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Search Results: 1 - 10 of 464248 matches for " Maria M. Byrne "
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Pheochromocytoma presenting as recurrent urinary tract infections : a case report
Roisin T Dolan, Joseph S Butler, Gerard P McEntee, Maria M Byrne
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-6
Abstract: A 43-year-old Caucasian woman was referred to us from primary care services with a three-month history of recurrent urinary tract infections on a background of hypertension, latent autoimmune diabetes of adulthood and autoimmune hypothyroidism. At 38 years she required insulin therapy. Despite medication compliance and dietary control, she reported a recent history of increased insulin requirements and uncontrolled hypertension with concomitant recurrent urinary tract infections. A renal ultrasound examination, to rule out underlying renal pathology, revealed an incidental 8cm right adrenal mass of both solid and cystic components. A subsequent computed tomography of her abdomen and pelvis confirmed a solid heterogeneous mass consistent with a pheochromocytoma. There were no other features suggestive of multiple endocrine neoplasia. Urinary collection over 24 hours revealed grossly elevated levels of catecholamines and metabolites. Following an open right adrenalectomy, our patient's insulin requirements were significantly reduced and her symptoms resolved. Two weeks post-operatively, an iodine-131-metaiodobenzylguanidine scintigraphy was negative for residual tumor and metastatic disease. Urinary catecholamine and metabolite concentrations were within the normal range at a follow-up six months later.Pheochromocytoma is a rare catecholamine-producing tumor requiring a high index of suspicion for early diagnosis. Our case report serves to highlight the importance of considering pheochromocytoma as a differential diagnosis in the atypical setting of recurrent urinary tract infections and concomitant autoimmune disease.Pheochromocytoma is a rare, insidious adrenal medullary neuroendocrine tumor representing approximately 5% of adrenal incidentalomas [1]. It is a sympathetic paraganglioma of chromaffin cell origin and catecholamine hypersecretion is a common clinical manifestation [2,3]. Today, 25% of all pheochromocytomas are discovered incidentally during imaging stud
Circulating CD36 Is Reduced in HNF1A-MODY Carriers
Siobhan Bacon, Ma P. Kyithar, Jasmin Schmid, Andre Costa Pozza, Aase Handberg, Maria M. Byrne
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074577
Abstract: Introduction Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor; hepatocyte nuclear factor 1 alpha (HNF1A) accounting for the majority of MODY cases. There is somewhat limited data available on the prevalence of macrovascular disease in HNF1A-MODY carriers with diabetes. Marked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers. The scavenger protein CD36 has been shown to play a substantial role in the pathogenesis of atherosclerosis, largely through its interaction with oxidised LDL. Higher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes. The aim of this study was to determine levels of sCD36 in participants with HNF1A-MODY diabetes and to compare them with unaffected normoglycaemic family members and participants with type 2 diabetes mellitus. Methods We recruited 37 participants with HNF1A-MODY diabetes and compared levels of sCD36 with BMI-matched participants with type 2 diabetes mellitus and normoglycaemic HNF1A-MODY negative family controls. Levels of sCD36 were correlated with phenotypic and biochemical parameters. Results HNF1A-MODY participants were lean, normotensive, with higher HDL and lower triglyceride levels when compared to controls and participants with type 2 diabetes mellitus. sCD36 was also significantly lower in HNF1A-MODY participants when compared to both the normoglycaemic family controls and to lean participants with type 2 diabetes mellitus. Conclusion In conclusion, sCD36 is significantly lower in lean participants with HNF1A-MODY diabetes when compared to weight-matched normoglycaemic familial HNF1A-MODY negative controls and to lean participants with type 2 diabetes mellitus. Lower levels of this pro-atherogenic marker may result from the higher HDL component in the lipid profile of HNF1A-MODY participants.
Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward
Siobhan Bacon, Ma Peyh Kyithar, Jasmin Schmid, Syed R Rizvi, Caroline Bonner, Rolf Graf, Jochen HM Prehn, Maria M Byrne
BMC Endocrine Disorders , 2012, DOI: 10.1186/1472-6823-12-13
Abstract: We analysed serum PSP/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY), and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed.PSP/reg1A serum levels were significantly elevated in HNF1A-MODY (n?=?37) subjects compared to controls (n?=?60) (median?=?12.50?ng/ml, IQR?=?10.61-17.87?ng/ml versus median?=?10.72?ng/ml, IQR?=?8.94-12.54?ng/ml, p?=?0.0008). PSP/reg1A correlated negatively with insulin levels during OGTT, (rho?=??0.40, p?=?0.02). Interestingly we noted a significant positive correlation of PSP/reg1A with age of the HNF1A-MODY carriers (rho?=?0.40 p?=?0.02) with an age of 25?years separating carriers with low and high PSP/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP/reg1A compared to controls, however this was independent of the duration of diabetes.Our data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25?years and over. PSP/reg1A may be developed as a serum marker to detect increased beta-cell apoptosis, or its therapeutic response.
