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Search Results: 1 - 10 of 221040 matches for " Maria Alice Rostom de; "
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METABOLISMO GLICíDICO EM MúSCULO ESTRIADO ESQUELéTICO DE RATOS EM REPOUSO SUBMETIDOS à RESTRI O PROTéICA ALIMENTAR
Miriam Gon?alves de CHAVES,Maria Alice Rostom de MELLO
Alimentos e Nutri??o , 2009,
Abstract: Com a finalidade de testar a capacidade bioquímica de organismos desnutridos para o exercício físico, analisou-se o metabolismo muscular da glicose, em modelo experimental utilizando ratos. Foram usados ratos wistar recém-desmamados (21 dias), alimentados com dietas hipoprotéica (6%) ou normoprotéica (17%) até atingirem a idade adulta (90 dias). Foram avaliadas, in vitro, capta o e oxida o de glicose, síntese de glicogênio e produ o de lactato pelo músculo sóleo isolado do animal na condi o de repouso. Os animais alimentados com a dieta hipoproteíca pesaram menos que os controles e apresentaram menores teores séricos de glicose, albumina e proteínas totais (p < 0,05). Os níveis de lipídios hepáticos e ácidos graxos livres séricos foram maiores no grupo hipoprotéico, indicando eficácia da dieta hipoprotéica em induzir desnutri o. N o houve diferen as entre os grupos quanto à capta o e oxida o de glicose, síntese de glicogênio, produ o de lactato pelo músculo sóleo isolado. Esses resultados indicam que, nas condi es do presente estudo, a desnutri o imposta após o desmame parece n o interferir no metabolismo muscular da glicose em repouso, embora comprometa o crescimento somático. PALAVRAS-CHAVE: Desnutri o protéica; ratos; metabolismo de glicose; músculo esquelético.
Glucose metabolism in rats submitted to skeletal muscle denervation
Nunes, Wilton Marlindo Santana;Mello, Maria Alice Rostom de;
Brazilian Archives of Biology and Technology , 2005, DOI: 10.1590/S1516-89132005000500006
Abstract: this study analyzed the local and systemic effects of immobilization by denervation of the skeletal muscle on glucose metabolism. the rats were submitted to section of the right paw sciatic nerve. a reduction was observed in glucose uptake by the isolated soleus muscle of the denervated paw after 3 and 7 days, but not after 28 days in relation to the control animals. there was no difference after 3 and 7 days in glucose uptake by the soleus muscle of the opposite intact paw in relation to the control. there was increased glucose uptake in the same paw 28 days after denervation. the rate of glucose removal in response to exogenous insulin after 28 days of denervation was significantly higher than in control animals and those observed after 3 and 7 days of denervation. these results suggest that immobilization by denervation interfered not only in glucose metabolism in the skeletal muscle involved but also in other tissues.
Metabolismo glicídico em ratos submetidos a desnerva??o do músculo esquelético e ao exercício de nata??o
Nunes, Wilton Marlindo Santana;Mello, Maria Alice Rostom de;
Revista Brasileira de Medicina do Esporte , 2009, DOI: 10.1590/S1517-86922009000100009
Abstract: denervation of the skeletal muscle involves well known alterations of the glucose metabolism; however, little is known about the influence of these alterations on the peripheral sensitivity to insulin of the animal as a whole. this study aimed to analyze the glucose metabolism in the soleus muscle of rats submitted to denervation as well as their response to exogenous insulin and to exercise. wistar rats aged from 3 to 5 months were submitted to section of the sciatic nerve in the right paw. after 48 hours, half of them started a swimming program of 1 hour/day, 5 days/week. intact animals, either submitted to exercise or not, were used as control. the rats were submitted to the insulin tolerance test after 28 days for evaluating the response to insulin. the results were analyzed by determination of the blood glucose removal rate (kitt). in another batch of animals, slices of the denerved soleus muscle and the counterlateral intact paw were incubated in the presence of glucose (5.5mm), containing [3h]2-deoxyglucose (0.5μci/ml) and [u14c] glucose (0.25μci/ml) and insulin (100u/ml), for analysis of glucose uptake, oxidation and glycogen synthesis. denerved rats submitted to exercise presented kitt (%/min) higher (7.22 ± 0.49) than the sedentary animals (5.31 ± 0.22), and the sedentary control animals (4.53 ± 0.27). glucose uptake (3.55 ± 0.21 μmol/g.h) by the denerved muscle was lower than those of the opposite muscle in the sedentary rats (5.12 ± 0.38 μmol/g.h). chronic exercise raised glucose uptake and oxidation in the counterlateral muscle (uptake: 6.53 ± 0.37, oxidation: 20.39 ± 1.91) and in the denerved muscle (uptake: 5.70 ± 0.41, oxidation: 20.54 ± 1.97). the same situation occurred with the exercised control group. these results suggest that restricted alterations of the muscular glucose metabolism influenced the response to insulin of the animals as a whole. furthermore, exercise improved the uptake and use of glucose in the denerved muscle.
