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Search Results: 1 - 10 of 660837 matches for " María Isabel Castrejón-Vázquez "
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Hypersensitivity to Aspirin as a Factor for Poor Control in Hereditary Angioedema  [PDF]
Carlos Alberto García-López, María Eugenia Vargas-Cama?o, Emmanuel Alcázar-Casarín, Guillermo Quintana Mexiac, Pablo León Gómez, Mario Alberto Ynga-Durand, Benjamín López-Velázquez, María Isabel Castrejón-Vázquez
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.53005
Abstract: Background: Hereditary angioedema (HAE) is a primary immunodeficiency disorder characterized by C1 complement inhibitor deficiency and unregulated activation of complement. Aspirin hypersensitivity is related to an increase in the amount of leukotrienes with eosinophil and mast cell activation and increased levels of glandular kallikrein with upregulated local conversion of bradykinin. Both conditions can be present in the same patient. Objectives: We present five patients with HAE; they were all being treated in similar ways according to the therapeuthic options available in our institute (danazol). However, three of them had recurrent episodes of angioedema; in these cases, it was identified aspirin hypersensitivity as a cause of poor disease control. A review of the literature is included. Case Presentation: We present the cases of four females and one male (age range 21 - 58 years) with type I HAE. Subjects were all ISSSTE beneficiaries (state workers) treated at the National Medical Center “20 de Noviembre”. Aspirin hypersensitivity was identified in three patients. Elimination of NSAIDs along with dietary elimination of high salicylate-containing foods improved control of angioedema crisis (severe and/ or recurrent episodes). Discussion: Aspirin hypersensitivity was identified as a factor for poor control in our patients with HAE. Such cases improved with dietary elimination of high salicylate-containing foods and avoidance of NSAIDs. Conclusions: This is the first report of patients with HAE and aspirin hypersensitivity as a cause of poor control. We recommend a deliberate search of these comorbidities, especially in cases of poor disease control. Further studies are needed to continue the investigation on this topic.
Phenocopies: Mimics of Inborn Errors of Immunity  [PDF]
Cesar Daniel Alonso-Bello, Sara Elva Espinosa-Padilla, Mariano Daniel Temix-Delfin, Fernando Lozano-Patino, Victoria Isabel Castaneda-Avila, Maria Eugenia Vargas-Camano, María Isabel Castrejón-Vázquez
Open Access Library Journal (OALib Journal) , 2020, DOI: 10.4236/oalib.1106041
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are called phenocopies. These are classified into two types, the associated with somatic mutations and those associated with auto-antibodies. The phenotypes that occur by any of the mechanisms mentioned are complex and varied. It is necessary to know the clinical manifestations of the pathologies classified in this group to enrich the possible differential diagnoses in individuals with suspected immunodeficiency.
Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians  [PDF]
García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camano María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel
Open Access Library Journal (OALib Journal) , 2019, DOI: 10.4236/oalib.1105419
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually <2500 xmm3) detected in blood cell cytometry that accompanies severe, recurrent infec-tions, autoimmune manifestations, atopy and cancer may suggest severe combined immunodeficiency. Causes of secondary immunodeficiency such as HIV should be ruled out. Conclusions: Persistent lymphopenia can be associated with severe combined immunodeficiency. The study should be extended in these cases by a specialist or refer the patient to a referral center for a complete evaluation.
