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Search Results: 1 - 10 of 3140 matches for " Marcel WM Post "
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Cross-cultural validity of four quality of life scales in persons with spinal cord injury
Szilvia Geyh, Bernd AG Fellinghauer, Inge Kirchberger, Marcel WM Post
Health and Quality of Life Outcomes , 2010, DOI: 10.1186/1477-7525-8-94
Abstract: A cross-sectional multi-centre study was conducted and the data of 243 out-patients with SCI from study centers in Australia, Brazil, Canada, Israel, South Africa, and the United States were analyzed using Rasch-based methods.The analyses showed high reliability for all 4 instruments (person reliability index .78-.92). Unidimensionality of measurement was supported for the WHOQoL-5 (Chi2 = 16.43, df = 10, p = .088), partially supported for the PWI (Chi2 = 15.62, df = 16, p = .480), but rejected for the LISAT-9 (Chi2 = 50.60, df = 18, p = .000) and the SWLS (Chi2 = 78.54, df = 10, p = .000) based on overall and item-wise Chi2 tests, principal components analyses and independent t-tests. The response scales showed the expected ordering for the WHOQoL-5 and the PWI, but not for the other two instruments. Using differential item functioning (DIF) analyses potential cross-country bias was found in two items of the SWLS and the WHOQoL-5, three items of the LISAT-9 and four items of the PWI. However, applying Rasch-based statistical methods, especially subtest analyses, it was possible to identify optimal strategies to enhance the metric properties and the cross-country equivalence of the instruments post-hoc. Following the post-hoc procedures the WHOQOL-5 and the PWI worked in a consistent and expected way in all countries.QoL assessment using the summary scores of the WHOQOL-5 and the PWI appeared cross-culturally valid in persons with SCI. In contrast, summary scores of the LISAT-9 and the SWLS have to be interpreted with caution. The findings of the current study can be especially helpful to select instruments for international research projects in SCI.In the general population, quality of life (QoL) is measured across countries to indicate the state and development of societies like, for example, in the annual Eurobarometer of the European Commission [1] or the World Values Survey [2]. National levels of QoL have been found to be related with wealth, human rights, ind
A multidisciplinary cognitive behavioural programme for coping with chronic neuropathic pain following spinal cord injury: the protocol of the CONECSI trial
Matagne Heutink, Marcel WM Post, Peter Luthart, Lilian EMA Pfennings, Catja A Dijkstra, Eline Lindeman
BMC Neurology , 2010, DOI: 10.1186/1471-2377-10-96
Abstract: CONECSI is a multicentre randomised controlled trial. A sample of 60 persons with chronic neuropathic spinal cord injury pain will be recruited from four rehabilitation centres and randomised to an intervention group or a waiting list control group. The control group will be invited for the programme six months after the intervention group. Main inclusion criteria are: having chronic (> 6 months) neuropathic spinal cord injury pain as the worst pain complaint and rating the pain intensity in the last week as 40 or more on a 0-100 scale. The intervention consists of educational, cognitive, and behavioural elements and encompasses 11 sessions over a 3-month period. Each meeting will be supervised by a local psychologist and physical therapist. Measurements will be perfomed before starting the programme/entering the control group, and at 3, 6, 9, and 12 months. Primary outcomes are pain intensity and pain-related disability (Chronic Pain Grade questionnaire). Secondary outcomes are mood (Hospital Anxiety and Depression Scale), participation in activities (Utrecht Activities List), and life satisfaction (Life Satisfaction Questionnaire). Pain coping and pain cognitions will be assessed with three questionnaires (Coping Strategy Questionnaire, Pain Coping Inventory, and Pain Cognition List).The CONECSI trial will reveal the effects of a multidisciplinary cognitive behavioural programme for people with chronic neuropathic spinal cord injury pain. This intervention is expected to contribute to the rehabilitation treatment possibilities for this population.Dutch Trial Register NTR1580.Around 65-85% of the people with spinal cord injury (SCI) experience persistent pain and around one-third of these suffer from severe pain [1]. People with SCI consistently rate chronic SCI pain (CSCIP) as one of the most difficult problems to manage, despite the presence of other problems that interfere with daily life [2], and it is a major impediment to effective rehabilitation [3]. Several
Effects of aerobic exercise therapy and cognitive behavioural therapy on functioning and quality of life in amyotrophic lateral sclerosis: protocol of the FACTS-2-ALS trial
Annerieke C van Groenestijn, Ingrid GL van de Port, Carin D Schr?der, Marcel WM Post, Hepke F Grupstra, Esther T Kruitwagen, Harmen van der Linde, Reinout O van Vliet, Margreet GH van de Weerd, Leonard H van den Berg, Eline Lindeman
BMC Neurology , 2011, DOI: 10.1186/1471-2377-11-70
