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Search Results: 1 - 10 of 78038 matches for " Maria Cecília Araripe;CHAMONE "
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Significance of isolated hepatitis B core antibody in blood donors from S?o Paulo
ALMEIDA NETO, Cesar de;STRAUSS, Edna;SABINO, Esther Cerdeira;SUCUPIRA, Maria Cecília Araripe;CHAMONE, Dalton de Alencar Fischer;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001, DOI: 10.1590/S0036-46652001000400005
Abstract: the clinical significance of isolated anti-hbc is still a challenge. to elucidate the real importance of this finding in our blood donors, an investigation algorithm was tested. one hundred and twelve isolated anti-hbc seropositive blood donors underwent clinical evaluation and retesting of hbv markers. those who presented repeatedly reactive isolated anti-hbc, received a single dose of hepatitis b recombinant vaccine to verify anti-hbs early response. a hbv-dna determination by pcr was done for those who did not test positive to anti-hbs after vaccine. the level of anti-hbc was recorded as a ratio of the sample-to-cut-off values (s:c ratio) in 57 candidates at donation. comparing true and false-positive anti-hbc results, the different s:c ratios of them were statistically significant and when less than 2, implying in a false-positive result probability over 80%. a high percent of false-positive results (16.07%) was verified after anti-hbc retesting. hbv immunity was characterized in 49.11%, either by anti-hbs detection in retesting (15.18%), or after a single dose hbv vaccination (33.93%). hbv-dna was negative in all tested donors. in conclusion, this algorithm was useful to clarify the meaning of isolated anti-hbc in most of our blood donors.
Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
Munerato Patrícia,Azevedo Maria Lúcia,Sucupira Maria Cecília Araripe,Pardini Regina
Brazilian Journal of Infectious Diseases , 2003,
Abstract: Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk. As the Brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country. There were 11.5% CCR5 heterozygotes among the HIV-1 infected population and 12.5% among uninfected individuals, similar to data from North America and Western Europe. The prevalence of CCR2-64I homozygotes and heterozygotes was 0.06 and 15.2%, respectively, also similar to what is known for North America and Western Europe.
Significance of isolated hepatitis B core antibody in blood donors from S o Paulo
ALMEIDA NETO Cesar de,STRAUSS Edna,SABINO Esther Cerdeira,SUCUPIRA Maria Cecília Araripe
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001,
Abstract: The clinical significance of isolated anti-HBc is still a challenge. To elucidate the real importance of this finding in our blood donors, an investigation algorithm was tested. One hundred and twelve isolated anti-HBc seropositive blood donors underwent clinical evaluation and retesting of HBV markers. Those who presented repeatedly reactive isolated anti-HBc, received a single dose of hepatitis B recombinant vaccine to verify anti-HBs early response. A HBV-DNA determination by PCR was done for those who did not test positive to anti-HBs after vaccine. The level of anti-HBc was recorded as a ratio of the sample-to-cut-off values (S:C ratio) in 57 candidates at donation. Comparing true and false-positive anti-HBc results, the different S:C ratios of them were statistically significant and when less than 2, implying in a false-positive result probability over 80%. A high percent of false-positive results (16.07%) was verified after anti-HBc retesting. HBV immunity was characterized in 49.11%, either by anti-HBs detection in retesting (15.18%), or after a single dose HBV vaccination (33.93%). HBV-DNA was negative in all tested donors. In conclusion, this algorithm was useful to clarify the meaning of isolated anti-HBc in most of our blood donors.
Prevalence, Incidence Density, and Genotype Distribution of GB Virus C Infection in a Cohort of Recently HIV-1-Infected Subjects in Sao Paulo, Brazil
Maria Teresa M. Giret,Jo?o Luiz Miraglia,Maria Cecília Araripe Sucupira,Anna Nishiya,José Eduardo Levi,Ricardo S. Diaz,Ester C. Sabino,Esper G. Kallas
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018407
Abstract: The results of previous studies elsewhere have indicated that GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus type 1 (HIV-1) due to similar transmission routes of both viruses. The aim of this study was to determine the prevalence, incidence density and genotypic characteristics of GBV-C in this population.
Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population
Munerato, Patrícia;Azevedo, Maria Lúcia;Sucupira, Maria Cecília Araripe;Pardini, Regina;Pinto, Gedson Humberto Novaes;Catroxo, Márcia;Souza, Inara Espinelli;Diaz, Ricardo Sobhie;
Brazilian Journal of Infectious Diseases , 2003, DOI: 10.1590/S1413-86702003000400002
Abstract: entry of human immunodeficiency type 1 virus (hiv-1) into target cells requires both cd4and one of the chemokine receptors. viruses predominantly use one, or occasionally both, of the major co-receptors ccr5 and cxcr4, although other receptors, including ccr2b and ccr3, function as minor co-receptors. a 32-nucleotide deletion (d32) within the b-chemokine receptor 5 gene (ccr5) has been described in subjects who remain uninfected despite extensive exposition to hiv-1. the heterozygous genotype delays disease progression. this allele is common among caucasians, but has not been found in people of african or asian ancestry. a more common transition involving a valine to isoleucine switch in transmembrane domain i of ccr2b (64i), with unknown functional consequences, was found to delay disease progression but not to reduce infection risk. as the brazilian population consists of a mixture of several ethnic groups, we decided to examine the genotype frequency of these polymorphisms in this country. there were 11.5% ccr5 heterozygotes among the hiv-1 infected population and 12.5% among uninfected individuals, similar to data from north america and western europe. the prevalence of ccr2-64i homozygotes and heterozygotes was 0.06 and 15.2%, respectively, also similar to what is known for north america and western europe.
