Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Search Results: 1 - 10 of 1398 matches for " Mandy Sanders "
All listed articles are free for downloading (OA Articles)
Page 1 /1398
Display every page Item
A Complimentary Ministry? The Psychological Type of Clergy Women in the Church in Wales  [PDF]
Mandy Robbins
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.615192
Abstract: The debate around the admission of women to the ministry of the Anglican churches has focused on a number of issues, not least, the extent to which women bring “balance” to ministry (see for example Furlong, 1991). Balance, when used in this context is usually seen as bringing different gifts to ministry. The assumption often made is that these “different gifts” will be those traditionally associated with women such as work with children. This argument has been employed by both those for and against the entry of women into holy orders (Harris & Shaw, 2004; Baker, 2004). Benjamin Schneider’s attraction-selection-attrition theory suggests that the group of people within an organisation move toward homogeneity. Schneider’s theory would suggest that the argument that women bring balance to ministry would not be supported. The current study employs psychological type theory to explore whether clergywomen in the Church in Wales do bring “balance” to ministry or “homogeneity”. The psychological type profile of a sample of 75 Church in Wales clergywomen measured by the Francis Psychological Type Scales (FPTS) is compared with a sample of 266 Church in Wales clergymen (Francis, Payne, & Robbins, 2013). The findings present no significant differences between the clergymen and clergywomen with regard to their judging function, perceiving function, orientation to the outer world or attitude toward the outer world. This finding lends support to Schneider’s theory. The implications of these findings for ministry in the Church in Wales are discussed.
Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group
Thomas Walker, Lisa Klasson, Mohammed Sebaihia, Mandy J Sanders, Nicholas R Thomson, Julian Parkhill, Steven P Sinkins
BMC Biology , 2007, DOI: 10.1186/1741-7007-5-39
Abstract: The sequencing of the wPip strain of Wolbachia revealed the presence of 60 ankyrin repeat domain (ANK) encoding genes and expression studies of these genes were carried out in adult mosquitoes. One of these ANK genes, pk2, is shown to be part of an operon of three prophage-associated genes with sex-specific expression, and is present in two identical copies in the genome. Another homolog of pk2 is also present that is differentially expressed in different Cx. pipiens group strains. A further two ANK genes showed sex-specific regulation in wPip-infected Cx. pipiens group adults.The high number, variability and differential expression of ANK genes in wPip suggest an important role in Wolbachia biology, and the gene family provides both markers and promising candidates for the study of reproductive manipulation.Wolbachia are obligate endosymbiotic bacteria that are maternally transmitted through the egg cytoplasm and are responsible for several reproductive disorders in arthropods, such as cytoplasmic incompatibility (CI) in infected Culex mosquitoes [1,2] and many other insects. Although Wolbachia are not found in mature sperm, they can modify developing sperm, possibly via chromatin binding proteins [3], such that when they fertilise an uninfected egg embryonic development is arrested. The reciprocal cross between infected females and uninfected males is, however, compatible; Wolbachia-infected females therefore produce a higher mean number of offspring than uninfected females. This unidirectional CI enables Wolbachia to rapidly invade uninfected populations [4], and provides a mechanism for driving anti-pathogen transgenes or a lifespan-shortening phenotype into mosquito populations [5,6]. Bidirectional CI can also occur between insect populations, usually when they are infected with different strains of Wolbachia.The genome sequence of the wMel strain [7], a CI-inducing Wolbachia strain found in Drosophila melanogaster, revealed an unusually high number of ankyrin
Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax
Andrew P. Jackson?,Sophie Goyard?,Dong Xia?,Bernardo J. Foth?,Mandy Sanders,Jonathan M. Wastling?,Paola Minoprio?,Matthew Berriman
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003975
Abstract: The parasitic flagellate Trypanosoma vivax is a cause of animal trypanosomiasis across Africa and South America. The parasite has a digenetic life cycle, passing between mammalian hosts and insect vectors, and a series of developmental forms adapted to each life cycle stage. Each point in the life cycle presents radically different challenges to parasite metabolism and physiology and distinct host interactions requiring remodeling of the parasite cell surface. Transcriptomic and proteomic studies of the related parasites T. brucei and T. congolense have shown how gene expression is regulated during their development. New methods for in vitro culture of the T. vivax insect stages have allowed us to describe global gene expression throughout the complete T. vivax life cycle for the first time. We combined transcriptomic and proteomic analysis of each life stage using RNA-seq and mass spectrometry respectively, to identify genes with patterns of preferential transcription or expression. While T. vivax conforms to a pattern of highly conserved gene expression found in other African trypanosomes, (e.g. developmental regulation of energy metabolism, restricted expression of a dominant variant antigen, and expression of ‘Fam50’ proteins in the insect mouthparts), we identified significant differences in gene expression affecting metabolism in the fly and a suite of T. vivax-specific genes with predicted cell-surface expression that are preferentially expressed in the mammal (‘Fam29, 30, 42’) or the vector (‘Fam34, 35, 43’). T. vivax differs significantly from other African trypanosomes in the developmentally-regulated proteins likely to be expressed on its cell surface and thus, in the structure of the host-parasite interface. These unique features may yet explain the species differences in life cycle and could, in the form of bloodstream-stage proteins that do not undergo antigenic variation, provide targets for therapy.
Fitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids
Bruce Humphrey, Nicholas R Thomson, Christopher M Thomas, Karen Brooks, Mandy Sanders, Anne A Delsol, John M Roe, Peter M Bennett, Virve I Enne
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-53
Abstract: For the IncP1 group pairwise in vitro growth competition demonstrated that the fitness cost of plasmid RP1 depends on the host strain. For the IncN group, plasmids R46 and N3 whose sequence is presented for the first time conferred remarkably different fitness costs despite sharing closely related backbone structures, implicating the accessory genes in fitness. Silencing of antimicrobial resistance genes was found to be beneficial for host fitness with RP1 but not for IncN plasmid pVE46.These findings suggest that the fitness impact of a given plasmid on its host cannot be inferred from results obtained with other host-plasmid combinations, even if these are closely related.Antibiotic resistance is a serious threat to human and animal health and new ways to combat it are urgently needed. Broad-host range plasmids, such as those belonging to the IncN and IncP1 groups are important to the dissemination of antibiotic resistance due to their ability to replicate in a variety clinically relevant bacterial species and environments [1,2]. Indeed, both IncN and IncP1 group plasmids have been shown to encode clinically important resistance determinants such as blaCTX-M, blaIMP, blaNDM, blaVIM and qnr [3-8], whilst IncN plasmids have also been strongly implicated in the recent spread of blaKPC encoded carbapenemases [9].Antimicrobial resistance can sometimes be accompanied by a reduction in biological fitness in the absence of antibiotic selection. Hence, less fit resistant bacteria may be outcompeted and displaced by fitter, susceptible bacteria in the absence of antibiotic use, leading to the suggestion that it may be possible to reduce the prevalence of antibiotic resistance by temporarily restricting prescribing. In practice, however, such approaches have enjoyed mixed success [10-14].A fitness cost of antibiotic resistance has often been demonstrated in the case of chromosomal mutations conferring resistance, for example in the case of fusA mutations conferring resistanc
Genomic Confirmation of Hybridisation and Recent Inbreeding in a Vector-Isolated Leishmania Population
Matthew B. Rogers equal contributor,Tim Downing equal contributor,Barbara A. Smith,Hideo Imamura,Mandy Sanders,Milena Svobodova,Petr Volf,Matthew Berriman,James A. Cotton ,Deborah F. Smith
PLOS Genetics , 2014, DOI: doi/10.1371/journal.pgen.1004092
Abstract: Although asexual reproduction via clonal propagation has been proposed as the principal reproductive mechanism across parasitic protozoa of the Leishmania genus, sexual recombination has long been suspected, based on hybrid marker profiles detected in field isolates from different geographical locations. The recent experimental demonstration of a sexual cycle in Leishmania within sand flies has confirmed the occurrence of hybridisation, but knowledge of the parasite life cycle in the wild still remains limited. Here, we use whole genome sequencing to investigate the frequency of sexual reproduction in Leishmania, by sequencing the genomes of 11 Leishmania infantum isolates from sand flies and 1 patient isolate in a focus of cutaneous leishmaniasis in the ?ukurova province of southeast Turkey. This is the first genome-wide examination of a vector-isolated population of Leishmania parasites. A genome-wide pattern of patchy heterozygosity and SNP density was observed both within individual strains and across the whole group. Comparisons with other Leishmania donovani complex genome sequences suggest that these isolates are derived from a single cross of two diverse strains with subsequent recombination within the population. This interpretation is supported by a statistical model of the genomic variability for each strain compared to the L. infantum reference genome strain as well as genome-wide scans for recombination within the population. Further analysis of these heterozygous blocks indicates that the two parents were phylogenetically distinct. Patterns of linkage disequilibrium indicate that this population reproduced primarily clonally following the original hybridisation event, but that some recombination also occurred. This observation allowed us to estimate the relative rates of sexual and asexual reproduction within this population, to our knowledge the first quantitative estimate of these events during the Leishmania life cycle.
