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Search Results: 1 - 10 of 286856 matches for " Maria Carolina L. do;Brasil "
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Synthesis, X-ray crystal structure and theoretical calculations of antileishmanial neolignan analogues
Nascimento, Josenaide P. do;Santos, Lourivaldo S.;Santos, Regina Helena A.;Tozzo, érica;Ferreira, Janaina G.;Carmo, Maria Carolina L. do;Brasil, Davi S. B.;Alves, Cláudio N.;
Journal of the Brazilian Chemical Society , 2010, DOI: 10.1590/S0103-50532010001000006
Abstract: the synthesis and x-ray crystal diffraction structure of two analogues of neolignans, 2-(4-chlorophenyl)-1-phenylethanone (20) and 2-[(4-chlorophenyl)thio]-1-(3,4-dimethoxyphenyl)propan-1-one (12) is described. the compound 12 presents activity against intracellular leishmania donovani and leishmania amazonensis amastigotes that cause cutaneous and visceral leishmaniasis. in addition, the density functional theory (dft) with the b3lyp hybrid functional was employed to calculate a set of molecular descriptors for nineteen synthetic analogues of neolignans with antileishmanial activities. afterwards, the stepwise discriminant analysis was performed to investigate possible relationship between the molecular descriptors and biological activities. through this analysis the compounds were classified into two groups active and inactive according to their degree of biological activities, and the more important properties were charges on some key atoms, electronic affinity and clogp.
Avalia o dos métodos de extra o sequencial de Tessier, Keller e Miller na determina o de ferro nativo em três tipos de solos: organico, brunizem e latossolo
L? Otavio Raymundo,Barra Cristina Maria,Amaral Sobrinho Nelson Moura Brasil do,Mazur Nelson
Química Nova , 2003,
Abstract: Sequential extraction is not totally effective to dissolve distinct forms of trace elements. The extractive solution, for example, can dissolve less of the target fraction and more than another not wished fraction. The goal of this work is to compare the extraction of native iron with three sequential extraction methods of the heavy metals, using three soils with different physical chemistry characteristics: a histosol, an oxisol, and a mollisol. The results obtained in this work demonstrate that a smaller relation soil/extractor results in a larger extraction in almost all phases. The use of many stages of the sequential extraction, with the purpose of more association of the metal with different components of the soil, can result, among other things, in modification of the substratum by the action of the reagents used, besides reducing the selectivity of the more specific extractors. Readsorption and redistribution of the heavy metals could have happened with larger intensity in the fraction where hidroxilamine was used with higher temperature. Sequential extraction of iron, without enrichment of soil samples, in the respective fractions in each method, it was important to better understand the behavior of the reagents considered specific to each form of the metal in soil.
Are There Schizophrenia Genetic Markers and Mutations? A Systematic Review and Meta-Analyses  [PDF]
Maria Auxiliadora Brasil Sampaio Cardoso, Tárcia Januário do Nascimento, Gabriel Pereira Bernardo, Lorena Pereira Bernardo, Maria Mirelle Ferreira Leite Barbosa, Pedro Januário Nascimento Neto, Danilo Ferreira de Sousa, Antonio Gilvan Teixeira Júnior, Marcos Antonio Pereira de Lima, Marcial Moreno Moreira, David de Sousa Gregório, Lídia Coelho do Nascimento Santos, Modesto Leite Rolim Neto
Health (Health) , 2017, DOI: 10.4236/health.2017.95058
Abstract:
Background: Schizophrenia is a severe psychiatric disorder with a complex genetic factor determining its disease onset. Nevertheless, it is not clear in this mental disorder. Objective: To conduct a systematic review of articles regarding the genetic markers and mutations in schizophrenia. Methods: A systematic review of articles on genetic markers and mutations in schizophrenia, published from January 1, 2011, to September 7, 2015, on SCOPUS database was carried out. Search terms were “Genetic markers”, “Mutation”, and “Schizophrenia”. Results: Of the 527 retrieved studies, 31 met the eligibility criteria. Genetic polymorphism, Immune-associated genes, TCF4 and ZNF804A association with microRNA, Neuregulin gene, Chromosome 13q32 and 11p15.4, genes involved in glutamatergic via schizophrenia and brain structure, appeared to be associated with the origin of schizophrenia. Conclusion: Some studies show genes involved in several pathways leading to the disease pathogenesis such as that one related with the dopaminergic and immune system, or rare alleles. Some genes present no involvement in the etiology of this mental disorder. These findings clarify the genetic complexity of schizophrenia and affirm that together, the genes have an overall effect greater than the sum of the individual effect of each gene.
