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Search Results: 1 - 10 of 4768 matches for " Marcus JH Huibers "
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Efficacy of confrontational counselling for smoking cessation in smokers with previously undiagnosed mild to moderate airflow limitation: study protocol of a randomized controlled trial
Daniel Kotz, Geertjan Wesseling, Marcus JH Huibers, Onno CP van Schayck
BMC Public Health , 2007, DOI: 10.1186/1471-2458-7-332
Abstract: The study design is a randomized controlled trial comparing confrontational counselling delivered by a respiratory nurse combined with nortriptyline for smoking cessation (experimental group), health education and promotion delivered by a respiratory nurse combined with nortriptyline for smoking cessation (control group 1), and "care as usual" delivered by the GP (control group 2). Early detection of smokers with mild to moderate airflow limitation is achieved by means of a telephone interview in combination with spirometry. Due to a comparable baseline risk of airflow limitation and motivation to quit smoking, and because of the standardization of number, duration, and scheduling of counselling sessions between the experimental group and control group 1, the study enables to assess the "net" effect of confrontational counselling. The study has been ethically approved and registered.Ethical as well as methodological considerations of the study are discussed in this protocol. A significant and relevant effect of confrontational counselling would provide an argument in favour of early detection of current smokers with airflow limitation. Successful treatment of tobacco dependence in respiratory patients requires repeated intensive interventions. The results of this study may also show that respiratory nurses are able to deliver this treatment and that intensive smoking cessation counselling is more feasible.Netherlands Trial Register (ISRCTN 64481813).Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease which is characterized by airflow limitation that is not fully reversible [1]. Spirometry is the gold standard for the diagnosis and assessment of the disease [1]. COPD is currently the fifth leading cause of death worldwide [2], and projections for 2020 indicate further increase in global mortality, placing COPD on the third position of lethal diseases [3]. Cigarette smoking is by far the most important risk factor for COPD, and smoking
Effectiveness, relapse prevention and mechanisms of change of cognitive therapy vs. interpersonal therapy for depression: Study protocol for a randomised controlled trial
Lotte HJM Lemmens, Arnoud Arntz, Frenk PML Peeters, Steven D Hollon, Anne Roefs, Marcus JH Huibers
Trials , 2011, DOI: 10.1186/1745-6215-12-150
Abstract: In a randomised trial we will compare (a) Cognitive Therapy (CT) with (b) Interpersonal therapy (IPT), and (c) an 8-week waiting list condition followed by treatment of choice. One hundred eighty depressed patients (aged 18-65) will be recruited in a mental health care centre in Maastricht (the Netherlands). Eligible patients will be randomly allocated to one of the three intervention groups. The primary outcome measure of the clinical evaluation is depression severity measured by the Beck Depression Intenvory-II (BDI-II). Other outcomes include process variables such as dysfunctional beliefs, negative attributions, and interpersonal problems. All self-report outcome assessments will take place on the internet at baseline, three, seven, eight, nine, ten, eleven, twelve and twenty-four months. At 24 months a retrospective telephone interview will be administered. Furthermore, a rudimentary analysis of the cost-effectiveness will be embedded. The study has been ethically approved and registered.By comparing CT and IPT head-to-head and by investigating multiple potential mediators and outcomes at multiple time points during and after therapy, we hope to provide new insights in the effectiveness and mechanisms of change of CT and IPT for depression, and contribute to the improvement of mental health care for adults suffering from depression.The study has been registered at the Netherlands Trial Register, part of the Dutch Cochrane Centre (ISRCTN67561918)With a lifetime prevalence of 17%, depression is a major health problem with serious clinical and social consequences. It is expected that depression will be the leading global cause of years of health lost due to disease in 2030 [1]. With initial response rates up to 60%, and the majority of patients regaining their normal level of functioning within three years, certain psychotherapies and antidepressant medication have proven efficacy in treating acute Major Depressive Disorder (MDD) [2,3]. This might sound promising,
Clinical and cost-effectiveness of computerised cognitive behavioural therapy for depression in primary care: Design of a randomised trial
L Esther de Graaf, Sylvia AH Gerhards, Silvia MAA Evers, Arnoud Arntz, Heleen Riper, Johan L Severens, Guy Widdershoven, Job FM Metsemakers, Marcus JH Huibers
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-224
