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Search Results: 1 - 10 of 78848 matches for " Maria Eugenia Vargas-Camano "
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Phenocopies: Mimics of Inborn Errors of Immunity  [PDF]
Cesar Daniel Alonso-Bello, Sara Elva Espinosa-Padilla, Mariano Daniel Temix-Delfin, Fernando Lozano-Patino, Victoria Isabel Castaneda-Avila, Maria Eugenia Vargas-Camano, María Isabel Castrejón-Vázquez
Open Access Library Journal (OALib Journal) , 2020, DOI: 10.4236/oalib.1106041
Abstract:
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are called phenocopies. These are classified into two types, the associated with somatic mutations and those associated with auto-antibodies. The phenotypes that occur by any of the mechanisms mentioned are complex and varied. It is necessary to know the clinical manifestations of the pathologies classified in this group to enrich the possible differential diagnoses in individuals with suspected immunodeficiency.
Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians  [PDF]
García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camano María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105419
Abstract:
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually <2500 xmm3) detected in blood cell cytometry that accompanies severe, recurrent infec-tions, autoimmune manifestations, atopy and cancer may suggest severe combined immunodeficiency. Causes of secondary immunodeficiency such as HIV should be ruled out. Conclusions: Persistent lymphopenia can be associated with severe combined immunodeficiency. The study should be extended in these cases by a specialist or refer the patient to a referral center for a complete evaluation.
Actividad de la enzima antioxidante superóxido dismutasa y niveles de cobre y zinc en pacientes con diabetes mellitus tipo 2
Alfonso Bravo,Sylvia Araujo,Maria Eugenia Vargas,Johan Mesa
Archivos Venezolanos de Farmacología y Terapéutica , 2007,
Abstract: Los seres vivos han desarrollado diversos mecanismos moleculares, donde participan antioxidantes enzimáticos y cofactores minerales, los cuales permiten la estabilización de estas especies reactivas y ofrecen protección contra sus efectos da inos. Se ha determinado que en la diabetes existe una mayor producción de radicales libres, razón por la cual el objetivo del presente estudio fue determinar la actividad de la enzima superóxido dismutasa (SOD) y su relación con los niveles de cobre (Cu) y zinc (Zn) en pacientes con diabetes mellitus tipo 2 (DM2). Fueron tomadas muestras sanguíneas en ayuno de 34 pacientes diabéticos y 30 sujetos no diabéticos (controles), para medir la actividad de la Cu /Zn-SOD eritrocitaria y cuantificar Cu y Zn en suero y eritrocitos, mediante métodos espectrofotométricos. Los pacientes con DM2 presentaron una actividad de la Cu /Zn-SOD significativamente inferior (1839±101 U/g Hb) a los controles (2573±161 U/g Hb) (p<0,05). En diabéticos, los niveles de cobre sérico (59,50±6,02 μg/dL) y eritrocitario (1,76±0,14 μg/g Hb) fueron significativamente mayores que en los controles (55,45±5,80 μg/dl y 1,27±0,13 μg/g Hb) (p<0,05). El Zn sérico en diabéticos (119,59±6,73 μg/dl) fue significativamente bajo en comparación con los controles (134,74±9,43 μg/dl), pero los diabéticos tenían más Zn en eritrocitos (39,13±1,05 μg/g Hb) que los controles (31,62±1,75 μg/g Hb) (p<0,05). La actividad de la Cu /Zn-SOD sólo se correlacionó positivamente con el Zn sérico en controles (r=0,712; p<0,05). Los resultados sugieren que los pacientes con DM2 presentan una alteración en el sistema de defensa antioxidante endógeno mediado por la SOD y sus cofactores. Living beings have developed