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Search Results: 1 - 10 of 15261 matches for " Marcos Flores-Alamo "
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“Anti-Michael” and Michael Additions in the Reactions of 2-Arylmethyliden-1,3-Indandiones with 2-Aminothiophenol  [PDF]
Jessica J. Sánchez García, Alberto D. Hernández-Suzan, Elena Martínez-Klimova, Marcos Flores-Alamo, Teresa Ramírez Apan, Elena I. Klimova
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.71006
Abstract: A novel 2-indano[2,3b]-2-ferrocenyl- and 2-indano[2,3b]-2-(p-methoxy-phenyl)[1,5]benzo-2,5-dihydrothiazepine 5a,b (addition Michael/cyclization) (~30.32%), indano[2,3b]-2-ferrocenyl- and 2-(p-methoxyphenyl)[1,4] benzothiazine 4a,b (addition “anti-Michael”/cyclization) (~45.43%), respectively, were obtained by the condensation of 2-ferrocenyl-and 2-(p-methoxy-phenyl)methyliden-1,3-indandiones 1a,b with o-aminothiophenol 2 in the presence of AcOH and HCl. A new “anti-Michael” addition reaction of 1,4-bis-heteronucleophile 2 into 2-arylmethyliden-1,3-indandiones was reported. As a result of this reaction the product 1a,b was obtained. The structures of the resultant compounds were elucidated by IR, 1H and 13C NMR spectroscopy, mass spectrometry, elemental and X-ray diffraction analysis. The in vitro antitumor activity of the obtained products was researched using the following human cancer cell lines: glioblastoma (CNS U-251), prostatic adenocarcinoma (PC-3), chronic myelogenous leukemia (K562), colorectal adenocarcinoma (HCT-15), mammary adenocarcinoma (MCF-7), and small cell lung cancer (SKLU) and the sulforhodamine B (SRB) method. Among these new compounds some thiazine and thiazepine derivatives showed compelling in vitro antitumor effects on cell lines K-562, HCT-15, SKLU-1 and MCF-7.
Intramolecular Transformations of 3-Cyanoamino- and 3-Cyanoimino-1,2-diferrocenylcyclopropenes
Elena Ivanovna Klimova,Tatiana Klimova,Marcos Flores-Alamo,Leon Vladimirovich Backinowsky,Marcos Martinez Garcia
Molecules , 2009, DOI: 10.3390/molecules14093161
Abstract: 3-Cyanoamino-1,2- and -2,3-diferrocenylcyclopropenes 6a,b and 11a,b prepared by the reaction of diferrocenylcyclopropenylium salts with sodium cyanamide undergo smooth intramolecular transformations with both conservation of the three-membered ring [affording 3-cyanoimino-1,2-diferrocenylcyclopropene (8)] and its opening [affording Z-3-morpholino- and Z-3-piperidino-3-(cyanoimino)-1,2-diferrocenylprop-1-enes 7a,b and Z-3-cyanoimino-2,3-diferrocenyl-1-methylthioprop-1-ene (10)]. 3-Cyano-imino-1,2-diferrocenylcyclopropene (8) reacts with hydrazine to form 3-amino-6-ferrocenyl-5-ferrocenylmethyl-1,2,4-triazine (12) and Z-2,3-diferrocenylacrylohydrazide N-cyanoimide (13) as a result of intramolecular transformations. The structures of the compounds obtained were determined by IR, 1H- and 13C-NMR spectroscopy and mass spectrometry. The structures of compounds 7a and 10 were additionally confirmed by their X-ray diffraction analysis data.
N-Crotylphthalimide
Marcos Flores-Alamo,María del Carmen Romero-Quiroz,Jorge Morgado
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810046039
Abstract: In the title compound {systematic name: 2-[(E)-but-2-en-1-yl]isoindoline-1,3-dione}, C12H11NO2, the phthalimide ring system is essentially planar, with a maximum deviation of 0.008 (1) , while the plane of the N-crotyl substituent is orthogonal to the phthalimide ring system, making a dihedral angle of 87.5 (1)°.
(R)-3,3-Diethyl-1-(2-hydroxy-1-phenylethyl)piperidin-2-one
Oscar Romero,Johana Ramírez,Joel L. Terán,Marcos Flores-Alamo
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536812025433
Abstract: In the title compound C17H25NO2, the piperidin-2-one ring adopts an envelope conformation with the C atom in the 5-position as the flap. The crystal packing is stabilized by intermolecular O—H...O hydrogen bonds, building a infinite chain along the b-axis direction. C—H...π interactions further stabilize the crystal packing.
[1,2-Bis(diisopropylphosphanyl)ethane-κ2P,P′](carbonato-κ2O,O′)nickel(II)
Illan Morales-Becerril,Marcos Flores-Alamo,Juventino J. Garcia
Acta Crystallographica Section E , 2013, DOI: 10.1107/s1600536813006521
Abstract: In the crystal of the title compound, [Ni(CO3)(C14H32P2)], the metal center in each of three independent molecules shows slight tetrahedral distortion from ideal square-planar coordination geometry, with angles between the normals to the planes defined by the cis-P—Ni—P and cis-O—Ni—O fragments of 3.92 (17), 0.70 (16) and 2.17 (14)° in the three molecules. In the crystal, there are intermolecular C—H...O hydrogen bonds that show a laminar growth in the ab plane.
