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Search Results: 1 - 10 of 3289 matches for " Margaret Gallagher "
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Myth and Reality in Women's Employment in Broadcasting. Ten Years of Equal Opportunity
Margaret Gallagher
MedieKultur : Journal of Media and Communication Research , 1986,
Abstract: Myth and Reality in Women's Employment in Broadcasting. Ten Years of Equal Opportunity
Rapid detection of the CYP2A6*12 hybrid allele by Pyrosequencing? technology
Deborah A Koontz, Jacqueline J Huckins, Antonina Spencer, Margaret L Gallagher
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-80
Abstract: A single set of PCR primers was designed to specifically amplify both the CYP2A6*1 wild-type allele and the CYP2A6*12 hybrid allele. An internal Pyrosequencing primer was used to generate allele-specific sequence information, which detected homozygous wild-type, heterozygous hybrid, and homozygous hybrid alleles. We first validated the assay on 104 DNA samples that were also genotyped by conventional two-step PCR and by cycle sequencing. CYP2A6*12 allele frequencies were then determined using the Pyrosequencing assay on 181 multi-ethnic DNA samples from subjects of African American, European Caucasian, Pacific Rim, and Hispanic descent. Finally, we streamlined the Pyrosequencing assay by integrating liquid handling robotics into the workflow.Pyrosequencing results demonstrated 100% concordance with conventional two-step PCR and cycle sequencing methods. Allele frequency data showed slightly higher prevalence of the CYP2A6*12 allele in European Caucasians and Hispanics.This Pyrosequencing assay proved to be a simple, rapid, and accurate alternative to conventional methods, which can be easily adapted to the needs of higher-throughput studies.Cytochrome P450 (CYP) is a diverse superfamily of enzymes that catalyzes the metabolism of a wide variety of compounds, including drugs and xenobiotics [1]. CYP2A6 is a member of this superfamily. It was first identified as the human coumarin 7-hydroxylase enzyme [2]. CYP2A6 is also the primary enzyme responsible for the metabolism of nicotine to cotinine. Substantial inter-individual and inter-ethnic differences in enzyme activity are thought to be attributable to genetics as well as to environmental factors [3]. Individuals lacking a functional CYP2A6 gene have impaired nicotine metabolism and are therefore less prone to nicotine addiction and possibly tobacco-related cancers [4].The CYP2A6 gene is located on chromosome 19, adjacent to the inactive and highly homologous CYP2A7 gene. Of the 17 different allelic variants in CYP2A
Analysis on the Growth Rhythm and Cold Tolerance of Five-Year Old Eucalyptus benthamii Plantation for Bioenergy  [PDF]
Aihua Yu, Tom Gallagher
Open Journal of Forestry (OJF) , 2015, DOI: 10.4236/ojf.2015.56052
Abstract: A research plot of Eucalyptus benthamii was planted to evaluate this species’ ability to supply the emerging bioenergy markets that are developing in the southern U.S. The plot was planted in two different densities to investigate the growth parameters and the cold tolerance. The stand was measured annually through five growing seasons. The results indicated that the growth difference among the young E. benthamii was noticeable. For example, the maximum and minimum value of five-year old trees at diameter breast height (DBH) was 27.9 centimeters and 1.27 centimeters; and the maximum and minimum value of tree height was 22.86 meters and 2.44 meters, respectively. The yearly change in DBH and height of E. benthamii had significant differences. The average annual survival rates of E. benthamii had differences under the two planting densities (1650 trees ha-1 and 1237 trees ha-1). The densities also had effects on the height and DBH growth of E. benthamii. The average DBH and height of 1650 trees ha-1 plantation were 11.18 centimeters and 15.03 meters, and the average DBH and height of 1237 trees ha-1 plantation were 13.46 centimeters and 16.28 meters. The volume per hectare of 1650 trees ha-1 and 1237 trees ha-1 plantation were 111.45 cubic meters and 101.15 cubic meters, respectively. Average diameter growth was almost 2.54 centimeters per year and average height growth was over 3 meters. E. benthamii plantations were considered tolerant to -7.4 degrees Celsius and a cold spell during early 2014 (-11.3 degrees Celsius for two consecutive nights) killed the plantation. The growth of E. benthamii also
Workplace mistreatment: Health, working environment and social and economic factors  [PDF]
Margaret Hodgins
Health (Health) , 2014, DOI: 10.4236/health.2014.65057
Abstract:

Objective: To explore patterns of workplace mistreatment, relationships with health and with selected workplace, economic and social factors in 34 countries. Methods: Secondary data analysis of the European Working Conditions Survey. Results: Patterns of ill treatment (across occupational groups, and sectors) were broadly consistent with smaller, less representative studies. Prevalence was lower than many studies but corresponds with estimates of serious mistreatment. Mistreatment increases the risk of both physical and mental ill health and is associated with a range of work environment factors. Mistreatment is more prevalent in countries with smaller gender gaps, better performance on the GINI index for income inequality and for countries with specific anti-bullying legislation. Conclusions: Mistreatment in work is complex, and interventions are required at the level of the organization. Implementation issues need to be addressed, as specific anti-bullying legislation does not appear to provide sufficient protection.