diverse molecular mechanisms, including enzymatic antioxidants and their mineral cofactors, which allow for the stabilization of these reactive species in order to offer protection against their damaging effects. An elevated production of free radicals has been associated with diabetes. The objective of this study was to determinate the activity of the enzyme superoxide dismutase (SOD) and its relations with the levels of copper (Cu) and zinc (Zn) in patients with type 2 diabetes mellitus (DM2). Fasting blood samples were taken in 34 diabetics and 30 non diabetic subjects (controls), with the purpose of measuring the erythrocyte activity of Cu/Zn-SOD, as well as to quantify serum and erythrocyte Cu and Zn with spectrophotometric methods. The SOD activity in patients with DM2 was significantly lower (1839±101 U/g Hb) than in controls (2573±161 U/g Hb) (p<0.05). Copper lev
Influencia del hábito de fumar sobre las concentraciones séricas de zinc, cobre y selenio en adultos jóvenes
Maria Eugenia Vargas,Ninfa Martínez,Alfonso Bravo,Lissette Bohórquez
Archivos Venezolanos de Farmacología y Terapéutica , 2007,
Abstract: Zinc, cobre y selenio son cofactores de enzimas antioxidantes, por lo que una disminución de sus niveles séricos, compromete su papel preventivo de enfermedades degenerativas. En este estudio se planteó evaluar la influencia del hábito de fumar cigarrillo sobre las concentraciones séricas de estos cofactores en adultos jóvenes. La muestra estuvo conformada por 40 individuos sanos del sexo masculino, con edades entre 18 y 25 a os, índice de masa corporal normal y consumo de nutrientes acorde con sus requerimientos nutricionales, divididos en grupo control (n=20) y grupo de fumadores crónicos (n=20), a los cuales se les cuantificó los niveles séricos de zinc, cobre, selenio y se les estimó la ingesta de nutrientes a través del recordatorio de 24 horas y la frecuencia de consumo de alimentos. En los fumadores los niveles séricos de zinc se mostraron severamente disminuidos (0,36 + 0,10 mg/L) y significativamente inferiores a los encontrados en los controles (0,71 + 0,09 mg/L), mientras que los niveles sérico de cobre y selenio no mostraron diferencia significativa. Los resultados indican que aún cuando el consumo de minerales en los fumadores fue adecuado, la dieta habitual no logró mantener la concentración sérica de zinc en los rangos normales, haciéndolos más susceptibles al estrés oxidativo. Zinc, copper, and selenium are cofactors of antioxidant enzymes. Low serum levels of these minerals can result in health risks, because they play a preventive role in degenerative diseases. The purpose of this study was to determine the influence of cigarette smoking habit on the serum concentrations of these cofactors in young adults. The study was performed on 40 healthy young men between the ages of 18 to 25 years, with normal body mass index, and adequate nutrient intake according to nutritional requirements. Sample was divided in a control group (n=20) and a chronic smokers group (n=20). Zinc, copper, and selenium were quantified in serum sample by atomic absorption spectrometry. Mineral intake was estimated by means of a 24 hours recall and food frequency consumption questionnaires. The serum level of zinc in the smokers (0,36 ± 0,10 mg/L) was significantly lower than in the controls (0,71 ± 0,09 mg/L). There were no significant differences in serum copper and selenium between smokers and controls. Results indicate that even though dietary intake of minerals in smokers was adequate, the habitual diet is not able to maintain the serum zinc concentration in the normal ranges, thus making them more susceptible to oxidative stress.
