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Search Results: 1 - 10 of 12838 matches for " Marcelo Chemin; "
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Paralisia de Bell subsequente a ritidoplastia
Ramos, Cristiano d. Silveira;Almeida, Marcelo Wilson Rocha;Souza Aguiar, Leonardo Fernandes de;Cury, Marcelo Chemin;
Revista Brasileira de Cirurgia Plástica , 2011, DOI: 10.1590/S1983-51752011000200030
Abstract: introduction: the peripheral facial palsy is a disease that can leave significant aesthetical and functional sequelae in patients. according to medical literature, bell's palsy (bp) is the most common cause, representing from 50 to 80% of the cases. however, it must be considered as an exclusion diagnosis. a slightly higher prevalence is estimated in women and its incidence is bimodal with peaks in the third and eighth life decades. most patients recover within weeks, though a worsening degree may be common in the first 48 hours. treatment must be performed to prevent complications and the medical procedures are not universally accepted. the following have been mentioned as bp risk factors: arterial hypertension, mellitus diabetes, pregnancy, puerperium and infection caused by type i herpes virus. although there are several bp associated risk factors, regarding face-lifting surgery there is only one reported case in medical literature. case report: in the present study, the authors describe the second case of bell's palsy after face-lifting surgery.
Laparoscopic Treatment of Intrauterine Fallopian Tube Incarceration
William Kondo,Rafael Frederico Bruns,Marcelo Chemin Nicola,Reitan Ribeiro,Carlos Henrique Trippia,Monica Tessmann Zomer
Case Reports in Obstetrics and Gynecology , 2013, DOI: 10.1155/2013/205957
Abstract: Herniation of the pelvic structures into the uterine cavity (appendix vermiformis, small bowel, omentum, or fallopian tube) may occur after uterine perforation. In this paper, we describe one case of intrauterine fallopian tube incarceration treated by means of laparoscopic surgery. 1. Introduction Uterine perforation during curettage is a potentially dangerous complication but may go unrecognized on many occasions [1]. Herniation of the pelvic structures into the uterine cavity, such as the appendix vermiformis, small bowel, omentum or fallopian tube, occurring after uterine perforation has been described in the medical literature but is very rare [1–5]. In this paper, we describe one case of intrauterine fallopian tube incarceration treated by means of laparoscopic surgery. 2. A Case Presentation A 22-year-old woman, gravida 2 para 2, came to our office complaining about pelvic pain and amenorrhea since her vaginal delivery. The symptoms of pain were intermittent, but they worsened in the last 3 days before she came to our service including persistent, cramping abdominal pain, and mild abdominal distension. Eleven months ago, she had her second vaginal delivery complicated by retained placenta. The placenta was delivered in multiple fragments followed by sharp curettage. Then, she presented postpartum hemorrhage requiring another curettage of the uterus. On physical examination, the abdominal examination was unremarkable. Gynecologic examination revealed a tender uterus with no adnexal abnormalities. Transvaginal ultrasound (Figure 1(a)) revealed a hypoechoic, irregular tissue within the endometrial cavity. The ovaries were normal. Pelvic MRI (Figure 1(b)) demonstrated a right hydrosalpinx that “infiltrated” the uterine fundus, extending to the endometrial cavity. A diagnostic laparoscopy (Figure 1(c)) was indicated, and during the procedure, the right fallopian tube was found to be adhered to the uterine fundus. The right ovary and the left adnexae were normal. The tube was progressively freed from the uterine wall. A right salpingectomy was conducted because the patient did not want to have any more pregnancies. The uterine wall defect was repaired in multiple layers using caprofyl (poliglecaprone 25) zero (Figure 1(d)). The patient was discharged 12 hours after the procedure. Figure 1: (a) Transvaginal ultrasound showing a hypoechoic structure (blue arrows) within the uterus (U). (b) Pelvic MRI demonstrating a herniation (blue arrow) of the right hydrosalpinx (H) through the uterine wall (U) going up to the endometrial cavity (EC). Both the right
Molecular basis of hepatitis C virus -associated hepatocarcinogenesis
Isabelle Chemin
Iatreia , 2007,
