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Search Results: 1 - 10 of 18 matches for " Manana Gordeziani "
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Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)  [PDF]
Manana Alibegashvili, Nato Veshapidze, Liana Ramishvili, Manana Gordeziani, Teimuraz Chigogidze, Nino Gabunia, Ana Khazaradze, Nanuli Kotrikadze
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.615136
Abstract: The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na+/K+-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na+/K+-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondinglyprotective abilities of an organism, which was proved by the anamneses of patients.
Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors  [PDF]
Irina Nakashidze, Anzor Diasamidze, Davit Baratashvili, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, Ana Khazaradze, Nanuli Kotrikadze
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.55047

Objectives: The aim of the investigation was to study the hormonal status (sex hormones: estradiol (E2), progesterone (P), testosterone (T); non-sex gonadotropic hormones-luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and malignant tumors of uterine body in the reproductive, menopause and postmenopause periods. Also the distribution features of the blood ABO system phenotype groups and their link to the development of uterine body tumors have been studied. Methods: The determination of hormones was made by the enzyme analysis method (ELAIZA), provided by the proper ELAIZA kits. For the study of blood ABO system antigens, internationally recognized immunoserology methods were used. Results: Investigations revealed the increased level of E2 and T on the background of the reduced P in the blood of the women with uterine tumors in the reproductive, menopause and post-menopause period. As for gonadotropic hormones, the decreased levels of LH and FSH have also been detected. From the ABO system phenotype groups A(II) group had the highest frequency between the women with malignant uterine tumor in the reproductive age. O

Laser Induced Fluorescence Studies of Blood Plasma and Tumor Tissue of Men with Prostate Tumors  [PDF]
Liana Ramishvili, Irma Bochorishvili, Nino Gabunia, Zurab Kuchukashvili, Teimuraz Chigogidze, Ana Khazaradze, Zaza Melikishvili, Nanuli Kotrikadze, Manana Gordeziani
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.511107
Abstract: Objectives: Fluorescence spectroscopy which can be used for optical tissue diagnosis of tumor pathology deserves special interest. The purpose of the work was to study blood plasma and tumor tissue of men with different forms of prostate tumors by using laser induced fluorescence. Blood plasma and tumor tissue of the patients with benign hyperplasia of the prostate (BHP), BHP with inflammation, BHP with high grade PIN (BHP with HGPIN) and adenocarcinoma of prostate (CaP) have been studied. Results: In case of blood plasma fluorescence, intensity of the plasma proteins corresponding peak (340 - 360 nm) was increasing in the following manner: control group → BHP → BHP with HGPIN → CaP. The intensity of the nicotinamide coenzymes correspond peak (440 - 460 nm) was increased in case of BHP with HGPIN and CaP patients, but decreased in case of BHP, compared to control. In case of tumor tissue, the changes of the collagen peak (390 - 400 nm) intensity have been revealed in all cases of prostate tumor tissues. These alterations point to altered collagen biosynthesis levels in different tumor tissues, that reflects the structural changes and characteristics of malignant transformation. Also the changes of the nicotinamide coenzymes peak (440 - 460 nm) intensity in all spectra of tumor tissues were observed. The highest intensity of the peak was observed in the spectra of BHP with HGPIN and in prostate cancer tissue. Conclusions: Alterations of the coenzymes peak intensities perfectly reflect and are in accordance with the specific energy metabolism of prostate epithelial cells. Normalization of fluorescent spectra from different forms of prostate tumor tissues has shown that, each form has typical spectral shape and ratio of fluorescence peaks intensities.
Prediction Capabilities of VLF/LF Emission as the Main Precursor of Earthquake
Manana Kachakhidze,Nino Kachakhidze
Physics , 2013,
Abstract: Recent satellite and ground-based observations proved that in earthquake preparation period in the seismogenic area we have VLF/LF and ULF electromagnetic emissions. According to the opinion of the authors of the present paper this phenomenon is more universal and reliable than other earthquake indicators. Hypothetically, in case of availability of adequate methodological grounds, in the nearest future, earth VLF/LF electromagnetic emission might be declared as the main precursor of earthquake. In particular, permanent monitoring of frequency spectrum of earth electromagnetic emission generated in the earthquake preparation period might turn out very useful with the view of prediction of large (M 5) inland earthquakes. The present paper offers a scheme of the methodology according to which the reality of the above given hypothesis can be checked up. To prove the prediction capabilities of earth electromagnetic emission we have used avalanche-like unstable model of fault formation and an analogous model of electromagnetic contour, synthesis of which, according to our opinion, is rather harmonious.