[1,2-Bis(diisopropylphosphanyl)ethane-κ2P,P′]dichloridonickel(II)
Nahury Y. Castellanos-Blanco,Juventino J. García,Marcos Flores-Alamo
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811021209
Abstract: In the crystal structure of title compound, [NiCl2(C14H32P2)], the NiII atom lies on a twofold rotation axis and shows a slightly distorted square-planar coordination geometry, with a dihedral angle of 10.01 (8)° between the cis-Cl—Ni—Cl and cis-P—Ni—P planes. There is no significant intermolecular interaction except very weak C—H...Cl interactions. The crystal studied was a racemic twin.
[1,2-Bis(diisopropylphosphanyl)ethane-κ2P,P′]dichloridonickel(II)–9H-carbazole (1/2)
Farah Cañavera-Buelvas,Marcos Flores-Alamo,Juventino J. García
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811010555
Abstract: In the title compound, [NiCl2(C14H32P2)]·2C12H9N, the neutral [Ni(dppe)Cl2] complex [dppe is 1,2-bis(diisopropylphosphanyl)ethane] consists of a tetracoordinated Ni2+ cation and has a crystallographic twofold axis passing through the metal atom and the mid-point of the CH2—CH2 bond of the dppe ligand. The metal atom shows slight tetrahedral distortion from an ideal square-planar coordination geometry, as reflected in the dihedral angle between NiCl2 and NiP2 planes of 15.32 (2)°. The 9H-carbazole ring system is essentially planar (r.m.s. deviation = 0.022 ). In the crystal packing, there are two symmetry-related 9H-carbazole molecules between two adjacent NiII complexes, with an angle between the carbazole mean planes of ca 77°.
1,3-Bis[(−)-(S)-(1-phenylethyl)iminomethyl]benzene
Tania García,Sylvain Bernès,Marcos Flores-Alamo,Guadalupe Hernández
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811021556
Abstract: The title compound, C24H24N2, is an enantiomerically pure bis-aldimine, which displays twofold crystallographic symmetry, with two C atoms of the central benzene ring lying on the symmetry axis. The imine group is slightly twisted from the benzene core, with a dihedral angle of 12.72 (16)° between the benzene ring and the C=N—C* plane. The terminal phenyl rings make an angle of 66.44 (4)° and are oriented in opposite directions with respect to the benzene ring. In the crystal, molecules interact weakly through a C—H...π interaction involving the phenyl rings, and form chains along the 21 screw-axis in the [100] direction.
Synthesis and Structural Characterization of Fluorinated Thiosemicarbazones
Juan L. Bautista,Marcos Flores-Alamo,Jorge Tiburcio,Rebeca Vieto,Hugo Torrens
Molecules , 2013, DOI: 10.3390/molecules181013111
Abstract: Six new fluorinated thiosemicarbazones R?C(R′)=N-NH-C(S)NH 2 (R = 2,4-C 6H 3F 2, R′ = H ( 1); R = 2,5-C 6H 3F 2, R′ = H ( 2); R = 2,6-C 6H 3F 2, R′ = H ( 3); R = 3,4-C 6H 3F 2, R′ = H ( 4); R = 3,5-C 6H 3F 2, R′ = H ( 5) and R = 4-C 6H 4F, R′ = C 6H 5, ( 6)) have been prepared. The molecular structures of compounds 1 to 6 have been determined.
Three-Component Reaction of Tautomeric Amidines with 3-Ferrocenylmethylidene-2,4-pentanedione. Formation of Polymeric Coordination Complexes of Potassium Ferrocenyl-(hexahydro)pyrimidoxides
Elena I. Klimova,Marcos Flores-Alamo,Tatiana Klimova,Sandra Cortez Maya,Irina P. Beletskaya
Molecules , 2014, DOI: 10.3390/molecules19010041
Abstract: Acetamidine hydrochloride and p-aminobenzamidine dihydrochloride interact with 3-ferrocenylmethylidene-2,4-pentanedione at 80–82 °C in the presence of K 2CO 3 in the water–alcohol medium in two tautomeric forms (the amidoimine and enediamine ones) with formation of mixtures of pyrimidine and piperidone derivatives and polymeric coordination complexes of potassium ferrocenyl(hexahydro)pyrimidoxides. The structure of the resultant compounds is elucidated on the basis of IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis data. The crystal structures of 6-ferrocenyl-4-hydroxy-4-methyl-2-piperidone, potassium 6-ferrocenyl-4-methyl-2-methylidene(hexahydro)pyrimidin-4-oxide and 2-(4-aminophenyl)-4-ferrocenyl-6-methyl-pyrimidine were determined by X-ray analysis of suitable single crystals.
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