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Search Results: 1 - 10 of 283553 matches for " Maria C Kastrinaki "
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Investigation of Telomerase/Telomeres system in Bone Marrow Mesenchymal Stem Cells derived from IPF and RA-UIP
Katerina M Antoniou, George A Margaritopoulos, Athanasia Proklou, Konstantinos Karagiannis, Ismini Lasithiotaki, Giannoula Soufla, Maria C Kastrinaki, Demetrios A Spandidos, Helen A Papadaki, Nikos M Siafakas:
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-27
Abstract: BM-MSCs were studied in 6 IPF patients, 7 patients with RA-UIP and 6 healthy controls. We evaluated the telomere length as well as the mRNA expression of both components of telomerase (human telomerase reverse transcriptase, h-TERT and RNA template complementary to the telomeric loss DNA, h-TERC).We found that BM-MSCs from IPF, RA-UIP cases do not present smaller telomere length than the controls (p?=?0.170). There was no significant difference regarding the expression of both h-TERT and h-TERC genes between patients and healthy controls (p?=?0.107 and p?=?0.634 respectively).We demonstrated same telomere length and telomerase expression in BM-MSCs of both IPF and RA-UIP which could explain similarities in pathogenesis and prognosis. Maintenance of telomere length in these cells could have future implication in cell replacement treatment with stem cells of these devastating lung disorders.
Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes
Maria-Christina Kastrinaki,Konstantia Pavlaki,Aristea K. Batsali,Elisavet Kouvidi,Irene Mavroudi,Charalampos Pontikoglou,Helen A. Papadaki
Journal of Immunology Research , 2013, DOI: 10.1155/2013/265608
Abstract: Immune-mediated bone marrow failure syndromes (BMFS) are characterized by ineffective marrow haemopoiesis and subsequent peripheral cytopenias. Ineffective haemopoiesis is the result of a complex marrow deregulation including genetic, epigenetic, and immune-mediated alterations in haemopoietic stem/progenitor cells, as well as abnormal haemopoietic-to-stromal cell interactions, with abnormal release of haemopoietic growth factors, chemokines, and inhibitors. Mesenchymal stem/stromal cells (MSCs) and their progeny (i.e., osteoblasts, adipocytes, and reticular cells) are considered as key cellular components of the bone marrow haemopoietic niche. MSCs may interfere with haemopoietic as well as immune regulation. Evidence suggests that bone marrow MSCs may be involved in immune-mediated BMFS underlying pathophysiology, harboring either native abnormalities and/or secondary defects, caused by exposure to activated marrow components. This review summarizes previous as well as more recent information related to the biologic/functional characteristics of bone marrow MSCs in myelodysplastic syndromes, acquired aplastic anemia, and chronic idiopathic neutropenia. 1. Introduction Immune-mediated bone marrow failure syndromes (BMFS), such as the myelodysplastic syndromes, acquired aplastic anemia, or chronic idiopathic neutropenia, are characterized by ineffective marrow haemopoiesis and subsequent peripheral cytopenias. Pathogenetic mechanisms involve a complex marrow deregulation, including genetic and epigenetic alterations, resulting in aberrant release of haemopoietic growth factors and inhibitors in the marrow, deregulated immune manifestations, all resulting in defective haemopoietic maturation and increased haemopoietic cell apoptosis. Normal haemopoiesis is regulated in the marrow by an extended network of specialized niches, maintaining haemopoietic stem cell (HSC) self-renewal and orchestrating HSC proliferation and differentiation to all blood cell types. Key cellular components of the bone marrow (BM) haemopoietic microenvironment include osteoblasts, sinusoidal endothelial cells, macrophages, adipocytes, and reticular cells, orchestrating the maintenance, proliferation, and differentiation of haemopoietic stem and progenitor cells (HSPCs). Osteoblasts, adipocytes, and reticular cells of the marrow stroma derive from a common progenitor cell, the mesenchymal stem/stromal cell (MSC) [1–5]. Since MSCs and their progeny are among the main components of the marrow stroma, it is reasonable to assume that patient BM MSCs may be partially defective,
Personality change in older adults with dementia: Occurrence and association with severity of cognitive impairment  [PDF]
Edward Helmes, Maria C. Norton, Truls ?stbye
Advances in Aging Research (AAR) , 2013, DOI: 10.4236/aar.2013.21004

Personality change is among criteria for the diagnosis of dementia. We examine first whether personality changes are related to severity of cognitive impairment in a linear or an inverted-U fashion in 1132 demented older people from the Canadian Study of Health and Aging (CSHA) and 921 unimpaired older people. The proportion with reported change was larger for all measures in the demented group than in the cognitively unimpaired group, and was more consistent with a linear increase in personality change with increasing cognitive impairment than with an inverted-U relationship, as seen in only one variable. In our second (longitudinal) study, we evaluate which aspects of personality change most in dementia; changes in mood and an exaggeration of existing traits were the variables most closely related to the development of dementia.

