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Search Results: 1 - 10 of 742941 matches for " Manuel S;Díaz de León Santiago "
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A Unified Methodology to Evaluate Supervised and Non-Supervised Classification Algorithms
Godoy Calderón, Salvador;Martínez Trinidad, José Francisco;Lazo-Cortes, Manuel S;Díaz de León Santiago, Juan Luis;
Computación y Sistemas , 2006,
Abstract: there is presently no unified methodology that allows the evaluation of supervised or non-supervised classification algorithms. supervised problems are evaluated through quality functions while non-supervised problems are evaluated through several structural indexes. in both cases a lot of useful information remains hidden or is not considered by the evaluation method, such as the quality of the sample or the structural change generated by the classification algorithm. this work proposes a unified methodology that can be used to evaluate both type of classification problems. this new methodology yields a larger amount of information to the evaluator regarding the quality of the initial sample, when it exists, and regarding the change produced by the classification algorithm in the case of non-supervised classification problems. it also offers the added possibility of making comparative evaluations with different algorithms.
Resultados de una encuesta nacional sobre hábito transfusional en unidades de cuidados intensivos
Quintana Díaz,Manuel; Sánchez Casado,Marcelino; Leal Noval,Santiago Ramón; García de Lorenzo y Mateos,Abelardo; ,;
Medicina Intensiva , 2009,
Abstract: introduction. blood derivatives are clinical products that are currently used, for which their lack of availability, clinical relevance and presence of associated side effect that make it necessary to known and evaluate their utility rigorously are characteristic. objective. to analyze knowledge of attitudes, knowledge and behavior on transfusional policy in the different spanish intensive care units (icu). design. a mail-based survey (electronic and conventional) in the icus. duration. the study was planned in 2005 and conducted during the year 2006. setting. spanish icus. patients and method. a 27-question questionnaire. results. most are middle-sized icus (10-20 beds), with predominantly medical activities. the staff member, alone or with the resident, generally decides the transfusion based on his/her experience, although with a tendency to follow the scientific guidelines. generally, there is no transfusional committee. when red blood packs are transfused, generally between 2 to 4 units are used. the hemoglobin value is orientative, although the decision is clear if < 7 g/dl (10 g/dl if there is heart disease). drug alternatives to transfusion are not generally used due to lack of evidence and price. in 50% of cases, the association between transfusion and increase in mortality is considered to be certain. conclusions. strong consideration must be made about transfusion and its over use should be avoided. for this purpose, educational guidelines and consensus meetings are necessary to establish recommendations on the use of blood products and their pharmacological alternatives.
Resultados de una encuesta nacional sobre hábito transfusional en unidades de cuidados intensivos Results of a national survey on transfusion habit in Intensive Care Units
Manuel Quintana Díaz,Marcelino Sánchez Casado,Santiago Ramón Leal Noval,Abelardo García de Lorenzo y Mateos
Medicina Intensiva , 2009,
Abstract: Introducción. Los hemoderivados son productos clínicos de uso habitual que presentan unas características de escasez, relevancia clínica y de efectos secundarios concomitantes que obligan a conocer y evaluar su utilización con rigurosidad. Objetivo. Analizar actitudes, conocimientos y conductas sobre la política transfusional de las diferentes unidades de cuidados intensivos (UCI) espa olas. Dise o. Encuesta mediante correo (electrónico y tradicional) en las unidades de cuidados intensivos. Periodo. Planificación durante 2004 y realización durante todo 2005. ámbito. UCI espa olas. Pacientes y método. Cuestionario de 27 preguntas. Resultados. La mayoría son UCI de tama o medio (10-20 camas), con actividad predominantemente médica. El adjunto, solo o con el residente, suele decidir la transfusión según su experiencia, aunque con tendencia a seguir las recomendaciones científicas. No suele haber comités transfusionales. Cuando se transfunden concentrados de hematíes, suelen ser entre 2 y 4 unidades. La cifra de hemoglobina es orientativa, aunque la decisión es clara si es < 7 g/dl (10 g/dl si hay cardiopatía). No se suele emplear alternativas farmacológicas a las transfusiones por motivos de escasa evidencia y precio. En el 50% de los casos se considera cierta la relación entre transfusión y aumento de mortalidad. Conclusiones. Debemos reflexionar sobre la transfusión y evitar la sobreutilización. Para ello se necesitan protocolos educacionales y conferencias de