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Search Results: 1 - 10 of 99032 matches for " Maria Tereza dos Santos Correia "
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In Vitro Evaluation of Gamma Irradiation on a Gel Formulation of Cratylia Mollis: Rheological Proporties and Microbiological Control  [PDF]
Maria Helena Madruga Lima-Ribeiro, Ralph Santos-Oliveira, Mauricélia Firmino de Santana, Terezinha de Jesus Andreoli Pinto, Irene Satiko Kikuchi, Cheila Gon?alves Mothé, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Ana Maria dos Anjos Carneiro-Le?o
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.22011
Abstract: Lectin Cramoll-1,4, obtained from Cratylia mollis seeds (beans camaratu) was structurally characterized, biologically and pharmacologically, but its use as a biopharmaceutical is not well documented. The objective of this study is to propose a biopharmaceutical formulation lectin Cramoll-1,4, test their hemagglutinating properties in vitro as well as the use of gamma radiation as a continuous process of decontamination formulation. It was made of the extraction and purification Cramoll-1,4, was developed a gel formulation using Carbopol? as a vehicle, at concentrations of 50, 100, 200, 300 and 600 μg was irradiated with 60Co gamma rays in a dose of 7.549 kGy·h–1. The proposed formulation at a concentration of 300 μg produced an increase in the hemagglutinating units Cramoll-1,4 due to the synergistic effect caused by gamma radiation. Considering the diverse use of lectins, specific molecular and structural factors, as well as changes resulting from its formulation, concentration, irradiation and route of administration is of utmost importance to continue the studies in vitro, for subsequent application in vivo to characterize the physiological and molecular processes involved in the response and cellular effects.
Stability of the Antioxidant Activity of Flavonoids after Gamma Irradiation  [PDF]
Ant?nio Fernando de Melo Vaz, Marthyna Pessoa de Souza, Adriana Carla Cavalcante Malta Arg?lo, Ana Maria Mendon?a de Albuquerque Melo, Maria Luiza Vilela Oliva, Haroldo Sátiro Xavier, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.25071
Abstract: Food irradiation has the purpose of destroying insects or microorganisms, thereby increasing the safety and shelf life of foods. Flavonoids are ubiquitous plant secondary products with radical scavenger ability. In the present study their antioxidant stability after gamma irradiation was evaluated. The flavonoids showed fast scavenger ability measured with the 2.2-diphenyl-1-picrylhydrazyl radical (DPPH) after high doses of radiation. The low damage caused by irra- diation on antioxidant capacity of the flavonoids shows their potential use in combating chemical oxidation of bio- molecules in irradiated foods.
Development of Animal Model for Studying Deep Second-Degree Thermal Burns
Danielle dos Santos Tavares Pereira,Maria Helena Madruga Lima-Ribeiro,Nicodemos Teles de Pontes-Filho,Ana Maria dos Anjos Carneiro-Le o,Maria Tereza dos Santos Correia
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/460841
Abstract: Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.
Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution
Beatriz Ferreira de Carvalho Patricio,Maria Helena Madruga Lima-Ribeiro,Maria Tereza dos Santos Correia,Ana Maria dos Anjos Carneiro-Le o,Marta de Souza Albernaz,Thiago Barboza,Sergio Augusto Lopes de Souza,Ralph Santos-Oliveira
International Journal of Peptides , 2011, DOI: 10.1155/2011/945397
Abstract: The cramoll 1,4 is a well-studied lectin. However, few studies about its biodistribution have been done before. In this study, we radiolabeled the cramol 1,4 with Tc-99m and analyzed the biodistribution. The results showed that the cramol has an abnormal uptake by the bowel with reflections on its clearance mechanism.