Abstract: In areas with an intermediate rate of Hepatocellular Carcinoma (HCC) such as Western Europe and Japan, hepatitis C is the predominant cause, whereas in low rate areas such as Western Europe and North USA, HCC is often related to other factors as alcoholic liver disease. There is a rising incidence in HCC in developed countries during the last two decades, due to the increasing rate of hepatitis C infection and improvement of the clinical management of cirrhosis (most of the time appear after cirrhosis), the total number of HCC cases annually registered should be multiplied by 3 until 2020. The pathogenesis of HCC in HCV infection has extensively been analysed. Hepatitis C virus-induced chronic inflammation and the effects of cytokines in the development of fibrosis and liver cell proliferation are considered as one of the major pathogenic mechanisms. Increasing experimental evidence suggests that HCV contributes to HCC by directly modulating pathways that promote the malignant transformation of hepatocytes. Hepatitis C virus is an RNA virus that does not integrate into the host genome but HCV proteins interact with many host-cell factors well beyond their roles in the viral life cycle and are involved in a wide range of activities at least in vitro, including cell signalling, transcription, cell proliferation, apoptosis, membrane rearrangements, vesicular trafficking and translational regulation. At least four of the HCV gene products, namely HCV core, NS3, NS4B and NS5A, have been shown to exhibit transformation potential in tissue culture and several potentially oncogenic pathways have been shown to be altered by the expression of HCV proteins. Both HCV core and NS5A induce the accumulation of wild-type betacatenin and the Wnt-beta-catenin pathway emerges as a common target for HCV (and HBV) in human HCCs, also independently from axin/beta-catenin gene mutations. Induction of both endoplasmic reticulum stress and oxidative stress by HCV proteins might also contribute to HCV transformation. HCV proteins were shown to have an action on tumor suppressor genes, mitosis, apoptosis. Most of the putative transforming functions of the HCV proteins have been defined in artificial cellular systems, which may not be applicable to HCV infection in vivo, and still need to be established in relevant infection and disease models. Despite numerous lines of epidemiologic evidence connecting HCV infection and the development of HCC, it remains controversial whether HCV itself plays a direct role or an indirect role in the pathogenesis of HCC. Through the use of transgen
Animal models for HCV and HBV studies
Isabelle Chemin
Iatreia , 2007,
Abstract: The narrow host range of infection and lack of suitable tissue culture systems for the propagation of hepatitis B and C viruses are limitations that have prevented a more thorough understanding of persistent infection and the pathogenesis of chronic liver disease. Despite decades of intensive research and significant progresses in understanding of viral hepatitis, many basic questions and clinical problems still await to be resolved. For example, the HBV cellular receptor and related mechanisms of viral entry have not yet been identified. Little is also known about the function of certain non-structural viral products, such as the hepatitis B e antigen and the X protein, or about the role of excess hepadnavirus subviral particles circulating in the blood stream during infection. Furthermore, the molecular mechanisms involved in the development of hepatocellular carcinoma and the role of the immune system in determining the fate of infection are not fully understood. The reason for these drawbacks is essentially due to the lack of reliable cell-based in vitro infection systems and, most importantly, convenient animal models. This lack of knowledge has been partially overcome for hepatitis B virus (HBV), by the discovery and characterization of HBV-like viruses in wild animals while for hepatitis C virus (HCV), related flaviviruses have been used as surrogate systems. Other laboratories have developed transgenic mice that express virus gene products and/or support virus replication. Some HBV transgenic mouse models develop fulminant hepatitis, acute hepatitis, or chronic liver disease after adoptive transfer, and others spontaneously develop hepatocellular carcinoma (HCC). Among HCV transgenic mice, most develop no disease, but acute hepatitis has been observed in one model, and HCC in another. Although mice are not susceptible to HBV and HCV, their ability to replicate these viruses and to develop liver diseases characteristic of human infections provides opportunities to study pathogenesis and develop novel therapeutics In the search for the mechanism of hepatocarcinogenesis in hepatitis viral infection, two viral proteins, the core protein of hepatitis C virus (HCV) and the HBx protein of hepatitis B virus (HBV), have been shown to possess oncogenic potential through transgenic mouse studies, indicating the direct involvement of the hepatitis viruses in hepatocarcinogenesis. This may explain the very high frequency of HCC in patients with HCV or HBV infection. Chimpanzees remain the only recognized animal model for the study of hepatitis C virus (HCV).
