oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

4 ( 1 )

3 ( 1 )

2019 ( 103 )

2018 ( 140 )

Custom range...

Search Results: 1 - 10 of 71025 matches for " Maria Sortino "
All listed articles are free for downloading (OA Articles)
Page 1 /71025
Display every page Item
Linagliptin: A thorough Characterization beyond Its Clinical Efficacy
Maria Angela Sortino,Tiziana Sinagra,Pier Luigi Canonico
Frontiers in Endocrinology , 2013, DOI: 10.3389/fendo.2013.00016
Abstract: Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long terminal half-life allowing prolonged exposure to the drug. It is eliminated predominately through the intestinal tract and only minimally into urine, so that it can be administered, without any dose adjustment, in conditions of renal impairment. Linagliptin is effective in modifying all parameters of hyperglycemia either in monotherapy, or as add-on therapy, together with metformin or a sulfonylurea. It also exhibits a good tolerability profile with few side effects, absence (when used in monotherapy), or low risk (when in combination with a sulfonylurea) of hypoglycemia. More importantly it has a weight neutral effect. A comprehensive report of the literature on linagliptin is provided, paying attention in particular to preclinical studies, interactions with other drugs, safety and tolerability, and results obtained in animal models that highlight properties of linagliptin suggestive of potential additional uses. Particularly promising appear the data demonstrating a positive effect of linagliptin on metabolic dysfunction and renal and/or cardiovascular damage together with more recently reported effects of linagliptin on tissue repair and neuroprotection.
Melanoma cutaneo: estudo de base populacional em Goiania, Brasil, de 1988 a 2000
Sortino-Rachou, Ana Maria;Curado, Maria Paula;Latorre, Maria do Rosário Dias de Oliveira;
Anais Brasileiros de Dermatologia , 2006, DOI: 10.1590/S0365-05962006000500007
Abstract: background: the goiania population-based cancer registry grants access to a 13-year temporal series on melanoma data, with a histopathologic confirmation of 96.6%. objective: to compare the world incidence, mortality and trends with data of the first populationbased study on cutaneous melanoma in brazil. methods: two hundred and ninety new cases of melanoma diagnosed in city residents (incidence) and 54 deaths reported to the goiania cancer registry (mortality) were analyzed between 1988 and 2000. the standardized coefficients of age and sex were calculated using the world population. the trends were analyzed by simple linear regression models. results: one hundred and forty-four cases of melanoma in women and 146 in men. the mean standardized incidence rates were increasing in both men (r2=0.33; p=0.040) and women (r2=0.41; p=0.019), with a significant increase in men over 60 years old and women aged up to 59. the mean standardized mortality rates were increasing in men (r2=0.32; p=0.042) and stable in women, with a significant increase in men aged over 60 years. conclusions: in goiania, as well as around the world, cutaneous melanoma incidence rates are increasing in both sexes. mortality rates tend to stabilize in women and increase in men.
Cutaneous melanoma in Latin America: a population-based descriptive study
Sortino-Rachou, Ana Maria;Curado, Maria Paula;Cancela, Marianna de Camargo;
Cadernos de Saúde Pública , 2011, DOI: 10.1590/S0102-311X2011000300016
Abstract: cutaneous melanoma incidences vary between geographic regions and are a health concern for caucasians and for all ethnic populations. in latin america, data from population-based cancer registries of cutaneous melanoma incidence rates have rarely been reported. we searched the cancer incidence in five continents volume ix (ci5-ix) database for cutaneous melanoma and select cases by topography (c43) from 11 population-based cancer registries in latin america. between 1998 and 2002, a total of 4,465 cutaneous melanoma cases were reported in latin america. the average age-standardized incidence rates (per 100,000 persons-year) was 4.6 (male) and 4.3 (female). this study presents an overview of cutaneous melanoma incidence in latin america, highlighting the need to enhance coverage of population-based cancer registries in latin america, to allow for a better understanding of this neoplasm in the region. thus it can help in implementing primary prevention programs for the whole latino population. at this point in time, early detection messages should target young women and older men in latin america.
Radiación y distribución de planta (Layout) como gestión empresaria
Roberto A. Sortino
Invenio , 2001,