Actividad de la enzima antioxidante superóxido dismutasa y niveles de cobre y zinc en pacientes con diabetes mellitus tipo 2
Bravo,Alfonso; Araujo,Sylvia; Vargas,Maria Eugenia; Mesa,Johan; Souki,Aida; Bermúdez,Valmore; Cano,Clímaco;
Archivos Venezolanos de Farmacología y Terapéutica , 2007,
Abstract: living beings have developed diverse molecular mechanisms, including enzymatic antioxidants and their mineral cofactors, which allow for the stabilization of these reactive species in order to offer protection against their damaging effects. an elevated production of free radicals has been associated with diabetes. the objective of this study was to determinate the activity of the enzyme superoxide dismutase (sod) and its relations with the levels of copper (cu) and zinc (zn) in patients with type 2 diabetes mellitus (dm2). fasting blood samples were taken in 34 diabetics and 30 non diabetic subjects (controls), with the purpose of measuring the erythrocyte activity of cu/zn-sod, as well as to quantify serum and erythrocyte cu and zn with spectrophotometric methods. the sod activity in patients with dm2 was significantly lower (1839±101 u/g hb) than in controls (2573±161 u/g hb) (p<0.05). copper levels in diabetic serum (59.50±6.02 mg/dl) and erythrocyte (1.76±0.14 μg/g hb) were significantly higher than in controls (55.45±5.80 mg/dl and 1.27±0.13 μg/g hb) (p<0.05). serum zn in diabetics (119.59±6.73 mg/dl) was significantly lower than in controls (134.74±9.43 mg/dl), but the diabetics had higher zn in erythrocyte (39.13±1.05 μg/g hb) than the controls (31.62±1.75 μg/g hb) (p<0.05). a significant positive correlation between cu/zn-sod activity and serum zn (r=0.712, p<0.05) was only found in controls. these results suggest that the patients with dm2 present an alteration in the endogenous system of antioxidant defences mediated by the sod and its cofactors.
Caracteriza??o da comunidade liquênica corticícola de Porto Alegre e áreas adjacentes, RS, Brasil
K?ffer, Márcia Isabel;Alves, Camila;Cáceres, Marcela Eugenia da Silva;Martins, Suzana Maria de Azevedo;Vargas, Vera Maria Ferr?o;
Acta Botanica Brasilica , 2011, DOI: 10.1590/S0102-33062011000400010
Abstract: lichens are symbiotic organisms found in a variety of habitats; however, in urban areas the lichen community can be altered due to the influence of anthropogenic factors. this study aimed to analyze the corticolous lichen community composition in porto alegre and adjacent areas, as well as to investigate the frequency, coverage and importance value of the reported taxa. a key to the urban species is also provided. three hundred phorophytes distributed in 30 sampling stations, divided among 33 city districts, were analyzed. one hundred and forty-four taxa of lichenized fungi were recorded with three probable new citations for brazil and two new records for rio grande do sul state. the most important species in the community were canoparmelia texana (tuck.) elix & hale and dirinaria picta (sw.) schaer. ex clem, which showed the highest values of importance, frequency and coverage. the high number of taxa found in the studied areas represents a significant contribution to lichenological research, mainly for use in air quality monitoring programs and to evaluate forest ecosystem structure.
Novas ocorrências de liquens corticícolas crostosos para a regi?o sul do Brasil
K?ffer, Márcia Isabel;Cárceres, Marcela Eugenia da Silva;Vargas, Vera Maria Ferr?o;Martins, Suzana Maria de Azevedo;
Acta Botanica Brasilica , 2010, DOI: 10.1590/S0102-33062010000400009
Abstract: twenty six new records of corticolous crustose lichen species for brazil and rio grande do sul state are presented; three are new records for brazil and 23 new records for the state. lichens were analyzed on 300 host trees distributed in 32 districts of the city of porto alegre and itapu? state park, viam?o, rs.
