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Search Results: 1 - 10 of 133138 matches for " Marcia V. Fournier "
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Nongenomic Mechanisms of PTEN Regulation
Jimmie E. Fata,Shawon Debnath,Edmund C. Jenkins Jr.,Marcia V. Fournier
International Journal of Cell Biology , 2012, DOI: 10.1155/2012/379685
Abstract: A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events. 1. PTEN: A Unique Dual-Specificity Phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten)/MMAC (mutated in multiple advanced cancers) has been identified simultaneously by two research groups as a candidate tumor suppressor gene located at 10q23 and encoding 403 amino acids [1, 2]. Another group identified the same gene in the search for new dual-specific phosphatases and named it TEP-1 (TGF-β regulated and epithelial cell-enriched phosphatase) [3]. PTEN is one of the most common targets of mutation in human cancer, with a mutation frequency approaching that of the tumor suppressor gene p53, and it is also mutated in inherited cancer predisposition disorders. PTEN belongs to the protein tyrosine phosphatase family with phosphatase activity on both lipids and proteins. PTEN’s lipid phosphatase catalyzes the conversion of phosphatidylinositol-(3,4,5)-triphosphate (PIP3) to phosphatidylinositol-4,5-bisphosphate (PIP2) [4, 5] and plays an important role in the PI3K pathway by catalyzing degradation of PIP3 generated by PI3K. This inhibits PI3K downstream targets, mainly PKB-Akt [6–10]. It should be noted, however, that lipid phosphatase attenuated or inactive PTEN mutants have been reported to still retain some tumor suppressing properties [11–15]. So far there is no report of redundancy for PTEN function, which could explain the high frequency with which PTEN inactivation is selected during tumor development [16]. By virtue of PTEN’s ability to attenuate and control the extent of PI3K signaling, PTEN influences many cellular functions, including cell growth, survival, proliferation, and metabolism [8]. PTEN contributes to cell cycle regulation by blocking cells entering the S-phase of the cell cycle and by upregulation of p27kip1, which is
Prognostic Breast Cancer Signature Identified from 3D Culture Model Accurately Predicts Clinical Outcome across Independent Datasets
Katherine J. Martin, Denis R. Patrick, Mina J. Bissell, Marcia V. Fournier
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002994
Abstract: Background One of the major tenets in breast cancer research is that early detection is vital for patient survival by increasing treatment options. To that end, we have previously used a novel unsupervised approach to identify a set of genes whose expression predicts prognosis of breast cancer patients. The predictive genes were selected in a well-defined three dimensional (3D) cell culture model of non-malignant human mammary epithelial cell morphogenesis as down-regulated during breast epithelial cell acinar formation and cell cycle arrest. Here we examine the ability of this gene signature (3D-signature) to predict prognosis in three independent breast cancer microarray datasets having 295, 286, and 118 samples, respectively. Methods and Findings Our results show that the 3D-signature accurately predicts prognosis in three unrelated patient datasets. At 10 years, the probability of positive outcome was 52, 51, and 47 percent in the group with a poor-prognosis signature and 91, 75, and 71 percent in the group with a good-prognosis signature for the three datasets, respectively (Kaplan-Meier survival analysis, p<0.05). Hazard ratios for poor outcome were 5.5 (95% CI 3.0 to 12.2, p<0.0001), 2.4 (95% CI 1.6 to 3.6, p<0.0001) and 1.9 (95% CI 1.1 to 3.2, p = 0.016) and remained significant for the two larger datasets when corrected for estrogen receptor (ER) status. Hence the 3D-signature accurately predicts breast cancer outcome in both ER-positive and ER-negative tumors, though individual genes differed in their prognostic ability in the two subtypes. Genes that were prognostic in ER+ patients are AURKA, CEP55, RRM2, EPHA2, FGFBP1, and VRK1, while genes prognostic in ER? patients include ACTB, FOXM1 and SERPINE2 (Kaplan-Meier p<0.05). Multivariable Cox regression analysis in the largest dataset showed that the 3D-signature was a strong independent factor in predicting breast cancer outcome. Conclusions The 3D-signature accurately predicts breast cancer outcome across multiple datasets and holds prognostic value for both ER-positive and ER-negative breast cancer. The signature was selected using a novel biological approach and hence holds promise to represent the key biological processes of breast cancer.
