animals (essentially rabbits, chicken, pigs and cows) are being genetically engineered. Their immunoglobulin genes are being inactivated and the corresponding human immunoglobulin genes are being transferred to them. These animals will be immunized and it is expected that large amounts of pure human polyclonal antibodies will be extracted from their blood to be administered to patients. The possible acceptability problem of this approach is under a case study of the European Union Pegasus project.
Classroom Assessment Techniques: An Assessment and Student Evaluation Method  [PDF]
Dawn-Marie Walker
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326136
Abstract: Some of the challenges that face Higher Education are how to ensure that assessment is meaningful and that feedback is prompt in order to promote learning. Another issue is how to provide lecturers with feedback regarding their efficacy, in a timely and non-judgmental manner. This paper proposes that Classroom Assessment Techniques (Angelo and Cross, 1993), maybe a good way of answering both of those issues. They are quick and easy tasks set within the lecture, which tests the student’s knowledge, providing an immediate opportunity for further elaboration if needed by the lecturer, therefore providing immediate feedback to the students. It also ensures that the lecturer has delivered the most salient messages, therefore also providing feedback to the lecturer.
Fuzzy Logic Strategy for Solving an Optimal Control Problem of Glucose and Insulin in Diabetic Human  [PDF]
Jean Marie Ntaganda
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.37052
Abstract:

This paper aims at the development of an approach integrating the fuzzy logic strategy for a glucose and insulin in diabetic human optimal control problem. To test the efficiency of this strategy, the author proposes a numerical comparison with the indirect method. The results are in good agreement with experimental data.

Hopf Bifurcation of a Two Delay Mathematical Model of Glucose and Insulin during Physical Activity  [PDF]
Jean Marie Ntaganda
Open Journal of Applied Sciences (OJAppS) , 2014, DOI: 10.4236/ojapps.2014.42006
Abstract: In this paper, we are interested in looking for Hopf bifurcation solutions for mathematical model of plasma glucose and insulin during physical activity. The mathematical model is governed by a system of delay differential equations. The algorithm for determining the critical delays that are appropriate for Hopf bifurcation is used. The illustrative example is taken for a 30 years old woman who practices regular three types of physical activity: walking, jogging and running fast.
Bank Characteristics and Procyclicality: A Theoretical Approach  [PDF]
Marie-Sophie Gauvin
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.33007
Abstract:

The 2007-2008 crisis highlighted liquidity management troubles. We witness a real estate asset price boom during the pre-crisis period and a difficulty for banks to raise funding afterwards. Consequently, bank choices in response to the conduct of the monetary policy along the cycle can be studied. Despite usual financial accelerator, the excessive (lack of) confidence of banks in the upward (down) phase explains procyclical balance sheet movements. Moreover, the monetary policy effects on bank behaviors vary according to their initial specifications. From a theoretical point of view, this paper examines the response of the banking sector to monetary authorities impulses, in function of their initial characteristics. So, the paper highlights a theoretical model, based on accounting identities, in which banks are distinguished in different categories according to their level of capitalization and liquidity. The principal result is that the less capitalized and liquid banks have more procyclical behaviors.

Psychological Distress in California: Identifying Those at Greatest Risk  [PDF]
Gina Marie Piane
Open Journal of Preventive Medicine (OJPM) , 2014, DOI: 10.4236/ojpm.2014.48075
Abstract:

In order to address the unmet need for prevention and treatment of psychological distress and mental disorders, program planners and treatment providers need to identify individuals at high risk. The results of the California Health Interview Survey from 2009 (n = 47,614) indicate that there are high relative risks by demographics and smoking status for reports of psychological distress and intermediate measures: feeling nervous, hopeless, worthless, depressed, restless, and that everything is an effort. Specific demographic factors and smoking status can predict a greater need for prevention and treatment of psychological distress and lack of insurance coverage for treatment. Profiles associated with high risk can help in referral for diagnosis or to plan prevention programs.

Maternal Mortality Correlates by Nation  [PDF]
Gina Marie Piane
Open Journal of Preventive Medicine (OJPM) , 2014, DOI: 10.4236/ojpm.2014.410085
Abstract: Background: This study reports the results of a secondary analysis of data provided by the World Health Organization to determine the correlates of maternal mortality among all reporting nations worldwide. Historically, maternal mortality ratios have declined in nations that provided a system for access to skilled care for the majority of its women. Currently, maternal mortality ratios are associated with access to skilled care as well as economic indicators, literacy, education, access to contraceptives, transportation and HIV prevalence. Methods: Descriptive statistics, bi-variate correlations and multiple linear regression analyses are reported using maternal mortality ratios as the dependent variable. In addition, an examination of countries that are exceptions to the regression is also reported. Results: Strong positive Pearson two-tailed correlations were found between MMR and infant mortality rate (0.866), total fertility rate (0.854), poverty rate (0.756), and adolescent fertility rate (0.710). Strong negative correlations were found between MMR and percentage of births attended by a skilled attendant (-0.786), percentage of women using contraceptives (-0.786), and adult literacy rate (-0.710). Eighty-one percent of the variation in MMR can be explained by differences in IMR, percent of births attended by a skilled provider, percent of women using contraceptive, total fertility rate, adolescent fertility rate, adult literacy rate and poverty. Discussion: Examination of the correlates of maternal mortality gives direction to the effort to achieve the WHO’s Millennium Development Goal of reducing maternal mortality by two-thirds from 1995-2015.
Web Semantic and Ontology  [PDF]
Elodie Marie Gontier
Advances in Internet of Things (AIT) , 2015, DOI: 10.4236/ait.2015.52003
Abstract: Ontologies have become a popular research topic in many communities. In fact, ontology is a main component of this research; therefore, the definition, structure and the main operations and applications of ontology are provided. Web content consists mainly of distributed hypertext and hypermedia, and is accessed via a combination of keyword based search and link navigation. Hence, the ontology can provide a common vocabulary, and a grammar for publishing data, and can supply a semantic description of data which can be used to preserve the ontologies and keep them ready for inference. This paper provides basic concepts of semantic web, and defines the structure and the main applications of ontology.
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