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Search Results: 1 - 10 of 533051 matches for " María José Martínez-García "
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Mercury in Canned Tuna in Spain. Is Light Tuna Really Light?  [PDF]
Montserrat González-Estecha, María José Martínez-García, Manuel Fuentes-Ferrer, Andrés Bodas-Pinedo, Alfonso Calle-Pascual, José María Ordó?ez-Iriarte, Cristina Fernández-Pérez, Nieves Martell-Claros, Miguel ángel Rubio-Herrera, Emilia Gómez-Hoyos, José Jesús Guillén-Pérez
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.47A007
Abstract:

In Spain, certain population-based studies have shown high blood mercury (Hg) levels due to the high consumption of fish. Some studies have stated that one of the most consumed fish in Spain is canned tuna. Different Spanish organisms consider that it is safe to consume canned tuna as it supposedly has a low mercury content, particularly in so-called light tuna. However, in Spain light tuna is mainly yellowfin and bigeye tuna, while in other countries it is mainly skipjack tuna. This study analyzed 36 cans of the most popular brands in Spain and examined the influence of the type of tuna, packaging medium (olive oil, sunflower seed oil, water or marinade), different brands, prices and expiration dates. Mercury concentrations (mg/kg) were measured by atomic absorption spectrometry and thermal decomposition amalgamation. The medians observed were (mg/kg): light tuna: 0.314; IQR: 0.205 - 0.594, white tuna: 0.338; IQR: 0.276 - 0.558, skipjack: 0.311; IQR: 0.299 - 0.322, frigate tuna: 0.219; IQR 0.182 - 0.257 and mackerel: 0.042; IQR 0.029 - 0.074. We found statistically significant differences between white tuna, light tuna and mackerel (p = 0.004); light tuna and mackerel (p = 0.002) and white tuna and mackerel (p = 0.006). However, we found no differences between white tuna and light tuna, or among packaging medium, brands, prices or expiration dates. The limit of 0.500 mg/kg of mercury in canned tuna was exceeded by the following percentages of the cans: 33.3% of light tuna, 16.7% of white tuna, and 0% of Skipjack, frigate tuna and mackerel. The mercury content of the cans of Spanish light tuna that were analyzed was variable and high. The results of this study indicate that stricter regulation of Hg in canned tuna is necessary. Until then, it is safer to recommend that vulnerable populations such as children and pregnant women consume canned mackerel, which has a markedly lower mercury content.

Tendencia de la incidencia de los tumores hepáticos en la infancia
Mejía-Aranguré,Juan Manuel; Beutelspacher-Vázquez,Olbeth; Juárez-Oca?a,Servando; Vázquez-Langle,José; Martínez-García,María del Carmen; Fajardo-Gutiérrez,Arturo;
Salud Pública de México , 2002, DOI: 10.1590/S0036-36342002000200003
Abstract: objective. to evaluate the incidence trends of hepatic tumors among children living in mexico city. material and methods. a cross-sectional hospital survey was conducted to yield two databases. the first database contains the registry of all the cases of hepatic tumors occurring during the period 1982-1991, in public hospitals of mexico city. the second database contains all hepatic tumor cases found between 1996 and 1999 in hospital de pediatría del centro médico nacional "siglo xxi" and in hospital general del centro médico la raza, both hospitals pertaining to instituto mexicano del seguro social (mexican institute of social security). the average annual incidence rates (aair) were calculated for each type of hepatic tumor. the rates were standardized with the direct method, using as standard the world population under 15 years of age. the trends were evaluated with the annual incidence rates and the average rate of change assuming a poisson distribution. results. the aair for hepatoblastoma during the period 1982-1991 was three times higher for men than for women, with a value of 0.6 x106. the group of 1-4 years of age was the most affected. for hepatocarcinomas the aair was two-fold for women (0.14) as compared to men. between 1996-1999 the aair for hepatoblastoma was 5.11 in women and 1.85 in men. the age group with the highest rate was women under one year of age. the aair for hepatocarcinoma was 0.64 for males and 1.23 for females. the most affected age group was males aged 10 to 14 years. no significant upward or downward trend was found in the incidence of hepatoblastomas. a non-significant change rate of 10% was found for hepatocarcinoma. conclusions. no significant trends were observed in the incidence of hepatic tumors in children of mexico city aged under 15 years, during the periods 1982-1991 and 1996-1999.
