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Search Results: 1 - 10 of 71027 matches for " Maria Palmira Daflon; "
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Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions
Urban, Maria Cristina Cocenza;Mainardes, Rubiana Mara;Gremi?o, Maria Palmira Daflon;
Brazilian Journal of Pharmaceutical Sciences , 2009, DOI: 10.1590/S1984-82502009000100010
Abstract: a simple, rapid, accurate and sensitive method was developed for quantitative analysis of dexamethasone acetate in microemulsions using high performance liquid chromatography (hplc) with uv detection. the chromatography parameters were stainless steel lichrospher 100 rp-18 column (250 mm x 4 mm i.d., 5 μm particle size), at 30 ± 2 oc. the isocratic mobile phase was methanol:water (65:35; v/v) at a flow rate of at 1.0 ml.min-1. the determinations were performed using uv-vis detector set at 239 nm. samples were prepared with methanol and the volume injected was 20 μl. the analytical curve was linear (r2 0.9995) over a wide concentration range (2.0-30.0 μg.ml-1). the presence of components of the microemulsion did not interfere in the results of the analysis. the method showed adequate precision, with a relative standard deviation (rsd) smaller than 3%. the accuracy was analyzed by adding a standard drug and good recovery values were obtained for all drug concentrations used. the hplc method developed in this study showed specificity and selectivity with linearity in the working range and good precision and accuracy, making it very suitable for quantification of dexamethasone in microemulsions. the analytical procedure is reliable and offers advantages in terms of speed and low cost of reagents.
Mucoadhesive drug delivery systems
Carvalho, Flávia Chiva;Bruschi, Marcos Luciano;Evangelista, Raul Cesar;Gremi?o, Maria Palmira Daflon;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000100002
Abstract: drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. these systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. several in vitro and in vivo methodologies are proposed for studying its mechanisms. however, mucoadhesion is not yet well understood. the aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
Thermoanalytical study of praziquantel-loaded PLGA nanoparticles
Mainardes, Rubiana Mara;Gremi?o, Maria Palmira Daflon;Evangelista, Raul Cesar;
Revista Brasileira de Ciências Farmacêuticas , 2006, DOI: 10.1590/S1516-93322006000400007
Abstract: polymeric nanoparticles have received great attention as potential controlled drug delivery systems. biodegradable polymers has been extensively used in the development of these drug carriers, and the polyesters such as polylactic acid, polyglycolic acid and their copolymers as poly-lactide-co-glycolide are the most used, considering its biocompatibility and biodegradability. thermal analysis techniques have been used for pharmaceutical substances for more than 30 years and are routine methods for screening drug-excipient interactions. the aim of this work is to use thermal analysis to characterize plga nanoparticles containing a hydrophobic drug, praziquantel. the results show that the drug is in an amorphous state or in disordered crystalline phase of molecular dispersion in the plga polymeric matrix and that the microencapsulation process did not interfere with the chemical structure of the polymer, mantaining the structural drug integrity.
Sistemas de libera??o de fármaco intrabolsa periodontal
Bruschi, Marcos Luciano;Panzeri, Heitor;Freitas, Osvaldo de;Lara, Elza Helena Guimar?es;Gremi?o, Maria Palmira Daflon;
Revista Brasileira de Ciências Farmacêuticas , 2006, DOI: 10.1590/S1516-93322006000100004
Abstract: periodontal disease is very common in the world population. it is caused by the accumulation of microbial components of the dental biofilm inside the subgingival areas, producing an inflammatory process that affects the supporting structures of tooth, periodontal pockets and loss of the teeth, if not treated. the conventional treatment consists of tooth surface mechanical cleaning and root planning, associated or not to the systemic use of high concentrations of antibiotics, but with reduced effectiveness, and adverse effects. the patient compliance to the therapeutic is committed too. in the last decades, the treatment has been optimized for the use of drug delivery systems to the periodontal pocket, with the advantage of delivering the drug in the specific site, sustaining and/or controlling the drug concentration. recently, the use of new drug delivery systems has been receiving great interest. this review approaches the main delivery systems for the administration of drugs to the periodontal pocket, their usefulness, as well as the available protocols for the evaluation of these systems effectiveness in the periodontal therapy.
Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel
Chaud, Marco Vinicius;Tamascia, Pollyanna;Lima, Andréa Cristina de;Paganelli, Maria Ondina;Gremi?o, Maria Palmira Daflon;Freitas, Osvaldo de;
Brazilian Journal of Pharmaceutical Sciences , 2010, DOI: 10.1590/S1984-82502010000300010
Abstract: the solubility behavior of drugs remains one of the most challenging aspects in formulation development. solid dispersion (sd) has tremendous potential for improving drug solubility. although praziquantel (pzq) is the first drug of choice in the treatment of schistosomiasis, its poor solubility has restricted its delivery oral route. in spite of its poor solubility, pzq is well absorbed in the gastrointestinal tract, but large doses are required to achieve adequate concentration at the target sites. the aim of this study was to improve the solubility and dissolution rate of pzq and to evaluate its intestinal absorption. sds were formulated with peg-60 castor oil hydrogenated (cr-60) using a fusion and evaporation method. pure pzq and physical mixtures (pm) and pzq-cr-60 (2:1; 1:1; 1:2 ratios) were compared as regards their solubility, dissolution and intestinal absorption. the experimental results demonstrated the improvement in the solubility, dissolution rate and intestinal absorption. in addition, the solubility behavior showed ph dependency and that the solubility of pzq was slower in acidic medium than in neutral and basic mediums. the increase in pzq solubility of the sd with the cr-60 could be attributed to several factors such as improved wettability, local solubilization, drug particle size reduction and crystalline or, interstitial solid solution reduction.
