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Search Results: 1 - 10 of 118106 matches for " Marguerite T. Littleton-Kearney "
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Effects of delayed estrogen treatment and 20-HETE synthesis inhibition on postischemic pial artery response to acetylcholine in rats  [PDF]
Chikao Miyazaki, Emil N. Zeynalov, Raymond C. Koehler, Marguerite T. Littleton-Kearney
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2014, DOI: 10.4236/ojmip.2014.41001
Abstract:

Relatively little is known about the effects of estrogen on postischemic cerebral vasomotor dynamics after ischemic injury. Emerging hypotheses suggest that the timing after menopause at which hormone replacement is initiated might be important and might modulate the potential benefits of estrogen on brain rescue once a cerebral ischemic event occurs. Therefore, we sought to determine if protracted hypoestrogenicity modifies estrogen’s protective effects on postischemic pial artery dilatory dysfunction and if the arachidonic acid metabolite 20-hydroxyeicosatetraeonic (20-HETE) contributes to the dysfunction. Pial artery dilation to acetylcholine was examined before and 1 hour after 15 minutes forebrain ischemia. The rat study groups included: sexually mature males (M), naive (N), OVX (OV), estrogen-treated OVX females (E1; estrogen started 1 week post ovariectomy) and delayed estrogen-treated (E10; started 10 weeks post ovariectomy) females. Postischemic responses were assessed before and after superfusion of the 20-HETE synthesis inhibitor N-hydroxy-N’-(4-butyl-2-methylphenyl)-formamidine (HET0016). Postischemic acetylcholine dilation was depressed in M, OV and E10 compared to N and E1 rats. Compared to E1, delayed estrogen replacement worsened acetylcholine-induced dilation. Postischemic microvascular estrogen receptor alpha (ERα) density was similar in the OV, E1 and E10 rats. Postischemic application of HET0016 failed to improve acetylcholine dilation. Continuous infusion of HET0016 during and after ischemia did not reverse postischemic pial vasodilatory dysfunction. Timing of estrogen replacement may be critical for vascular health after cerebral ischemic injury. Postischemic loss of acetylcholine reactivity does not appear to involve mechanisms related to 20-HETE synthesis or microvascular ERα expression.

Reproductive Senescence Blunts Response of Estrogen Receptor-α Expression to Estrogen Treatment in Rat Post-Ischemic Cerebral Microvessels
Emil Zeynalov, Niloofar Rezvani, Chikao Miyazaki, Xiaoguang Liu, Marguerite T. Littleton-Kearney
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102194
Abstract: Background Several studies demonstrate that estrogen treatment improves cerebral blood flow in ischemic brain regions of young ovariectomized (OVX) rats. Estrogen receptor-α (ER-α) may mediate estrogen’s beneficial actions via its effects on the cerebral microvasculature. However, estrogen-derived benefit may be attenuated in aged, reproductively senescent (RS) rats. Our goal was to determine the effects of aging, estrogen deprivation and estrogen repletion with oral conjugated estrogens (CE) on postischemic cerebral microvascular protein expression of ER-α and ER-β. Methods Fisher-344 (n = 37) female rats were randomly divided into the following groups: OVX, OVX CE-treated, RS untreated, and RS CE-treated. After 30 days pretreatment with CE (0.01 mg/kg) rats were subjected to15 min. transient global cerebral ischemia. Non-ischemic na?ve, OVX and RS rats were used as controls. Expression of ER-α and ER-β in isolated cortical cerebral microvessels (20 to 100 μm in diameter) was assessed using Western blot and immunohistochemistry techniques. Results Age and reproductive status blunted nonischemic ER-α expression in microvessels of OVX rats (0.31±0.05) and RS rats (0.33±0.06) compared to na?ve rats (0.45±0.02). Postischemic microvascular expression of ER-α in OVX rats (0.01±0.0) was increased by CE treatment (0.04±0.01). Expression of ER-α in microvessels of RS rats (0.03±0.02) was unaffected by CE treatment (0.01±0.02). Western blot data are presented as a ratio of ER-α or ER-β proteins to β-actin and. Oral CE treatment had no effect on ER-β expression in postischemic microvessels of OVX and RS rats. Statistical analysis was performed by One-Way ANOVA and a Newman-Keuls or Student’s post-hoc test. Conclusion Chronic treatment with CE increases ER-α but not ER-β expression in cerebral microvessels of OVX rats. Aging appears to reduce the normal ability of estrogen to increase ER-α expression in postischemic cerebral microvessels.