RESTRI O ALIMENTAR DURANTE A GESTA O E SUAS IMPLICA ES SOBRE O BIN ”MIO M E/FETO. UM MODELO EXPERIMENTAL UTILIZANDO RATAS JOVENS E ADULTAS
FL??VIA FERRARI,PATR?-CIA REGINA DE MORAIS GABRIELLI,MARIA ALICE ROSTOM DE MELLO
Alimentos e Nutri??o , 2009,
Abstract: RESUMO: Foi realizado um estudo para verificar os efeitos da restri § £o alimentar durante a gesta § £o sobre o bin ′mio m £e/feto num modelo experimental utilizando ratas. Para atingir este objetivo foram avaliados em ratas jovens (45 dias) e adultas (90 dias), gr vidas ou n £o, controles (a § £o ad libitum) e desnutridas (ra § £o com 50% de restri § £o quantitativa), ingest £o e efici ancia alimentares; peso ao nascer dos filhotes; tamanho da ninhada; n -veis de glicose circulante; cidos graxos livres; colesterol, hem cias, leuc 3citos e hemoglobina; hemat 3cito e teor de glicog anio hep tico. As ratas desnutridas n £o gr vidas mostraram algumas caracter -sticas comumente observadas em seres humanos e animais desnutridos, tais como redu § £o do ganho de peso, do coeficiente de efici ancia alimentar, da quantidade de leuc 3citos circulantes, aumento dos cidos graxos livres e do colesterol circulantes, parecendo, portanto, ser um modelo vi vel de desnutri § £o experimental. As ratas adultas desnutridas gr vidas mostraram redu § £o no ganho de peso na gesta § £o e crias de baixo peso, sugerindo que o modelo pode ser otil nos estudos dos fatores envolvidos no retardo do desenvolvimento fetal causado pela leucopenia, indicando que os efeitos da restri § £o alimentar durante a gesta § £o s £o mais acentuados no animal jovem do que no adulto nas condi § μes do presente experimento. PALAVRAS-CHAVE: Desnutri § £o; gesta § £o; retardo no desenvolvimento fetal; gestantes jovens e adultas.
Exercício contínuo e intermitente: efeitos do treinamento e do destreinamento sobre a gordura corporal de ratos obesos
Ribeiro Braga,Larissa; Rostom de Mello,Maria Alice; Gobatto,Claudio Alexandre;
Archivos Latinoamericanos de Nutrición , 2004,
Abstract: summary. exercise training is often recommended in prevention and treatment of obesity. the present study was designed to compare the effects of intermittent and continuous exercise on weight loss and carcass composition in obese rats. obese male wistar rats (monosodium glutamate [msg] administration, 4 mg/g of body weight every other day from birth to 14 days old) were used. after drug administration, the rats were separated into three groups: msg-sed (sedentary), msg-cont (continuous, swimming, 45 min/day, 5 days/week, with and overload of 5% body weight for 12 weeks) and msg-int (intermittent, 15s swimming intermitted by 15s rest, during 45 min, 5 days/week, with and overload of 15% body weight for 12 weeks). rats of the same age and strain, administered with saline were used as control (sal), and subdivided into three groups: sal-sed, sal-cont and sal-int. the animals were evaluated at the 10 weeks of training and 8 weeks of its interruption. msg rats showed higher carcass fat as well as weight and cell size in epididymal adipose tissue than sal rats, indicting the efficacy of the drug in producing obesity. intermittent training protocol led to a reduction in blood lactate accumulation during acute exercise and both protocols reduced body weight gain during the experiment in msg rats. after 8 weeks of training interruption no differences were observed among groups in the examined parameters. only intermittent exercise training improved aerobic fitness but both protocols were similarly efficient in determining weight loss. however, the effects were transitory, since they disappeared after detraining.