Abstract: A multicentre, single-blinded, randomized controlled trial with a postponed information model will be conducted. A sample of 120 patients with ALS (1 month post diagnosis) will be recruited from 3 university hospitals and 1 rehabilitation centre. Patients will be randomized to one of three groups i.e. (1) AET + usual care, (2) CBT + usual care, (3) Usual care. AET consists of a 16-week aerobic exercise programme, on 3 days a week. CBT consists of individual psychological support of patients in 5 to 10 sessions over a 16-week period. QoL, functioning and secondary outcome measures will be assessed at baseline, immediately post intervention and at 3- and 6-months follow-up.The FACTS-2-ALS study is the first theory-based randomized controlled trial to evaluate the effects, and the maintenance of effects, of AET and CBT on functioning and QoL in patients with ALS. The results of this study are expected to generate new evidence for the effect of multidisciplinary care of persons with ALS.Dutch Trial Register NTR1616.Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder affecting motor neurons in the spinal cord, brainstem, and motor cortex. Patients are afflicted by progressive wasting and weakness of limb, bulbar, and respiratory muscles, and die on average within 3 years after symptom onset, usually because of respiratory failure [1]. In the absence of an established biological marker, the diagnosis of ALS is primarily clinical, based on El Escorial criteria [2]. The median age of onset of ALS is 55 years [1]. The incidence of ALS is between 1.5 and 2.5 per 100,000 person-years of follow-up in industrialized countries [3], and life-time risk of ALS is estimated to be between 1/600 and 1/2000 [1,4], which makes it the most common motor neuron disease.ALS is familial in 5% of cases, with a Mendelian pattern of inheritance. The clinical phenotype of familial ALS (FALS) is similar to that of the sporadic form of the disease. At least 13 gene
Well being of obstetric patients on minimal blood transfusions (WOMB trial)
Babette W Prick, Eric AP Steegers, AJ Gerard Jansen, Wim CJ Hop, Marie-Louise Essink-Bot, Nina CJ Peters, Carin A Uyl-de Groot, Dimitri NM Papatsonis, Bettina MC Akerboom, Godfried CH Metz, Henk A Bremer, Aren J van Loon, Rob H Stigter, Joris AM van der Post, Marcel van Alphen, Martina Porath, Robbert JP Rijnders, Marc EA Spaanderman, Daniela H Schippers, Kitty WM Bloemenkamp, Kim E Boers, Hubertina CJ Scheepers, Frans JME Roumen, Anneke Kwee, Nico WE Schuitemaker, Ben Willem J Mol, Dick J van Rhenen, Johannes J Duvekot
BMC Pregnancy and Childbirth , 2010, DOI: 10.1186/1471-2393-10-83
Abstract: The WOMB trial is a multicentre randomised non-inferiority trial. Women with acute anaemia due to postpartum haemorrhage, 12-24 hours after delivery and not initially treated with RBC transfusion, are eligible for randomisation. Patients with severe physical complaints are excluded. Patients are randomised for either RBC transfusion or expectant management. Health related quality of life (HRQoL) will be assessed at inclusion, at three days and one, three and six weeks postpartum with three validated measures (Multi-dimensional Fatigue Inventory, ShortForm-36, EuroQol-5D). Primary outcome of the study is physical fatigue three days postpartum. Secondary outcome measures are general and mental fatigue scores and generic health related quality of life scores, the number of RBC transfusions, length of hospital stay, complications and health-care costs.The primary analysis will be by intention-to-treat. The various longitudinal scores will be evaluated using Repeated Measurements ANOVA. A costs benefit analysis will also be performed. The power calculation is based on the exclusion of a difference in means of 1.3 points or greater in favour of RBC transfusion arm regarding physical fatigue subscale. With missing data not exceeding 20%, 250 patients per arm have to be randomised (one-sided alpha = 0.025, power = 80%).This study will provide evidence for a guideline regarding RBC transfusion in the postpartum patient suffering from acute anaemia. Equivalence in fatigue score, remaining HRQoL scores and physical complications between both groups is assumed, in which case an expectant management would be preferred to minimise transfusion reactions and costs.ClinicalTrials.gov NCT00335023, Nederlands Trial Register NTR335One of the most frequent complications of delivery is primary postpartum haemorrhage (PPH), defined as blood loss greater than or equal to 500 ml within 24 hours after birth and severe PPH as blood loss greater than or equal to 1000 ml within 24 hours [1]. Be
Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs
Parthiban Chinnagounder Periyasamy,Jeroen C. H. Leijten,Pieter J. Dijkstra,Marcel Karperien,Janine N. Post
Journal of Nanomaterials , 2012, DOI: 10.1155/2012/673968
Abstract: Nanotechnology has found its potential in every possible field of science and engineering. It offers a plethora of options to design tools at the nanometer scale, which can be expected to function more effectively than micro- and macrosystems for specific applications. Although the debate regarding the safety of synthetic nanomaterials for clinical applications endures, it is a promising technology due to its potential to augment current treatments. Various materials such as synthetic polymer, biopolymers, or naturally occurring materials such as proteins and peptides can serve as building blocks for adaptive nanoscale formulations. The choice of materials depends highly on the application. We focus on the use of nanoparticles for the treatment of degenerative cartilage diseases, such as osteoarthritis (OA). Current therapies for OA focus on treating the symptoms rather than modifying the disease. The usefulness of OA disease modifying drugs is hampered by side effects and lack of suitable drug delivery systems that target, deliver, and retain drugs locally. This challenge can be overcome by using nanotechnological formulations. We describe the different nanodrug delivery systems and their potential for cartilage repair. This paper provides the reader basal understanding of nanomaterials and aims at drawing new perspectives on the use of existing nanotechnological formulations for the treatment of osteoarthritis.