Management Implications of Aquifer Fractures on Ecosystem and Habitat Suitability for Panthers in Southern Florida  [PDF]
Wenjing Xu, Sergio Bernardes, Sydney T. Bacchus, Marguerite Madden
Journal of Geoscience and Environment Protection (GEP) , 2018, DOI: 10.4236/gep.2018.62012
Abstract: Our case study analyzed the proximity of previously mapped fractures in the aquifer matrix to 93 Florida panther (Puma concolor coryi) dens mapped from 2007-2016 in south Florida. Dens occurred in five counties (Collier = 77, Dade = 1, Hendry = 9, Lee = 5, and Monroe = 1) and three sub-basins of the Greater Everglades Basin (Big Cypress Swamp = 83, Caloosahatchee = 3, and Everglades = 7). Fractured aquifers occur worldwide, but are not the focus of habitat suitability studies, despite evidence that fractures influence plant species composition and density. Habitat alterations can occur many kilometers from the surface footprint of groundwater alterations in the regional Floridan aquifer system via preferential flow through fractures. Increased natural discharge from and recharge to the aquifer occur at fracture intersections. Greater induced recharge and habitat changes also may occur at fracture intersections. All dens were within 5 km of a previously mapped fracture; 36% and 74% were within 1 km and 2 km, respectively, of those fractures; and 47%, 74%, and 90% of dens were within 2 km, 3.25 km and 5 km, respectively, from the nearest fracture intersection. Results suggest fractures influence the suitability and/or availability of habitat for panther dens, selection of den sites, and availability as well as abundance of high quality prey items essential for the nutritional demands of successfully rearing panther kittens in the wild. We recommend more detailed investigations of: a) vegetation characteristics near dens, b) groundwater alterations and cumulative impacts of those alterations associated with fractures in panther habitat (e.g., altered plant species composition and density), and c) influence of aquifer fractures in all habitats underlain by fractures.
Australia’s Out-Dated Concern over Fishing Threatens Wise Marine Conservation and Ecologically Sustainable Seafood Supply  [PDF]
Robert Kearney
Open Journal of Marine Science (OJMS) , 2013, DOI: 10.4236/ojms.2013.32006
Abstract:

Seafood plays an important role in human nutrition and its increased consumption is actively recommended for sustenance and health benefits in both developing and developed countries. In parallel to this, the public receives confusing advice as to what seafood is sustainably produced and is frequently misled about the environmental impacts of fishing, especially in locations such as Australia where contemporary fishery management has a conservation and sustainability focus. It is recognised globally that Australia’s traditional fishery management driven by strict sustainability and biodiversity regulations, has achieved impressive results in managing both fish stocks and the effects of fishing on marine environments. Despite this, continued pressure from non-government organisations (NGOs) and a perpetuation of the misuse of management terms such as overfished is used to promote the misguided need for ever increasing fishing restrictions, most obviously in protected areas. This paper questions the motives of some NGOs and governments in Australia in pursuing additional restrictions on fishing which are mostly unnecessary and disproportionate to the sustainability requirements of other sources of food. This is done within the context of the global need for sustainable seafood supply and the need for effective marine conservation that addresses all threats to marine ecosystems in proportion to the magnitude of each threat.

Thrombocytopenia in HIV
N Littleton
Continuing Medical Education , 2007,
Abstract:
L’économie sociale : diversité des définitions et des constructions théoriques
Beno?t Lévesque,Marguerite Mendell
Interventions économiques , 2005,
Abstract: Depuis une vingtaine d’années et dans la plupart des pays, on peut observer une multitude d’initiatives de la société civile dans le domaine du développement économique et du développement social, très souvent avec l’aide ou le soutien de l’état. Ces initiatives et ces expérimentations socioéconomiques qui se veulent différentes aussi bien du secteur public que du secteur privé, sont de plus en plus reconnues comme pouvant réussir là où ces deux secteurs ont échoué isolément ou même en tandem. Dans cet article, nous esquissons à grands traits un aper u de l’économie sociale au Canada, en s’en tenant à ce que plusieurs appellent la nouvelle économie sociale qui s’est manifestée à partir des années 1970, mais surtout durant les années 1980. Nous donnons également un aper u des définitions et approches utilisées par les chercheurs pour rendre compte de cette nouvelle réalité.