Avalia??o dos métodos de extra??o sequencial de Tessier, Keller e Miller na determina??o de ferro nativo em três tipos de solos: organico, brunizem e latossolo
L, Otavio Raymundo;Barra, Cristina Maria;Amaral Sobrinho, Nelson Moura Brasil do;Mazur, Nelson;Velloso, Ary Carlos Xavier;
Química Nova , 2003, DOI: 10.1590/S0100-40422003000300007
Abstract: sequential extraction is not totally effective to dissolve distinct forms of trace elements. the extractive solution, for example, can dissolve less of the target fraction and more than another not wished fraction. the goal of this work is to compare the extraction of native iron with three sequential extraction methods of the heavy metals, using three soils with different physical chemistry characteristics: a histosol, an oxisol, and a mollisol. the results obtained in this work demonstrate that a smaller relation soil/extractor results in a larger extraction in almost all phases. the use of many stages of the sequential extraction, with the purpose of more association of the metal with different components of the soil, can result, among other things, in modification of the substratum by the action of the reagents used, besides reducing the selectivity of the more specific extractors. readsorption and redistribution of the heavy metals could have happened with larger intensity in the fraction where hidroxilamine was used with higher temperature. sequential extraction of iron, without enrichment of soil samples, in the respective fractions in each method, it was important to better understand the behavior of the reagents considered specific to each form of the metal in soil.
Yacon Product (PBY) Modulates Intestinal Constipation and Protects the Integrity of Crypts in Wistar Rats  [PDF]
M?nica de Souza Lima Sant’Anna, Vivian Carolina Rodrigues, Tatiane Ferreira Araújo, Tania Toledo de Oliveira, Maria do Carmo Gouveia Pelúzio, Célia Lúcia de Luces Fortes Ferreira
Food and Nutrition Sciences (FNS) , 2018, DOI: 10.4236/fns.2018.912101
Abstract: This study investigated the use of a product based on yacon (PBY) in microbiological, physical-chemical and intestinal characteristics of Wistar rats artificially constipated with Loperamide®. Thirty-two rats were divided into four groups: Control (C), Constipated Control (CC), PBY (not constipated) and Constipated PBY (PBYC). The dosage of 0.14 g of FOS+ inulin/kg was tested. Microbiota, pH and faeces characteristics of faeces and caecal contents were evaluated. Caecal weight, morphometry of caecal villi and the concentration of short-chain fatty acids were determined. Higher caecal weight was identified in the PBYC animals as well as higher width, height and depth of cripts. The PBY group showed the highest (p < 0.05) concentration of butyrate (93.2 ± 65.5 mmol/L). The supplementation with PBY positively altered the intestine epithelial tissue in constipated animals, keeping the integrity of the caecum crypts.