Oxidative stress during rehabilitation from protein malnutrition associated with aerobic exercise in rats
Prada, Francisco José Andriotti;Macedo, Denise Vaz;Mello, Maria Alice Rostom de;
Brazilian Archives of Biology and Technology , 2007, DOI: 10.1590/S1516-89132007000100006
Abstract: this study was designed to evaluate biomarkers of oxidative stress in rats with or without aerobic exercise during recovery from protein malnutrition. from the 30th to the 90th day of life, male wistar rats were fed a low protein diet (lp + 6%) followed by a normal protein diet (np = 17%) until the 120th day and separated in two groups: sedentary (s) and exercise trained (e = swimming 1h/day, 5 days/week, with from the 90th to the 120th day). rats fed a normal protein diet were used as controls. results showed that physical exercise had beneficial effects on body weight gain during nutrition rehabilitation. erythrocytes catalase and glutathione reductase (biomarkers of the antioxidant system) were significantly reduced in all groups in comparison to the sedentary control group. the plasma concentration of tbars (biomarkers of the oxidative damage) was also lower in the recovered rats, suggesting that the improvement in body growth after nutritional rehabilitation with physical exercise could be related to a decrease in the oxidative stress level.
Treinamento físico durante a recupera??o nutricional n?o afeta o metabolismo muscular da glicose de ratos
Santhiago, Vanessa;Silva, Adelino Sanchez Ramos da;Gobatto, Claudio Alexandre;Mello, Maria Alice Rostom de;
Revista Brasileira de Medicina do Esporte , 2006, DOI: 10.1590/S1517-86922006000200004
Abstract: this study had the main aim to assess the food intake, the weight gain, and the muscular glucose metabolism in rats submitted to aerobic training while recovering of protean malnutrition. for this, 60 male wistar rats were separated in two groups: normoprotean (np) and hypoprotean (hp), according to the diet: np (17% protein), or hp (6% protein), respectively, which was received after the ablactation (21 days) on their 90th day of life. then, very animal received the np diet, and they were submitted or not (trained tra; sedentary sed) to physical training that consisted in running on a treadmill for 25 m/min., 50 min/day for 5 days a week for 30 days, compounding the np-sed, np-tra, hp/np-sed, and hp/np-tra groups. the glucose metabolism was assessed in slices of the soleum muscle incubated in the presence of insulin (100 mu/l), and glucose (5.5 mm containing glucose [c14], and 2-deoxyglycose [h3]). the daily food intake (g/100 g of the body weight) for the hp/np-tra group (24.39 ± 4.07) was larger than the hp/np-sed group (21.62 ± 4.69). the weight gain (g) was similar in both groups hp/np-tra (203.80 ± 34.03) and hp/np-sed (214.43 ± 30.54). there was no difference between both groups in relation to the following parameters: glucose uptake and oxidation, and glycogen synthesis by the soleum muscle. thus, it can be concluded that the aerobic training did not have any impact on the nutritional recovery, as there was no metabolic or somatic differences among recovered animals in the presence or absence of the training.
A influência do ultrassom e do treinamento físico sobre os triglicérides séricos e intramusculares em ratos diabéticos experimentais
Dalia, Rodrigo Augusto;Guerino, Marcelo Renato;Parizotto, Nivaldo Antonio;Mello, Maria Alice Rostom de;Luicano, Eliete;
Revista Brasileira de Medicina do Esporte , 2011, DOI: 10.1590/S1517-86922011000200011
Abstract: therapeutic ultrasound is seen today as one of the most useful resources in the practice of clinical medicine and physical exercise is consolidated as an effective and efficient therapeutics in several cases; however, they are still little investigated when associated. therefore, the present work has as the aim to analyze the influences of ultrasound and physical exercise on serum and muscle triglycerides concentrations in experimental diabetes rats. adult wistar rats were used and divided in eight groups: sedentary diabetics (sd), trained diabetics (td), sedentary diabetic and ultrasound (sdus), trained diabetic and ultrasound (tdus), sedentary control (sc), trained control (tc), sedentary and ultrasound controls (sucs), trained control and ultrasound (tcus). the training protocol was composed of swimming exercise five days a week, 30 daily minutes and with maximum load of 8% of body mass during three weeks. the ultrasound therapy was performed five days a week, for two weeks, with intensity of 0.2w/cm2 and frequency of 1.0mhz. no significant differences were observed in the serum triglycerides or in the tibialis anterior and gastrocnemius muscles. concerning the soleus muscle, the diabetic groups showed lower concentrations compared to the control groups and td, and tdus groups showed lower concentrations compared to sd and sdsu, with the trained groups presenting the lowest concentrations. the pulsed ultrasound in the intensity investigated did not influence serum triglycerides or imtg. however, exercise was effective in reducing soleus muscle triglycerides.
