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Search Results: 1 - 10 of 222 matches for " Maren Kuhne "
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Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis
Heiner Appel, Wolfgang Kuon, Maren Kuhne, Peihua Wu, Stefanie Kuhlmann, Simon Kollnberger, Andreas Thiel, Paul Bowness, Joachim Sieper
Arthritis Research & Therapy , 2004, DOI: 10.1186/ar1221
Abstract: Chlamydia-triggered reactive arthritis (Ct-ReA) is strongly associated with HLA-B27 like other spondylarthropathies, and especially ankylosing spondylitis [1,2]. ReA occurs 1 to 4 weeks after urogenital infection with Chlamydia trachomatis or gastroenteral infection with enterobacteria such as Yersinia enterocolitica [3]. After acute onset, most patients have a self-limiting course, but up to 20% suffer from a disease duration of more than 1 year [4]. Of HLA-B27+-reactive arthritis patients, 20–40% move on to ankylosing spondylitis after 10–20 years, suggesting that the ReA-associated bacteria can cause ankylosing spondylitis [5] and that immune mechanisms triggering the disease are induced by T cell responses to microbial antigens. The main hypothesis advanced for the association between HLA-B27 and spondylarthropathies is the arthritogenic peptide theory. It states that some HLA-B27 subtype alleles, owing to their unique amino acid residues, bind a specific arthritogenic peptide that is recognized by CD8+ T cells [6-9]. Recently we and several other groups have reported on Chlamydia-specific CD8+ T cells capable of lysing target cells primed with Chlamydia antigens [10-12]. CD8+ T cell responses in spondylarthropathies other than Ct-ReA have also been described [13-15].Recently a new method for antigen-specific T cell recognition has been established by using multimerized MHC/peptide molecules [16]. These molecules are called tetramers because they contain four soluble and biotinylated MHC molecules linked to labelled streptavidin that specifically bind with high avidity to T cell receptors. In comparison with intracellular cytokine staining, the major advantage of tetramer technology is the identification of antigen-specific T cells independently of their cytokine secretion profile, the possibility of sorting unstimulated T cells and of having a tool for the antigen-specific detection of T cells in experiments in situ [17].In humans, MHC class I tetramers are wid
Critical Behavior of Heisenberg Chains Coupled to Phonons
R. Kuhne
Physics , 1999,
Abstract: This paper has been withdrawn by the author due to unspecified problems.
Possible Observation of a Second Kind of Light
R. Kuhne
Physics , 2000,
Abstract: According to classical electrodynamics, sunlight that is passed through an iron layer can be detected with the naked eye only if the thickness of the layer is less than 170nm. However, in an old experiment, August Kundt was able to see the sunlight with the naked eye even when it had passed an iron layer with thickness greater than 200nm. To explain this observation, we propose a second kind of light which was introduced in a different context by Abdus Salam. A tabletop experiment can verify this possibility.
Tabletop Experiment to Verify Magnetic Monopoles
R. W. Kuhne
Physics , 1997,
Abstract: Recently, we suggested a model of magnetic monopoles (hep-ph/9708394). Here we will propose a tabletop experiment to test this model. The verification of the predicted effect would have far-reaching consequences.
Possible Observation of a Second Kind of Light - Magnetic Photon Rays
Rainer W. Kuhne
Physics , 2004,
Abstract: Several years ago, I suggested a quantum field theory which has many attractive features. (1) It can explain the quantization of electric charge. (2) It describes symmetrized Maxwell equations. (3) It is manifestly covariant. (4) It describes local four-potentials. (5) It avoids the unphysical Dirac string. My model predicts a second kind of light, which I named ``magnetic photon rays.'' Here I will discuss possible observations of this radiation by August Kundt in 1885, Alipasha Vaziri in February 2002, and Roderic Lakes in June 2002.
A Model of Magnetic Monopoles
Rainer W. Kuhne
Physics , 1997, DOI: 10.1142/S0217732397003277
Abstract: The possibility of the existence of magnetic charges is one of the greatest unsolved issues of the physics of this century. The concept of magnetic monopoles has at least two attractive features: (i) Electric and magnetic fields can be described equivalently. (ii) In contrast to quantum electrodynamics models of monopoles are able to explain the quantization of electric charge. We suggest a quantum field theoretical model of the electromagnetic interaction that describes electricity and magnetism as equivalent as possible. This model requires the cross-section of Salam's ``magnetic photon'' to depend on the absolute motion of the electric charge with which it interacts. We suggest a tabletop experiment to verify this magnetic photon. Its discovery by the predicted effect would have far-reaching consequences: (i) Evidence for a new gauge boson and a new kind of radiation which may find applications in medicine. (ii) Evidence for symmetrized Maxwell equations. (iii) Evidence for an absolute rest frame that gives rise to local physical effects and violation of Einstein's relativity principle.
On the Cosmic Rotation Axis
Rainer W. Kuhne
Physics , 1997, DOI: 10.1142/S0217732397002594
Abstract: Recently, Nodland and Ralston reported to have discovered a cosmic axis. We argue that their axis is supported by an earlier independent observation on the spin axes of galaxies in the Perseus-Pisces supercluster and explainable within the framework of Godel's cosmology.
Short popular review of quantum electromagnetodynamics
R. W. Kuhne
Physics , 2002,
Abstract: The aim of this note is to give a short and popular review of the ideas which led to my model of magnetic monopoles (hep-ph/9708394) and my prediction of the second kind of electromagnetic radiation. I will also point out the many and far-reaching consequences if these magnetic photon rays would be confirmed.
Cartan's Torsion: Necessity and Observational Evidence
Rainer W. Kuhne
Physics , 2004,
Abstract: This article starts with the mathematical definition, concrete description, and physical meaning of Cartan's torsion. I proceed with the argumentation that torsion is required for the description of intrinsic spin. Moreover I argue that the duality between curvature and torsion is analogous to the duality between electricity and magnetism. I conclude this article by pointing out that the aligned rotation axes of the galaxies of the Perseus-Pisces supercluster may be interpreted as a topological defect generated by torsion.
General Relativity Requires Absolute Space and Time
Rainer W. Kuhne
Physics , 2002,
Abstract: We examine two far-reaching and somewhat heretic consequences of General Relativity. (i) It requires a cosmology which includes a preferred rest frame, absolute space and time. (ii) A rotating universe and time travel are strict solutions of General Relativity.
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