Occult HBV infection and HCC
Isabelle Chemin
Iatreia , 2007,
Abstract: A number of risk factors appear to play a role in Hepatocellularcinoma (HCC), HBV infection being one of the most important. Chronic inflammation and cytokines are key determinants in the development of fibrosis and liver cell proliferation. HBV DNA integration into host cellular DNA, has been extensively studied and may disrupt or promote expression of cellular genes that are important in cell growth and differentiation. Moreover, expression of HBV proteins may have a direct effect on cellular functions, and some of these gene products may lead to malignant transformation. Several HBV genes have been frequently found in infected tissues including truncated pre-S2/S, hepatitis B X gene, and a novel spliced transcript of HBV (hepatitis B spliced protein). The proteins expressed from these integrated genes have been shown to have intracellular activities, including effects on cellular growth and apoptosis. Occult hepatitis B virus (HBV) infection is characterized by persistence of HBV DNA into the tissue of hep atitis B surface antigen-negative individuals. The clinical relevance of this peculiar infection, in particular, the impact of occult HBV infection in cases of HCC has been a matter of debate. Prevalence and molecular status of occult HBV in patients with HCC has been investigated in several studies. HCC patients from Italy, France, Japan, Morocco, the United States, Canada etc…..who had no detectable HBsAg in their serum have been studied. In these HBsAg-negative HCC patients, HBV DNA was detected in tumorous and/or in adjacent non tumorous liver tissue using polymerase chain reaction (PCR) in almost half of the patients, being anti-HCV positive or not. Some of the patients are positive for anti-HBc antibodies as the only marker of HBV infection, but not all. Covalently closed circular HBV DNA may be detected indicating that at least some of these patients had actively replicating HBV infections. Observational cohort study showed that, among the HBsAg-negative patients with chronic hepatitis C, HCC develops for the most part in carriers of occult HBV. One of the markers in HCC cases, HBsAg (-), has been the presence of the HBV-X gene expression in HCC since positivity for the HBV-X protein in liver tissue in several studies reached half of the liver tissues specimens. In all studies, the significant association of occult HBV with HCC was irrespective of age, sex, and may be contemporary with hepatitis C virus infection. Both integrated viral DNA and covalently closed circular HBV genomes were detected in patients with occult HBV. Moreover, the pre
A educa ao para e pelo lazer no ambito municipal =The education for and through leasure in the municipal ambit
Chemin, Beatris Francisca
Educa??o , 2009,
Abstract: A CF/1988 incluiu vários direitos sociais, dentre eles a educa o e o lazer, além de destacar que o Município dentro da distribui o constitucional de competências baseada na predominancia do interesse, é responsável pelo atendimento das aspira es locais e cotidianas dos municípes, dentre as quais se inserem o lazer e a educa o. Assim, o artigo exp e a cria o dos direitos sociais, destacando o lazer e a educa o, detalha a "pedagogia da anima o" e salienta a prepara o que a escola pode fazer com rela o ao tempo de lazer. Analisa, por fim, a importancia da efetiva o de políticas públicas municipais para e pelo lazer, ou seja, compreende o lazer como instrumento e como objetivo de educa o, com vista à melhoria da qualidade de vida dos cidad os e ao maior desenvolvimento pessoal e social, principalmente de crian as e jovens das comunidades do Município.
Le rapprochement Chercheur-Consultant en aménagement du territoire : un apport à haute valeur ajoutée ?
Christine Chemin,Emmanuel Thimonier
EchoGéo , 2010,
Abstract: En aménagement du territoire, de nouvelles pratiques partenariales semblent émerger lors de la réalisation d'expertises (études, ingénierie de projets, audits, etc.). Si le recours aux cabinets-conseils – au Consultant – et aux laboratoires scientifiques – au Chercheur – par les services de l'Etat ou les collectivités territoriales existe depuis de nombreuses années, le rapprochement et le partenariat entre les consultants et les chercheurs est récent. Certes, cette pratique n’est pas encore systématique en aménagement du territoire mais elle constitue, selon les commanditaires publics, un apport à haute valeur ajoutée dans les prestations de services. In urban planning new partnership practices seem to appear through the realization of expertises (studies, projects engineering, audits…). Although the appeal to consulting firms – to consultants – and in the scientific laboratories – to researchers – by the State services or local government, exists for a long time now, the partnership between consultants and researchers is recent. Even though this partnership is not systematic in urban planning, it brings a contribution with a high added value in the services, according to the public partners.