consensos que establezcan recomendaciones sobre el uso de los hemoderivados y sus alternativas farmacológicas. Introduction. Blood derivatives are clinical products that are currently used, for which their lack of availability, clinical relevance and presence of associated side effect that make it necessary to known and evaluate their utility rigorously are characteristic. Objective. To analyze knowledge of attitudes, knowledge and behavior on transfusional policy in the different Spanish Intensive Care Units (ICU). Design. A mail-based survey (electronic and conventional) in the ICUs. Duration. The study was planned in 2005 and conducted during the year 2006. Setting. Spanish ICUs. Patients and Method. A 27-question questionnaire. Results. Most are middle-sized ICUs (10-20 beds), with predominantly medical activities. The staff member, alone or with the resident, generally decides the transfusion based on his/her experience, although with a tendency to follow the scientific guidelines. Generally, there is no transfusional committee. When red blood packs are transfused, generally between 2 to 4 uni
Efectos contráctiles dependientes del calcio intracelular inducidos por la serotonina en la arteria umbilical humana
Briones-Gardu?o, Jesús Carlos;Castillo-Henkel, Carlos;López-Canales, Jorge Skiold;Díaz de León-Ponce, Manuel;
Gaceta médica de México , 2005,
Abstract: background: absence of innervation is a hallmark of human umbilical vessels. intervillous space blood flow is regulated by vasoactive substances and calcium dependent contractility, both in normal and pathological conditions such as preeclampsia eclampsia. objective: to obtain additional information on the intracellular calcium contractile effects of serotonin in human umbilical arteries. materials and methods: umbilical arteries from normal pregnancies were dissected, cut in 5 mm rings and mounted in a temperature controlled isolated organ chamber, using calciumfree krebs solution. the contractile effects of serotonin, lantane, verapamil and cyclopiazonic acid were evaluated at different concentrations using a computer coupled biopac polygraph. results: no differences in response were observed in the presence and absence of intracellular calcium. the positive contractile effects observed with serotonin were significantly decreased with repeated stimulation. an increase in the basal tone of the vessel was observed after calcium supplementation was added to the solution. this effect was minimized in the presence of verapamil and lantane. the contractile effects of serotonin in the calcium free solution were not affected by the presence of cyclopiazonic acid. conclusions: serotonin contractile effects in the human umbilical artery depend mainly on intracellular calcium levels which favor the gradual entrance of this ion over time. calcium influx induced by serotonin is possible through l and non-l channels apparently insensitive to cyclopiozonic acid.
En la población Canaria, la función de Framingham estima mejor el riesgo de mortalidad cardiovascular que la función SCORE
Cabrera de León,Antonio; Alemán Sánchez,José J.; Rodríguez Pérez,María C.; Castillo-Rodríguez,José C. del; Domínguez-Coello,Santiago; Almeida-González,Delia; Anía Lafuente,Basilio; Aguirre Jaime,Armando; Brito Díaz,Buenaventura;
Gaceta Sanitaria , 2009, DOI: 10.1590/S0213-91112009000300009
Abstract: introduction: to compare the performance of the framingham and score functions to estimate fatal cardiovascular events. in addition, we explored the ability of both functions to detect the risk contributed by factors not included in their equations: sedentariness, obesity, abdominal circumference, abdomen/height razón, abdomen/pelvis ratio, and excessive alcohol consumption. methods: we performed a cross-sectional study of 5,289 individuals aged 30 to 69 years old, recruited by random sampling of the general population of the canary islands. we calibrated the framingham and score functions and estimated their concordance. the cardiovascular mortality rate for the population in this age range was compared with the risk predicted by the two functions. results: among males, the mortality rate per 100,000 inhabitants was 67.4, while the framingham, score-low and score-high estimations were 80, 140, and 270, respectively. among females, the mortality rate was 19.3 while the estimations were 30, 50, and 70, respectively. both functions detected the increased risk contributed by the factors studied, except for sedentariness among females with score, and excessive alcohol consumption with both functions. among males, taking cut points of > 12%, > 15%, and > 20% for framingham, the concordance with score-low yielded kappa values of 0.6, 0.7, and 0.5, respectively. conclusions: the framingham function yielded the best estimate of cardiovascular mortality rates. only framingham detected the cardiovascular risk contributed by sedentariness in both genders. we recommend the use of the calibrated framingham function for this population.