Abstract: En el presente artículo se realizaron acotaciones sobre la distribución (LAYOUT) y radicación de plantas, tendientes a optimizar esta distribución. Al acercarnos a un mundo cada vez más globalizado, de movimientos virtuales, es evidente que toda regla, experiencia o método adquirido a través de a os quedan de lado rápidamente. Lo más dificultoso precisamente se halla en que, en la complejidad de las decisiones, tanto para la radicación como para la distribución, aparecen innumerables factores macro no relacionados con reglas básicas de la ingeniería, sino con un sinnúmero de variables mucho más complejas. El autor intenta proveer herramientas de análisis de estos factores tan importantes, de cuyo acierto o error puede depender la vida de la propia empresa
Growth and Yield Performance of Five Guar Cultivars in a Mediterranean Environment
Orazio Sortino,Fabio Gresta
Italian Journal of Agronomy , 2008, DOI: 10.4081/ija.2007.359
Abstract: In order to evaluate growth and yield performance of guar (Cyamopsis tetragonoloba L.) in Mediterranean area, main morphological parameters (plant height, dry weight of single plant parts, branch and leaf number), dry biomass accumulation and seed yield response of five varieties of guar (Esser, Malosan, Kinman, Lewis and Santa Cruz) were studied. Seed crude protein and fibre content were also determined. Irrigation was applied to ensure that water availability did not limit production. The growing season of guar lasted for 120 days for all the varieties. Average plant height at harvest was about 63 cm (ranging from 56.0 to 70.6 cm). The highest dry weight increment was recorded during 55-70 days after sowing. Malosan, Santa Cruz and Kinman showed the highest individual seed weight (> 30 mg). Above average leaf and branch number were observed in Kinman, Esser and Santa Cruz. The greatest seed protein content was observed in Lewis and Esser (35.6% and 34.7%). High yield and seed quality were obtained in these environments with limited water supply, indicating that guar may represent a valid alternative multipurpose crop for semiarid regions.
Growth and Yield Performance of Five Guar Cultivars in a Mediterranean Environment
Orazio Sortino,Fabio Gresta
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2007.359
Abstract: In order to evaluate growth and yield performance of guar (Cyamopsis tetragonoloba L.) in Mediterranean area, main morphological parameters (plant height, dry weight of single plant parts, branch and leaf number), dry biomass accumulation and seed yield response of five varieties of guar (Esser, Malosan, Kinman, Lewis and Santa Cruz) were studied. Seed crude protein and fibre content were also determined. Irrigation was applied to ensure that water availability did not limit production. The growing season of guar lasted for 120 days for all the varieties. Average plant height at harvest was about 63 cm (ranging from 56.0 to 70.6 cm). The highest dry weight increment was recorded during 55-70 days after sowing. Malosan, Santa Cruz and Kinman showed the highest individual seed weight (> 30 mg). Above average leaf and branch number were observed in Kinman, Esser and Santa Cruz. The greatest seed protein content was observed in Lewis and Esser (35.6% and 34.7%). High yield and seed quality were obtained in these environments with limited water supply, indicating that guar may represent a valid alternative multipurpose crop for semiarid regions.
Hyperalgesic activity of kisspeptin in mice
Simona Spampinato, Angela Trabucco, Antonella Biasiotta, Francesca Biagioni, Giorgio Cruccu, Agata Copani, William H Colledge, Maria Sortino, Ferdinando Nicoletti, Santina Chiechio
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-90
Abstract: Immunofluorescent staining in the mouse skin showed the presence of GPR54 receptors in PGP9.5-positive sensory fibers. Intraplantar injection of kisspeptin (1 or 3 nmol/5 μl) induced a small nocifensive response in naive mice, and lowered thermal pain threshold in the hot plate test. Both intraplantar and intrathecal (0.5 or 1 nmol/3 μl) injection of kisspeptin caused hyperalgesia in the first and second phases of the formalin test, whereas the GPR54 antagonist, p234 (0.1 or 1 nmol), caused a robust analgesia. Intraplantar injection of kisspeptin combined with formalin enhanced TRPV1 phosphorylation at Ser800 at the injection site, and increased ERK1/2 phosphorylation in the ipsilateral dorsal horn as compared to naive mice and mice treated with formalin alone.These data demonstrate for the first time that kisspeptin regulates pain sensitivity in rodents and suggest that peripheral GPR54 receptors could be targeted by novel drugs in the treatment of inflammatory pain.Kisspeptin is a 54-amino acid peptide originally discovered for its activity as metastasis-suppressor [1]. It is encoded by the Kiss1 gene as a 145-amino acid precursor protein and cleaved to a 54-amino acid protein as well as into shorter products (kisspeptin-10,-13,-14) known to play a critical role in the neuroendocrine regulation of reproduction [2-5].In the brain, kisspeptin is localized not only in areas involved in gonadotropin secretion, but also in other regions such as the amygdala, hippocampus, and the periacqueductal gray [6,7].Its action is mediated by a 7-TM receptor named GPR54, also known as KISS1R, which is coupled to polyphosphoinositide hydrolysis via a Gq/11 GTP binding protein [2,8].Loss-of-function mutations of GPR54 cause a non-Kallman variant of hypogonadotropic/hypogonadism in humans (i.e. hypogonadotropic/hypogonadism without anosmia) [2,9]. Interestingly, the expression of kisspeptin and GPR54 is not restricted to the hypothalamus. Relatively high levels of kisspeptin and GPR5
Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury
Tiziana Genovese, Salvatore Cuzzocrea, Rosanna Di Paola, Marco Failla, Emanuela Mazzon, Maria Sortino, Giuseppina Frasca, Elisa Gili, Nunzio Crimi, Achille P Caputi, Carlo Vancheri
Respiratory Research , 2005, DOI: 10.1186/1465-9921-6-58
Abstract: Mice subjected to intratracheal administration of bleomycin developed a significant lung injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in lungs from bleomycin-treated iNOSWT mice.The intensity and degree of nitrotyrosine staining was markedly reduced in tissue section from bleomycin-iNOSKO mice. Treatment of iNOSWT mice with of GW274150, a novel, potent and selective inhibitor of iNOS activity (5 mg/kg i.p.) also significantly attenuated all of the above indicators of lung damage and inflammation.Taken together, our results clearly demonstrate that iNOS plays an important role in the lung injury induced by bleomycin in the mice.Pulmonary fibrosis is a progressive interstitial lung disease of unknown etiology. Pulmonary fibrosis is characterized by inflammatory cell infiltration, fibroblast proliferation, and excessive deposition of extracellular matrix proteins in the lung parenchyma [1,2]. The disease most commonly affects middle-age adults, although infants and children are also affected. Various studies have also indicated that the treatment with bleomycin during cancer chemotherapy in humans also induces interstitial fibrosis [3,4].Nitric oxide (NO) is a pleiotropic mediator, which acts in a variety of physiological and pathophysiological processes [5-8]. NO is produced from the oxidation of L-arginine by the enzyme NO synthase [9,10] which occurs in three major isoforms; two are constitutive (endothelial and neuronal, indicated with cNOS), and one is inducible (macrophagic). The constitutively expressed enzyme (cNOS) are calcium-dependent, release NO under physiological condition in various cells, including endothelial cells and neurons, and NO released by these isoform are involved in the regulation of blood pressure in organ blood flow distribution, in the inhibition of the adhesion and activation of platelets and polymorphonuclear granulocytes and in neuronal transmission. The inducible isoform of NOS (iNOS) is calcium-i
PROJETO EMPREENDER NAS ASSOCIA ES COMERCIAIS E INDUSTRIAIS DA REGI O DO ABCD
Carla Sortino Bassi,Priscila Ferreira Perazzo
Revista da Micro e Pequena Empresa , 2011,
Abstract: Este artigo tem como objetivo apresentar o Projeto Empreender desenvolvido nas Associa es Comerciais e Industriais de Santo André, S o Bernardo do Campo, S o Caetano do Sul e Diadema, e a abordagem das possibilidades do associativismo a partir da avalia o dos principais gestores dessas entidades. Por meio da história oral, fez-se a análise sobre as potencialidades e as restri es acerca dessa prática, sua forma de aplica o e os possíveis resultados diante da diversidade de atores envolvidos. Essa proposta justifica-se pela necessidade da compreens o de novos modelos organizacionais, que respondam às necessidades atuais cada vez mais complexas, e que sejam capazes de atender às dimens es dos seres humanos da sociedade em geral.
Reswitching of Techniques in the Modern Agriculture: a Theoretical Background
Antonio SORTINO,Margherita CHANG TING FA
Annals of Dun?rea de Jos University. Fascicle I : Economics and Applied Informatics , 2008,
Abstract: The industrialization of the agricultural sector has resolved, at least inEurope, United States and Japan, the thousand year-old problem of the lack of food.Unfortunately, during the last years the environmental limits of such an agricultureclearly exploded. Through our contribution we define the concepts of traditionaland modernized styles of farming. We also hypothesize three future scenarios formodernized agriculture. We shall study in particular the “return of techniques”scenario that foresees the conversion to sustainability through the return oftraditional techniques. In order to analyze this scenario, we shall introduce theSraffian framework of the “reswitching of techniques” from the neo-ricardiantheory (Sraffa 1960). Sraffa, within the “reswitching” framework, pointed out that alow-capital-intensive technique may be competitive both at a relatively low andhigh rate of profit. Finally, we shall show that, at least theoretically, it is possiblethat traditional agricultural techniques could be convenient in a context of both lowand high profit level.
Page 1 /71025
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.