Abstract: In a randomised trial we will compare (a) computerised cognitive behavioural therapy with (b) treatment as usual by a GP, and (c) computerised cognitive behavioural therapy in combination with usual GP care. Three hundred mild to moderately depressed patients (aged 18–65) will be recruited in the general population by means of a large-scale Internet-based screening (N = 200,000). Patients will be randomly allocated to one of the three treatment groups. Primary outcome measure of the clinical evaluation is the severity of depression. Other outcomes include psychological distress, social functioning, and dysfunctional beliefs. The economic evaluation will be performed from a societal perspective, in which all costs will be related to clinical effectiveness and health-related quality of life. All outcome assessments will take place on the Internet at baseline, two, three, six, nine, and twelve months. Costs are measured on a monthly basis. A time horizon of one year will be used without long-term extrapolation of either costs or quality of life.Although computerised cognitive behavioural therapy is a promising treatment for depression in primary care, more research is needed. The effectiveness of online computerised cognitive behavioural therapy without support remains to be evaluated as well as the effects of computerised cognitive behavioural therapy in combination with usual GP care. Economic evaluation is also needed. Methodological strengths and weaknesses are discussed.The study has been registered at the Netherlands Trial Register, part of the Dutch Cochrane Centre (ISRCTN47481236).Major depression is a common mental health problem in the general population [1] and it is reported to be the second most common and costly mental health problem in general practice [2]. Depression is associated with substantial decreases in quality of life through its impact on physical, social and emotional functioning, and well-being [3,4]. By 2020, depression is estimated to be th
Disrupting the rhythm of depression: design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants
Claudi LH Bockting, Hermien J Elgersma, Gerard D van Rijsbergen, Peter de Jonge, Johan Ormel, Erik Buskens, A Dennis Stant, Peter J de Jong, Frenk PML Peeters, Marcus JH Huibers, Arnoud Arntz, Peter Muris, Willem A Nolen, Aart H Schene, Steven D Hollon
BMC Psychiatry , 2011, DOI: 10.1186/1471-244x-11-8
Abstract: Therefore, we will compare the effectiveness and cost-effectiveness of brief CT while tapering AD to maintenance AD and the combination of CT with maintenance AD. In addition, we examine whether the prophylactic effect of CT was due to CT tackling illness related risk factors for recurrence such as residual symptoms or to its efficacy to modify presumed vulnerability factors of recurrence (e.g. rigid explicit and/or implicit dysfunctional attitudes). This is a multicenter RCT comparing the above treatment scenarios. Remitted patients on AD with at least two previous depressive episodes in the past five years (n = 276) will be recruited. The primary outcome is time related proportion of depression relapse/recurrence during minimal 15 months using DSM-IV-R criteria as assessed by the Structural Clinical Interview for Depression. Secondary outcome: economic evaluation (using a societal perspective) and number, duration and severity of relapses/recurrences.This will be the first trial to investigate whether CT is effective in preventing relapse to depression in recurrent depression while tapering antidepressant treatment compared to antidepressant treatment alone and the combination of both. In addition, we explore explicit and implicit mediators of CT.Netherlands Trial Register (NTR): NTR1907Major depressive disorder (MDD) is projected to rank second on a list of 15 major diseases in terms of burden of disease in 2030 [1]. The major contribution of MDD to disability and health care costs is largely due to its highly recurrent nature [2,3]. Accordingly, efforts to reduce the disabling effects of depression should shift to preventing recurrences, especially in patients at high risk of recurrence. Several international guidelines (e.g., [4,5]) report that patients remitted from prior depressive episodes belong to such high risk groups. The preventive strategy globally suggested, i.e. continuation of antidepressants (AD) for years, is certainly not in line with the fact th
Dephasing in Open Quantum Dots
A. G. Huibers,M. Switkes,C. M. Marcus,K. Campman,A. C. Gossard
Physics , 1997, DOI: 10.1016/S0921-4526(98)00129-X
Abstract: Shape-averaged magnetoconductance (weak localization) is used for the first time to obtain the electron phase coherence time $\tau_{\phi}$ in open ballistic GaAs quantum dots. Values for $\tau_{\phi}$ in the range of temperature T from 0.335 to 4 K are found to be independent of dot area, and are not consistent with the $\tau_{\phi} \propto T^{-2}$ behavior expected for isolated dots. Surprisingly, $\tau_{\phi}(T)$ agrees quantitatively with the predicted dephasing time for disordered two-dimensional electron systems.
High Bias Transport and Magnetometer Design in Open Quantum Dots
M. Switkes,A. G. Huibers,C. M. Marcus,K. Campman,A. C. Gossard
Physics , 1997, DOI: 10.1063/1.120789
Abstract: We report transport measurements as a function of bias in open semiconductor quantum dots. These measurements are well described by an effective electron temperature derived from Joule heating at the point contacts and cooling by Wiedemann-Franz out-diffusion of thermal electrons. Using this model, we propose and analyze a quantum dot based sensor which measures absolute magnetic field at micron scales with a noise floor of $\sim 50 \mu\phi_{0} / \sqrt{Hz}$ at 300 mK.