Size Variation in Small-Bodied Humans from Palau, Micronesia
Andrew Gallagher
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003939
Abstract: Background Recent discoveries on Palau are claimed to represent the remains of small-bodied humans that may display evidence insular size reduction. This claim has yet to be statistically validated Methodology/Principal Findings Published postcranial specimens (n = 16) from Palau were assessed relative to recent small-bodied comparative samples. Resampling statistical approaches were employed to test specific hypotheses relating to body size in the Palau sample. Results confirm that the Palau postcranial sample is indisputably small-bodied. Conclusions/Significance A single, homogenous body size morph is represented in early prehistoric postcrania from Palau. Small body size in early Palauans is an ancestral characteristic and was likely not a consequence of in-situ size reduction. Specimens from Palau have little bearing upon hypothesised insular size reduction in the ancestral lineage of Homo floresiensis.
Hermeneutyka i nauki kognitywne
Shaun Gallagher
Avant : Journal of Philosophical-Interdisciplinary Vanguard , 2011,
Abstract: Philosophical hermeneutics, understood as the theory of nterpretation, investigates some questions that are also asked in the cognitive sciences. The nature of human understanding, the way that we gain and organize knowledge, the role played by language and memory in these considerations, the relations between conscious and unconscious knowledge, and how we understand other persons, are all good examples of issues that form the intersection of hermeneutics and the cognitive sciences. Although hermeneutics is most often contrasted with the natural sciences, there are some clear ways in which hermeneutics can contribute to the cognitive sciences and vice versa.
Map it @ WSU: Development of a Library Mapping System for Large Academic Libraries
Paul Gallagher
Code4Lib Journal , 2010,
Abstract: The Wayne State Library System launched its library mapping application in February 2010, designed to help locate materials in the five WSU libraries. The system works within the catalog to show the location of materials, as well as provides a web form for use at the reference desk. Developed using PHP and MySQL, it requires only minimal effort to update using a unique call number overlay mechanism. In addition to mapping shelved materials, the system provides information for any of the over three hundred collections held by the WSU Libraries. Patrons can do more than just locate a book on a shelf: they can learn where to locate reserve items, how to access closed collections, or get driving maps to extension center libraries. The article includes a discussion of the technology reviewed and chosen during development, an overview of the system architecture, and lessons learned during development.
An approach to dyspnea in advanced disease.
Gallagher R
Canadian Family Physician , 2003,
Abstract: INTRODUCTION: To describe an approach to assessment and treatment of dyspnea. SOURCES OF INFORMATION: New level I evidence can guide management of dyspnea in advanced illness. Assessment and use of adjuvant medications and oxygen relies on level II and III evidence. MAIN MESSAGE: Opioids are first-line therapy for managing dyspnea in advanced illness. They are safe and effective in reducing shortness of breath. Neuroleptics are useful adjuvant medications. Evidence does not support use of oxygen for every patient experiencing dyspnea; it should be tried for patients who do not benefit from first-line medications and nonmedicinal therapies. CONCLUSION: Opioids relieve dyspnea and are indicated as first-line treatment for dyspnea arising from advanced disease of any cause.
New Results from the MINOS Experiment
Hugh Gallagher
Physics , 2008, DOI: 10.1088/1742-6596/136/2/022014
Abstract: In this paper we present the latest results from the MINOS Experiment. This includes a new measurement of the atmospheric neutrino oscillation parameters based on 3.36 x 10^20 protons-on-target of data and a first analysis of neutral current events in the Far Detector. The prospects for nu-e appearance measurements in MINOS are also discussed.
Genetics of a sex-linked recessive red eye color mutant of the tarnished plant bug, Lygus lineolaris  [PDF]
Margaret Louise Allen
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.32A001
Abstract: An inbred colony of the tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Miridae: Hemiptera), was observed to contain specimens with abnormal traits including red eyes, deformed antennae, and deformed legs. These specimens were isolated and back crossed to create stable phenotypic strains. The only successful strain established was a red eyed strain named Cardinal. The trait was more prevalent and stable in males, suggesting that it could be sex linked. To test the hypothesis that the trait was based on a recessive sex linked allele, classical genetic crosses were performed. The hypothesis was confirmed, and the eye color phenotype was measured and characterized using color analysis software. The trait is similar to other red eyed phenotypes described in this species, but is clearly based on a different mutation since it is sex linked rather than autosomal. The results of crossing experiments also suggest that inbreeding in this species results in substantial fitness cost to laboratory insects.
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