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Search Results: 1 - 10 of 77770 matches for " Maria Auxiliad?ra Fontes; "
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Macrolactamas bioativas e síntese de macrociclos por rea??o de carbocicliza??o radicalar mediada por hidreto de tri-n-butilestanho
Faraco, Renata Fontes Prado;Pires, Magno Carvalho;Rocha, Ana Paula Campos;Prado, Maria Auxiliadra Fontes;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000600041
Abstract: this review presents natural, semi-synthetic and synthetic bioactive macrolactams and their structure-activity relationships when available. for macrolactams in clinical use the advantages and disadvantages in relation to other drugs are presented, and for synthetic macrolactams the method used in the cyclization is showed. regarding macrocyclic synthesis by the tri-n-butyltin hydride-mediated radicalar carbocyclization reaction the precursor, the reaction conditions, products and yields, mechanism and cyclization mode are discussed.
Síntese de aliloxi-orto-iodobenzamida derivada de d-glicose e rea o de cicliza o radicalar mediada por hidreto de tri-n-butilestanho
Dias Danielle Ferreira,Prado Maria Auxiliadra Fontes,Pinto Gleydson Daniel,Alves Ricardo José
Química Nova , 2006,
Abstract: Methyl 6-O-allyl-2,3-di-O-benzyl-4-deoxy-4-(2 -iodobenzoylamine)-alpha-D-glucopyranoside was synthesized in nine conventional steps from methyl alpha-D-glucopyranoside. Its Bu3SnH-mediated aryl radical cyclization provided a benzomacrolactam, resulting from 11-endo aryl radical cyclization and the reduced uncyclized product methyl 6-O-allyl-4-benzoylamine-2,3-di-O-benzyl-4-deoxy- alpha-D-glucopyranoside. The structures of the three new products were supported by 1H and 13C NMR spectroscopy and DEPT, COSY and HMQC experiments.
Síntese de β-D-galactopiranosídeos de arila diméricos para avalia??o de sua intera??o com a lectina de Erythrina cristagalli
Figueiredo, Rute Cunha;Meyer, Nádia Burkowski;Prado, Maria Auxiliadra Fontes;Alves, Ricardo José;Rojo, Javier;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000800026
Abstract: the synthesis of two new d-galactose-based dimers having a 1,4-butanediamine spacer is reported aiming at the evaluation of their interaction with the erythrina cristagalli lectin. the title compounds were prepared in four and five steps from 2,3,4,6-tetra-o-acetyl-β-d-galactopyranoside bromide, in 20 % and 15 % overall yield, respectively, using the doebner modification of the koenavenagel reaction as the key sep. the lectin-carbohydrate interaction could be evaluated for only one dimer, due to solubility problems. a twofold enhancement of affinity was observed, compared to the corresponding monovalent ligand.
Síntese de 2-iodobenzamidas e 3-(iodoacetamido)benzamidas ligadas à D-galactose e suas rea??es de carbocicliza??o radicalar mediadas por hidreto de tri-n-butilestanho
Leal, Daniel Henriques Soares;Queiroga, Carla Graziella;Pires, Magno Carvalho;Prado, Maria Auxiliadra Fontes;Alves, Ricardo José;Cesar, Amary;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000900029
Abstract: starting from methyl 6-o-allyl-4-azido-2,3-di-o-benzyl-4-deoxy-α-d-galactopyranoside, four new derivatives containing 2-iodobenzamido and 3-(iodoacetamido)benzamido groups were synthesized. these four compounds were submitted to tri-n-butyltin hydride mediated radical cyclization reactions, resulting in two macrolactams from 11- and 15-endo aryl radical cyclization. the corresponding four hydrogenolysis products were also obtained. the structures of the new compounds were elucidated by 1h and 13c nmr spectroscopy, dept, cosy, hmqc and hmbc experiments.
Rea??es de carbocicliza??o radicalar de orto-iodoaliloxibenzoatos derivados de d-glicose e d-galactose e compara??o com as rea??es de seus análogos benzamidas
Binatti, Ildefonso;Alves, Rosemeire Brondi;Souza Filho, José Dias de;Dias, Danielle Ferreira;Prado, Maria Auxiliadra Fontes;Alves, Ricardo José;
Química Nova , 2005, DOI: 10.1590/S0100-40422005000600017
Abstract: two ortho-iodoallyloxybenzoates, methyl 4-o-allyl-2,3-di-o-benzyl-6-o-(2-iodobenzoyl)- a-d-glucopyranoside (3) and methyl 4-o-allyl-2,3-di-o-benzyl-6-o-(2-iodobenzoyl)- a-d-galactopyranoside (4) were synthesized in seven conventional steps from methyl a-d-glucopyranoside and methyl a-d-galactopyranoside, respectively. bu3snh-mediated aryl radical cyclization of 3 provided exclusively the hydrogenolysis product 12. the reaction of 4 gave the reduced uncyclized product 13 and only traces of 4a, resulting from 11-endo aryl radical cyclization. in previous papers we described that in similar bu3snh-mediated radical reaction of ortho-iodoallyloxybenzamides, analogs of 3 and 4, we obtained macrolactams resulting from 11-endo cyclization. an hypothesis to explain the differences is presented. it was assumed that in the aryl radical formed from iodobenzamides there is a suitable conformation to cyclization, which is stabilized by an intramolecular hydrogen bond.