Estilo de vida y adherencia al tratamiento de la población canaria con diabetes mellitus tipo 2
Cabrera de León,Antonio; Castillo Rodríguez,José Carlos del; Domínguez Coello,Santiago; Rodríguez Pérez,María del Cristo; Brito Díaz,Buenaventura; Borges álamo,Carlos; Carrillo Fernández,Lourdes; Almeida González,Delia; Alemán Sánchez,José Juan; González Hernández,Ana; Aguirre-Jaime,Armando;
Revista Espa?ola de Salud Pública , 2009, DOI: 10.1590/S1135-57272009000400008
Abstract: background: the canary islands population experiences the highest type 2 diabetes (dm2) mortality in spain. we studied lifestyle, unknown dm2 and treatment adherence in diabetics of these islands. methods: cross-sectional study of 6729 subjects from the general population (age 18-75) that participate in the cohort study "cdc of the canary islands". we found out their medical problems, diet, physical activity, medications, smoking, etc. results: prevalence of dm2 was 12% in men and 10% in women (p=0.005). the disease was unknown in 22% of men and 9% of women (p < 0.001). considering unknown dm2, lack of treatment and lack of adherence, 48% of men and 28% of women did not follow a regular treatment. diabetics' men prevalences of smoking (28%; ci95%=23-33) and sedentariness (62%; ci95%=56-68) were similar to non diabetic men, but obesity was more frequent in diabetics (45 versus 25%; p < 0.001). diabetics women showed a higher obesity (54 versus 27%; p < 0.001) and a lower smoking prevalence (11 versus 22%; p < 0,001) than non diabetics, but they presented a similar sedentariness (75%; ci95%=70-79). in both sexes, energy intake was lower in diabetics (p < 0.001), but 93% of them (ci95%=91-95) showed a high consumption of calories from saturated fat and 69% (ci95%=65-72) presented metabolic syndrome. conclusions: the canarian diabetics are a sedentary and obese population that show a high consumption of saturated fats and high prevalence of metabolic syndrome. the proportion of them following regular treatment is low, specially in diabetic men that, in addition, still smoke.
Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis
Leonardo Lorente, María M Martín, Lorenzo Labarta, César Díaz, Jordi Solé-Violán, José Blanquer, Josune Orbe, José A Rodríguez, Alejandro Jiménez, Juan M Borreguero-León, Felipe Belmonte, Juan C Medina, Maria C LLimi?ana, José M Ferrer-Agüero, José Ferreres, María L Mora, Santiago Lubillo, Manuel Sánchez, Ysamar Barrios, Antonio Sierra, José A Páramo
Critical Care , 2009, DOI: 10.1186/cc8115
Abstract: This was a multicenter, observational, and prospective study carried out in six Spanish Intensive Care Units. We included 192 (125 surviving and 67 nonsurviving) patients with severe sepsis and 50 age- and sex-matched healthy controls in the study. Serum levels of MMP-9, MMP-10, TIMP-1, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10 were measured in patients with severe sepsis at the time of diagnosis and in healthy controls.Sepsis patients had higher levels of MMP-10 and TIMP-1, higher MMP-10/TIMP-1 ratios, and lower MMP-9/TIMP-1 ratios than did healthy controls (P < 0.001). An association was found between MMP-9, MMP-10, TIMP-1, and MMP-9/TIMP-1 ratios and parameters of sepsis severity, assessed by the SOFA score, the APACHE-II score, lactic acid, platelet count, and markers of coagulopathy. Nonsurviving sepsis patients had lower levels of MMP-9 (P = 0.037), higher levels of TIMP-1 (P < 0.001), lower MMP-9/TIMP-1 ratio (P = 0.003), higher levels of IL-10 (P < 0.001), and lower TNF-α/IL-10 ratio than did surviving patients. An association was found between MMP-9, MMP-10, and TIMP-1 levels, and TNF-α and IL-10 levels. The risk of death in sepsis patients with TIMP-1 values greater than 531 ng/ml was 80% higher than that in patients with lower values (RR = 1.80; 95% CI = 1.13 to 2.87;P = 0.01; sensitivity = 0.73; specificity = 0.45).The novel findings of our study on patients with severe sepsis (to our knowledge, the largest series reporting data about MMP levels in sepsis) are that reduced MMP-9/TIMP-1 ratios and increased MMP-10 levels may be of great pathophysiologic significance in terms of severity and mortality, and that TIMP-1 levels may represent a biomarker to predict the clinical outcome of patients with sepsis.Matrix metalloproteinases (MMPs) are a family of zinc-containing endoproteinases implicated in degradation and remodelling of the extracellular matrix (ECM). They can be classified broadly by substrate specificity into collagenases (MMP-1