Entropy-based disciplinarity indicator: role taxonomy of journals in scientific communication systems and isolation degree. Knowledge importation/exportation profiles from journals and disciplines
J. Manana-Rodriguez
Computer Science , 2013,
Abstract: In this research, a new indicator of disciplinarity-multidisciplinarity is developed, discussed and applied. EBDI is based on the combination of the frequency distribution of subject categories of journals citing or cited by the analysis unit and the spread and diversity of the citations among subject categories measured with Shannon-Wiener entropy. Its reproducibility, robustness and consistence are discussed. Four of the combinations of its values when applied to the cited and citing dimensions lead to a suggested taxonomy of the role that the studied unit might have in terms of the transformation of knowledge from different disciplines in the scientific communication system and its position respect a hypothetical thematic core of the discipline in which it has been classified. The indicator is applied to the journals belonging to the first quartile of JCR-SSCI 2011 Library and Information Science and an indicator-based taxonomy is applied and discussed, pointing to differential thematic roles of the journals analyzed.
The Comparative Analysis of Perfect in German, English and Old Russian
Seda Asaturovi,Tamar Mikeladze,Manana Napireli
European Researcher , 2012,
Abstract: The article studies Perfect in German, English and Old Russian. Perfect is a complicated past tense, which is formed by the auxiliary verb and Perfect. The comparative analysis showed that these three languages have much in common in Perfect forming and its meaning, although Perfect doesn’t exist in modern Russian.
Problems of Russian enterprises switch to modern quality management
Manana I. Pachkoriya,Irina N. Markaryan
European Researcher , 2011,
Abstract: The article determines the problems of enterprises switch to quality management system in the modern context, characterizes Total Quality Management.
Fractions of proton, helium, middle and heavy nuclei in primary cosmic rays at energy 10**16eV
Maia Kalmakhelidze,Nina Roinishvili,Manana Svanidze
Physics , 2001,
Abstract: Classification of gamma-hadron families, registered by the Pamir collaboration, on four groups of nuclei (P, He, middle and heavy), responsible for their generation, is made, and fractions of families in each of the groups are estimated. Results show, that below the knee of the energy spectrum the chemical composition of primary cosmic rays remains close to the normal one.
Primary cosmic ray chemical composition in the energy region around 10**16 eV investigated by means of gamma-hadron families
Maia Kalmakhelidze,Nina Roinishvili,Manana Svanidze
Physics , 2001,
Abstract: Primary Cosmic Ray Chemical Composition is investigated in energy region close to 10**16 eV. Studies are based on comparisons of gamma-hadron families observed by Pamir and Pamir-Chacaltaya Collaboration, with families generated by means of quasi-scaling model MC0. It is shown, that all characteristics of observed families, including their intensity, are in a very good agreement with simulated event properties at the normal chemical composition and are in disagreement at heavy dominant compositions. Code CORSICA with VENUS and DPM models also contradicts with experimental data of families. One- and multi-dimensional methods of recognition of Fe-like families is worked up and approved. They are based on family characteristics sensitive to atomic number of induced nuclei and are not correlated between each others. It is shown that the fraction of Fe-like families is consistent with the normal chemical composition and strongly contradicts to heavy dominant ones. The success of MC0 model, in description of families properties, is due to large inelasticity coefficient of soft interactions at superhigh energies.
Novel Diazole/Triazole and Dibenzothiophene Dioxide Containing Pentacyclic Systems with Promising Biological Activities  [PDF]
Mamuka Maisuradze, Giorgi Phalavadishvili, Nana Gakhokidze, Manana Matnadze, Sofo Tskhvitaia, Elene Kalandia
International Journal of Organic Chemistry (IJOC) , 2017, DOI: 10.4236/ijoc.2017.71004
Abstract: The aim of the current work is to synthesize the new heterocyclic pentacyclic condensed systems that combine benzothiophen and benzimidazole/triazole into one molecule. The dibenzothiophene was taken as an initial compound and by consistent “extension” was annihilated the imidazole and triazole nucleuses. As a result two new pentacyclic systems were produced: 3H-, 7H-diimidazole[4,5-b][5,4-g] dibenzothiophene-5,5-dioxide and 3H-, 7H-ditriazole[4,5-b][5,4-g] dibenzothiophene-5,5-dioxide with the promising antimi-crobial activity. Their spectral characteristics were studied.
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