Caspase-1 genetic variation is not associated with Alzheimer's disease risk
José Vázquez-Higuera, Eloy Rodríguez-Rodríguez, Pascual Sánchez-Juan, Ignacio Mateo, Ana Pozueta, Ana Martínez-García, Ana Frank, Fernando Valdivieso, José Berciano, María J Bullido, Onofre Combarros
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-32
Abstract: We examined genetic variations of CASP1 by genotyping haplotype tagging SNPs (htSNPs) (rs501192, rs556205 and rs530537) in a group of 628 Spanish AD cases and 722 controls.There were no differences in the genotypic, allelic or haplotypic distributions between cases and controls in the overall analysis or after stratification by age, gender or APOE ε4 allele.Our negative findings in the Spanish population argue against the hypothesis that CASP1 genetic variations are causally related to AD risk.A chronic inflammatory process might contribute to the neurodegeneration associated with Alzheimer's disease (AD), by overexpression of cytokines, such as interleukin-1 (IL-1), and other inflammatory molecules in activated microglia surrounding amyloid plaques [1]. Increased expression of IL-1 in AD has been implicated in the formation of amyloid plaques and neurofibrillary tangles, the spread of these neuropathological lesions across cerebral cortical regions, and the accompanying neuronal cell injury and loss [2]. The predominant β isoform of IL-1 is generated from an inactive precursor through the action of caspase-1 (CASP1), a cystein protease formerly called IL-1β converting enzyme (ICE), and CASP1 expression appears to be significantly increased in post-mortem brain tissue from patients with AD [3-5]. In addition, CASP1 messenger RNA expression has been closely associated with neurofibrillary tangle and, to a lesser extent, amyloid plaque density [4]. Several studies have reported associations between IL-1β genetic polymorphisms and AD, but findings from different studies have been controversial [6]. Although genetic markers of the CASP1 region were not found associated to AD in recent genome-wide association studies [7-10], Blankenberg et al. [11] sequenced the CASP1 gene in a case-control study of myocardial infarction (MI), and found that CASP1 genetic variation is associated with cardiovascular risk. The present study investigated the genetic variability of the CASP1
Drying Parameters of Half-Cut and Ground Figs (Ficus carica L.) var. Mission and the Effect on Their Functional Properties
Juan José Martínez-García,José Alberto Gallegos-Infante,Nuria Elizabeth Rocha-Guzmán,Patricia Ramírez-Baca,María Guadalupe Candelas-Cadillo,Rubén Francisco González-Laredo
Journal of Engineering , 2013, DOI: 10.1155/2013/710830
Abstract: Drying of ground and half-cut figs (Ficus carica L., var. Mission) was investigated at three temperatures (45, 55, and 65°C). Their effective moisture diffusivity ( ) was estimated by using the slope method. values for ground figs were 5.15 × 10?10, 9.96 × 10?10, 1.07 × 10?9?m2?s?1 and for half cut figs 5.88 × 10?10, 1.66 × 10?9, and 2.08 × 10?9?m2?s?1 at 45, 55, and 65°C, respectively. Dehydrating fig samples showed a similar behavior: higher values at higher temperatures and activation energy ( ) values in the range of other foodstuffs. Half-cut figs needed about twice more energy and time than ground figs to carry out the dehydration; values were 56.86 and 28.21?kJ?mol?1, respectively. The drying process increased the total phenolic content and degraded the anthocyanin content of figs; however, it enhanced the dried figs antioxidant activity. Dehydrating ground figs was faster and maintained its functional properties better than half-cut figs. 1. Introduction Many studies have demonstrated that daily intake of fruit and vegetable is associated with the reduction of chronic-degenerative diseases [1, 2]. In other investigations, it has been observed that fruit- and vegetable- rich diets protect against different diseases, including cancer and cardiovascular diseases. Etiology for these diseases is pointing to the free radicals as promoters of protein, nucleic acids, and cellular lipids oxidations that damage biological systems; fruits and vegetables contain a great number of components with antioxidant activity, such as flavonoids, carotenoids, and vitamins C and E [3]. Nowadays, the study for different vegetables species is promoted in order to identify their diverse functional capacities; since the human organism cannot produce phytochemicals such as polyphenols, they have to be obtained from food [4]. The most viable alternative is to consume fresh fruit and vegetables, since it is well known that after harvesting, their components can change during processing and storage and relatively lose part of its biological activity. Although there are some factors that can limit its intake such as seasonal availability, market accessibility, cost, and shelf life, it is important to process them by freezing, canning, or drying, but these conservation methods can reduce the bioactive component contents [5]. Fig tree (Ficus carica L.) is widely found in tropical and subtropical countries, and its fruit has a high commercial value. Fig production is mainly located around the Mediterranean Sea or in places with similar weather such as California, Australia, or
Correlations between Different Heavy Metals in Diverse Body Fluids: Studies of Human Semen Quality