Replacement of a Cuticular Apophysisin Larval Sarcopha Bullata(Diptera, Insecta) During Moulting
Mandy Kotzman
Psyche , 1989, DOI: 10.1155/1989/59798
Quality Education and the Marketplace: An Exploration of Neoliberalism and its Impact on Higher Education
Mandy Frake
Brock Education : a Journal of Educational Research and Practice , 2010,
Abstract: This paper is an in attempt to open discussion about the impact of globalization and theories of neoliberalism on higher education. More specifically, viewing higher education institutions as a market place, where the more a product costs, the greater supply and quality of the product should be received; the quality of education received by university students should also reflect this. Considering the conflict between teaching and research in higher education, quality of education becomes questionable. This paper explores issues of neoliberalism resulting in a greater demand for the completion of research in higher education institutions. Furthermore, the imperialism of higher education leading towards the demand for more research, the teaching versus research nexus within universities, and discussion of how these theories impact international students will be examined throughout this paper
Quantitative Convergence for Cerebral Processing of Information within the Geomagnetic Environment  [PDF]
Mandy A. Scott, Michael A. Persinger
Journal of Signal and Information Processing (JSIP) , 2013, DOI: 10.4236/jsip.2013.43036

Human cerebral systems are immersed in the earth’s magnetic field. To be consistent with the results of several correlational studies, we found that the most accurate detection of information at 50 m occurred when the geomagnetic activity was ~5 nT. The corresponding magnetic energy within the cerebral volume is equivalent to approximately 3 million bits of Landauer Limit quantum which is equivalent to low resolution photographs. Non-linear analyses indicated that the induced electric fields from the typical time variation of geomagnetic intensity converged with the Adey voltages for the threshold for background entropy. The relevance of signal/noise ratios and the recent evidence indicate that imagery and cognition may actually reflect fields of biophotons within a fixed volume, which indicates that a natural processing system may be occurring under very specific conditions that involves detection of recondite information at a distance.

Walking and Aerobic Capacity in Old Adults after Concentric and Eccentric Endurance Exercise at Self-Selected Intensities  [PDF]
Mandy L. Gault, Mark E. T. Willems
Health (Health) , 2014, DOI: 10.4236/health.2014.68085
Abstract: Self-selected exercise intensity can be a useful exercise prescription tool for older adults; however, it is not known if it can elicit improvements in walking and aerobic capacity. In older adults, effects of concentric or eccentric endurance exercise at self-selected walking speed were examined on 1-mile indoor walk performance, predicted maximum oxygen uptake and physiological parameters. Twenty-four older adults (67 ± 4 years) completed 3 × 30 min treadmill walks per week for 12-weeks on level (LTW, n = 11, 0%) or downhill (DTW, n = 13, ﹣10%) treadmill gradient at a self- selected speed, which progressed every 4 weeks. Maximal oxygen uptake was predicted using a 1-mile walk at 4-week intervals with physiological responses recorded using a portable metabolic system. One-mile walking speed increased from baseline following 8- and 12-weeks (12 weeks: LTW: 13% ± 6%, DTW: 14% ± 9%, P < 0.01). Both groups increased predicted maximal oxygen uptake following 8-weeks of walking (LTW: 15% ± 15%; DTW: 23% ± 30%, P < 0.01). At 12-weeks, the 1-mile walk was performed with higher heart rates and minute ventilation (P < 0.01). It is concluded that an exercise programme of concentric or eccentric endurance exercise, at self-selected exercise intensity, is sufficient to elicit similar improvements in maximum oxygen uptake.
Responses of Macroinvertebrate Community Metrics to a Wastewater Discharge in the Upper Blue River of Kansas and Missouri, USA  [PDF]
Barry C. Poulton, Jennifer L. Graham, Teresa J. Rasmussen, Mandy L. Stone, Mandy L. Stone
Journal of Water Resource and Protection (JWARP) , 2015, DOI: 10.4236/jwarp.2015.715098
Abstract: The Blue River Main wastewater treatment facility (WWTF) discharges into the upper Blue River (725 km2), and is recently upgraded to implement biological nutrient removal. We measured biotic condition upstream and downstream of the discharge utilizing the macroinvertebrate protocol developed for Kansas streams. We examined responses of 34 metrics to determine the best indicators for discriminating site differences and for predicting biological condition. Significant differences between sites upstream and downstream of the discharge were identified for 15 metrics in April and 12 metrics in August. Upstream biotic condition scores were significantly greater than scores at both downstream sites in April (p = 0.02), and in August the most downstream site was classified as non-biologically supporting. Thirteen EPT taxa (Ephemeroptera, Plecoptera, Trichoptera) considered intolerant of degraded stream quality were absent at one or both downstream sites. Increases in tolerance metrics and filtering macroinvertebrates, and a decline in ratio of scrapers to filterers all indicated effects of increased nutrient enrichment. Stepwise regressions identified several significant models containing a suite of metrics with low redundancy (R2 = 0.90 - 0.99). Based on the rapid decline in biological condition downstream of the discharge, the level of nutrient removal resulting from the facility upgrade (10% - 20%) was not enough to mitigate negative effects on macroinvertebrate communities.
Page 1 /1398
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.