Setting Parameters for Biological Models With ANIMO
Stefano Schivo,Jetse Scholma,Marcel Karperien,Janine N. Post,Jaco van de Pol,Rom Langerak
Computer Science , 2014, DOI: 10.4204/EPTCS.145.5
Abstract: ANIMO (Analysis of Networks with Interactive MOdeling) is a software for modeling biological networks, such as e.g. signaling, metabolic or gene networks. An ANIMO model is essentially the sum of a network topology and a number of interaction parameters. The topology describes the interactions between biological entities in form of a graph, while the parameters determine the speed of occurrence of such interactions. When a mismatch is observed between the behavior of an ANIMO model and experimental data, we want to update the model so that it explains the new data. In general, the topology of a model can be expanded with new (known or hypothetical) nodes, and enables it to match experimental data. However, the unrestrained addition of new parts to a model causes two problems: models can become too complex too fast, to the point of being intractable, and too many parts marked as "hypothetical" or "not known" make a model unrealistic. Even if changing the topology is normally the easier task, these problems push us to try a better parameter fit as a first step, and resort to modifying the model topology only as a last resource. In this paper we show the support added in ANIMO to ease the task of expanding the knowledge on biological networks, concentrating in particular on the parameter settings.
High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes
Muhammad Riaz, Anieta M Sieuwerts, Maxime P Look, Mieke A Timmermans, Marcel Smid, John A Foekens, John WM Martens
Breast Cancer Research , 2012, DOI: 10.1186/bcr3317
Abstract: TWIST1 mRNA expression level was analyzed by quantitative real-time reverse polymerase chain reaction (RT-PCR) in 1,427 primary breast cancers. In uni- and multivariate analysis using Cox regression, TWIST1 mRNA expression level was associated with metastasis-free survival (MFS), disease-free survival (DFS) and overall survival (OS). Separate analyses in lymph node-negative patients (LNN, n = 778) who did not receive adjuvant systemic therapy, before and after stratification into estrogen receptor (ER)-positive (n = 552) and ER-negative (n = 226) disease, were also performed. The association of TWIST1 mRNA with survival endpoints was assessed using Kaplan-Meier analysis. Using gene expression arrays, genes showing a significant Spearman rank correlation with TWIST1 were used to identify overrepresented Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG)-annotated biological pathways.Increased mRNA expression level of TWIST1 analyzed as a continuous variable in both uni- and multivariate analysis was associated with shorter MFS in all patients (hazard ratio (HR): 1.17, 95% confidence interval, (95% CI):1.09 to 1.26; and HR: 1.17, 95% CI: 1.08 to 1.26; respectively), in LNN patients (HR: 1.22, 95% CI: 1.09 to 1.36; and HR: 1.21, 95% CI: 1.07 to 1.36; respectively) and in the ER-positive subgroup of LNN patients (HR: 1.34, 95% CI: 1.17 to 1.53; and HR: 1.32, 95% CI: 1.14 to 1.53; respectively). Similarly, high TWIST1 expression was associated with shorter DFS and OS in all patients and in the LNN/ER-positive subgroup. In contrast, no association of TWIST1 mRNA expression with MFS, DFS or OS was observed in ER-negative patients. Genes highly correlated with TWIST1 were significantly enriched for cell adhesion and ECM-related signaling pathways. Furthermore, TWIST1 mRNA was highly expressed in tumor stroma and positively related to tumor stromal content (P <0.001).TWIST1 mRNA expression is an independent prognostic factor for poor prognosis in LNN
Five-year effect of community-based intervention Hartslag Limburg on quality of life: A longitudinal cohort study
Saskia PJ Verkleij, Marcel C Adriaanse, WM Monique Verschuren, Eric C Ruland, Gerrie CW Wendel-Vos, Albertine J Schuit
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-11