Differences in the experience of fatigue in patients and healthy controls: patients' descriptions
Marieke F Gielissen, Hans Knoop, Petra Servaes, Joke S Kalkman, Marcus J Huibers, Stans Verhagen, Gijs Bleijenberg
Health and Quality of Life Outcomes , 2007, DOI: 10.1186/1477-7525-5-36
Abstract: 961 participants filled out the FQL (28 adjectives). A component and confirmatory factor analyses were performed and psychometric properties were evaluated. Differences on factor scores between different patients' groups were investigated and pre- and post treatment scores were compared in demonstrating change of perceptions after treatment of fatigue.Four independent factors were found with adequate psychometric properties. Different perceptions were found between the patients' groups. Patients who were recovered after treatment for fatigue showed similar scores on the factors as healthy controls.The FQL appears to be a promising tool in measuring different perceptions of fatigue, which can be especially interesting for clinical practice.What is meant by fatigue? Most people are familiar with the experience of fatigue, but the meaning of this sensation can differ between people and even within one person the meaning of fatigue can change. Therefore, fatigue can be defined in different ways and there is no 'gold standard'. Healthy people would characterise fatigue as a pleasant, acute, normal and regulating phenomenon after exercise or a busy day, disappearing after a good night's sleep or a period of rest. However, fatigue can also have a more negative connotation as in fatigue experienced by patients with a health problem. To them fatigue can be a chronic, disabling and life- and activity-limiting experience [1-6].There are also differences in the factors underlying fatigue severity between patients with different somatic conditions. Processes involved in the experience of fatigue in patients with chronic fatigue syndrome (CFS) are clearly different from processes related to the experience of fatigue in patients with multiple sclerosis (MS) [2] and there are many differences between severely fatigued breast cancer survivors and females with CFS [7].Because fatigue is not clearly defined, poor communication regarding fatigue exist in the clinical practice [8]. Addi
Low-Temperature Saturation of the Dephasing Time and Effects of Microwave Radiation on Open Quantum Dots
A. G. Huibers,J. A. Folk,S. R. Patel,C. M. Marcus,C. I. Duruoz,J. S. Harris, Jr
Physics , 1999, DOI: 10.1103/PhysRevLett.83.5090
Abstract: The dephasing time of electrons in open semiconductor quantum dots, measured using ballistic weak localization, is found to saturate below ~ 100 mK, roughly twice the electron base temperature, independent of dot size. Microwave radiation deliberately coupled to the dots affects quantum interference indistinguishably from elevated temperature, suggesting that direct dephasing due to radiation is not the cause of the observed saturation. Coulomb blockade measurements show that the applied microwaves create sufficient source drain voltages to account for dephasing due to Joule heating.
Distributions of the Conductance and its Parametric Derivatives in Quantum Dots
A. G. Huibers,S. R. Patel,C. M. Marcus,P. W. Brouwer,C. I. Duruoz,J. S. Harris, Jr
Physics , 1998, DOI: 10.1103/PhysRevLett.81.1917
Abstract: Full distributions of conductance through quantum dots with single-mode leads are reported for both broken and unbroken time-reversal symmetry. Distributions are nongaussian and agree well with random matrix theory calculations that account for a finite dephasing time, $\tau_\phi$, once broadening due to finite temperature $T$ is also included. Full distributions of the derivatives of conductance with respect to gate voltage $P(dg/dV_g)$ are also investigated.
Statistics of Coulomb Blockade Peak Spacings
S. R. Patel,S. M. Cronenwett,D. R. Stewart,A. G. Huibers,C. M. Marcus,C. I. Duruoz,J. S. Harris,K. Campman,A. C. Gossard
Physics , 1997, DOI: 10.1103/PhysRevLett.80.4522
Abstract: Distributions of Coulomb blockade peak spacing are reported for large ensembles of both unbroken (magnetic field B = 0) and broken (B <> 0) time reversal symmetry in GaAs quantum dots. Both distributions are symmetric and roughly gaussian with a width ~ 2-6% of the average spacing, with broad, non-gaussian tails. The distribution is systematically wider at B = 0 by a factor of ~ 1.2 +- 0.1. No even-odd spacing correlations or bimodal structure in the spacing distribution is found, suggesting an absence of spin-degeneracy. There is no observed correlation between peak spacing and peak height.
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