Protein Bodies in Cotyledon Cells Exhibit Differential Patterns of Legumin-Like Proteins Mobilization during Seedling Germinating States  [PDF]
Jose C. Jimenez-Lopez, Maria C. Hernandez-Soriano
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.412304

Olive (Olea europaea L.) tree is one of the most extensive and important agricultural crop in Mediterranean countries due to its beneficial health and nutritional properties and its high economic value. Currently, olive tree constitutes the sixth most important cultivated plant in the world, spreading from the Mediterranean region of origin to new production areas such as Australia, South and North America and South Africa. However, the mobilization processes of storage materials i.e. reserve proteins during seed germination, which are largely involved in essential physiological process including plant growth and development, remain poorly understood. Morphometric and immunohistochemistry analyses of protein bodies contained in olive seed storage tissues, cotyledon and endosperm, were performed by using different microscopy techniques, including light (bright-field and fluorescence) microscopy and transmission electron microscopy. Furthermore, we used legumin-like proteins (11S-type globulins) as a molecular marker to study the mobilization of reserve proteins from PBs of cotyledons at germinating seedling stages by using immunofluorescence assays. Results demonstrated that cotyledon and endosperm are characterized by distinct PBs populations containing legumin-like proteins, distinctly discriminated by the number of PBs per cell and tissue, size, immunofluorescence and histochemical staining. These features reflect differential PBs biogenesis during development and maturation processes in olive seed tissues endosperm and cotyledon, in relation to proteins (polypeptides) final composition, SSPs processing and/or packaging during seed maturation. Three different mobilization patterns of legumin-like proteins were identified for the first time in cotyledon PBs

Social Development in a Game Context  [PDF]
Ana Lucia Petty, Maria Thereza C. C. de Souza
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.512152

Social development is a fundamental subject that challenges professionals who work with children and teenagers. Questions such as how to behave adequately, what limits must be defined, and at the same time, how to stimulate autonomy and create a cooperative environment, are daily made, but solutions are not always satisfactory. The aim of this paper is to present a possible contribution to the discussion, describing highlights of a successful initiative. The practice in seeing children with learning disabilities at the Laboratory of Studies about Development and Learning (University of Sao Paulo), also identifies the same questions and there is a permanent search for creative solutions. For the last 25 years, groups of children from the Fundamental School were seen by professionals who organized activities in a game context, challenging them to play, develop reasoning and construct favourable attitudes. Results show that playing games in an intervention context stimulated changes in attitudes and social behaviour. As a consequence, it enabled children interact and establish a better quality of relation, based on cooperation and mutual respect.