Raciocínio contrafactual e modelos mentais
Byrne,Ruth M. J.; Quelhas,Ana Cristina;
Análise Psicológica , 1999,
Abstract: the central idea in this study is that ?... thinking about matters of fact and thinking about matters of possibility and impossibility are based on similar sorts of mental representations and cognitive processes? (byrne, 1997, p. 107). that is to say that people reason by constructing and revising mental models (e.g., johnson-laird, & byrne, 1991). counterfactual conditionals require reasoners to keep in mind not only what is presupposed to be true, but also what is suppositionally true but factually false (byrne, 1997, p. 117; cf. johnson-laird, & byrne, 1991, pp. 72-73). and the hypothesis that the initial representation of a counterfactual conditional is more explicit than the initial representation of a factual conditional, allows the prediction that modus tollens and denial of the antecedent inferences would be made more frequently from the counterfactual than from the factual conditionals. byrne and tasso (in press) found evidence for those predictions. in the present study, we look for replication of the data found by byrne and tasso, and we add some hypothesis related with the latencies to understand both kinds of conditionals, and to choose a conclusion. we use neutral conditionals like ?if there was a circle, then there was a triangle?, and we presented to participants the four conditional syllogisms in the superlab program.
Possibilities for carbon sequestration in Irish forests. COST E21 Workshop. Contribution of forests and forestry to mitigate greenhouse effects. Joensuu (Finland). 28-30 Sep 2000
Byrne K.A.,Perks M.
Biotechnologie, Agronomie, Société et Environnement , 2000,
Abstract: Ireland has a rapidly expanding forest estate which covers some 9/ of the land area. It is government policy to increase this to 17/ by the year 2030. Preliminary studies suggest that forestry activities have the potential to contribute significantly to the mitigation of greenhouse gas emissions. Although some studies have been carried out the determination of the carbon stores and sinks in Irish forests will require a considerable research effort in the future. A key aspect of such studies will be field based studies which measure all components of the carbon cycle and their relationship to climatic and environmental conditions as well as management practices. Many of these issues will be addressed in the recently announced research programme of the Council for Forest Research and Development (COFORD).
Epigenetic modulation in the treatment of atherosclerotic disease
Mikaela M. Byrne,Anthony W. Ryan
Frontiers in Genetics , 2014, DOI: 10.3389/fgene.2014.00364
Abstract: Cardiovascular disease is the single largest cause of death in the western world and its incidence is on the rise globally. Atherosclerosis, characterized by the development of atheromatus plaque, can trigger luminal narrowing and upon rupture result in myocardial infarction or ischemic stroke. Epigenetic phenomena are a focus of considerable research interest due to the role they play in gene regulation. Epigenetic mechanisms such as DNA methylation and histone acetylation have been identified as potential drug targets in the treatment of cardiovascular disease. miRNAs are known to play a role in gene silencing, which has been widely investigated in cancer. In comparison, the role they play in cardiovascular disease and plaque rupture is not well understood. Nutritional epigenetic modifiers from dietary components, for instance sulforaphane found in broccoli, have been shown to suppress the pro-inflammatory response through transcription factor activation. This review will discuss current and potential epigenetic therapeutics for the treatment of cardiovascular disease, focusing on the use of miRNAs and dietary supplements such as sulforaphane and protocatechuic aldehyde.
Robust inverse energy cascade and turbulence structure in three-dimensional layers of fluid
D. Byrne,H. Xia,M. Shats
Physics , 2011, DOI: 10.1063/1.3638620
Abstract: Here we report the first evidence of the inverse energy cascade in a flow dominated by 3D motions. Experiments are performed in thick fluid layers where turbulence is driven electromagnetically. It is shown that if the free surface of the layer is not perturbed, the top part of the layer behaves as quasi-2D and supports the inverse energy cascade regardless of the layer thickness. Well below the surface the cascade survives even in the presence of strong 3D eddies developing when the layer depth exceeds half the forcing scale. In a bounded flow at low bottom dissipation, the inverse energy cascade leads to the generation of a spectral condensate below the free surface. Such coherent flow can destroy 3D eddies in the bulk of the layer and enforce the flow planarity over the entire layer thickness.
Turbulence damping as a measure of the flow dimensionality
M. Shats,D. Byrne,H. Xia
Physics , 2010, DOI: 10.1103/PhysRevLett.105.264501
Abstract: The dimensionality of turbulence in fluid layers determines their properties. We study electromagnetically driven flows in finite depth fluid layers and show that eddy viscosity, which appears as a result of three-dimensional motions, leads to increased bottom damping. The anomaly coefficient, which characterizes the deviation of damping from the one derived using a quasi-two-dimensional model, can be used as a measure of the flow dimensionality. Experiments in turbulent layers show that when the anomaly coefficient becomes high, the turbulent inverse energy cascade is suppressed. In the opposite limit turbulence can self-organize into a coherent flow.
Ring geometries, Two-Weight Codes and Strongly Regular Graphs
E. Byrne,M. Greferath,T. Honold
Mathematics , 2007,
Abstract: It is known that a linear two-weight code $C$ over a finite field $\F_q$ corresponds both to a multiset in a projective space over $\F_q$ that meets every hyperplane in either $a$ or $b$ points for some integers $a
Optimizing The Integrator Step Size for Hamiltonian Monte Carlo
M. J. Betancourt,Simon Byrne,Mark Girolami
Statistics , 2014,
Abstract: Hamiltonian Monte Carlo can provide powerful inference in complex statistical problems, but ultimately its performance is sensitive to various tuning parameters. In this paper we use the underlying geometry of Hamiltonian Monte Carlo to construct a universal optimization criteria for tuning the step size of the symplectic integrator crucial to any implementation of the algorithm as well as diagnostics to monitor for any signs of invalidity. An immediate outcome of this result is that the suggested target average acceptance probability of 0.651 can be relaxed to $0.6 \lesssim a \lesssim 0.9$ with larger values more robust in practice.
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