Lidia Mínguez-Alarcón,Jaime Mendiola,Manuela Roca,José J. López-Espín,José J. Guillén,José M. Moreno,Stella Moreno-Grau,María J. Martínez-García,Nuria Vergara-Juárez,Belén Elvira-Rendueles,Antonio García-Sánchez,Jorge Ten,Rafael Bernabeu,Alberto M. Torres-Cantero
Advances in Urology , 2012, DOI: 10.1155/2012/420893
Abstract: It has been hypothesized that exposure to heavy metals may impair male reproduction. To measure the effect produced by low doses of heavy metals on semen parameters, it is necessary to clarify in which body fluids those measurements must be performed. Sixty-one men attending infertility clinics participated in our study. Concentrations of lead, cadmium, and mercury were measured in whole blood, blood plasma, and seminal plasma using spectroanalytical and electrochemical methods. Semen analyses were performed according to World Health Organization criteria. For statistical analysis, Spearman's rank correlations, mean comparison tests, and discriminant analysis were calculated. Significant correlations between the measured concentrations of the three heavy metals in the same biological fluids were observed. However, no similar relationship was seen when comparing the concentrations in different body fluids of the same metal. According to our results and previous publications, seminal plasma might be the best body fluid for assessing impairment of human semen parameters. 1. Introduction Over time there has been a significant decline of human fertility [1]. Like other European countries, Spain is since 1981 well below the 2.1 children needed to maintain replacement level [2]. Birth rate, have declined mainly due to changes in lifestyle and social mores and increased contraception [3]. These demographic transformations, as much as they are socially valued and desirable, have important clinical consequences. The fertility decline has resulted in a major delay in the average age of conception. The first pregnancy is postponed to ages at which women fecundity is decreased [4]. That may be one important reason why the medical reproductive units have taken on such a relevant role in developed countries. Between 2002 and 2004, more than 6% of Danish children were born through assisted reproduction techniques [1]. Consequently, social and medical considerations about infertility have become an important concern in recent years. In parallel, it has been hypothesized that there is a worldwide decline in male semen quality [5–8], but it is clearly not uniform [9]. The decline in semen quality has been linked to environmental and work-related toxic exposures [10, 11]. For example, heavy metals may compromise male reproduction, as demonstrated by epidemiological and animal studies [12–22]. Our research interests are related to the measurement of the exposure to lead (Pb), cadmium (Cd), and mercury (Hg), and its relationship with human semen quality. The main results
Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study
Jaime Mendiola, José M Moreno, Manuela Roca, Nuria Vergara-Juárez, María J Martínez-García, Antonio García-Sánchez, Belén Elvira-Rendueles, Stella Moreno-Grau, José J López-Espín, Jorge Ten, Rafael Bernabeu, Alberto M Torres-Cantero
Environmental Health , 2011, DOI: 10.1186/1476-069x-10-6
Abstract: The current study assessed the associations between seminal and hormonal parameters and the concentration of the 3 most frequent heavy metal toxicants (lead, cadmium and mercury) in three different body fluids. Sixty one men attending infertility clinics that participated in a case-control study to explore the role of environmental toxins and lifestyles on male infertility were analyzed. Concentration of lead, cadmium and mercury were measured in blood and seminal plasma and whole blood using anodic stripping voltammetry and atomic absorption spectrophotometry. Serum samples were analyzed for follicle-stimulating hormone, luteinizing hormone and testosterone. Semen analyses were performed according to World Health Organization criteria. Mann-Whitney test and Spearman's rank correlations were used for unadjusted analyses. Multiple linear regression models were performed controlling for age, body mass index and number of cigarettes per day.There were no significant differences between cases and controls in the concentrations of heavy metals in any of the three body fluids. In multivariate analyses using all subjects no significant associations were found between serum hormone levels and metal concentrations. However there was a significant positive association between the percentage of immotile sperms and seminal plasma levels of lead and cadmium.Our results suggest that the presence of lead and cadmium in the reproductive tract of men may be related to a moderate alteration of their seminal parameters.Human, animal and in vitro studies suggest that heavy metals may have adverse impacts on male reproductive health [1-10], even at relatively low-level exposures [11]. Heavy metals could adversely affect the male reproductive system, either by causing hypothalamic-pituitary axis disruption or by directly affecting spermatogenesis, resulting in impair semen quality [12].Several metals - mainly lead (Pb), cadmium (Cd) - are considered reproductive toxicants and/or suspecte
La validez discriminante como criterio de evaluación de escalas: ?teoría o estadística?