Topical Application Effect of the Isolectin Hydrogel (Cramoll 1,4) on Second-Degree Burns: Experimental Model
Danielle dos Santos Tavares Pereira,Maria Helena Madruga Lima-Ribeiro,Ralph Santos-Oliveira,Carmelita de Lima Bezerra Cavalcanti,Nicodemos Teles de Pontes-Filho,Luana Cassandra Breitenbach Barroso Coelho,Ana Maria dos Anjos Carneiro-Le o,Maria Tereza dos Santos Correia
Journal of Biomedicine and Biotechnology , 2012, DOI: 10.1155/2012/184538
Abstract: This study aimed at evaluating the use of hydrogel isolectin in the treatment of second-degree burns. Twenty male rats were randomly divided into two groups (G1 = treatment with hydrogel containing 100 μg/mL Cramoll 1,4 and G2 = Control, hydrogel). After 7, 14, 21, 28, and 35 days, animals were euthanized. On the 7th day, G1 showed intense exudates, necrosis and edema. On the 14th day, G1 showed tissue reepithelialization and moderate autolysis. On the 21st day, G1 showed intense fibroblastic proliferation, presence of dense collagen, and moderate fibrosis. On the 28th day, G1 showed complete tissue epithelialization. On the 35th day, G1 showed modeled dense collagen. The significant wound contraction was initiated from day, 14 in the G1. There were no significant differences in biochemical and hematological parameters analyzed. These results extend the potential of therapeutic applications for Cramoll 1,4 in the treatment of thermal burns.
O eletrocardiograma no diagnóstico da hipertrofia ventricular de pacientes com doen?a renal cr?nica
Costa, Francisco de Assis;Rivera, Ivan Romero;Vasconcelos, Mirian Lira Castro de;Costa, André Falc?o Pedrosa;Póvoa, Rui Manoel dos Santos;Bombig, Maria Tereza Nogueira;Luna Filho, Bráulio;Lima, Valter Correia de;
Arquivos Brasileiros de Cardiologia , 2009, DOI: 10.1590/S0066-782X2009001000011
Abstract: background: left ventricular hypertrophy (lvh) is an independent predictor of cardiovascular risk, and its characterization and prevalence in chronic renal disease (crd) should be further studied. objective: to establish the diagnosis of lvh in patients with stage-5 crd using six different electrocardiographic criteria, and to correlate them with left ventricular mass index (lvmi) as obtained by echocardiography. methods: cross-sectional study including 100 patients (58 men and 42 women, mean age 46.2 ± 14.0 years) with crd of all causes undergoing hemodialysis (hd) for at least six months. electrocardiography (ecg) and echocardiography were performed in all patients, always up to one hour after the end of the hd sessions. results: lvh was detected in 83 patients (83%), of whom 56 (67.4%) had the concentric pattern and 27 (32.6%) the eccentric pattern of lvh. diagnostic sensitivity, specificity and accuracy of all the electrocardiographic methods studied were higher than 50%. using pearson's linear correlation for lvmi, only the sokolow-lyon voltage criterion did not show a > 0.50 coefficient. calculation of the likelihood ratio, in turn, showed that ecg has a discriminatory power for the diagnosis of lvh in the population studied, with emphasis on the cornell-product and romhilt-estes criteria. no correlation was observed between lvmi and qtc and qtc dispersion. conclusion: ecg is a useful, efficient, and highly reproducible method for the diagnosis of lvh in hd patients. in this population, the cornell-product proved to be the most reliable criterion for the detection of lvh.
Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines
Rodrigo da Silva Ferreira, Dongwen Zhou, Joana Gasperazzo Ferreira, Mariana Cristina Cabral Silva, Rosemeire Aparecida Silva-Lucca, Reinhard Mentele, Edgar Julian Paredes-Gamero, Thiago Carlos Bertolin, Maria Tereza dos Santos Correia, Patrícia Maria Guedes Paiva, Alla Gustchina, Alexander Wlodawer, Maria Luiza Vilela Oliva
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064426
Abstract: A protein isolated from the bark of Crataeva tapia (CrataBL) is both a Kunitz-type plant protease inhibitor and a lectin. We have determined the amino acid sequence and three-dimensional structure of CrataBL, as well as characterized its selected biochemical and biological properties. We found two different isoforms of CrataBL isolated from the original source, differing in positions 31 (Pro/Leu); 92 (Ser/Leu); 93 (Ile/Thr); 95 (Arg/Gly) and 97 (Leu/Ser). CrataBL showed relatively weak inhibitory activity against trypsin (Kiapp = 43 μM) and was more potent against Factor Xa (Kiapp = 8.6 μM), but was not active against a number of other proteases. We have confirmed that CrataBL contains two glycosylation sites and forms a dimer at high concentration. The high-resolution crystal structures of two different crystal forms of isoform II verified the β-trefoil fold of CrataBL and have shown the presence of dimers consisting of two almost identical molecules making extensive contacts (~645 ?2). The structure differs from those of the most closely related proteins by the lack of the N-terminal β-hairpin. In experiments aimed at investigating the biological properties of CrataBL, we have shown that addition of 40 μM of the protein for 48 h caused maximum growth inhibition in MTT assay (47% of DU145 cells and 43% of PC3 cells). The apoptosis of DU145 and PC3 cell lines was confirmed by flow cytometry using Annexin V/FITC and propidium iodide staining. Treatment with CrataBL resulted in the release of mitochondrial cytochrome c and in the activation of caspase-3 in DU145 and PC3 cells.