Inocula??o de variedades locais de feij?o macassar com estirpes selecionadas de rizóbio
Vieira, Carolina L.;Freitas, Ana D.;Silva, Acácia F.;Sampaio, Everardo V.;Araújo, Maria do S.;
Revista Brasileira de Engenharia Agrícola e Ambiental , 2010, DOI: 10.1590/S1415-43662010001100006
Abstract: the efficient combination of cowpea variety and rhizobia strain is important to raise crop productivity. however, selected strains have not been tested with most of the varieties cultivated in the semiarid area of northeast brazil. to evaluate the efficiency of four recommended strains with six cowpea varieties cultivated in the agreste region of paraíba, a completely randomized factorial experiment, with three replications, was conducted in leonard pots filled with sterilized substrate. varieties "ipa 206", "sedinha", "corujinha", "canapu", "sempre verde" and "azul" were inoculated with br 3267, br 2001, ei 6 and nfb 700 strains, plus two treatments with, and without, n fertilizer. plants were harvested 40 days after sowing. br 3267 and br 2001 strains produced the highest biomass, n concentrations and contents and nodule numbers. inoculation with ei 6 resulted in poor plant performance, especially with variety ipa 206. performance with nfb 700 was slightly better than with ei 6. sedinha and sempre verde were the best varieties regarding biomass, n content and nodule numbers.
Avalia??o do conhecimento dos pais sobre seguran?a no transporte de crian?as em veículos automotores e motocicletas
Pereira, Luiza do Nascimento G;Cancelier, Ana Carolina L;Londero Filho, Ozir Miguel;Franciotti, Débora Lins;Müller, Maria Carolina;Jornada, Luciano Kurtz;
Revista Paulista de Pediatria , 2011, DOI: 10.1590/S0103-05822011000400023
Abstract: objective:to evaluate parents' knowledge on safe transport of children in motor vehicles and motorcycles. methods: cross-sectional study that applied a questionnaire to parents and guardians who were accompanying children in the waiting room for outpatient public and private services. to evaluate knowledge on safe transport of children, the recommendations of the brazilian association on traffic medicine were used. data analysis was performed using the chi-square and mann-whitney tests for categorical and numerical variables respectively, being significant p<0.05. results: the sample consisted of 248 parents, 119 from private and 129 public medical services. among the issues related to motorcycles, 76% of those who usually carry children in this vehicle answered correctly the minimum age allowed for that, however more than 30% of them did not know the safest position to carry children on motorcycles. considering the automobile transport, the question with the highest percentage of correct answers was about the minimum age to use the front seat, with 64% of correct answers. in other issues, the percentage of correct answers ranged from 24 to 46%. conclusions: knowledge of the studied population about safe transport of children in motor vehicles is poor, especially regarding the use of the restraint system, the prerequisites for front seat use, as well the age and the correct form of transporting children on motorcycles.
Susceptibility testing of Candida albicans isolated from oropharyngeal mucosa of HIV+ patients to fluconazole, amphotericin B and Caspofungin: killing kinetics of caspofungin and amphotericin B against fluconazole resistant and susceptible isolates
Lemos, Janine de Aquino;Costa, Carolina Rodrigues;Araújo, Crystiane Rodrigues de;Souza, Lúcia Kioko Hasimoto e;Silva, Maria do Rosário Rodrigues;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000100028
Abstract: a clear understanding of the pharmacodynamic properties of antifungal agents is important for the adequate treatment of fungal infections like candidiasis. for certain antifungal agents, the determination of minimal fungicidal concentration (mfc) and time kill curve could be clinically more relevant than the determination of the minimal inhibitory concentration (mic). in this study, mic and mfc to fluconazole, amphotericin b and caspofungin against c. albicans isolates and the killing patterns obtained with caspofungin and amphotericin b against susceptible and resistant strains to fluconazole were determined. the results of mics showed that all c. albicans isolates were highly susceptible to amphotericin b, but two isolates were fluconazole resistant. the comparative analysis between mic and mfc showed that mfc of fluconazole was fourfold higher than mic in 41.9% of the c. albicans isolates. same values of mfc and mic of amphotericin b and caspofungin were found for 71% of the isolates. correlation between time kill curves and mfc of amphotericin b and caspofungin against all 4 isolates tested was observed. the caspofungin killing effect was more evident at mfc in 6 hours of incubation than at mic in this time, suggesting dependence of concentration. the similarity of results of time-kill curve and mfc values indicate that determination of mfc is an alternative for the detection of the fungicidal activity of these drugs.
