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Search Results: 1 - 10 of 226852 matches for " Maria Regina Andrade de Azevedo "
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Platelet Indices in Patients with Acute Coronary Syndrome  [PDF]
Silvia Cristina Costa, Carmen Guilherme de Matos Vinagre, Ana Paula Marte Chacra, Maria Regina Andrade de Azevedo
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.311009
Abstract: The platelet indices Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Plate-letcrit (PCT) provided by automated hematology analysis are rarely used in clinical practice. Platelets play a central role in the pathogenesis of acute coronary syndromes (ACS) and high MPV has been associated to more reactive platelets and regarded as an independent risk factor for myocardial infarction. In this study, platelet indices were evaluated in 39 patients with ACS presenting two altered biochemical parameters, C reactive protein (CRP) and creatine kinase fraction MB (CK-MB). The results obtained showed significantly higher MPV and PDW values in the group with ACS in comparison to the control group. Also observed was a weak but significant positive correlation between MPV and CK-MB. In view of findings of previous studies, which have associated macroplatelets with higher thrombotic potential our results suggest that the use of the MPV and PDW indices as additional and complementary markers may contribute to the investigation and follow-up of thrombotic risk in patients with ACS.
Efeito protetor do extrato de agaricus sylvaticus em fígado de ratos do tipo wistar inoculado com pristane
Edgar Matias Bach Hi,Maria Regina Andrade de Azevedo,Erna Elisabeth Bach,Terezinha Regina Prupere Ogata
Saúde Coletiva , 2008,
Abstract: Los hongos Agaricus son usados por más de mil a os por sus propiedades medicinales incluso el antitumoral, antiangiogénico, el antihiperlipidémico, inmunomodulador, el antibacteriano, liberación de óxido nítrico, y otros. El objetivo de este trabajo fue evaluar el efecto del extracto concentrado de Agaricus sylvaticus producido por la compa ía Cogumelo del Sol inoculados en ratos con Pristane (2,6,10,14-tetrametilpentadecano). Una droga carcinogénica. Después de los sacrificios de los ratos, se realizó dosificaciones séricas de albúmina, aminotransferases (ALT e AST); además de anatomo y el histopatológico del hígado afectados por pristane. Los resultados mostraron que el pristane es un agente carcinogénico, y muestra que el extracto de Agaricus sylvaticus tiene actividad protectora y la posible actividad inmunomoduladora, sin producir efecto tóxico en los animales estudiados
Análise de teses e disserta??es em avalia??o psicológica disponíveis na BVS-PSI Brasil
Joly, Maria Cristina Rodrigues Azevedo;Berberian, Arthur de Almeida;Andrade, Regina Gioconda de;Teixeira, Tatiana Cristina;
Psicologia: Ciência e Profiss?o , 2010, DOI: 10.1590/S1414-98932010000100013
Abstract: the present study aimed to verify the scientific production of the thesis and dissertations in psychological assessment in brazil, all which are from the biblioteca virtual em saúde do brasil (bvs-psi brasil). 141 theses’ and dissertations’ abstracts that referred to studies with psychological assessment, psychometric, validity, reliability and psychological tests as keywords were analyzed. the results showed that 54,6% of the abstracts were from masters’ dissertations, 43,3% of phd’s thesis and 2,1% were from post-doctoral thesis. 19,15% of the studies were defended in universities established in the south region of the country, 80,14% in the southeast and 0,71% in the northeast region. it can be seen that most of the scientific production in psychological assessment comes from the southeast region. it was verified that 60,3% were aimed to search psychometrics parameters and 27,7% had the purpose of using the test to validate intervention protocols, describe specific abilities and study relations between variables, being most of them from transversal studies. the constructs most studied are personality and intelligence and the clinic and the school are the areas of application where the psychological assessment is most used, according to the study’s results.
The Chlorine reference value in whole blood using ANAA
Oliveira, Laura Cristina;Zamboni, Cibele Bugno;Lins, Patricia da Silva;Oliveira, Maria Regina Andrade de Azevedo e;
Brazilian Journal of Physics , 2005, DOI: 10.1590/S0103-97332005000500019
Abstract: the absolute neutron activation analysis (anaa) technique was used to estimate the reference value for cl in whole blood of healthy group, selected from blood banks at s?o paulo city, to provide information which can help in diagnosis of patients. the results show that the indicative interval obtained for cl in serum from the nuclear analysis (3.41 - 3.69 μg ·ml-1) is in agreement with the reference value adopted (3.44 - 3.76 μg ·ml-1) in addition, an indicative interval for cl (2.75 - 2.95 μg ·ml-1) could be proposed for whole blood. the advantages and limitations of using this nuclear methodology were discussed.
Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions
Bianchi, Juliana Vieira dos Santos;Azevedo, Maria Regina Andrade de;Jens, Eduardo;Nukui, Youko;Chamone, Dalton Alencar Ficher;
Revista Brasileira de Hematologia e Hemoterapia , 2012, DOI: 10.5581/1516-8484.20120050
Abstract: objective: the objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions. methods: platelet antigen genotyping was performed by sequence-specific primer polymerase chain reaction (ssp-pcr) for the hpa-1a, hpa-1b, hpa-2a, hpa-2b, hpa-3a, hpa-3b, hpa-4a, hpa-4b, hpa-5a, hpa-5b; hpa-15a, hpa-15b alleles in 150 patients of the hematology service of the hospital das clínicas (fmusp). results: the allele frequencies found were: hpa-1a: 0.837; hpa-1b: 0.163; hpa-2a: 0.830; hpa-2b: 0.170; hpa-3a: 0.700; hpa-3b: 0.300; hpa-4a: 1; hpa-4b: 0; hpa-5a: 0.887; hpa-5b: 0.113; hpa-15a: 0.457 and hpa-15b: 0.543. conclusions: data from the present study showed that the a allele is more common in the population than the b allele, except for hpa-15. this suggests that patients homozygous for the b allele are more predisposed to present alloimmunization and refractoriness to platelet transfusions by immune causes. platelet genotyping could be of great value in the diagnosis of alloimmune thrombocytopenia and to provide compatible platelet concentrates for these patients.
Serologic survey of hantavirus in a rural population from the northern State of Mato Grosso, Brazil
Santos, Ioni Oliveira;Figueiredo, Glauciane Garcia de;Figueiredo, Luiz Tadeu Moraes;Azevedo, Maria Regina Andrade de;Novo, Neil Ferreira;Vaz, Celidéia Aparecida Coppi;
Revista da Sociedade Brasileira de Medicina Tropical , 2012, DOI: 10.1590/S0037-86822012005000002
Abstract: introduction: hantavirus is a genus of ribonucleic acid (rna) viruses included in the family bunyaviridae. hantaviruses are rodent-borne zoonoses that, in the last 18 years, became an emergent public health problem in the americas, causing a severe cardiopulmonary syndrome. this disease has no specific treatment and has a high case fatality. the transmission of hantavirus to man occurs by inhaling aerosols of rodent excreta. the aim of this study was to determine the prevalence of antibodies to hantavirus in the population of the rural settlement of tup? in the county of marcelandia, state of mato grosso, brazil. methods: the participants of the serologic survey were visited at their homes and selected randomly among the settlement population. blood samples of the participants were collected by venopuncture. the serum samples were tested by an igg-elisa using an n recombinant protein of araraquara hantavirus as antigen, using the protocol previously established by figueiredo et al. results: igg antibodies to hantavirus were detected in 7 (13%) of the 54 participants. the positivity was higher among men. it was observed that there was an association of seropositivity to hantavirus within the participants born in the south of brazil. conclusions: the results suggest that, in this rural area, everyone is exposed to the same risk of becoming infected with hantavirus, and, therefore, there is a need to intensify surveillance activities and education of the local people to prevent this viral infection.
Photo-Induced Thermally Stimulated Depolarization Current (TSDC) in Natural and Synthetic Alexandrite (BeAl2O4:Cr3+)  [PDF]
Neilo Marcos Trindade, Ana Regina Blak, Elisabeth Mateus Yoshimura, Luis Vicente de Andrade Scalvi, Rosa Maria Fernandes Scalvi
Materials Sciences and Applications (MSA) , 2016, DOI: 10.4236/msa.2016.712067
Abstract: The investigation of electrical properties in alexandrite (BeAl2O4:Cr3+) in synthetic and natural forms is presented in this paper. Alexandrite is a rare and precious mineral that changes color according to the light incident on it. In the synthetic form, it is used technologically as an active laser medium. The electrical characterization was obtained using the Thermally Stimulated Depolarization Current (TSDC) technique, an interesting tool to study the behavior of impurities in insulators. Alexandrite presented the electric dipole relaxation phenomenon, both in natural and in synthetic samples. It was possible to observe TSDC bands for the synthetic sample at around 170 K, and at around 175 K for the natural sample. Besides, photo-induced TSDC measurements were performed through the excitement of the samples by using a continuous wave argon laser. In addition, photoluminescence measurements were performed to verify in advance whether the laser light would be absorbed by the sample, and in order to complement the photo-induced TSDC measurements analysis. The results of photo-induced TSDC experiments have contributed to the understanding of the TSDC bands behavior: the results obtained with the technique suggest that there is an effective participation of Cr3+ ions in the formation of TSDC bands because they were more intense when the sample was exposed to the argon laser beam.