Fórmula abreviada para la transformación de puntajes de variables a una misma escala
Marco V. Fournier,Luis A. Garner
Revista Latinoamericana de Psicología , 1990,
Abstract: The theoretical foundation and the development of a mathematical formula to transform variable seores expressed in different seales, to the same rale, are presented. The procedure is very useful for developing indicators since (1) the variables must have the same lower limit, and (2) they must be expressed in the same seale they must have the same range) . An example is presented for the formula′s application, for the COMPUTE subroutine of the SPSS (Statistical Package for the Social Sciences). The advantages of the formula to work with a O-lOO scale are discussed
Biodiversity, Extinction, and Humanity’s Future: The Ecological and Evolutionary Consequences of Human Population and Resource Use
Jeffrey V. Yule,Robert J. Fournier,Patrick L. Hindmarsh
Humanities , 2013, DOI: 10.3390/h2020147
Abstract: Human actions have altered global environments and reduced biodiversity by causing extinctions and reducing the population sizes of surviving species. Increasing human population size and per capita resource use will continue to have direct and indirect ecological and evolutionary consequences. As a result, future generations will inhabit a planet with significantly less wildlife, reduced evolutionary potential, diminished ecosystem services, and an increased likelihood of contracting infectious disease. The magnitude of these effects will depend on the rate at which global human population and/or per capita resource use decline to sustainable levels and the degree to which population reductions result from increased death rates rather than decreased birth rates.
ESTADO DA ARTE: uma forma especial de educa o médica continuada
Paola Angelo A. V. de,Barbosa Marcia
Arquivos Brasileiros de Cardiologia , 1998,
Abstract:
Cinqüenta anos de monitoriza o da qualidade cardiológica brasileira
Paola Angelo A. V. de,Barbosa Marcia
Arquivos Brasileiros de Cardiologia , 1998,
Abstract:
First Note on the Definition of S2-Convexity  [PDF]
Pinheiro Marcia
Advances in Pure Mathematics (APM) , 2011, DOI: 10.4236/apm.2011.11001
Abstract: In this short, but fundamental, note, we start progressing towards a mathematically sound definition of the real functional classes 2sK
For the love and respect of the service: Applied aesthetics and palliative care  [PDF]
Marcia Brennan
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.610A1001
Abstract: In this article, the author discusses her experiences as an artist in residence in the Department of Palliative Care and Rehabilitation Medicine at the University of Texas M. D. Anderson Cancer Center. Emphasis is placed on applied aesthetics in palliative care and their implications for addressing communication, spiritual, and health care issues for military service members. Drawing on six vivid case studies, the author examines the various ways in which end of life narratives can shed valuable light on key issues concerning individuals’ life experiences in the Navy, the Army, and the Air Force. These cherished images strengthened people’s spirits at the end of life, and each of the men told their stories with pride.
Starants: A New Model for Human Networks  [PDF]
Marcia Pinheiro
Applied Mathematics (AM) , 2016, DOI: 10.4236/am.2016.73024
Abstract:

In this paper, we will explain the relevance of the starant graphs, graphs created by us in the year of 2002. They were basically circulant graphs with a star graph that connects to all the vertices of the circulant graphs from inside of them, but they did not exist as a separate object of study in the year of 2002, as for all we knew. We now know that they can be used to model even social networking interactions, and they do that job better than any other graph we could be trying to use there. With the development of our mathematical tools, lots of conclusions will be made much more believable and therefore will become much more likely to get support from the relevant industries when attached to new queries.

Para reescrever a biografia de Marcel Mauss...
Fournier, Marcel;
Revista Brasileira de Ciências Sociais , 2003, DOI: 10.1590/S0102-69092003000200001
Abstract: there's a "mauss mystery:" the question is to understand how mauss-the tiny jew of épinal, mauss-the philosophy professor who didn't study at the école normale, mauss-the nephew always in the shade of his uncle, émile durkheim, mauss-the intellectual and the militant, became the "father of modern anthropology," contributing in a distinct way to the development of the human sciences. after the publication of the first biography of marcel mauss (paris, fayard), the publication of his political writings (écrits politiques, paris, fayard), and the publication of his correspondence with durkheim (paris, puf), i propose a reflexion on two aspects: 1) the situation of biography in the social sciences; and 2) the difficulties of writing a biography of marcel mauss (1872-1950). the question raised by the biographer in the beginning of his researches, "failure or success of a life?" turns, in the end of the paper, into another question: "failure or success of a biography?"
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