Abstract: A longitudinal cohort study comparing 5-year mean change in QoL between the intervention (n = 2356) and reference group (n = 758). QoL outcomes were the physical and mental health composite scores (PCS and MCS) measured by the RAND-36. Analyses were stratified for gender and socio-economic status (SES).After 5-years of intervention we found no difference in mean change in PCS and MCS between the intervention and reference group in both genders and low-SES. However, for the moderate/high SES intervention group, the scales social functioning (-3.6, 95% CI:-6.1 to -1.2), physical role limitations (-5.3, 95% CI:-9.6 to -1.0), general mental health (-3.0, 95% CI:-4.7 to -1.3), vitality (-3.2, 95% CI:-5.1 to -1.3), and MCS (-1.8, 95% CI:-2.9 to -0.6) significantly changed compared with the reference group. These differences were due to a slight decrease of QoL in the intervention group and an increase of QoL in the reference group.Hartslag Limburg has no beneficial effect on people's physical and mental QoL after 5-years of intervention. In fact, subjects in the intervention group with a moderate/high SES, show a decrease on their mental QoL compared with the reference group.During the past decade there has been growing interest in measuring people's quality of life (QoL). Traditionally, outcome measurements in health care have mostly been determined by objective medical evaluation [1]. The interest in assessing QoL stems from recognition of the importance of patients' own perception of their health status and well-being. QoL has become an accepted measure of disease impact, therapeutic outcome, and evaluation of interventions.Chronic diseases often affect people's QoL. Research shows that people with diabetes mellitus type 2, obesity, and cardiovascular diseases (CVD) have an decreased QoL [2-5]. Moreover, people with favourable levels of CVD risk factors have greater longevity and tend to have a better QoL [2]. Therefore, health promotion may not only stimulate a health
Diversity and distribution of the free-living freshwater Cyclopoida (Copepoda: Crustacea) in the Neotropics
Silva, WM.;
Brazilian Journal of Biology , 2008, DOI: 10.1590/S1519-69842008000500016
Abstract: cyclopoida species from the neotropics are listed and their distributions are commented. the results showed 148 species in the neotropics, where 83 species were recorded in the northern region (above upon equator) and 110 species in the southern region (below the equator). species richness and endemism are related more to the number of specialists than to environmental complexity. new researcher should be made on to the copepod taxonomy and the and new skills utilized to solve the main questions on the true distributions and cyclopoida diversity patterns in the neotropics.
Elderly versus young patients with appendicitis 3 years experience
WM Ghnnam
Alexandria Journal of Medicine , 2012,
Abstract: Background: Appendicitis in the elderly continues to be a challenging surgical problem. Patients continued to present late with atypical presentations. Results might improve with earlier consideration of the diagnosis in elderly patients with abdominal pain, followed by prompt surgical operation. We aimed to present our experience with a series of elderly patients with acute appendicitis who were subjected to appendectomy to find out the difference in the course and outcome of acute appendicitis in elderly patients. Patients and methods: We reviewed medical records of elderly patients (aged >60 years) who underwent appendectomy for acute appendicitis at our hospital. Variables selected for analysis included age, sex, presenting symptoms, operative approach, operative findings, duration of hospitalization. Patients were compared to a control group, less than 31 years admitted during the same period. Results: Twenty-three patients’ records aged > 60 years with acute appendicitis were compared to a group of 40 patients aged< 30 years. There were significant differences between the two groups with regard to duration of symptoms preoperative hospital stay and total hospital stay. All young patients group had an uneventful postoperative recovery only two cases (5%) had wound infection. There was one death in the elderly group thus mortality rate was 4.3%. These two groups of patients showed significant differences in relation to the stage of disease at operation and postoperative complications. Elderly group of patients had perforated appendix in 16 cases (69.5%) while in group II patients eight cases (20%) had perforated appendix Conclusion: Acute appendicitis in the elderly remains a challenge for practicing surgeons and continues to be associated with high morbidity and mortality. Results might improve with earlier consideration of the use of CT abdomen for diagnosis in elderly patients with abdominal pain, followed by prompt surgical operation.
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