DESNUTRI O PROTéICO-CALóRICA E CRESCIMENTO CORPORAL. INFLUêNCIA DO EXERCíCIO NA RECUPERA O NUTRICIONAL DE RATOS
Renato ROCHA,Graziela Cristina SIM?ES,Marcelo PORTO,Maria Alice Rostom de MELLO
Alimentos e Nutri??o , 2009,
Abstract: RESUMO: O exercício pode ser benéfico durante a recupera o da desnutri o protéico-calórica. Constatou-se que crian as em recupera o nutricional ganharam mais massa magra e cresceram mais rapidamente quando estimuladas a participar de programa de atividade física. Os resultados de estudos feitos com animais de laboratório s o conflitantes. O presente estudo visou avaliar o efeito de dois programas de atividade física regular sobre o crescimento corporal de ratos que se recuperavam de desnutri o protéico-calórica. O estudo foi delineado em duas etapas. Na primeira etapa, ratos jovens (40 dias) foram separados em dois grupos (N=6): Controles: (dieta 25% proteína por 30 dias) e Desnutridos: (dieta 6% proteína por 30 dias). Os ratos desnutridos apresentaram menores pesos e comprimentos corporais e da tíbia, proteinemia e albuminemia, bem como maiores concentra es circulantes de ácidos graxos livres e de gordura no fígado de que os Controles, mostrando a eficácia da dieta 6% proteína em causar retardo no crescimento e outros sinais de desnutri o. Na segunda etapa, formaram-se três grupos (N=6) de animais Controles (dieta 25% proteína por 65 dias): Sedentários; Nata o (suportando sobrecarga equivalente a 5% do peso corporal, 60 minutos diários, 5 dias por semana, durante os últimos 35 dias) e Corrida (em esteira rolante à velocidade de 24m/min, 75 minutos por dia, 5 dias por semana, durante os últimos 35 dias). Formaram-se três grupos equivalentes (N=6) de animais recuperados (dieta 6% proteína por 30 dias, dieta 25% proteína por 35 dias). Ao final dessa etapa, todos os animais mostraram valores semelhantes para proteínas totais, albumina e ácidos graxos livres séricos e gordura hepática. Os animais recuperados apresentaram pesos e comprimentos corporais e da tíbia semelhantes entre si, porém inferiores aos dos Controles, indicando que ambos os protocolos falharam em acelerar o crescimento dos ratos em recupera o nutricional. PALAVRAS-CHAVE: Deficiência protéica; realimenta o; atividade física regular; crescimento linear.
Apoptosis and physical exercise: effects on skeletal muscle
Fabrício Azevedo Voltarelli,Maria Alice Rostom de Mello,José Alberto Ramos Duarte
Revista Brasileira de Cineantropometria e Desempenho Humano , 2008,
Abstract: This brief review will discuss an exciting new area in exercise science, namely the role of apoptosis programmed cell death in exercise. Apoptotic cell death differs morphologically and biochemically from necrotic cell death, although both appear to occur after exercise. Accelerated apoptosis has been documented to occur in a variety of disease states, such as AIDS and Alzheimer’s disease, as well as in the aging heart. In striking contrast, failure to activate this genetically regulated cell death may result in cancer and certain viral infections. Here, the apoptosis phenomenon will be discussed, as it occurs in skeletal muscle, and its relation to physical exercise, as well as the interaction with the HSP70 protein. We speculate that exercise-induced apoptosis is a normal regulatory process that serves to remove certain damaged cells without a pronounced inflammatory response, thus ensuring optimal organism function. Resumo Esta breve revis o irá discutir uma nova e excitante área em ciências do exercício, conhecida como o papel da apoptose ou morte celular programada no exercício. A morte celular por apoptose difere morfológica e bioquimicamente da morte celular por necrose, embora ambas parecem ocorrer após o exercício. A ocorrência de apoptose acelerada tem sido relatada em uma grande variedade de doen as, tais como a AIDS e o mal de Alzheimer, bem como em problemas cardíacos relacionados com o envelhecimento. Por outro lado, falhas ao ativar essa regula o genética de morte celular pode resultar em cancer e em certas infec es virais. Aqui será discutido o fen meno da apoptose, na musculatura esquelética, relacionado com o exercício físico, assim como a intera o com a proteína HSP70. Nós especulamos que a apoptose induzida pelo exercício é um processo regulatório normal, que se torna útil no sentido de remover certas células lesadas com ausência de resposta inflamatória pronunciada, otimizando, assim, as fun es do organismo.
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