O conhecimento em sala de aula: a organiza??o do ensino numa perspectiva interdisciplinar
Azevedo, Maria Antonia Ramos de;Andrade, Maria de Fátima Ramos de;
Educar em Revista , 2007, DOI: 10.1590/S0104-40602007000200015
Abstract: this paper is a bibliographic research about interdisciplinarity and its organization in the curriculum. the concept of interdisciplinarity is discussed and a few epistemologic-methodological approaches are proposed to introduce the interdisciplinary practice in the school routine. as a conclusion, it is emphasized that interdisciplinarity should be taken as an instrument that may allow school to be an environment where critical and collective knowledge may be produced. to such end, curriculum should be redesigned and continuing teacher education practiced. it is needed, on one hand, to plan and operate knowledge vertically through the curriculum matrix, relating the idea of increasing complexity and deepening (vertical dimension), and in the other hand to relate the knowledge of one discipline to another (horizontal dimension). the idea of interdisciplinarity should delicately bring together the vertical and horizontal dimensions through curriculum and teacher practice, to allow the emergence of new knowledge with relational and contextual meaning.
Fibronectin glycation increases IGF-I induced proliferation of human aortic smooth muscle cells
Maria Corrêa-Giannella, Maria Regina de Azevedo, Derek LeRoith, Daniel Giannella-Neto
Diabetology & Metabolic Syndrome , 2012, DOI: 10.1186/1758-5996-4-19
Abstract: Both type I and type II diabetes are powerful and independent risk factors for coronary artery disease, stroke, and peripheral arterial disease [1,2]. Prolonged exposure to hyperglycemia is recognized as the primary casual factor in the pathogenesis of diabetic complications [3,4]. Hyperglycemia induces a large number of alterations in vascular tissue that potentially promote accelerated atherosclerosis. Glycation of proteins is an important biochemical mechanism by which glucose mediates tissue damage, leading to the generation of advanced glycation endproducts (AGEs) and modifying the structure and function of several proteins, such as those which comprise extracellular matrixes [5]. It has been demonstrated that AGE formation alters some functional properties of collagen [6], vitronectin [7], laminin [8], and fibronectin (FN) [9], affecting their self-assembly and their binding to each other. AGEs can also induce synthesis and secretion of cytokines and growth factors after binding to AGE receptors (RAGE) in different cell types [7]. Monocytes exposed to AGE-modified matrix release tumor necrosis factor-α (TNF-α) [10], platelet-derived growth factor (PDGF) [11] and insulin-like growth factor-I (IGF-I) [12]. In vascular smooth muscle cells (SMC) AGE-RAGE interaction has been shown to activate cell signalling pathways linked to expression of inflammatory and prothrombotic genes, such as ERK1/ERK2 kinases and NF-kB [13].The SMC, which constitute the medial layer of arteries, are normally in a differentiated contractile phenotype, but during the development of atherosclerotic lesions, a subpopulation of SMC is converted to a synthetic phenotype that is able to migrate and proliferate. Extracellular matrix proteins actively participate in this process, affecting SMC phenotype and modulating the cellular response to growth-regulatory molecules [14]. FN, which is found in increased amounts in early atherosclerotic plaques [15,16], can interact with cell surface receptor
Representa??es sociais da depress?o em jovens universitários com e sem sintomas para desenvolver a depress?o
Fonseca, Aline Arruda da;Coutinho, Maria da Penha de Lima;Azevedo, Regina Lígia Wanderlei de;
Psicologia: Reflex?o e Crítica , 2008, DOI: 10.1590/S0102-79722008000300018
Abstract: the objective of this research was to understand the social representations of depression in the students of the psychology course from a university in the city of jo?o pessoa, pb. a number of 56 university students participated of the research, from both genders, aged between 18 and 26 years old. as instruments, the beck depression inventory for the screening of the sample and the test of free association of words were used. data were processed by tri-deux-mots software (version 2.2) and were analyzed through the factorial analysis of correspondence. the results obtained showed that the students objectified their representations of depression in the melancholy and disillusion, in a bond of support and necessity of care. lack of affection was also pointed as a depressive fact, and the factors associated to the perception of themselves are elaborated with the social reality of the context in which they live, showing that the semantic associations brought by the university students are a result of the problems that surround their position in the society, as well as the information they gave about the illness.
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