Síntese de aliloxi-orto-iodobenzamida derivada de d-glicose e rea??o de cicliza??o radicalar mediada por hidreto de tri-n-butilestanho
Dias, Danielle Ferreira;Prado, Maria Auxiliadra Fontes;Pinto, Gleydson Daniel;Alves, Ricardo José;Alves, Rosemeire Brondi;Souza Filho, José Dias de;
Química Nova , 2006, DOI: 10.1590/S0100-40422006000300008
Abstract: methyl 6-o-allyl-2,3-di-o-benzyl-4-deoxy-4-(2 -iodobenzoylamine)-a-d-glucopyranoside was synthesized in nine conventional steps from methyl a-d-glucopyranoside. its bu3snh-mediated aryl radical cyclization provided a benzomacrolactam, resulting from 11-endo aryl radical cyclization and the reduced uncyclized product methyl 6-o-allyl-4-benzoylamine-2,3-di-o-benzyl-4-deoxy- a-d-glucopyranoside. the structures of the three new products were supported by 1h and 13c nmr spectroscopy and dept, cosy and hmqc experiments.
Corpo e gênero: uma análise da revista TRIP Para Mulher
Matos, Auxiliadra Aparecida de;Lopes, Maria de Fátima;
Revista Estudos Feministas , 2008, DOI: 10.1590/S0104-026X2008000100005
Abstract: this work investigates the social representations of the body in the trip for woman magazine, considering the body and gender theories systematically elaborated by the existing feminisms. it is assumed that the beliefs, the representation and the meanings of what it is to be a man or a woman in a certain society and moment are crystallized in the bodies. thus, it is possible to infer the gender representations that are mediated and inscribed in the body.
Synthesis of Benzomacrolactam by 11?endo Selective Aryl Radical Cyclization of 2?Iodobenzamide Derived from D?Galactose
Binatti, Ildefonso;Prado, Maria Auxiliadra F.;Alves, Ricardo J.;Souza Filho, José D.;
Journal of the Brazilian Chemical Society , 2002, DOI: 10.1590/S0103-50532002000500005
Abstract: encouraged by our previous studies of tri-n-butyltin-mediated radical cyclization reaction of o-iodobenzamides, we applied this methodology to the synthesis of benzomacrolactam 2 from methyl 4-o-allyl-2,3-di-o-benzyl-6-deoxy-6-(2-iodobenzoylamino)- α-d-galactopyranoside 1. apart from the macrolactam 2, resulting from regioselective 11-endo aryl radical cyclization, the hydrogenolysis produt 3 was obtained. the o-iodobenzamide 1 was prepared in eight conventional synthetic steps from methyl α-d-galactopyranoside. the unequivocal structures of 1, 2 and 3 were supported by 1h, 13c and dept nmr spectroscopy and by cosy and hmqc experiments.
Synthesis of Benzomacrolactam by 11-endo Selective Aryl Radical Cyclization of 2-Iodobenzamide Derived from D-Galactose
Binatti Ildefonso,Prado Maria Auxiliadra F.,Alves Ricardo J.,Souza Filho José D.
Journal of the Brazilian Chemical Society , 2002,
Abstract: Encouraged by our previous studies of tri-n-butyltin-mediated radical cyclization reaction of o-iodobenzamides, we applied this methodology to the synthesis of benzomacrolactam 2 from methyl 4-O-allyl-2,3-di-O-benzyl-6-deoxy-6-(2-iodobenzoylamino)- alpha-D-galactopyranoside 1. Apart from the macrolactam 2, resulting from regioselective 11-endo aryl radical cyclization, the hydrogenolysis produt 3 was obtained. The o-iodobenzamide 1 was prepared in eight conventional synthetic steps from methyl alpha-D-galactopyranoside. The unequivocal structures of 1, 2 and 3 were supported by 1H, 13C and DEPT NMR spectroscopy and by COSY and HMQC experiments.
tri-n-butyltin hydride-mediated radical reaction of a 2-iodobenzamide: formation of an unexpected carbon-tin bond
Oliveira, Marcelo T.;Prado, Maria Auxiliadra F.;Alves, Rosemeire B.;Cesar, Amary;Alves, Ricardo J.;Queiroga, Carla G.;Santos, Leonardo S.;Eberlin, Marcos N.;
Journal of the Brazilian Chemical Society , 2007, DOI: 10.1590/S0103-50532007000200018
Abstract: the tri-n-butyltin hydride-mediated reaction of methyl 2,3-di-o-benzyl-4-o-trans-cinnamyl -6-deoxy-6-(2-iodobenzoylamino)-a-d-galactopyranoside afforded an unexpected aryltributyltin compound. the structure of this new tetraorganotin(iv) product has been elucidated by 1h, 13c nmr spectroscopy, cosy and hmqc experiments and electrospray ionization mass spectrometry (esi-ms). the formation of this new compound via a radical coupling reaction and a radical addition-elimination process is discussed.
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