A slow bar in a dark matter dominated galaxy
Laurent Chemin,Olivier Hernandez
Physics , 2009, DOI: 10.1051/0004-6361/200912019
Abstract: We report on an estimate of the bar pattern speed Omega_p for the low surface brightness spiral galaxy UGC 628. We applied the Tremaine-Weinberg method to high resolution Halpha velocity and integrated emission maps of this dark matter dominated galaxy. Observations were made at the CFHT using the optical Fabry-Perot interferometer, FaNTOmM. The Tremaine-Weinberg method estimates a bar pattern speed of (11.3 +/- 2.0) km/s/kpc for UGC 628, which is among the lowest values found for a spiral galaxy. The corotation radius Rc of the bar and the gaseous disc is Rc = 9.8 (+2.9/-2.0) kpc, implying a ratio R = Rc/Ab of 2.0 (+0.5/-0.3), where Ab is the bar radius. The ratio is well beyond the usual range of values, 1.0< R <1.4, found for fast bars of high surface brightness barred galaxies. It implies that the bar in UGC 628 is slow. As shown through the use of numerical simulations, fast bars survive when the inner mass distribution of galaxies is dominated by the baryons over the dark matter. Our result suggests that the presence of slow bars in galaxies is likely related to the dominance of dark matter over the mass distribution.
Deep wide field HI imaging of Messier 31
Laurent Chemin,Claude Carignan,Tyler Foster
Physics , 2009,
Abstract: We report on preliminary results from a new deep 21-cm survey of the Andromeda galaxy, based on observations performed with the Synthesis Telescope and the 26-m antenna at DRAO. The HI distribution and kinematics of the disc are analyzed and basic dynamical properties are derived. New HI structures are discovered, like thin HI spur-like structures and an external arm in the disc outskirts. The HI spurs are related to perturbed stellar clumps outside the main disc of M31. The external arm lies on the far, receding side of the galaxy and has no obvious counterpart in the opposite side. These HI perturbations probably result from tidal interactions with companions. It is found a dynamical mass of 4.7 +/- 0.5 x10^11 Msol enclosed within a radius R = 38 kpc and a total mass of ~1 x10^12 Msol inside the virial radius.
HI kinematics and dynamics of Messier 31
Laurent Chemin,Claude Carignan,Tyler Foster
Physics , 2009, DOI: 10.1088/0004-637X/705/2/1395
Abstract: [Abridged] We present a new deep 21-cm survey of the Andromeda galaxy, based on high resolution observations performed with the Synthesis Telescope and the 26-m antenna at DRAO. The HI distribution and kinematics of the disc are analyzed and basic dynamical properties are given. The rotation curve is measured out to 38 kpc, showing a nuclear peak, a dip around 4 kpc, two distinct flat parts and an increase in the outermost regions. Except for the innermost regions, the axisymmetry of the gas rotation is very good. A very strong warp of the HI disc is evidenced. The central regions appear less inclined than the average disc inclination, while the outer regions appear more inclined. Mass distribution models by LCDM NFW, Einasto or pseudo-isothermal dark matter halos with baryonic components are presented. They fail to reproduce the exact shape of the rotation curve. No significant differences are measured between the various shapes of halo. The dynamical mass of M31 enclosed within a radius of 38 kpc is (4.7 +/- 0.5) x 10^11 Msol. The dark matter component is almost 4 times more massive than the baryonic mass inside this radius. A total mass of 1.0 x 10^12 Msol is derived inside the virial radius. New HI structures are discovered in the datacube, like the detection of up to five HI components per spectrum, which is very rarely seen in other galaxies. The most remarkable new HI structures are thin HI spurs and an external arm in the disc outskirts. A relationship between these spurs and outer stellar clumps is evidenced. The external arm is 32 kpc long, lies on the far side of the galaxy and has no obvious counterpart on the other side of the galaxy. Its kinematics clearly differs from the outer adjacent disc. Both these HI perturbations could result from tidal interactions with galaxy companions.
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