Influencia del hábito de fumar sobre las concentraciones séricas de zinc, cobre y selenio en adultos jóvenes
Vargas,Maria Eugenia; Martínez,Ninfa; Bravo,Alfonso; Bohórquez,Lissette; Araujo,Sylvia; Souki,Aida; Paz,Peggi; Fernández,Ana Cristina; Ferrer,Desireé;
Archivos Venezolanos de Farmacología y Terapéutica , 2007,
Abstract: zinc, copper, and selenium are cofactors of antioxidant enzymes. low serum levels of these minerals can result in health risks, because they play a preventive role in degenerative diseases. the purpose of this study was to determine the influence of cigarette smoking habit on the serum concentrations of these cofactors in young adults. the study was performed on 40 healthy young men between the ages of 18 to 25 years, with normal body mass index, and adequate nutrient intake according to nutritional requirements. sample was divided in a control group (n=20) and a chronic smokers group (n=20). zinc, copper, and selenium were quantified in serum sample by atomic absorption spectrometry. mineral intake was estimated by means of a 24 hours recall and food frequency consumption questionnaires. the serum level of zinc in the smokers (0,36 ± 0,10 mg/l) was significantly lower than in the controls (0,71 ± 0,09 mg/l). there were no significant differences in serum copper and selenium between smokers and controls. results indicate that even though dietary intake of minerals in smokers was adequate, the habitual diet is not able to maintain the serum zinc concentration in the normal ranges, thus making them more susceptible to oxidative stress.
Placenta Prévia: Fatores de risco para o Acretismo
Torloni, Maria Regina;Moron, Antonio Fernandes;Camano, Luiz;
Revista Brasileira de Ginecologia e Obstetrícia , 2001, DOI: 10.1590/S0100-72032001000700002
Abstract: purpose: to investigate risk factors associated with accretion in placenta previa (pp) patients. methods: this was a retrospective case-control study of all the records of patients who delivered between 1986-1998 at maternidade escola de vila nova cachoeirinha (s?o paulo) with a diagnosis of placenta previa. the groups with and without accretion were compared regarding age, parity, previous history of miscarriage, curettage and cesarean section, type of pp and predominant area of placental attachment. possible associations between the dependent (accretion) and independent (maternal and placental characteristics) variables were evaluated using the c2 test, univariate and multivariate analyses. results: reviewing 245 cases of pp, two risk factors were significantly associated with accretion: central placenta previa (odds ratio (or): 2.93) and two or more previous cesarean sections(or: 2.54). based on these data, a predictive model was constructed, according to which a patient with central pp and two more previous cesarean sections has a 44.4% risk for accretion. conclusions: results of the current study may help obstetricians in the classification of their patients with pp in different risk categories for accretion. this could be useful in preparing for possible delivery complications in those patients considered at a higher risk for accretion.
Placenta Prévia: Fatores de risco para o Acretismo
Torloni Maria Regina,Moron Antonio Fernandes,Camano Luiz
Revista Brasileira de Ginecologia e Obstetrícia , 2001,
Abstract: Objetivo: investiga o dos fatores de risco associados ao acretismo em pacientes com placenta prévia (PP). Métodos: foi realizada uma análise retrospectiva caso-controle de todos os prontuários de pacientes com diagnóstico de PP que tiveram seus partos na Maternidade Escola Vila Nova Cachoeirinha (S o Paulo) entre 1986 e 1998. O grupo com acretismo foi comparado ao grupo sem acretismo quanto à idade, paridade, antecedentes de abortamentos, curetagens e cesarianas, o tipo de PP e a área predominante de inser o placentária. Para avaliar a associa o entre a variável dependente (acretismo placentário) e as variáveis independentes (características maternas e placentária) foram utilizados o teste do chi2, análise univariada e multivariada, considerando-se significantes os valores de p < 0,05. Resultados: o levantamento de 245 casos de PP evidenciou que os fatores de risco, significativamente associados ao acretismo, foram o tipo de PP centro-total (odds ratio (OR): 2,93) e o antecedente de duas ou mais cesarianas (OR: 2,54). Utilizando estes resultados foi possível construir um modelo preditivo para a probabilidade de ter acretismo, segundo o qual uma paciente com PP centro-total e duas ou mais cesáreas teria uma probabilidade de 44,4% de apresentar acretismo placentário. Conclus es: os resultados deste estudo podem ajudar o obstetra a classificar suas gestantes com PP em diferentes categorias de risco para o acretismo, o que possibilita a ado o de medidas apropriadas para lidar com possíveis complica es no parto daquelas pacientes com maior risco de acretismo.
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