Ferromagnetic Levan Composite: An Affinity Matrix to Purify Lectin
Renata Angeli,Nathalia V. N. da Paz,Jackeline C. Maciel,Flávia F. B. Araújo,Patrícia M. G. Paiva,Glícia M. T. Calazans,Ana Paula Valente,Fábio C. L. Almeida,Luana C. B. B. Coelho,Luiz B. Carvalho Jr.,Maria da Paz C. Silva,Maria Tereza dos Santos Correia
Journal of Biomedicine and Biotechnology , 2009, DOI: 10.1155/2009/179106
Abstract: A simple and inexpensive procedure used magnetite and levan to synthesize a composite recovered by a magnetic field. Lectins from Canavalia ensiformis (Con A) and Cratylia mollis (Cramoll 1 and Cramoll 1,4) did bind specifically to composite. The magnetic property of derivative favored washing out contaminating proteins and recovery of pure lectins with glucose elution. Cramoll 1 was purified by this affinity binding procedure in two steps instead of a previous three-step protocol with ammonium sulfate fractionation, affinity chromatography on Sephadex G-75, and ion exchange chromatography through a CM-cellulose column.
Biological features on epibiosis of Amphibalanus improvisus (Cirripedia) on Macrobrachium acanthurus (Decapoda)
Farrapeira, Cristiane Maria Rocha;Calado, Tereza Cristina dos Santos;
Brazilian Journal of Oceanography , 2010, DOI: 10.1590/S1679-87592010000700003
Abstract: this study aimed to describe the epibiosis of barnacles amphibalanus improvisus on eight adult macrobrachium acanthurus males from the mundaú lagoon, state of alagoas, brazil. the number of epibiont barnacles varied from 247 to 1,544 specimens per prawn; these were distributed predominantly on the cephalothorax and pereiopods, but also on the abdomen and other appendices. although some were already reproducing, most barnacles had been recruited recently or were still sexually immature; this suggests recent host arrival in that estuarine environment. despite the fact that other barnacles occur in this region, a. improvisus is the only species reported as an epibiont on macrobrachium acanthurus; this was also the first record of epibiosis on this host. the occurrence of innumerable specimens in the pereiopods' articulations and the almost complete covering of the carapace of some prawns (which also increased their weight) suggest that a. improvisus is adapted to fixate this kind of biogenic substrate and that the relationship between the two species biologically damages the basibiont.
Iara Regina dos Santos Parisotto,Maria Tereza Saraiva de Souza
GEST?O.Org : Revista Eletr?nica de Gest?o Organizacional , 2012,
Abstract: The aim of this study was to analyze the investments in social and environmental actions by the Brazilian banking sector, as disclosed in their annual social and sustainability report referring to the period between 2007 and 2009, relating to added value, net operating income and net income. The sample comprises a population of 136 banks, in the National Financial System. The ranges were established according to the size of the banks, through the criterion of Total Assets. The research is descriptive and quantitative, using documentary procedure. The analysis shows that all institutionshave decreased net income (LL) in relation to Net Operating Income(NOI), except for one bank. When comparing the social investmentsinternal, external and environment, compared to LL, it was observed that, despite all the banks have increased their domestic socialinvestment in relation to LL only two of them increased, the social investment foreign banks increased by two, but in relation to LL,this percentage is considerably lower. The only increase in investments in the environment occurred in one institution that had the same increase over the LL.
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