Uneven chances of breastfeeding in Spain
Río Isabel,Luque álvaro,Castelló-Pastor Adela,Sandín-Vázquez María del Val
International Breastfeeding Journal , 2012, DOI: 10.1186/1746-4358-7-22
Abstract: Background No large scale studies on breastfeeding onset patterns have been carried out in Spain. This work aims to explore the prevalence and the risk factors for not initiating breastfeeding in hospitals from Catalonia (CAT) and Valencia (V), two regions accounting approximately for 30% of the annual births in Spain. Methods The prevalence of not initiating breastfeeding was calculated by maternal/neonatal characteristics and type of hospital, and logistic regression models were used to estimate crude and adjusted risks of not breastfeeding in each region. Results Prevalence of breastfeeding initiation was 81.7% and 82.5% in Catalonia and Valencia, respectively. We identified conspicuous regional differences in the adjusted-risk of not breastfeeding, especially for multiple [CAT = 3.12 (95% CI: 2.93, 3.31), V = 2.44 (95% CI: 2.23, 2.67)] and preterm and low birth weight deliveries [very preterm and very low birth weight: CAT = 7.61 (95% CI: 6.50, 8.92), V = 4.03 (95% CI: 3.13, 5.19); moderate preterm and moderate low birth weight: CAT = 4.28 (95% CI: 4.01, 4.57), V = 2.55 (95% CI:2.34, 2.79)]. Conclusions Our results suggest the existence of regional variations in breastfeeding initiation in Spain. Taking into account the known short and long-term benefits of breastfeeding it is recommended that further research should explore these differences in order to prevent potential inequities in neonatal, child and adult health.
Evaluación de impacto en salud: valorando la efectividad de las políticas en la salud de las poblaciones
Sandín-Vázquez,María; Sarría-Santamera,Antonio;
Revista Espa?ola de Salud Pública , 2008, DOI: 10.1590/S1135-57272008000300003
Abstract: health impact assessment is a comprehensive methodology proposed by the world health organization to determine the impact on health of projects, policies and strategies that are no originally specifically health-related but that could have on effect on health. this work aims to review the methodological approaches to health impact assessment, and determine its value in public health. health impact assessment is a multidisciplinary process that combines both qualitative and quantitative evidence in a decision-making frame. it is based on a model of health that includes the economic, political, social, psychological, and environmental determinants of health. if interventions with a real impact on the population?s health require a comprehensive and structural approach, with public health measures taken at political level, those responsible for implementing such measures have to engage in the decision-making process and in the assessment of its effectiveness. to conduct health impact assessment it is necessary to facilitate the integration of the existing data in order to perform the initial diagnosis and be able to investigate the late effects of the policy measures implemented. this way it will be possible to systematically monitor the effects on health of the actions which derive from health impact assessment, thus maximizing potential positive effects on health and preventing the potential adverse effects.
Glomerulonefritis membranosa, psoriasis y etanercept: ?Asociación casual o causal?
Florit,Enrique A.; úbeda-Aranda,Isabel; Delgado-Conde,Pablo; Rodríguez-Cubillo,Beatriz; Monzón-Vázquez,Tania; Flor Merino,José C. De la; Valga-Amado,Francisco; Barrientos-Guzmán,Alberto;
Nefrología (Madrid) , 2012,
Abstract: psoriasis is a cutaneous disease with systemic involvement. tisular damage is consider to be immunomediated, and actually is being effectively treated with etanercept. kidney damage of this patological condition is not completely clarified in the literature. we present a case of membranous nephropathy with c1q deposits that subsequently developed psoriasis. in this article we make a review of a possible association between these diseases and the respose to that biological molecule.
Probing a Polar Cluster in the Retinal Binding Pocket of Bacteriorhodopsin by a Chemical Design Approach
Rosana Simón-Vázquez, Marta Domínguez, Víctor A. Lórenz-Fonfría, Susana álvarez, José-Luís Bourdelande, ángel R. de Lera, Esteve Padrós, Alex Perálvarez-Marín
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042447
Abstract: Bacteriorhodopsin has a polar cluster of amino acids surrounding the retinal molecule, which is responsible for light harvesting to fuel proton pumping. From our previous studies, we have shown that threonine 90 is the pivotal amino acid in this polar cluster, both functionally and structurally. In an attempt to perform a phenotype rescue, we have chemically designed a retinal analogue molecule to compensate the drastic effects of the T90A mutation in bacteriorhodopsin. This analogue substitutes the methyl group at position C13 of the retinal hydrocarbon chain by and ethyl group (20-methyl retinal). We have analyzed the effect of reconstituting the wild-type and the T90A mutant apoproteins with all-trans-retinal and its 20-methyl derivative (hereafter, 13-ethyl retinal). Biophysical characterization indicates that recovering the steric interaction between the residue 90 and retinal, eases the accommodation of the chromophore, however it is not enough for a complete phenotype rescue. The characterization of these chemically engineered chromoproteins provides further insight into the role of the hydrogen bond network and the steric interactions involving the retinal binding pocket in bacteriorhodopsin and other microbial sensory rhodopsins.