Analysis of HIV-1 Protease Gene Reveals Frequent Multiple Infections Followed by Recombination among Drug Treated Individuals Living in S?o Paulo and Santos, Brazil
Edsel Renata De Morais Nunes, Jean Paulo Zukurov, Juliana Terzi Maricato, Maria Cecília Araripe Sucupira, Ricardo Sobhie Diaz, Luíz Mário Ramos Janini
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084066
Abstract: The present study investigated the prevalence of HIV-1 multiple infections in a population composed by 47 patients under HAART failure and enrolled at the National DST/AIDS, Program, Ministry of Health, Brazil.Detection of multiple infections was done using a previously published RFLP assay for the HIV-1 protease gene, which is able of distinguishing between infections caused by a single or multiple HIV-1 subtypes. Samples with multiple infections were cloned, and sequence data submitted to phylogenetic analysis. We were able to identify 17 HIV-1 multiple infections out of 47 samples. Multiple infections were mostly composed by a mixture of recombinant viruses (94%), with only one case in which protease gene pure subtypes B and F were recovered. This is the first study that reports the prevalence of multiple infections and intersubtype recombinants in a population undergoing HAART in Brazil. Based on the data there was a steep increase of multiple infections after the introduction of the combined antiretroviral therapy in Brazil. Cases of multiple infections may be associated with HIV-1 genetic diversity through recombination allowing for the generation of viruses showing a combination of resistance mutations.
A apropria??o da linguagem escrita e o trabalho alfabetizador na escola
Goulart, Cecília Maria;
Cadernos de Pesquisa , 2000, DOI: 10.1590/S0100-15742000000200007
Abstract: the article presents a study on the process of production of texts written by ten children, during school time, in the elementary class, attended by six years old children. the pedagogical work of the children's teacher is theoretically and methodologically relevant to the study. two aims were defined: (i) to characterize the strategies used by children to come close to the conventions of the writing system, specially the alphabetic principle and the segmentation of the text in words; and (ii) to characterize the continuous activity of elaboration and reelaboration of linguistic knowledge, from where we think the subject in/of the language. a corpus of 115 texts produced along a semester was analyzed. the methodology utilized is that of indicial investigation, based on ginzburg (1989). the analysis of the data showed the children's singular and general strategies to come close to the writing system. the children's production is organized, chiefly, according to knowledge originated from the written texts accessible to them. the children's epilinguistic activity was expressed during the whole semester, on different levels. the analysis of the children's procedures pointed out that the process of constructing up written texts is peculiar to each subject; the process is based on social writing and tends toward social writing, in individually different ways.
Coronary heart disease in women: a challenge for the 21st century
Solimene, Maria Cecília;
Clinics , 2010, DOI: 10.1590/S1807-59322010000100015
Abstract: heart disease is the first killer of women in the modern era, regardless of age, race and of ethnicity, although its prevalence rises after menopause. modern women have professional and housewife responsibilities, consume excess of fat and carbohydrates, smoke, do not exercise regularly and do not have enough time to rest. this situation leads to overweight, dyslipidemia, arterial hypertension, impaired glucose tolerance and diabetes. women do not often participate in preventive studies and still undergo less intensive and invasive evaluation and treatment for chest pain when compared to men. however, the rate of coronary death is twice higher in women than in men after myocardial infarction and revascularization procedures. the objective of this review is to analyze the main gender differences regarding symptoms, diagnosis, management and prognosis of coronary heart disease and to discuss the influence of hormonal replacement therapy in the prevention of cardiovascular disease in postmenopausal women.
As relativas que s?o fáceis na aquisi??o do português brasileiro
PERRONI, Maria Cecília;
DELTA: Documenta??o de Estudos em Lingüística Teórica e Aplicada , 2001, DOI: 10.1590/S0102-44502001000100003
Abstract: the acquisition of portuguese by two brazilian children (aged 2;0 -5;0) is discussed in an attempt to describe and explain the first relative clauses produced in naturalistic, observational studies, according to the framework of generative syntax theory. the results show that at around 3;0: a) the child starts to deal with relative clauses as modifiers of n; b) cleft sentences appear before relative clauses, and c) the first relatives confirm the prevalence of the vernacular strategy of relativization in brazilian portuguese identified by other studies based on adult data.
Tens?o ou oposi??o entre ciência e política na pós-gradua??o? Um falso problema?
Coimbra, Cecília Maria;
Psicologia & Sociedade , 2004, DOI: 10.1590/S0102-71822004000100007
Abstract: resisting, denouncing, tiring, sometimes becoming indignant, most of the time we are living the final moments of brazilian public universities, specially in the area known as social and human sciences. in the neoliberal ideal of minimum state, the resources and financings that have been allocated in public college-education in our country are, each year, more insignificant. it interests that, in a same public university, the several centers, institutes and departments ferociously struggle among themselves for the amount of money repassed in crumbs and coming as almses. the teams, the professors, the students compete against each other for the rare financings. these are the comments i bring in this text as introductory notes on the issue of brazilian universities today, specially concerned with devastation that, the so called "humanity" area has been suffering in post-graduation courses.
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