Analysis and Extent of Santa Fe River Flooding in North Florida Attributed to Rainfall and Wind Damage Associated with Hurricane Irma  [PDF]
Sergio Bernardes, Lou Manglass, Sydney T. Bacchus, Marguerite Madden
Journal of Geoscience and Environment Protection (GEP) , 2019, DOI: 10.4236/gep.2019.711019
Abstract: The Santa Fe River (SFR) is within the north Florida area of the regional Floridan aquifer system. The extent of recent flood damage in the SFR and tributaries in Bradford County has been attributed to rainfall and wind damage to trees associated with Hurricane Irma, September 2017. Implications of the determined cause of a disaster can include the allocation of disaster relief funds. Bradford County, Florida obtained approximately $2.5 million from the United States Department of Agriculture’s (USDA) Natural Resources Conservation Service (NRCS) for emergency flood abatement assistance and $255,875 from the Suwannee River Water Management District (SRWMD), combined with $13,750 in-kind match provided by the county, based on the attributed cause of that damage to rainfall and winds from Hurricane Irma. On January 2, 2018, Bradford County commissioners also approved grant applications to the SRWMD for $2.2 million for Alligator Creek Flood Mitigation and for $90,250 for Hampton Lake Canal to Santa Fe River Flood Mitigation, requiring in-kind matches from the county of $110,000 and $4750, respectively. Our study analyzed historical precipitation data for the SFR Basin and headwaters from 1895 through 2017 and recorded discharge and gage heights from the United States Geological Survey (USGS) to evaluate that presumed cause of flood damage in that basin and to provide a better understanding of historical relationships between precipitation, gage data and flooding in that basin. Recorded USGS peak gage height and Digital Elevation Models (DEMs) also were used to illustrate the lateral extent and relative depth of flooding associated with an extreme precipitation event in the lower SFR vicinity of O’Leno State Park. Finally, we evaluated the condition of the trees in the SFR Basin as an indicator of long-term anthropogenic groundwater alterations. Those data and analyses did not support the conclusion that Hurricane Irma was the only cause of the magnitude and extent of SFR flooding and tree damage in Bradford County and adjacent counties. Other contributors to stream flow in the SFR basin include heavy mineral mining wastewater discharges that have exceeded the maximum discharge volume of “40 million gallons a day” (MGD) under the National Pollutant Discharge Elimination System (NPDES) permit issued by the Florida Department of Environmental Protection (FDEP) to the Chemours Company TT LLC (Chemours, formerly DuPont) for Trail Ridge mining operations. The magnitude of those discharges suggests that those discharges and extensive Trail Ridge mining in Baker,
Narrativa
Kearney, Richard;
Educa??o & Realidade , 2012, DOI: 10.1590/S2175-62362012000200006
Abstract: stories offer us some of the richest and most enduring insights into the human condition and have preoccupied philosophy since aristotle. this article, based on the affirmative view of narrativity advanced by theorists like ricoeur, rorty and macintyre, argues that historical truth is as much the property of narrative knowledge as it is of so-called objective knowledge. it proposes a critical dialogue between aristotelian poetics and contemporary hermeneutic readings, discussing the relations between narrative and memory, fiction and history, catharsis and testimony, narrative identity and moral responsibility. considering the new possibilities of interactive and non-linear narration in the digital era, narrative is seen as an open-ended invitation to ethical and poetic responsiveness.
Desde el indigenismo a los derechos humanos: Etnicidad y política más allá de la mixteca
Michael Kearney
Nueva antropología , 1994,
Abstract:
Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice
Anna Israyelyan, Vladimir N Chouljenko, Abolghasem Baghian, Andrew T David, Michael T Kearney, Konstantin G Kousoulas
Virology Journal , 2008, DOI: 10.1186/1743-422x-5-68
Abstract: The OncdSyn virus caused extensive virus-induced cell fusion in cell culture. The oncolytic potential of the OncSyn and OncdSyn viruses was tested in the highly metastatic syngeneic mouse model system, which utilizes 4T1 murine mammary cancer cells implanted within the interscapular region of Balb/c mice. Mice were given three consecutive intratumor injections of OncSyn, OncdSyn, or phosphate buffered saline four days apart. Both OncSyn and OncdSyn virus injections resulted in significant reduction of tumor sizes (p < 0.05) compared to control tumors. Virus treated mice but not controls showed a marked reduction of metastatic foci in lungs and internal organs. Mouse weights were not significantly impacted by any treatment during the course of the entire study (p = 0.296).These results show that the attenuated, but highly fusogenic OncSyn and OncdSyn viruses can effectively reduce primary and metastatic breast tumors in immuncompetent mice. The available bac-cloned OncSyn and OncdSyn viral genomes can be rapidly modified to express a number of different anti-tumor and immunomodulatory genes that can further enhance their anti-tumor potency.Recent advances in molecular virology have enabled investigators to construct viruses that selectively destroy cancer cells (oncolytic virotherapy). Genetically engineered viruses belonging to different viral families have been evaluated for their potential as therapeutic agents in the treatment of malignant tumors [1-4]. Efficient replication, cell lysis and spread of HSV, and their natural broad host range make them attractive candidates as oncolytic viral agents [5-7]. Furthermore, the recent availability of cloned HSV genomes into bacterial artificial chromosome vectors greatly facilitates the rapid construction of new recombinant viruses carrying multiple transgenes of interest [8-10]. Tumor treatment with oncolytic HSV has been shown to induce anti-tumor immune responses [11-15]. Although the majority of people are seropositi
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