Determining the True Polarity and Amplitude of Synaptic Currents Underlying Gamma Oscillations of Local Field Potentials
Gonzalo Martín-Vázquez, Julia Makarova, Valeri A. Makarov, Oscar Herreras
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075499
Abstract: Fluctuations in successive waves of oscillatory local field potentials (LFPs) reflect the ongoing processing of neuron populations. However, their amplitude, polarity and synaptic origin are uncertain due to the blending of electric fields produced by multiple converging inputs, and the lack of a baseline in standard AC-coupled recordings. Consequently, the estimation of underlying currents by laminar analysis yields spurious sequences of inward and outward currents. We devised a combined analytical/experimental approach that is suitable to study laminated structures. The approach was essayed on an experimental oscillatory LFP as the Schaffer-CA1 gamma input in anesthetized rats, and it was verified by parallel processing of model LFPs obtained through a realistic CA1 aggregate of compartmental units. This approach requires laminar LFP recordings and the isolation of the oscillatory input from other converging pathways, which was achieved through an independent component analysis. It also allows the spatial and temporal components of pathway-specific LFPs to be separated. While reconstructed Schaffer-specific LFPs still show spurious inward/outward current sequences, these were clearly stratified into distinct subcellular domains. These spatial bands guided the localized delivery of neurotransmitter blockers in experiments. As expected, only Glutamate but not GABA blockers abolished Schaffer LFPs when applied to the active but not passive subcellular domains of pyramidal cells. The known chemical nature of the oscillatory LFP allowed an empirical offset of the temporal component of Schaffer LFPs, such that following reconstruction they yield only sinks or sources at the appropriate sites. In terms of number and polarity, some waves increased and others decreased proportional to the concomitant inputs in native multisynaptic LFPs. Interestingly, the processing also retrieved the initiation time for each wave, which can be used to discriminate afferent from postsynaptic cells in standard spike-phase correlations. The applicability of this approach to other pathways and structures is discussed.
Crecimiento urbano y especialización económica en México. Una caracterización regional de las funciones dominantes
Adrián Guillermo Aguilar,María Isabel Vázquez
Investigaciones geográficas , 2000,
Abstract: El trabajo tiene por objetivo determinar la especialización funcional de las principales ciudades del país, a partir del análisis estadístico de componentes principales, con base en las variables de población ocupada en los diferentes sectores económicos en 1990. Para tal efecto se seleccionaron 101 ciudades que se ubican en el rango de 50 mi a más de un millón de habitantes. A partir de este método multivariado se identificaron funciones económicas dominantes para agrupar ciudades con características similares, y así relacionarlas con su rango-tama o y con su distribución regional.
Efectividad del coaching en los procesos de mejora de gestión de empresas
María Dolores Vidal-Salazar,Eulogio Cordón-Pozo,Vera Ferrón-Vílchez
Universia Business Review , 2011,
Abstract: En el actual contexto empresarial, las prácticas dirigidas a la formación y desarrollo del personal constituyen una herramienta clave para los gerentes. Este trabajo analiza la eficacia de una novedosa técnica relacionada con la capacitación y desarrollo personal: el coaching. Utilizando una muestra de 40 Pymes, se analizan los efectos que produce la aplicación del coaching ejecutivo a fin de analizar su impacto en la implantación de procesos de mejora dentro de las empresas.
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