MARTíNEZ-GARCíA,JOSé ANTONIO; MARTíNEZ-CARO,LAURA;
Universitas Psychologica , 2009,
Abstract: discriminant validity is one of the usual criteria for evaluating measurement scales that define latent constructs in social sciences. this article shows how different statistical procedures frequently used for accomplishing this aim can yield misleading results. authors recommend a theoretical judgement about divergence among scales that are manifestation of latent concepts. therefore, content validity represents a robust condition against certain covariance statistical based analysis.
Discriminant Validity as a Scale Evaluation Criterion: Theory or Statistics?
José Antonio Martínez-García,Laura Martínez-Caro
Universitas Psychologica , 2009,
Abstract: Discriminant validity is one of the usual criterions for evaluating measurement scales that define latent constructs in social sciences. This article shows how different statistical procedures frequently used for accomplishing this aim can yield misleading results. Authors recommend a theoretical judgement about divergence among scales that are manifestation of latent concepts. Therefore, content validity represents a robust condition against certain covariance statistical based analysis.
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO
Rojas,Mariana; Martínez-García,Francisco; Cobo,Paz; Palacios,José; Nistal,Manuel; Regadera,Javier;
Revista chilena de anatomía , 1998, DOI: 10.4067/S0716-98681998000100003
Abstract: keratins are intermediate filaments of the cytoskeleton of epithelial cells. they express themselves in simple (ks. 7, 8, 18, 19 y 20) or stratitified epithelia (ks. 1, 2, 5, 9, 10, 11, 16). the different expression of these multigenic cytoskeletal proteins is related to cell specific differentiation programs (osborn & weber, 1983; nagle, 1988); for these reasons the analysis of keratins are very relevant for the study of new aspects of histology, histopathology and developmental biology. moreover, evaluation of keratins by immunofluorescent or immunohistochemistry is useful for the proper identification and characterization of normal, displasic and neoplasic cells (osborn & weber, 1983; nagle). the different patterns of expression of keratins are related to the degree of differentiation of inmature epithelial cells, as well as the degree of differentiation of malignant tumours (fuchs & green, 1980; franke et al., 1981b; moll et al, 1892a; schaafsma & ramaekers, 1994). lastly, evaluation of the changes of immunoexpresion of keratins is useful for the differential diagnosis between typical and atypical squamous metaplasia, including moderate and severe epithelial displasia and intraepithelial neoplasia -formerly known as carcinoma in situ- (moll et al., 1982a; tseng et al., 1982; quinlan et al., 1985; huszar et al., 1986; gigi-leitner et al; heid et al.,1988)
KERATINAS: BIOLOGIA CELULAR Y SIGNIFICADO FUNCIONAL NORMAL Y PATOLOGICO KERATINS: CELL BIOLOGY AND ITS NORMAL AND PATOLOGY FUNCTIONAL SIGNIFICANCE
Mariana Rojas,Francisco Martínez-García,Paz Cobo,José Palacios
Revista chilena de anatomía , 1998,
Abstract: Keratins are intermediate filaments of the cytoskeleton of epithelial cells. They express themselves in simple (Ks. 7, 8, 18, 19 y 20) or stratitified epithelia (Ks. 1, 2, 5, 9, 10, 11, 16). The different expression of these multigenic cytoskeletal proteins is related to cell specific differentiation programs (OSBORN & WEBER, 1983; NAGLE, 1988); For these reasons the analysis of keratins are very relevant for the study of new aspects of histology, histopathology and developmental biology. Moreover, evaluation of keratins by immunofluorescent or immunohistochemistry is useful for the proper identification and characterization of normal, displasic and neoplasic cells (OSBORN & WEBER, 1983; NAGLE). The different patterns of expression of keratins are related to the degree of differentiation of inmature epithelial cells, as well as the degree of differentiation of malignant tumours (FUCHS & GREEN, 1980; FRANKE et al., 1981b; MOLL et al, 1892a; SCHAAFSMA & RAMAEKERS, 1994). Lastly, evaluation of the changes of immunoexpresion of keratins is useful for the differential diagnosis between typical and atypical squamous metaplasia, including moderate and severe epithelial displasia and intraepithelial neoplasia -formerly known as carcinoma in situ- (MOLL et al., 1982a; TSENG et al., 1982; QUINLAN et al., 1985; HUSZAR et al., 1986; GIGI-LEITNER et al; HEID et al.,1988)
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