Communicative Development in a Game Context  [PDF]
Maria Thereza C. C. de Souza, Ana Lucia Petty
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.82014
Abstract: This report is a short overview of an intervention program in which communicative development in a game context is focused. Mastering languages and different ways of communication are indicators of cognitive development. These are some of the goals of the intervention program held at the Laboratory of Studies about Development and Learning (Institute of Psychology) to help children from the fundamental school with learning difficulties develop affective, cognitive, motor and social attitudes, in a context of problem-solving situations with games. As a consequence, they improve competence to express and interpret more adequately, as well as discuss strategies and solve different challenges, regarding the capacity of learning from others and enhancing language skills. To observe children playing communicative games allows to analyze how they think and act, which generates important information to intervene in pro of changing the attitudes that do not work in favour of the learning and developing processes. Analysis was made from data registered on records, and six children who participated at the program during three semesters were described for illustrative purpose. It indicates that this context, in which narratives are produced and where there is adult mediation, contributes to help them modify inadequate attitudes and improve the domain of different languages, expanding the repertoire of communication.
Nurse Faculty Enrichment and Competency Development in Oral-Systemic Health
Maria C. Dolce
Nursing Research and Practice , 2012, DOI: 10.1155/2012/567058
Abstract: Nurses are positioned to play a significant role in oral health promotion and disease prevention across the life cycle. Oral health has not been a high priority in nursing practice, and educating nurses about oral health has been inadequate particularly regarding the interrelationship between oral health and overall health. The first step for developing a nursing workforce with core competencies in oral health promotion and disease prevention is to prepare nurse faculty with the requisite knowledge, skills, attitudes, and best practices in oral-systemic health. The purpose of this paper is to present Smiles for Life: A National Oral Health Curriculum as a knowledge framework that nurse faculty can use for faculty enrichment and competency development in oral health across the life cycle. A variety of teaching-learning strategies and resources are provided to assist nurse faculty with integrating oral-systemic health into existing nursing curricula. 1. Introduction Nurses are positioned to play a significant role in oral health promotion and disease prevention across the life cycle, and in expanding access to preventive care services especially for vulnerable and underserved populations across health care settings [1–5]. Oral health promotion and preventive care services, such as basic risk assessments, oral health examinations, referrals, counseling, and anticipatory guidance, are well within the scope of professional nursing practice. Recognizing the significance of oral health in achieving overall health and well-being, nurses can empower individuals, families, and communities with oral health information and resources to support healthy choices regarding oral hygiene, diet, tobacco, and alcohol use. Historically, oral health has not been a high priority in nursing practice [1]. Education and training of nurses about basic oral health and oral-systemic health has been inadequate [5–7]. In 2007, a survey of academic deans and administrators from accredited dental schools in the United States and Canada found that only 2.3% of respondents strongly agreed that nurses and physicians in their health science center or academic campus were well educated about oral-systemic health [8]. The potential role of nurses in improving oral health outcomes across the life cycle and expanding access is contingent upon enhancing nursing curricula in undergraduate- and graduate-level programs and professional development programs for practicing nurses [1]. The initial step for developing a nursing workforce with core competencies in oral health promotion and disease
Gut structure of two species of the neotropical genus Tauritermes Krishna (Isoptera: Kalotermitidae)
Godoy, Maria C.;
Neotropical Entomology , 2004, DOI: 10.1590/S1519-566X2004000200006
Abstract: gut morphology of two species of the neotropical genus tauritermes krishna was analyzed. detailed description of the coiling gut and the cuticular armature of the gizzard and first and second proctodeal segments of pseudergates are given. the characteristics of tauritermes gut followed the pattern previously known for the family, but some differences among this genus and other kalotermitidae genera were: the length of the midgut, the structure and cuticular ornamentation of the first and second proctodeal segments, the junction of the third and fourth proctodeal segments and the armature of the rectal valve. tauritermes was differentiated from other kalotermitidae genera by means of the gut characters, currently used in termite systematics and phylogeny.
Manejo clínico das disfun??es orais na amamenta??o
Sanches, Maria Teresa C.;
Jornal de Pediatria , 2004, DOI: 10.1590/S0021-75572004000700007
Abstract: objective: to address aspects associated with the early detection and clinical management of oral disorders in breastfeeding. source of data: review of bibliographic sources (research articles, technical books, dissertations and national and international publications) focused on the clinical management of oral disorders in breastfed babies. summary of the findings: suction disorders may lead to inadequate actions that can compromise the mother/baby relation during breastfeeding. healthcare professionals may have an important role in these cases, as they can early detect such disorders. for that end, they must be able to assess breastfeeding and be prepared to manage oral disorders clinically. in the clinical management of babies with breastfeeding difficulties significant aspects of the oral physiology and breastfeeding observation should be considered. we stress the importance of an interdisciplinary team work and the need for oral training and specialized care in most complex cases. conclusion: the baby's oral disorders in breastfeeding can be corrected if they were early detected. healthcare professionals may help mothers and babies to overcome these problems if they have knowledge that enable them to perform right clinical procedures.
Releitura da Biblioteca Nacional
Portella, Célia Maria;
Estudos Avan?ados , 2010, DOI: 10.1590/S0103-40142010000200016
Abstract: history and memory of the national library. the concept of public and national library. integration between physical and digital library. reading and citizenship. transparency. accessibility. a new conception of the national library foundation, based upon an unitarian structure of time, wich holds past present and future, wich gathers a retropective, perspective and prospective approach. lesson and life of the national library foundation.
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