Degradabilidade in situ da matéria seca, proteína bruta e fibra em detergente neutro de algumas gramíneas sob pastejo contínuo
Prado, Ivanor Nunes do;Moreira, Fernanda Barros;Zeoula, Lúcia Maria;Wada, Fábio Yoshimi;Mizubuti, Ivone Yurika;Neves, Carolina Antunes;
Revista Brasileira de Zootecnia , 2004, DOI: 10.1590/S1516-35982004000500027
Abstract: the degradation kinetics, effective degradability (ed) of dry matter (dm), neutral detergent fiber (ndf), and crude protein (cp) with or without correction for microbial protein were evaluated from black oat, momba?a, star grass and millet, taken from pastures at a continuous grazing. the forage was collected from different points of pasture every 14 days for black oat and every 28 days for the other grasses. the feeds were incubated in the rumen using nylon bag at different times (0, 6, 12, 24, 48, 72 and 96 h). three bulls of 350 kg bw were used. for correction of microbial protein contamination in incubation residue the neutral detergent insoluble protein analyses were performed. for dm, black oat and millet had higher soluble fraction (a = 32 and 24%) and higher ed at 5%/h (53 and 48%). the winter stargrass presented the lowest soluble fraction (14%) and the lowest dm ed at 5%/h (23%). for corrected cp, black oat and millet had higher ed (80 and 75%) than the other grasses (average ed of 67%). the degradation rate and ed of cp were underestimated when the correction for microbial contamination was not done. for ndf, black oat presented higher ed at 5%/h (40%) followed by millet (35%), star grass-summer (23%), star grass-winter (19%) and momba?a (16%). black oat and millet showed higher soluble fraction, higher degradation and higher ed of dm, cp and ndf when compared to stargrass and momba?agrass.
Substitui??o parcial de silagem de milho por farelo de glúten de milho desidratado na alimenta??o de vacas holandesas em lacta??o
Alves, Ana Carolina do Nascimento;Mattos, Wilson Roberto Soares;Santos, Flávio Augusto Portela;Lima, Maria Lúcia Pereira;Paz, Claudia Cristina Paro de;Pedroso, Alexandre Mendon?a;
Revista Brasileira de Zootecnia , 2007, DOI: 10.1590/S1516-35982007000700018
Abstract: the objective was to study the effects of partial replacing of corn silage by corn gluten feed (cgf-21) dehydrated on milk production and composition of milk and in the blood parameters of dairy cows, beyond the economic evaluation. inclusion levels of 0, 8 and 16% of cgf-21 (% dm) to the diets were evaluated. thirty cows were used for study of milk production and composition and fifteen cows for blood parameters study. a 3 x 3 latin square experimental design with ten replications was used. there was difference among diets for milk yield and for 3.5% fat correct milk. no difference among diets was observed for the other studied characteristics. the results obtained for milk yield were: 22.44, 23.69 and 23.88 kg/anim.d and for 3.5% fat correct milk were: 23.25, 24.71 and 24.44 kg/anim.d, respectively, for the inclusionj levels of cgf-21 for the inclusion levels of 0, 8 and 16% of cgf-21 in the diet. the results obtained for the composition of milk were: percentage of fat, 3.69, 3.76 and 3.65%; milk protein, 3.22; 3.20 and 3.25%; lactose, 4.29, 4.32 and 4.31%; total solids, 12.12, 12.23 and 12.14%; n-ureic milk, 16.57, 16.50 and 14.96mg/dl, and for blood parameters were: plasma n ureic, 109.92, 21.17 and 20.21 mg/dl, seric glucose, 55.69, 56.50 and 54.78 mg/dl, respectively, for the inclusion levels of 0, 8 and 16% of cgf-21 in the diet. the diet with the inclusion of 16% of cgf-21 result on a greater profit.
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