Operadores k-estadísticos para morfología matemática de conjuntos
Díaz de León Santiago,Juan; Gamino,Arturo; Salgado,Julio; Trujillo,Valentín; Ortiz,Alicia;
Revista Facultad de Ingeniería Universidad de Antioquia , 2009,
Abstract: a generalization of the basic operators in mathematical morphology is presented in this paper. the resulting generalization lead to the construction of the k-statistical operators, due to its ability to obtain geometricaly the statistical descriptors within the range of the operator (z={0,1}). these operators can be less strict as to the expected result as in the basic operators of dilation and erosion. furthermore, a single k-statistical operator represents a functional complete set that includes erosion and dilation as particular cases. in a k-statistical operator, the condition to obtain the resulting set depends on whether the area (number of elements) of intersection between the translated structural set and the original set is at least equal to k. as a consecuence, a single parameter (k) is able to create a manifold of operators ranging from erosion to dilation. hence, other kinds of openings and closings with new behavior are created as alternative solutions to binary image processing problems.
Memorias Asociativas Basadas en Relaciones de Orden y Operaciones Binarias
Yá?ez Márquez, Cornelio;Díaz de León Santiago, Juan Luis;
Computación y Sistemas , 2003,
Abstract: a new model for associative memories is proposed in this paper. the mathematical tools used in this new model, include two binary operators designed specifically for the memories developed here. these operators were arbitrarily named as the first two letters from the greek alphabet: α and β. the new associative memories (αβ) are of two kinds and are able to operate in two different modes. the operator α is useful at the learning phase, and the operator β is the basis for the pattern recall phase. the properties within the algebraic operators α and β, allow the αβ memories to exhibit similar characteristics to the ones inherent to the binary version of the morphological associative memories, in the sense of: learning capacity, type and amount of noise against which the memory is robust, and the sufficient conditions for perfect recall. moreover, it is important to point out that the arithmetic density of the proposed memories is smaller than the arithmetic density exhibited by the morphological ones. the main reason for taking the morphological associative memories as the reference point for the genesis of the proposed ones, consist in that the authors of the first ones have already shown that the morphological associative memories are superior in some aspects to the known models of associative memories, up to the beginning of the third millenium.
Un paradigma proactivo orientado a objetos
Sarmiento Tovilla, Juan Carlos;Díaz de León Santiago, Juan Luis;Chimal Eguía, Juan Carlos;
Computación y Sistemas , 2010,
Abstract: at present, some researchers consider that languages like c + +, java and c # have an interactive guide. the use of interactive programming by developers often produces unnecessary system development's costs; this involves the developer to extra knowledge when applying the software re-engineering. this paper presents an approach based on proactive computing, which looks electronic devices to interact in benefit of the human being. due to this need, we developed and formalized the base of an object-oriented proactive-paradigm. that is, the proposed paradigm provides an alternative to solve some problems that need to be incremental, based on the passage of messages. this perspective adds rules to the object-oriented paradigm, which allows itself the objects to communicate by called methods: activators and activated.
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