Microemuls?es e fases líquidas cristalinas como sistemas de libera??o de fármacos
Formariz, Thalita Pedroni;Urban, Maria Cristina Cocenza;Silva Júnior, Arnóbio Ant?nio da;Gremi?o, Maria Palmira Daflon;Oliveira, Anselmo Gomes de;
Revista Brasileira de Ciências Farmacêuticas , 2005, DOI: 10.1590/S1516-93322005000300003
Abstract: depending on the proportions, the mixture of surfactants with water, in the presence or absence of oil, may form different types of supramolecular aggregates. among these, polymorphic structures represented by microemulsions (me) and lyotropic mesophases-liquid crystals (lc), closely related with the nature and the proportion of the constituents, can exist. in this work, the role of these systems in the incorporation of drugs with different physico-chemical properties, influencing strongly the drug release as well as the bioavailability of the drugs, was discussed. aspects about the formation and the characterization of me and lc were also discussed. the analysis of the literature indicate that depending on the drug polarity the effect of me or lc can be used to optimizes therapeutic effects through the control of rates and the drug release mechanisms.
Corrositex?, BCOP and HET-CAM as alternative methods to animal experimentation
Cazedey, Edith Cristina Laignier;Carvalho, Flávia Chiva;Fiorentino, Flávia Angélica Másquio;Gremi?o, Maria Palmira Daflon;Salgado, Hérida Regina Nunes;
Brazilian Journal of Pharmaceutical Sciences , 2009, DOI: 10.1590/S1984-82502009000400021
Abstract: tests in animals are used as models in toxicological and investigative studies. however, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. international organizations, such as the interagency coordinating committee on the validation of alternative methods (iccvam), the national institute of health (nih), the organization for economic co-operation and development (oecd), that regulate and develop new alternative animal models, have indicated the running of preliminary assays and execution of sequential tests, which consider physical-chemical properties and data of in vitro assays, before performing in vivo studies. towards this background, the objective of the present article was to select promising alternative methods such as corrositex?, bcop and het-cam, intended to refine or replace the use of animals and reduce their suffering.
Efeito da concentra??o do amido de milho na libera??o de paracetamol de comprimidos
Castro, Ana Dóris de;Vicente, Joice Alessandra;Mour?o, Samanta Cardozo;Bueno, José Hamilton Ferreira;Evangelista, Raul Cesar;Gremi?o, Maria Palmira Daflon;
Revista Brasileira de Ciências Farmacêuticas , 2003, DOI: 10.1590/S1516-93322003000300008
Abstract: this paper describes the influence of maize starch concentration on the physical characteristics and on in vitro release of acetaminophen from compressed tablets. the granulates were analyzed in relation to size distribution and bulk and compacted densities, and the tablets in relation to mean weight, thickness, hardness, friability and disintegration time. the tablets were prepared from granulates made by wet granulation with 10% starch paste in three formulations. although the tablets obtained have presented characteristics in accordance with pharmacopeial limits, the results indicate that variations on starch concentration cause differences on the several physical parameters studied. higher starch concentration probably originates an interaction among the ingredients of the formulations, interfering on the in vitro drug release.this fact demonstrates the importance in optimizing the concentration of the adjutants in a tablet formulation, because, although a short variation in this concentration has no significant effect on disintegration time, the amount of released drug can be substantially modified.
Rádice: passado e futuro
Santos, Alessandra Daflon dos;Jacó-Vilela, Ana Maria;
Psicologia & Sociedade , 2005, DOI: 10.1590/S0102-71822005000300004
Abstract: this paper presents "rádice" - a psychology magazine, published by psychologists from rio de janeiro between 1976 and 1981. this publication had a huge intellectual and emotional importance for a generation of psychology students graduated during the period of militar dictatorship in brazil. "rádice" offered to its readers papers on diverse and polemical themes, unusual to psychology publications of that epoch, such as political repression, nonhuman treatment in psychiatric hospitals, regulation of the psychologist profession, and corporal therapies. "rádice" was, like other small publications, part of the alternative press committee, and had an active participation on the political debates of that time. "rádice", thus, allows us to analyze the history of psychology in rio de janeiro, being one of the fews devices to present other ways of doing psychology.
1o Encontro sobre e Portefólio / Aprendizagem Formal e Informal
Lia Raquel Oliveira,Maria Palmira Alves
Revista Portuguesa de Educa??o , 2007,
Abstract:
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